Articles tagged with Oxidative Stress
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Scientists have discovered a novel mechanism that helps cells respond to oxidative stress, a major cause of Parkinson's and Alzheimer's diseases. The new mechanism involves a protein modification called ubiquitination, which stabilizes ribosome function and promotes protein synthesis.
A new study found that BPA exposure during pregnancy causes oxidative stress, which may lead to the development of diabetes and heart disease. Researchers analyzed blood samples from mother-infant pairs and found higher levels of BPA associated with increased oxidative stress in both mothers and babies.
Researchers at Ruhr-University Bochum discovered a protein called RidA that protects intestinal bacteria E. coli from immune activity caused by chlorine. In the presence of chlorine, RidA binds to other proteins, preventing them from coagulating and losing their function.
A study published in Pediatrics reveals that late clamping of the umbilical cord increases antioxidant capacity and reduces inflammatory effects in newborns. This research led by the University of Granada found a beneficial effect on newborn development after delaying clamping by two minutes.
Researchers at Temple University discovered that oxygen free radicals bind to a protein receptor in the brain called the thromboxane receptor, transmitting signals that increase amyloid beta and tau production. Blocking this receptor has shown promise in neutralizing Alzheimer's disease symptoms.
Researchers at the University of Michigan School of Public Health found an association between phthalate exposure and increased levels of biomarkers of oxidative stress in pregnant women. Oxidative stress may be related to preterm birth, adverse fetal development, and maternal health complications.
Chronic mental stress, obesity, and inflammation contribute to excessive sodium retention in blacks, increasing the risk of heart damage. Researchers aim to develop effective therapeutic strategies to treat this condition by testing angiotensin receptor blockers and other treatments.
A new study found that smoking status significantly influences neurocognitive recovery in treatment-seeking alcohol-dependent individuals. Active-smoking ALC showed poorer recovery than never-smoking ALC on measures of learning and processing speed, while former-smoking ALC recovered less than never-smoking ALC on processing speed meas...
Researchers found that an ancient protein-making enzyme, TyrRS, has a second major function: protecting DNA during cellular stress. This discovery could lead to better therapies for radiation injuries and hereditary disorders like Charcot-Marie-Tooth disease.
Researchers at the University of Missouri have discovered a molecule that effectively treats oxidative stress, which is linked to cancer, Alzheimer's, and Parkinson's disease. The compound, HPP-4382, has shown promise in fighting free radicals and could eventually be developed into a drug.
The study investigates DJ-1's role in the oxidative stress cell death cascade after stroke, revealing its importance as an anti-oxidative stress therapeutic target. DJ-1 translocation to mitochondria may mitigate mitochondrial injury and promote neuroprotection.
Researchers found that green tea polyphenols effectively protect spinal cord neurons against hydrogen peroxide-induced oxidative stress. The study published in Neural Regeneration Research revealed that green tea polyphenols inhibit neuronal apoptosis, indicating a protective role in spinal cord neurons under oxidative stress.
A prospective study found that baseline levels of fluorescent oxidation products (FlOP_320) predicted the risk of future hip fracture in postmenopausal women. Women with higher FlOP_320 readings had a significantly increased risk of hip fractures, with those in the upper 30% having 2.67 times the risk.
Researchers have discovered that preventing abnormalities in the insulating sheath surrounding nerve cells is associated with better function following neurotrauma. Treatment strategies, including calcium channel inhibitors and red/near-infrared irradiation therapy, can preserve myelin and prevent long-term loss of function.
Researchers found that 3-n-butylphthalide improved neuronal morphology in the cerebral cortex and hippocampus, reducing oxidative stress caused by chronic cerebral ischemia. The compound also inhibited amyloid beta accumulation and improved cholinergic function in rats with chronic cerebral ischemia.
A recent study published in Nutrients found that cyclists who consumed Montmorency tart cherry juice concentrate before exercise experienced less inflammation and oxidative stress. The researchers attributed the recovery benefits to the natural compounds in tart cherries, particularly anthocyanins.
A grape-enriched diet resulted in a protective effect on retinal structure and function, with three-fold higher rod and cone photoreceptor responses compared to control diets. The study also found lower levels of inflammatory proteins and higher amounts of protective proteins in the retinas.
A study by Columbia University's Mailman School of Public Health found that stress degrades sperm quality in men, leading to lower concentrations and impaired motility. The researchers studied 193 men and found associations between subjective and objective measures of stress and semen concentration.
A new study by UTMB researchers discovered that exposure to oxidative stress, triggered by cigarette smoke, leads to premature aging of the placenta. This can result in preterm birth, a condition affecting millions worldwide. The findings suggest alternative strategies may be needed to prevent preterm births beyond current interventions.
