Articles tagged with Oxidative Stress
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
Research reveals deletion of adipose oxidative stress decreases lipid accumulation in the liver, improving insulin resistance and inducing metabolically healthy obesity. Oxidative stress suppresses lipogenic genes in adipocytes, leading to de novo lipogenesis suppression.
Researchers found that taking a mitochondrial-specific antioxidant supplement improved blood vessel dilation by 42%, making them appear younger. The improvement was due to reduced oxidative stress and associated with a 13% reduction in heart disease risk.
A new model considers three stages of oxidation and predicts that heavy loads compress alloys, absorbing less oxygen, while stresses pull them apart, allowing more oxygen to infiltrate. The team's framework matches data in microelectromechanical devices, aiming to improve device performance.
A recent study by University of Tokyo scientists has identified the Ask genes as crucial for regulating circadian rhythms and responding to cellular stress. The research found that cells lacking these genes are impaired in their ability to adapt to daily changes in environmental conditions, leading to disruptions in sleep-wake cycles.
A biochemical pathway in the Golgi apparatus helps cells counter oxidative stress, and researchers found it can be activated by a drug called monensin, which may protect cells against Huntington's disease.
Researchers discovered that small noncoding RNAs orchestrate the resilience of Haloarchaea to oxidative stress by degrading messenger RNA and silencing transposons. This finding could lead to a better understanding of how other species, like humans, resist damage from oxidative stress.
New research found that e-cigarette flavoring chemicals can cause significant inflammation in monocytes, a type of white blood cell, and many compounds are toxic. Mixing flavors is more damaging than vaping just one, with cinnamon, vanilla, and buttery flavors being the worst offenders.
Researchers are using a unique imaging technique, Quest MRI, to study the earliest signs of Alzheimer's disease in mice. The technique measures oxidative stress in specific brain regions over time and has shown promise as a potential biomarker for AD.
Scientists discover that pain medicine pentazocine preserves vision in a model of severe retinal degeneration by activating the Nrf2-Keap1 antioxidant pathway. The drug normalizes Nrf2 levels, potentially restoring its protective function and preventing oxidative stress.
Researchers are investigating a novel treatment approach for Parkinson's disease by inhibiting the protein Bach1, which blocks the body's natural protection against oxidative stress. By removing Bach1, scientists aim to restore balance and promote the activation of neuroprotective genes.
Scientists used a novel gene editing technique to uncover the genetic basis of paraquat-induced Parkinson's disease. The study identified three genes - POR, ATP7A and SLC45A4 - that confer resistance to paraquat, suggesting these genes may be responsible for the toxicity.
A Spanish research team found that urban house sparrows suffer from more stress due to toxic effects of air pollution and unhealthy diets compared to their country counterparts. This could have health implications for people living in cities.
A new UCLA study found that healthy nonsmokers experienced increased adrenaline levels in their heart after one electronic cigarette (e-cigarette) with nicotine. The findings suggest that e-cigarettes with nicotine may not be safe for all users, especially those without known cardiac disease.
Researchers found that oxidative stress produces microfractures in amniotic membranes, increasing the risk of early water breakage and preterm birth. The study used specialized microscopic techniques to detect these fractures in donated amniotic membranes.
A new study found that exposure to e-cigarettes with nicotine increases cardiac adrenaline levels, as indicated by abnormal heart rate variability. This increase is associated with a higher risk of death in people with known cardiac disease and those without, suggesting that e-cigarettes may not be safe for nonsmokers.
Scientists at Temple University Health System uncover the mechanism underlying energy loss from heart dysfunction in sepsis, proposing NOX2 inhibition as a potential treatment. The research builds on earlier findings and aims to provide extra time for anti-inflammatory treatments to work.
Researchers identified a specific genome type, ST121, that contains the SSI-2 sequence, a stress survival island that helps Listeria monocytogenes strains cope with alkaline and oxidative stress. The discovery provides new insights into food safety strategies.
A study published by the American Heart Association found that exposure to high levels of fine particulate matter increased stress hormone levels and negative metabolic changes in healthy young adults. Air purifiers reduced these effects, with significant benefits seen in blood pressure, insulin resistance, and biomarkers of inflammation.
Researchers at the University of British Columbia developed a novel method to assess malaria progression using RBC deformability, which can indicate hemin-induced oxidative stress. This simple microfluidic device can determine RBC rigidity in minutes, providing a valuable tool for disease diagnosis and treatment.
