Articles tagged with Oxidative Stress
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Scientists at Temple University Health System have identified Kruppel-like factor 5 as a key protein driving both oxidative stress and toxic lipid accumulation in the heart. This discovery opens up new avenues for treating various types of cardiac disease, including diabetes and heart attack.
A large data analysis of over 7,100 U.S. adults found that vaping combined with smoking results in similar levels of inflammation and oxidative stress as smoking cigarettes exclusively. Researchers also found that dual use of both products does not reduce risk.
A recent in vitro study published in Journal of Dietary Supplements found that ergothioneine helped preserve telomere length and reduce oxidative stress. The study suggests that ergothioneine as part of a healthy diet could potentially mitigate the negative effects of oxidative stress and support healthy aging by preserving telomeres.
Researchers have found that reductive stress promotes protein aggregation and impaired neurogenesis in neuroblastoma cells. This suggests a new role for reductive stress in the onset and progression of neurodegenerative diseases, including Alzheimer's, Parkinson's, and Huntington's.
Researchers found that severe reactive astrocytes cause irreversible neurodegeneration and cognitive deficits in just 30 days. Mild reactive astrocytes can reverse their reactivity, but excessive oxidative stress transforms them into neurotoxic severe reactive astrocytes.
Researchers found that supplementing people with HIV with GlyNAC, a combination of glycine and N-acetylcysteine, improves multiple deficits associated with premature aging. The supplement boosts glutathione levels, a natural antioxidant that neutralizes free radicals and helps maintain cellular function.
A team of researchers at the University of Münster has discovered a new mechanism that regulates myocardial distensibility, which is the elasticity of the heart muscle. This mechanism, called UnDOx, is triggered by oxidative stress and changes the stiffness of the cardiac walls.
A RUDN University biologist found that adding tryptophan to the diet of rainbow trout under stress increases immune response and reduces oxidative stress. The study suggests a potential solution for preventing fish death while maintaining high-density fish populations in farms.
A study published in PLOS ONE found that captive black rhinoceroses have higher iron levels, inflammation, and oxidative stress compared to white rhinoceroses. This suggests a link between iron accumulation and the development of diseases like organ failure.
Researchers at the University of Tokyo have discovered a new mechanism by which cells respond to oxidative stress. MTK1, an oxidative stress sensor, perceives the cellular redox state and transduces it into SAPK signaling pathways, leading to cell death and inflammatory cytokine production.
Research suggests that a genetic variant common in people of East Asian descent may make them more susceptible to adverse responses to e-cigarettes. The study found that mice with this gene had significantly higher heart rates and increased oxidative stress when exposed to e-cigarette aerosols compared to those without the gene. These ...
Researchers at the Josep Carreras Leukaemia Research Institute have identified a new enzymatic activity of Sirtuin SIRT7 that regulates the cellular response to metabolic stress. This discovery opens the door to new therapeutic targets for treating leukaemia and other malignant haemopathies.
Research suggests that antioxidant treatment after acute ischemic stroke could delay the onset of Alzheimer's dementia by reducing oxidative stress and promoting mitochondrial function. Studies have shown promising results with molecules like edaravone and nerinetide, but more research is needed to confirm these findings.
A study by University of Colorado Boulder researchers found that TMAO, a compound produced in the gut from red meat metabolism, impairs artery function and hastens aging. Adults with higher blood levels of TMAO had significantly worse artery function and greater signs of oxidative stress.
Researchers at Vanderbilt University Medical Center discovered that C. diff uses a protein system called HsmRA to capture heme from blood cells, building a protective shield against threats from the immune system and antibiotics. This finding suggests novel strategies for weakening its defenses.
Researchers found that excessive antioxidants can lead to pathological changes in hearts, causing enlarged hearts and diastolic dysfunction. Chronic antioxidant consumption without knowing one's redox state might result in reductive stress, which can induce pathology and slowly damage the heart.
Researchers at UNSW Sydney have developed a new imaging technique that uses the color of cells as a 'thermometer' for molecular imbalance. This technology has the potential to revolutionize medical diagnostics by allowing scientists to detect and decode cell colors without needing to extract samples from the body.
Scientists found that PTSD patients exhibit changes in small blood vessels, leading to abnormal responses in the sympathetic nervous system. Antioxidant supplements can reduce oxidative stress and improve blood vessel function.
Scientists have created a comprehensive atlas of toxic immune cells that damage the brain, revealing a potential new drug target for multiple sclerosis and possibly other neurodegenerative diseases. The 'atlas' was generated using a novel method called Tox-seq, which links gene expression to function in single cells.