Researchers found that chronically stressed women who consume high-fat, high-sugar foods are more prone to metabolic risks such as increased waistlines, insulin resistance, and oxidative damage. The study suggests a stress pathway that influences biology through diet, highlighting the importance of treating chronic stress.
Scientists at the University of Arizona have discovered a molecular pathway that could help create new therapies for end-stage liver disease. By understanding how Nrf2 is suppressed in cirrhotic livers, researchers have identified Hrd1 as a key player in exacerbating the disease process.
Two studies examine the effects of spaceflight on mouse eyes, revealing oxidative stress as a key mechanism behind eye damage. Researchers found genes involved in response to oxidative stress and potential indicators of optic nerve damage, highlighting the need for countermeasures to protect astronauts' vision.
Researchers found that disrupting a core clock gene in mice accelerated oxidative stress and inflammation in nerve cells, raising possibilities for therapeutic approaches to delay neurodegeneration. The study suggests the molecular clock plays a crucial role in protecting the brain from damage.
A study found profound changes in mouse eyes after a 13-day spaceflight, including oxidative stress, DNA damage repair genes, and apoptotic pathways. These changes were partially reversible upon return to Earth.
Researchers found that disrupting Nrf2 reduces reductive stress, cardiac protein aggregation, and extends survival in mice with heart failure. This study suggests restoring balance in reduction-oxidation chemical reactions can prevent heart disease.
Researchers from ETH Zurich found that vitamin niacin and its metabolite nicotinamide increase lifespan by promoting the formation of free radicals in roundworms. This contradicts common textbook opinion on antioxidants' role in health.
A study published in Neural Regeneration Research found that resveratrol improved learning and memory ability in rats with vascular dementia. The compound also reduced malonyldialdehyde levels and increased superoxide dismutase activity and glutathione levels, indicating a potential therapeutic effect.
Researchers found that muscle cells in knockout mice grew larger, but lost strength due to oxidative stress. The study suggests that limiting oxidative stress could help prevent age-related muscle loss and improve overall health.
Recent research suggests that oxidative stress and mitochondrial damage are key contributors to the development of neurodegenerative diseases. The study highlights the importance of mitigating mitochondrial dysfunction as a potential therapeutic strategy for treating various neurodegenerative diseases.
A Tel Aviv University study found that the saliva of heavy cell phone users showed higher oxidative stress levels, a process that damages human cells and is linked to cancer. The research adds to growing evidence that cell phone use may be harmful in the long term.
Researchers at Scripps Research Institute discover that parkin enzyme loss leads to reduced levels of protective protein Fbw7β, causing neuronal stress and death. Targeting Fbw7β may offer a new neuroprotective strategy for Parkinson's disease and other neurodegenerative disorders.
Researchers discovered that antibiotics can cause oxidative stress, damaging human cells and leading to side effects. The team found two novel strategies: using bacteriostatic antibiotics or antioxidants like N-acetylcysteine to prevent or remediate oxidative stress.
Researchers at UNC Charlotte have uncovered a previously unknown surveillance mechanism to monitor oxidatively damaged DNA. A novel trigger has been found for the ATR-Chk1 checkpoint pathway, providing new insights into cell response and repair mechanisms in oxidative stress.
New study finds Down syndrome neurons have reduced connections and high levels of oxidative stress, which could contribute to accelerated aging and increased susceptibility to Alzheimer's disease. Researchers hope to use these cells to test potential treatments for the condition.
Researchers found that mice deficient in glutathione, a molecule essential for cellular protection against oxidations, had impaired parvalbumin neurons when stressed at young age. However, treatment with N-acetylcysteine from birth onwards protected these neurons, suggesting a potential preventive measure for psychiatric disorders.
Researchers have discovered a protein that turns into a 'cell executioner' when damaged by oxidative stress, opening up new options for treating conditions such as ALS and spinal cord injuries. This modified protein is linked to various health problems, including heart disease, cancer, and aging.
Researchers from P&G Beauty & Grooming present advancements in skin aging and stress sweat, including a facial moisturizer that improves uneven skin texture and a study showing niacinamide's ability to prevent and restore cellular metabolism. The findings have potential for innovation in Olay and Secret brand products.
Tomatoes grown on organic farms have higher levels of sugars, vitamin C and antioxidants compared to conventional farming methods. This increase in bioactive compounds is linked to the stressful growth conditions experienced by organic tomatoes.
Researchers found blocking JNK interaction with Sab can protect against neuronal damage, suggesting a potential new target for drug development. The study also showed that inhibiting JNK signaling leaves other cell signaling intact, which could mean fewer side effects in future therapies.
