Articles tagged with Oxidative Stress
A new study reveals that benzyl butyl phthalate (BBP) causes oxidative stress and DNA strand breaks, leading to cell death and abnormal chromosomes in egg cells. The research suggests that BBP exposure can lead to lower quality egg cells with compromised genomic integrity.
Researchers at Weill Cornell Medicine identified a unique enzyme called FTSJ1 that enables melanoma cells to escape oxidative stress and spread. By targeting this enzyme, therapies may prevent or treat metastasis with minimal side effects.
Researchers detected microplastic particles in the breath of wild bottlenose dolphins, suggesting inhalation may be a key route of exposure. The study supports the idea that dolphins could be exposed to potentially harmful microplastics through this pathway.
In this study, researchers from Tokyo Institute of Technology found that hydrogen sulfide-dependent transcription factor YgaV regulates iron uptake dynamics in Escherichia coli. The team observed elevated intracellular H2S levels resulting in increased antibiotic resistance and upregulated genes involved in sulfur metabolism.
A research team at Hiroshima University developed an analytical pipeline to identify unexploited genes associated with Parkinson's disease and oxidative stress. The study revealed two novel candidate genes, NUPR1 and UHRF2, which were absent from current gene-disease associations databases.
Researchers at the University of Illinois Chicago have identified a cellular pathway essential to obesity-induced atrial fibrillation. Blocking NOX2, an enzyme that produces reactive oxygen species, may prevent and reverse changes in heart structure and function caused by high-fat diets.
A study by Baylor College of Medicine researchers reveals that Tau protein mitigates neuronal damage caused by reactive oxygen species and promotes healthy aging. The findings support a new neuroprotective role for Tau against the toxicity associated with ROS.
Researchers validate increase of specific t-Cys sites associated with aging in human proteome, suggesting potential role in age-related diseases. The study expands beyond classical proteinopathic paradigms, highlighting trioxidized cysteine as a key molecular mechanism underlying aging.
A study found that men infected with high-risk types of HPV could experience sperm death from oxidative stress, leading to impaired fertility. The researchers also discovered a weakened local immune response in the urogenital tract, which may contribute to these effects.
Researchers have discovered that dialyl-sulfide and trans-chalcone can prevent breast cancer by targeting SULT1E1 and HIF1a-MMPs. These compounds neutralize oxidative stress and induce the expression of SULT1E1, leading to decreased HIF1a and MMP production.
A recent Vanderbilt University Medical Center study found that both hyperoxia and normoxia are safe during cardiac surgery, contradicting previous assumptions. The research discovered no significant differences in organ injury between the two oxygen levels.
A study published in Cardiovascular Research Journal found that a gene deficiency in patients with atrial fibrillation leads to reduced energy production in heart cells. PITX2-deficient cardiac cells have smaller and less efficient mitochondria, pushing the heart into an oxygen-deficient stress state.
A new study found that low energy availability among female athletes impairs performance by up to 18% in short-term tests and increases systemic stress, compromising immune function. Athletes who restrict their food intake experience muscle loss and decreased physical performance.
Researchers found increased liver oxidative stress and impaired antioxidant defenses in a DS murine model. The study suggests potential therapeutic strategies targeting oxidative stress and lipid metabolism to prevent or mitigate liver-related complications.
Researchers at Howard University have identified a new therapeutic strategy to combat prostate cancer by depleting amino acids. This depletion induces oxidative stress and DNA damage in cancer cells, making them more susceptible to treatment with DNA repair-targeted and immune checkpoint blockade therapies.
Researchers found that colder temperature exposure increases oxidative stress in the nasal cavity, leading to worsened asthma symptoms in children. The study used nasal fluid samples and measured malondialdehyde (MDA) levels as a biomarker of oxidative stress.
A new review paper explores the mechanistic links between peripheral vascular dysfunction, cerebral vascular dysfunction, and reduced brain health with aging. The study suggests that targeting fundamental aging mechanisms may be a promising strategy to reduce dementia risk.
The CCR4-NOT complex plays a crucial role in regulating RNA metabolism and stress response in C. elegans, compromising stress resistance and decreasing lifespan when depleted of subunits. This study highlights an important new role for the CCR4-NOT complex in normal aging and longevity.
A recent study published in The Open Sports Sciences Journal found that Ascorbic acid supplementation reduced exercise-induced oxidative stress and inflammation in healthy women. The supplement also increased plasma ascorbic acid levels and reduced post-exercise MDA levels, suggesting a potential protective effect against muscle injury.
Weo electrolyzed water (WEW) has been shown to attenuate cellular senescence in both normal fibroblasts and breast cancer cells. The study found that WEW modulated markers of cellular senescence, inflammation, and stress response genes in a cell type-dependent manner.
