Articles tagged with Oxidative Stress
Researchers discovered that 15-deoxy-prostamide-J2 induces ER stress-mediated apoptosis selectively in tumor cells, reducing melanoma growth. The molecule activates PERK, IP3R, and the mitochondrial permeability transition pore, leading to cell death.
Regenstrief Institute Research Scientist Sikandar Khan received the prestigious Paul Beeson Emerging Leaders Career Development Award to study the role of reactive oxygen species in cognitive impairment. The award supports his work on delirium, a common complication in ICU patients with acute respiratory failure, which can lead to post...
Researchers discovered that krill oil protects dopaminergic neurons from age-related degeneration through temporal transcriptome rewiring and suppression of several hallmarks of aging. Krill oil increases neuronal resilience, promoting anti-oxidative stress and anti-inflammation, and abrogating multiple aging hallmarks.
A study found that higher levels of glutathione in the nucleus accumbens correlate with better performance in motivation tasks. Nutritional interventions targeting GSH levels may improve motivation by modifying behavior and facilitating effortful endurance.
Researchers found that increasing arginase 1 availability helps alleviate unhealthy responses and interrupt destructive inflammation in diabetic retinopathy and retinopathy of prematurity. This is achieved by reducing L-arginine levels, which in turn reduces inducible nitric oxide synthase activity.
The conference highlights recent discoveries on polyphenol applications in microbiota, adipose tissue, nervous system, senolytic activity, ageing, and endothelial function. Over 131 communications will be presented during three days.
A study by HKU Dentistry found that 'positive stress' can induce good changes in tooth stem cells, making them more resistant to injury and disease. The research team developed a preconditioning protocol that modified the cells genetically to mimic low oxygen conditions, which activated protective mechanisms.
Scientists propose a new therapy for preeclampsia by correcting placental defects with BH4 treatment. The treatment restores placental and fetal weight, lowers blood pressure, and resolves symptoms of excess protein in urine and cardiovascular abnormalities.
A new University of Illinois study shows that fathead minnows can handle simulated heatwaves with few nasty side effects. Most minnows rapidly returned to normal physiological functioning after cooling down, but some became more susceptible to oxidative stress.
Researchers found 560 proteins were differentially expressed, with 32 significantly altered, in reductive stress hearts. The proteome signature revealed oxidative stress-related pathways and mitochondrial dysfunction.
Researchers developed a non-invasive ocular imaging method to detect flavoprotein fluorescence in the eye, indicating mitochondrial oxidative stress. This technique may predict glaucoma progression earlier than current methods, with similar sensitivity to visual field changes.
A team from Osaka University developed a silicon-based agent that generates hydrogen when reacting with water, reducing inflammation and symptoms of ulcerative colitis in a mouse model. The study suggests the Si-based agent may be an effective treatment method for this disease.
A UC Riverside study reports that switching from combustible cigarettes to electronic cigarettes does not restore the nasal epithelium to that of a non-smoker. The researchers found alterations in gene expression profiles associated with cigarette smokers, indicating potential harm from prolonged EC use.
The new human cell line, ABC, was developed from retinal pigment epithelial cells and retains their properties, allowing for the study of events relevant to normal repair processes. The research may lead to discoveries in senescence gene programming, neuroprotection, and cellular replacement therapies for blinding eye diseases
Researchers discover G6PD's pivotal role in activating pentose phosphate pathway to counter oxidative stress, leading to increased cell death and tumor shrinkage. Ovarian cancer cells' reliance on fatty acid metabolism fuels oxidative compound production, which can be offset by G6PD inhibition.
A new study reveals that oxidative damage to telomeres can trigger cellular senescence, leading to the development of 'zombie cells'. Researchers found that damage at telomeres disrupts DNA replication and induces stress signaling pathways, contributing to age-related diseases.
Researchers at Karolinska Institutet have improved the ability of a protein to repair oxidative DNA damage, creating a new drug development concept. The technique can lead to improved treatments for diseases involving oxidative stress.
The USPSTF recommends against using beta carotene or vitamin E supplements to prevent cardiovascular disease (CVD) or cancer. Inflammation and oxidative stress play a role in both CVD and cancer, but dietary supplements have shown anti-inflammatory and antioxidative effects, leading to proposals for their use as preventive measures.
Researchers discovered that dermal contact with nicotine concentrations found in thirdhand smoke and electronic cigarette spills can impair wound healing, increase susceptibility to skin infections, and cause oxidative stress in skin cells. The study suggests that even a short exposure of 24 hours is sufficient to cause skin damage.
The 24th International Conference on Oxidative Stress Reduction, Redox Homeostasis & Antioxidants, shed light on the latest redox field innovations and the future of redox medicine. Keynote speaker Prof. Helmut Sies discussed stringently selective modulation of enzymatic oxidant sources and sinks in redox nanomedicine.