A Duke University study reveals that rush hour commutes may be more hazardous to human health than previously thought. The levels of particulate matter and chemicals causing oxidative stress found in car cabins were twice as high as roadside sensors, posing a significant risk to drivers' health.
Researchers found that viral acute respiratory infections (ARIs) in infants may lead to oxidative stress and recurrent wheezing in early childhood. Oxidative stress is an imbalance between free radicals and antioxidants in the body, and measuring it in urine samples during a viral ARI may predict the development of recurrent wheeze.
A new study found that children exposed to high levels of outdoor particulate air pollution during pregnancy and high maternal stress were more likely to develop asthma by age six. Boys were particularly affected, possibly due to slower lung maturation and increased risk of oxidative stress.
Researchers found that NDP1, a signaling molecule made from DHA, triggers the production of a protective protein against toxic free radicals and injury in the brain and retina. The discovery may contribute to possible therapeutic interventions for retinal degenerations and ischemic stroke.
Research by TUM found that low zinc levels can affect the heart's ability to deal with oxidative stress, leading to increased risk of heart disease. Zinc deficiency was also linked to upregulation of genes responsible for programmed cell death.
A research team at Mount Sinai has identified biological pathways involved in diabetic kidney disease, providing a potential diagnostic test and therapeutic strategy. The study found that blocking a cellular receptor can prevent kidney damage in mice with diabetic kidney failure.
A diet rich in fruit and vegetables is associated with a significantly lower risk of chronic lung disease (COPD) in former and current smokers. The study found that each additional daily serving was linked to a 4-8% lower risk, with the strongest influence coming from apples, green leafy vegetables, and peppers.
A subset of genes involved in daily circadian rhythms become active late in life or during intense stress, helping to protect critical life functions. These 'late-life cyclers' may combat serious stresses associated with age, disease, or environmental challenges.
Researchers from the University of Maryland have developed a blood test that can help doctors diagnose schizophrenia more quickly. The test measures oxidative stress in blood samples, which may be linked to the disorder and its treatment response.
Researchers found that as cells age, their fat content changes and lipid-related genes become more actively expressed. Lipid triacylglycerols may help the body cope with oxidative stress, protecting cells from damage caused by reactive oxygen species.
Scientists have designed a new class of molecular donors that can release therapeutic levels of hydrogen sulfide, a gas with protective effects on cells. This breakthrough could lead to treatments for conditions such as Alzheimer's and Parkinson's disease, where oxidative stress causes cellular damage.
A Japanese research team has found that 2-aminobutyric acid (2-AB) can effectively increase glutathione levels in the body, a major antioxidant component. The study suggests that 2-AB could be used as a biomarker for early detection of oxidative stress and potentially treat conditions such as Alzheimer's disease and heart failure.
Researchers used MRI measurements to detect higher levels of oxidative stress in patients with schizophrenia compared to healthy individuals and those with bipolar disorder. The study suggests that oxidation imbalance may contribute to the development and progression of schizophrenia.
Researchers induced oxidative stress in cultured RPE cells to explore the development of age-related macular degeneration (AMD). Oxidative stress led to cell senescence and proliferation inhibition, highlighting its potential role in AMD progression. The study suggests antioxidants may be a new treatment approach for AMD intervention.
Researchers found that combining FLT3 inhibition with drugs inducing oxidative stress improves efficacy against acute myeloid leukemia (AML). This approach, which targets genes involved in antioxidant response, shows promise for combination therapy.
Researchers investigate whether reducing sodium intake can lower inflammation and oxidative stress, key factors in cardiovascular disease. The study aims to connect the dots between salt consumption and cardiovascular risks.
Research from North Carolina State University shows that traveling honey bees have shorter lives and greater oxidative stress levels than stationary bees. Access to readily available food or supplemental nutrition can mitigate these negative impacts, particularly during periods of high flower scarcity.
Researchers found guarana to have higher antioxidant capacity than green tea due to its high catechin content. The study showed guarana reduced oxidative stress and improved lipid profiles in healthy volunteers.
A study by UMass Amherst researcher Alicia Timme-Laragy investigates the link between early life pollutant exposure and future diabetes risk. The researchers will expose zebrafish embryos to toxic chemicals, aiming to understand how environmental contaminants affect pancreas development.
A study published in PNAS reveals that cysteine deficiency contributes to oxidative stress and nerve cell damage in Huntington's disease. Cysteine levels affect the activity of ATF4, a protein involved in antioxidant defenses.
Antioxidant supplements have been linked to cardiovascular disease, cancer, diabetes, and other conditions due to their impact on oxygen radicals. However, the review suggests that targeting specific sources of oxygen molecules may be a more effective approach.