Researchers discover that cells under oxidative stress deposit oxidized glutathione in a cellular waste repository called the vacuole, protecting themselves from damage. This finding challenges previous assumptions about oxidative stress and its link to various diseases.
Researchers identify β-hydroxybutyrate as a key compound in protecting cells from oxidative stress, potentially slowing aging and age-related diseases. The discovery reveals a new avenue for treating or preventing conditions like Alzheimer's disease, Parkinson's, autism, and traumatic brain injury.
Researchers found oxidative stress in an animal model of alpha-1-antitrypsin deficiency, which may benefit from antioxidant treatment. The study identifies potential alterations in gene expression pathways that could modify disease development.
A recent study found that larger female Atlantic cod are healthier and less stressed than their male counterparts, with longer telomeres and higher antioxidant capacity. This discovery highlights the importance of conserving older females to maintain healthy fish populations and prevent overfishing.
Researchers found that a commercially available acai berry product can triple the lifespan of fruit flies under oxidative stress conditions. Acai also protected normal flies against oxidative stress and neurotoxic effects of paraquat.
Scientists measured reactive oxygen species in worms and found high levels during early development, which may determine lifespan. Mutant worm variants lived longer due to better oxidative stress coping mechanisms.
DNA damage drives aging by activating NF-κB, a transcription factor that responds to cellular stress; inhibiting NF-κB reduces oxidative stress and senescence in mice.
A new study finds that obstructive sleep apnea is independently associated with diabetic peripheral neuropathy in patients with type 2 diabetes. The severity of DPN is correlated with OSA and nocturnal hypoxemia severity, suggesting a potential mechanism for the relationship between the two conditions.
Obese patients have an increased risk of developing kidney damage, or acute kidney injury, after heart surgery. Oxidative stress associated with obesity plays a role in this increased risk. Acute kidney injury affects 5% to 30% of heart surgery patients.
Researchers found that naked mole rats have a greater number of proteasomes and higher protein-disposal activity in liver cells, enabling them to maintain good health. The discovery provides insights into the molecular mechanisms underlying the animal's exceptional ability to resist aging.
Researchers found that regular exercise reduces oxidative stress in individuals with sickle cell trait, increasing antioxidants and nitric oxide levels. This reduction in oxidative stress may help combat the increased morbidity and mortality associated with SCT.
A Scripps Research Institute scientist has been awarded a $1 million grant to develop new tests for stress-associated diseases, including atherosclerosis, Alzheimer's disease, and Parkinson's disease. The goal is to identify drug leads that can prevent oxidative damage in zebrafish.
Researchers discovered that the Nrf2 protein plays a crucial role in protecting cells from oxidative stress, which is often exploited by cancer cells to become resistant to treatment. By selectively inhibiting Nrf2, cancer cells may become more susceptible to chemotherapy and radiation therapy.
A recent clinical trial found Pycnogenol to significantly improve signs and symptoms of menopause, including reduced oxidative stress. The study showed that Pycnogenol improved irregular heartbeat and digestive problems, as well as decreased bloating.
Researchers found that stressful conditions increase chromosomal instability in yeast, allowing cells to rapidly adapt and acquire diverse aneuploid chromosome numbers. This stress-induced genetic variation enables yeast cells to thrive in environments with harsh conditions.
A new study found that eating cocoa can help prevent intestinal complaints linked to oxidative stress and colon carcinogenesis. The study, published in the journal Molecular Nutrition & Food Research, showed that a cocoa-rich diet reduced aberrant crypts in the colon and improved antioxidant defenses.
The study reveals a DNA repair mechanism that can mitigate oxidative damage, which is linked to various diseases including cancer and Alzheimer's. This discovery holds promise for developing less invasive cancer therapies and early detection tests.
A study led by Durham University has identified a potential drug therapy for premature ageing diseases, including Hutchinson Gilford Progeria Syndrome. The treatment, N-acetyl cysteine (NAC), controlled oxidative stress and DNA damage in cells, suggesting a possible model for understanding processes that cause us to age.
A Joslin study found that stimulation of the metabolism-sensing enzyme AMP kinase regulates crucial gene expression, causing neural tube defects and other heart defects in babies born to diabetic mothers. Even with controlled blood sugar levels, the risk is still twice that of the general population.
Researchers at Emory University School of Medicine have identified a set of genes that act in muscles to modulate aging and resistance to stress in fruit flies. Mutations in these genes speed up the process of aging and make the flies more sensitive to oxidative stress.
Researchers identify key protein CFH that blocks inflammatory immune response to oxidative stress, found in conditions like atherosclerosis and AMD. The study reveals potential therapeutic target for treating chronic inflammatory diseases.