Scientists have discovered that oxidative stress, a process disrupting genetic code by damaging DNA, is the culprit behind inflammation's link to cancer. The study provides crucial insights into roles of inflammation and oxidative stress in certain cancers.
Researchers evaluated the toxicological effects of BaP on bay scallops, finding increased immune response-related parameters with time at higher concentrations. The study suggests that BaP dampens the immune response of scallops and decreases their capacity to respond to oxidative stress.
A recent study published in Pharmaceutics suggests that berberine can suppress the proliferation of lung cancer cells, reduce airway inflammation, and modulate genes involved in inflammation. The researchers used liquid crystalline nanoparticles to enhance safety and effectiveness.
Researchers at Marshall University Joan C. Edwards School of Medicine are studying the role of obesity and oxidative stress in Alzheimer's disease. Obesity is a key predictive factor for Alzheimer's disease, which affects 14 million Americans by 2060.
A new study suggests that oxidative stress overactivates a glucose metabolism enzyme in the developing hippocampus, impairing learning and memory. However, inhibiting this enzyme can reverse cognitive deficits, paving the way for treatment of neonatal brain injuries.
A new review highlights the risks of fatty liver disease caused by metabolic dysfunction, characterized by fat accumulation in liver cells and oxidative stress. The progression of the disease can lead to inflammation, fibrosis, and cirrhosis with a high risk of hepatocellular carcinoma.
Academic researchers will present newest discoveries on redox in aging, immunity, ocular disorders, and fertility. The conference highlights the mechanisms of redox control like Nrf2 signaling pathway.
A University of Cincinnati study found that adding blueberries to middle-aged diets may lower the chances of developing late-life dementia. The researchers discovered that blueberries' high level of micronutrients and antioxidants helped improve cognitive function and metabolic function.
Researchers found that maintaining hard water reduces zinc accumulation and oxidative stress in goldfish, mitigating toxic effects. This study provides an eco-friendly approach to address aquatic ecosystem pollution caused by heavy metal contamination.
Researchers at Shibaura Institute of Technology discovered that tocotrienols, a subtype of vitamin E, can lower body weight, reduce white adipose tissue, and protect the liver in mice fed with a high-fat diet. The study suggests a potential compound to prevent obesity and its secondary diseases.
A new study published in PLOS ONE finds that high and very high cardiovascular risk are associated with depressive symptoms, especially in women. The researchers used data from a Mediterranean Diet trial and found that participants with higher cardiovascular risk had lower depressive status scores after following the diet.
A team of researchers found significant differences in lipid profiles between sperm and erythrocytes, with more closely related species showing similarities. The study's results help improve understanding of oxidative stress on reproductive processes and assisted reproduction measures.
A study led by Frank Keppler and Ilka Bischofs reveals that all organisms release methane, with the process driven by reactive oxygen species. The researchers verified this finding in over 30 model organisms, including bacteria, archaea, yeasts, plant cells, and human cell lines.
Researchers found that GlyNAC supplementation can increase lifespan and improve multiple key age-associated defects in mice. The supplement corrected glutathione deficiency, oxidative stress, mitochondrial dysfunction, and other hallmarks of aging.
A study by Barcelona Institute for Global Health found that exposure to vegetation is associated with lower levels of oxidative stress in children. The association was observed regardless of the children's physical activity levels, suggesting that green spaces may have a direct impact on biological processes.
Researchers found elevated plasma xanthine oxidase activity and more fragments of damaged mitochondrial DNA in Black adults with resistant hypertension compared to white adults. These findings suggest an important underlying cause of increased cardiovascular risk in Blacks with difficult-to-treat hypertension.
Researchers at UC Davis MIND Institute found a novel gene linked to autism spectrum disorder in newborns. The study analyzed DNA methylation signatures in the placenta, which reflected fetal brain development and early autism diagnosis.
Scientists demonstrate a definitive link between mitochondrial oxidative damage and cognitive dysfunction in Alzheimer's disease using a transgenic mouse model. The study found that Aβ1-42 aggregation in the hippocampus caused cognitive impairment, while oxidation led to mitochondrial dysfunction.
Researchers investigated the effects of insulin aggregation on human health, finding strategies to prevent it. Additionally, a study revealed that amphiphilic membrane environments can regulate enzymatic behaviors in Salmonella proteins.
Prunes have been found to help prevent or delay bone loss in postmenopausal women by reducing inflammation and oxidative stress. This is due to their potential to alter the gut microbiome, which can lead to lower levels of pro-inflammatory cytokines and markers of oxidative damage.
Researchers found that CBN preserves mitochondrial function and prevents oxidative damage to nerve cells, suggesting potential for treating age-related neurodegenerative diseases like Alzheimer's. The compound works independently of cannabinoid receptors, making it a promising therapeutic option.