A recent study found nearly 1 in 20 US adults use e-cigarettes, with a rise in current use among women, middle-aged adults, and former smokers. Blood samples suggest e-cigarette exposure is equivalent to tobacco smoke in promoting oxidative stress and heart disease.
A growing body of evidence suggests that antioxidant treatment in acute ischemic stroke may delay the onset of Alzheimer's dementia. Oxidative stress plays a major role in the pathogenesis of AD, and antioxidants have shown promise in animal models and some clinical trials.
Researchers identified a key strategy of cells to deal with misfolded proteins, where cells form aggregates to protect them from degradation. This approach is favored over fixing folding or destroying proteins, allowing for recovery under optimal conditions.
Researchers at EPFL discovered that fruit flies remove and excrete damage-causing lipids, preventing lipid peroxidation and ROS-induced inflammatory oxidized lipids. This mechanism may play an important role in other insects and even animals, helping to protect against oxidative stress damage.
Fruit fly sleep is driven by oxidative stress, an imbalance of free radicals and antioxidants. This discovery may explain why chronic lack of sleep shortens life expectancy. By sleeping, cells may mitigate damage from accumulated oxidative stress.
Intranasal insulin-like growth factor-1 (IGF-1) treatment reduces trigeminal pain pathway activation and oxidative stress levels in a rat model of migraine. The therapy has a unique potential to safely prevent migraine headaches through multiple novel mechanisms.
Australian researchers have discovered a further 148 previously unknown proteins affected by oxidative stress in the human body, linked to major diseases such as heart disease and cancer. The new chemical tool developed at Flinders University's Chalker Lab has mapped over 1000 proteins modified under oxidative stress.
Researchers at the University of Michigan discovered that oxidative stress in early life increases subsequent stress resistance later in life. Oxidative stress, which occurs when cells produce more oxidants than they can deal with, is part of the aging process but can also arise from stressful conditions.
Researchers warn of e-cigarette dangers, citing damage to brain, heart, and blood vessels, as well as increased risk of nicotine addiction. Governments are urged to take action to prevent young people's access to tobacco products and curb marketing.
Research from the Alkema lab reveals that the 'fight-or-flight' response triggers tyramine release, which stimulates insulin pathways to satisfy energy demands but down-regulates cellular protection against environmental stress. This dynamic regulation negatively impacts health and aging in nematode worms.
Researchers found that bilirubin protects the brain against oxidative stress by regulating superoxide levels. The study suggests a novel therapeutic approach for neurodegenerative diseases. Bilirubin's unique chemical structure allows it to neutralize harmful superoxide molecules.
Researchers at DZNE associate oxidative stress with the spreading of abnormal alpha-synuclein protein in Parkinson's disease, a neurodegenerative disorder. The findings suggest that oxidative stress may trigger the formation and aggregation of toxic alpha-synuclein species, leading to progressive pathology and neuronal damage.
A team from the University of Córdoba studied protein oxidation in western Mediterranean mice to detect environmental pollution levels in Doñana National Park. The research found high levels of oxidation in rice fields near the park, highlighting the presence of pollutants in the area.
Fruit flies' stress tolerance is linked to aging, with higher levels of PKG conferring protection but costing locomotor activity later in life. The study reveals a novel role for the PKG pathway in healthy aging and senescence.
Researchers found that targeting telomeres with oxidative stress can shorten them, leading to accelerated cellular aging and DNA instability. This could lead to potential cancer treatment strategies by stopping cancer cells from dividing.
Researchers found that birds have significantly lower cellular rates of energy use and antioxidant capacity compared to mammals. This may contribute to their longer lifespans, as oxidative stress is a major factor in aging. The study's authors plan to investigate the link between oxidative stress and immune defenses further.
Agricultural pesticide fludioxonil kills fungi by delivering a metabolic shock through the formation of reactive stress molecules, which triggers a biochemical cascade leading to cell death. The researchers discovered that fludioxonil produces methylglyoxal, a highly reactive chemical, which activates the lethal HHK cascade.
Researchers at the University of Oxford have found that oxidative stress leads to both sleep disturbances and aging. The study, published in Nature, suggests that targeting the mechanism behind sleep-regulating neurons could lead to a powerful new type of sleeping pill with fewer side effects.
Research suggests that an aging microbiome may be the key to understanding vascular decline and cardiovascular disease risk. The study found that suppressing the microbiome in old mice restored vascular health to that of young mice, highlighting the potential for gut-friendly diets and supplements.
Researchers found that joint use of tobacco and alcohol increased reactive oxygen species and pro-inflammatory cytokines in the rat brain, leading to lower levels of a growth factor essential for neuron survival. The study suggests that alcoholics who smoke may be at additional risk for neural damage.