Research suggests that oxidative stress (OS) may trigger Alzheimer's disease and that enriching brain glutathione (GSH) could be a way forward. Clinical studies indicate GSH depletion in the hippocampus initiates early onset of AD prior to amyloid beta deposition and tau phosphorylation.
Twendee X reduces oxidative stress, improves skin and lung health, and suppresses fibrosis in SSc mouse models. The supplement's antioxidant effects are likely more potent than individual compounds alone.
Researchers assessed swimming performance and survival under stress to evaluate the effects of three compounds on health and lifespan in Caenorhabditis. The study found complex relationships among median lifespan, oxidative stress resistance, thermotolerance, and mobility vigor.
Researchers investigate the neuroprotective effects of tocotrienols in alleviating obesity-induced cognitive decline. The study found that T3s treatment improved cognitive function and mitigated oxidative stress in mice fed with a high-fat, high-sucrose diet.
Researchers found that geraniol reduces oxidative stress and neuroinflammation-mediated cognitive impairment in a mouse aging model. Geraniol treatment improved spatial learning and memory by enhancing anti-oxidant and anti-inflammatory effects.
A review of mitochondrial energy metabolism in diabetic cardiomyopathy reveals disrupted dynamics and oxidative stress as key triggers. Targeted therapies, such as antioxidants and ketogenic diets, show promise in combating this debilitating condition.
Long-term treatment with methylene blue (MB) and mitoquinone (MitoQ) did not alter age-related bone loss in mice. Antioxidant interventions are insufficient to inhibit skeletal aging, suggesting alternative approaches may be needed.
A blended antioxidant supplement improved spatial learning ability and short-term memory in supplement-treated aged mice. The discovery suggests that the supplements may also prevent age-related cognitive decline in humans and mitigate muscle frailty.
Researchers developed an oxidative stress-based prognostic model for bladder cancer, identifying distinct molecular subtypes and predicting patient outcomes. The model shows promise in tailoring personalized treatment approaches, particularly for patients with low-risk profiles.
Researchers at Aarhus University discovered that RNA modification N4-acetylcytidine (ac4C) plays a key role in stress granule formation and function. Acetylated transcripts are localized to stress granules, regulating their assembly and dispersal.
Researchers developed protein-like polymers to disrupt the Keap1/Nrf2 protein-protein interaction, preventing cellular damage and oxidative stress. This approach holds promise for treating neurodegenerative diseases such as Alzheimer's, Parkinson's, and ALS.
The Redox Medicine Society will host its 26th International Conference on Redox Medicine in Paris, featuring keynotes, sessions, and round-table discussions on advancements and applications in clinical settings. The conference aims to facilitate innovation and excellence in the field of redox medicine.
Repeated sexual rejection in fruit flies causes social stress, leading to increased aggression and reduced resilience to starvation and toxic herbicide exposure. The response is mediated by the brain's neuropeptide F signaling system, which also plays a role in reward- and stress-responses in other organisms.
A new study found that nicotine-free vape fluid can increase inflammation and oxidative stress in the lungs, causing damage similar to patients with lung injury. The research identified a protein called ARF6 as a key regulator of this damage.
The project will assess how xanthophyll carotenoids in NutraMaize Orange Corn mitigate negative health effects associated with heat-induced oxidative stress. The researchers aim to improve egg-laying hen health and performance during heat stress events.
Researchers identified Elovanoid-34, a molecule that modulates the activity of TXNRD1 protein, which regulates antioxidant defenses. This discovery opens new therapeutic avenues for degenerative brain and eye diseases, as well as promoting healthy aging.
A study published in Environmental Health Perspectives found that exposure to phthalates can lower the odds of getting pregnant, but not lead to pregnancy loss. The researchers also discovered associations between preconception phthalate exposure and changes in women's reproductive hormones, inflammation, and oxidative stress.
Researchers at Texas A&M University found that it takes over a month for negative alcohol effects to wear off, and fathers' sperm are still negatively impacted by drinking even during the withdrawal process. The study suggests that men should abstain from alcohol at least three months prior to conceiving.
Scientists at Johns Hopkins Medicine have identified a molecular pathway involving oxidative stress and the protein HIF-1 that contributes to both wet and dry age-related macular degeneration. Researchers found that while HIF-1 promotes blood vessel growth in retinal cells, it also protects against cell death in advanced dry AMD.
Scientists developed a high-throughput method to study oxidized lipids in ALS. Analysis of blood plasma from rats with ALS revealed 17 oxylipin alterations associated with oxidative stress and inflammation. Oxylipins may serve as biomarkers for monitoring disease progression.