Researchers found that a unique protein variant in modern humans offers better protection against oxidative stress, but also increases the risk of vascular disease and inflammatory bowel disease. The Neanderthal variant is carried by around 1-2% of the population on the Indian subcontinent.
Researchers found that COVID-19 patients have significantly increased levels of oxidative stress and oxidant damage, as well as markedly reduced levels of glutathione. This study suggests that supplementation with GlyNAC may be beneficial to combat these defects in COVID-19 patients.
Researchers from Hiroshima University analyzed 839 collections of genetic material to identify common features of oxidative stress. They found two genes, CRIP1 and CRIP3, downregulated during oxidative stress, suggesting a relationship with zinc homeostasis. The study also identified shared biological processes between the two types of...
Researchers have discovered that certain molecules inhibiting thioredoxin reductase (TrxR) have a more specific effect than gold-based therapy auranofin. TRi-1 and TRi-2 compounds show promise as anticancer drugs, with higher specificity in their inhibition of TrxR.
Researchers discovered that chemotherapy drugs can affect protein synthesis in muscle cells, even at low doses. This finding has significant implications for cancer treatment and exercise rehabilitation programs, suggesting that even non-oxidative stress effects of chemotherapy should be considered.
Researchers found that activated neutrophils release proteins like galectin-9, triggering chronic inflammation and oxidative stress. Early screening for HIV is crucial, and finding ways to reduce negative effects of the infection could be key to improving outcomes.
Researchers at Rockefeller University identified SLC25A39 as a transporter protein that brings glutathione, the body's major antioxidant, into cell mitochondria. This discovery opens new avenues for studying oxidative stress and its role in diseases like cancer and neurodegeneration.
A preclinical study found that blocking the Bach1 protein slowed brain cell deterioration in Parkinson's disease. The researchers identified a potent inhibitor of Bach1 called HPPE, which protected cells from inflammation and oxidative stress, and showed promise as a potential therapeutic target.
A new study suggests that drinking 100% orange juice significantly reduces interleukin 6, a well-established marker of inflammation, in both healthy and high-risk adults. However, the results did not quite reach statistical significance for two additional inflammatory and oxidative stress markers.
Researchers found an early indicator of Alzheimer's disease is an oxidation-antioxidant imbalance in the blood. Oxidative markers increase up to five years before the onset of the disease, suggesting a potential avenue for prevention through antioxidant intake.
A new treatment approach targets angiogenesis, inflammation, and oxidative stress in glioblastoma multiforme, reducing tumor volume and growth by up to 89%. The combination of LAU-0901, Elovanoids, and Avastin shows promise in improving survival rates for patients with this deadly cancer.
Research by University of Arizona Health Sciences identifies chronic arsenic exposure as a risk factor for developing insulin resistance and glucose intolerance. The study found that prolonged activation of NRF2 protein leads to shifts in metabolic pathways, increasing glucose production in the liver.
Researchers at Nanyang Technological University have developed a 3D model of the human artery blood vessel wall to study atherosclerosis. The model, called an 'arterial wall-on-a-chip', helps understand how cholesterol and inflammatory cells contribute to the disease.
A study by Kazan Federal University found that probiotics administered to antibiotic-treated mice improved behavior, reduced oxidative stress, and restored gut microbiota diversity. The researchers demonstrated a strong link between the gut microbiota and brain functioning, with potential therapeutic benefits for treating dysbiosis-rel...
A recent study published in European Heart Journal: ESC heart failure shows that increased oxidative stress during exercise adversely affects heart failure prognosis. Tailoring exercise therapy to individual patients based on their level of oxidative stress may be more effective than conventional exercise therapies.
A new UCLA study found that even one vaping session can significantly increase cellular oxidative stress in healthy younger nonsmokers. The researchers discovered a two- to four-fold increase in oxidative stress levels after a 30-minute vaping session, highlighting the alarming effects of e-cigarettes on young people's health.
A study published in Scientific Reports describes the putative molecular regulators of reductive stress — a microRNA network. The researchers identified a subset of miRNAs that appeared to be direct and dose-dependent targets of Nrf2, and thus putative regulators of reductive stress.
Research found that mice with impaired methylglyoxal detoxification systems exhibited schizophrenia-like behavioral abnormalities, including social interaction and cognitive memory impairments. Low levels of vitamin B6 were also observed in mice and patients with schizophrenia.
A UCLA-led study comparing human and mouse astrocytes found that mouse cells are more resilient to oxidative stress, a key mechanism behind many neurological disorders. The findings have important implications for basic and translational research into conditions like Alzheimer's disease, Parkinson's disease, and amyotrophic lateral scl...