Researchers from Lobachevsky University have discovered that erythrocytes undergo changes in their nanostructure when subjected to stress, which can lead to programmed cell death. This finding has significant implications for the development of optimal treatment regimens for patients with atherosclerosis and coronary heart disease.
Scientists propose using microalgae biomarkers to detect environmental pollution, which is triggered by oxidative stress and reactive oxygen species. The use of microalgae as an indicator can provide early warnings of environmental problems.
Mice exposed to ultrafine particles in utero show reduced immune responses and increased inflammation, indicating a possible link between prenatal pollution and respiratory health issues.
Research found that living in areas with dense vegetation is associated with lower stress levels, better blood vessel health, and improved cardiovascular function. The study's findings suggest that increasing green spaces in neighborhoods could be a significant public health intervention for reducing heart disease risk.
Researchers discovered that zinc can activate a molecule helping to shield against oxidative stress, which contributes to aging and illnesses. Zinc combined with polyphenols in foods like coffee, tea, and chocolate may provide natural protection.
Chemists at Friedrich Schiller University Jena have discovered a previously unknown metabolic pathway in plankton that produces a key compound in the global sulfur cycle. This finding provides valuable information about the earth's sulfur cycle and has important implications for atmospheric and climatic models.
A new study published by the American Academy of Ophthalmology suggests that taking metformin, a common diabetes medication, can lower the risk of age-related macular degeneration. Researchers found that patients who took metformin had half as many cases of AMD compared to those who did not.
A root extract of Fallopia multiflora has been shown to extend the lifetime of nematodes by almost 19% and protect them from oxidative stress. The primary component of the extract, similar in structure to resveratrol, activates sirtuins that control ageing.
Researchers at Brigham and Women's Hospital have developed a new model of heart failure that allows for the specific study of oxidative stress using chemogenetics. The approach enables researchers to activate or inactivate reactive oxygen species in the heart, leading to advanced cardiac dysfunction.
Researchers found that inoculation of rice plants with Brevibacterium linens RS16 improved photosynthetic traits and reduced volatile emissions in response to salt stress. This non-invasive approach enhances plant salinity tolerance, offering a potential solution for crop productivity under saline conditions.
Research suggests that early life stress can lead to increased levels of 'danger' molecules, which can overwhelm the body's natural system and cause chronic inflammation. This can ultimately result in a host of health problems, including cardiovascular disease.
Researchers found that nasal cells have a stronger antiviral response, while lung cells have a stronger defense against oxidative stress. This trade-off can make individuals more susceptible to rhinovirus infection when exposed to another stressor like cigarette smoke.
A researcher has linked the mysterious illness affecting American and Canadian diplomats in Cuba and China to radiofrequency/microwave radiation. The study's findings may aid in treating affected individuals and shed light on a larger population of people experiencing similar health problems.
Researchers found that higher oxidative stress in males reduces the production of nitric oxide, a powerful blood vessel dilator. An antioxidant treatment restored similar production levels of protective nitric oxide between males and females.
Research found that bigger eggs are advantageous in rainy weather, while smaller eggs are better suited for hot temperatures. House sparrows compensate for variable egg sizes by laying varying egg sizes within the same clutch.
A new study found that injectable trace minerals alleviate inflammation and oxidative stress in lactating Holstein cows exposed to aflatoxin. The researchers discovered that the minerals increased liver concentrations of selenium and iron and boosted serum glutathione peroxidase activity.
A new study found that Lutemax 2020 supplementation reduces photoreceptor damage caused by blue light exposure. The supplement's lutein and zeaxanthin isomers protect the eye by decreasing oxidative and endoplasmic reticulum stress.
Researchers at UH College of Pharmacy discovered that Angiotensin 1-7, a peptide found in humans, can relieve oxidative stress and reduce blood pressure. This finding offers a potential alternative to current medication with fewer side effects.
A recent study suggests that some level of reactive oxygen species (ROS) may be essential to health and development, contrary to the common assumption that they are harmful. The research, led by Purdue University's Daniel Suter, found that inhibiting an enzyme producing ROS in zebrafish embryos resulted in developmental complications.
Researchers found that short-sleeping fruit fly mutants are sensitive to acute oxidative stress, supporting the idea that sleep defends against oxidative damage. The study suggests a bi-directional relationship between sleep and oxidative stress, with sleep helping to reduce oxidative stress and vice versa.
Researchers at the University of Córdoba have discovered that a selenium-enriched diet can partially repair cell damage caused by the pesticide DDT in mice. The study found that selenium stimulates antioxidant defenses in cells, preventing oxidative stress and damage similar to cancer cells.