Mitochondrial fragmentation is a key mechanism underlying ventilator-induced diaphragm dysfunction (VIDD), leading to excessive reactive oxygen species production and calcium homeostasis impairment. Blocking mitochondrial fission at the initiation of mechanical ventilation with a molecule like P110 could potentially prevent VIDD.
Researchers from Columbia University have validated GLS2's ability to promote ferroptosis in murine models. This study suggests that targeting GLS2 may be a potential therapeutic strategy against liver diseases, particularly hepatocellular carcinoma.
Researchers found that DNA damage accumulates in arteries with aging and contributes to impaired vascular function. In mice lacking or heterozygous for the double-strand DNA break repair protein ATM kinase, aging accelerated vascular dysfunction, including increased arterial stiffness and oxidative stress.
Researchers at Chalmers University of Technology have shown that graphene oxide nanoflakes can reduce the accumulation of misfolded amyloid peptides in yeast cells, which are similar to human neurons affected by Alzheimer's disease. This suggests that graphene oxide may hold great potential for treating neurodegenerative diseases.
Researchers have developed a synthetic peptide that could help reduce vascular problems associated with acute respiratory distress syndrome in COVID-19. The peptide, called TIP, works by binding to a subunit of the epithelial sodium channel, which helps maintain barrier function and prevent damage from viral proteins.
A UNIGE team investigated the destruction of neurons at different times of the day using fruit fly models and found that cellular stress was more deleterious to neurons at night. This suggests that the circadian clock exerts a protective effect on dopaminergic neurons against oxidative stress.
Researchers at City University of Hong Kong have developed a new class of near-infrared-activated photo-oxidants that can effectively kill cancer cells without requiring oxygen. The discovery offers a promising direction for developing anti-cancer drugs and could overcome existing limitations of photodynamic therapies.
A new study found that high-stress caregivers had higher klotho levels and longer telomeres in specific immune cells, which may provide protection against aging. In contrast, low-stress caregivers showed no significant associations between klotho levels and telomere length.
A new UMass Amherst study aims to develop a more robust understanding of the effects of ambient air pollution on women's reproductive health. The researcher will analyze data from 1,228 participants to identify mechanisms and susceptible reproductive processes across the menstrual cycle and early pregnancy.
A daily dose of 500 mg propolis improved immunity, reduced free radicals, and attenuated chronic inflammation in asymptomatic HIV patients. The study showed a significant reduction in plasma levels of malondialdehyde and an increase in total antioxidant capacity.
Researchers used a new transgenic mouse model to study the impact of oxidative stress on neurons and blood vessels, revealing that high levels of stress can cause sensory neuron degeneration and cardiac hypertrophy. This combination is associated with Friedreich's ataxia, a progressive neurodegenerative disease.
Researchers at Beckman Institute found fetal exposure to PCBs made it harder for mice to recover from sound-related trauma. Oxidative stress appears to be key mediator of the effect, suppressing auditory system's ability to heal.
Researchers confirm hydrogen inhalation improves brain function and alleviates pathological damage caused by hindlimb unloading. The study suggests a potential protective measure for astronauts during spaceflight, involving changes in PGC-1α and BDNF expression.
Scientists at Medical College of Georgia are investigating the impact of HIV treatment on bone and muscle aging. They found that common antiretroviral cocktails can accelerate aging by about a decade, leading to increased inflammation and oxidative stress in bone marrow stem cells.
A research team at Hokkaido University has developed a system to deliver antioxidants to mitochondria in the liver, reducing oxidative stress and damaging caused by ROS. The system, called CoQ10-MITO-Porter, was found to be more effective when downsized particles were used.
Researchers investigated the cardiovascular effects of glucocorticoids on chicken embryos, finding that Betamethasone (Beta) caused more severe growth restriction, cellular stress, and cardiac dysfunction compared to Dexamethasone (Dex). Dex triggered oxidative stress, while Beta sustained glucocorticoid receptor activation
A new study presents a chronic wound murine model that characterizes the role of persistent senescent cell accumulation in delayed wound closure. The molecular profiles of senescent cells demonstrate the adverse influence of SASP factors, highlighting a potential root-cause-driven therapeutic strategy.
Scientists found that cells use helper molecules to repair damaged ribosomes caused by oxidative stress, fixing the damage and restoring protein production. This discovery has implications for understanding diseases such as cancer and aging.
A pilot study at the University of Eastern Finland found metabolites related to oxidative stress and transsulfuration to be associated with a history of sexual or physical abuse in depressed adolescent outpatients. The study's findings suggest that further research into the biological mechanisms underlying trauma is needed.
Scientists discover that cancer cells use an alternative sugar breakdown pathway when GAPDH is inactivated by oxidative stress, enabling them to tolerate high levels of oxidants. This mechanism also protects cancer cells from chemotherapy and radiotherapy.