A pain medicine has been shown to preserve vision in a model of severe retinal degeneration by activating a receptor vital to a healthy retina. The drug (+)-pentazocine enables the survival of cone cells, allowing detailed color vision to remain intact.
People with major depressive disorder may have altered purine metabolism, with higher levels of xanthine and lower inosine and guanosine. This dysregulation may be the body's compensatory mechanism to combat increased oxidative stress caused by depression.
A systematic review published in Journal of Medicinal Food found that consuming sesame-based ingredients can increase antioxidants and reduce oxidative stress in individuals with high blood pressure and type 2 diabetes. Sesame oil has also been shown to prevent atherosclerosis in preclinical studies.
Researchers found that six genes, including four from a peroxiredoxin family, were affected by titanium dioxide nanoparticles in human HeLa cells and monkey kidney cells. The effect was seen after 24-hour exposure, with changes of about 50% in enzyme expression.
A study published in Nature Communications found that visceral fat is strongly linked to metabolic disease and insulin resistance. Researchers identified the regulatory molecule TRIP-Br2 as a key player in this process, which could lead to potential therapeutic agents against obesity.
A diet rich in grapes helps preserve retinal structure and function by countering oxidative stress. Grapes' natural components promote antioxidant activity, suggesting potential benefits for eye health and preventing age-related macular degeneration.
A study published in Neurobiology of Disease found that neurons with a defective DJ1 gene experience oxidative stress and immune response imbalances due to disrupted glutamine and serine metabolism. This knowledge could lead to novel therapeutic strategies by targeting affected metabolic pathways.
A study found that subcutaneous insulin infusion does not prevent oxidative stress and inflammation in the liver, despite reducing glycemic variability. The therapy also failed to preserve balance of anti- and pro-oxidant species.
Scientists discovered a 'master switch' in cancer cells that allows them to survive stress conditions by overriding the normal stress response. The Brf2 protein acts as a sensor and regulates gene activity, enabling cancer cells to thrive under stress.
A newly discovered mechanism in worms suggests that mothers sacrifice their health for future generations, fueling egg cell development with fats. This phenomenon raises the possibility of a similar trait in humans, potentially impacting reproductive success and lifespan.
Research suggests that cranberries can help reduce the incidence of symptomatic UTIs, potentially reducing antibiotic use and mitigating antibiotic resistance. Cranberry's unique blend of polyphenol antioxidants may also assist in preserving heart and cognitive health, protecting against oxidative stress.
Research published in the Journal of Leukocyte Biology suggests that ER stress is linked to poor glycemic control, dyslipidemia, and insulin resistance in patients with type 2 diabetes. Targeting ER stress may be an effective treatment strategy for diabetes.
Researchers discovered a potential mechanism for neurodegenerative diseases, suggesting that HSD10 reduces oxidative stress and promotes cell repair in humans. This breakthrough provides a fresh perspective on Alzheimer's disease etiology and could inform novel drug strategies.
Researchers discover that high nighttime temperatures cause rice plants to produce a stress hormone, leading to losses in yield and quality. They also find that root pruning can occur due to rice water weevils, affecting plant growth.
Scientists found that sigma 1 receptor helps regulate oxidative stress response in Müller cells, which support the retina. Removing sigma 1 receptor increases levels of reactive oxygen species, leading to vision loss and disease progression.
Researchers found that aging actually offers significant protection against oxidative stress, as the endothelium adapts to regulate ROS and minimize cell death. This adaptation helps ensure arteries of older individuals can still function properly.
A new pilot study found that Montmorency tart cherry juice reduced upper respiratory tract symptoms in marathon runners. The study also showed lower markers for inflammation compared to a placebo group. This research provides encouraging evidence of the potential role of tart cherries in reducing exercise-induced respiratory problems.
A new study by ETH Zurich researchers has identified a critical link between oxidative stress and the immune system's ability to fight off viruses. Vitamin E was shown to be effective in protecting T cells from cell death caused by oxidative stress, a breakthrough that could have implications for treating chronic infections.
Researchers found that an intermittent feast-and-famine diet increased sirtuin proteins, which promote longevity and protect against age-related diseases. The diet also decreased insulin levels, potentially having an anti-diabetic effect.
Researchers found common biomarkers of sleep debt in humans and rats, indicating a link to metabolic disorders such as weight gain, diabetes, and cardiovascular disease. The study also identified potential biomarkers, oxalic acid and diacylglycerol 36:3, which could serve as indicators of sleep quality and quantity.