A study published in Molecular Psychiatry found that about 65% of patients who developed psychosis after age 40 showed abnormal tau buildup, compared to 15% of healthy older controls. The findings suggest diverse tau-related brain changes may be involved in late-onset psychosis.
Researchers found that tau buildup in PSP affects brain networks involved in thinking, including the prefrontal cortex and anterior cingulate cortex. The study suggests that symptoms arise from both local tau-related damage and remote disruption of a broader cognitive network.
Researchers developed a new magnetic memory material that can be rewritten using laser light, allowing for faster and more energy-efficient storage and processing of information. This breakthrough could help reduce power consumption in data centers and support future high-speed information systems.
Researchers developed biocompatible molecular quantum nanosensors that operate inside living cells, enabling absolute temperature measurements with subcellular spatial resolution. The sensors also detect radical-related spin signals in the cytoplasm and nucleus of cancer cells.,
Researchers developed a new imaging method to visualize how food spreads through ant groups in real time, offering insights into collective health and potential early warning signs of disruption. The technique allows for precise measurement of food distribution patterns across various species.
A study published by the National Institutes for Quantum Science and Technology found that carbon-ion radiotherapy provided durable tumor control with minimal side effects while preserving breast appearance in carefully selected patients who were unable or unwilling to undergo surgery. The treatment resulted in excellent local control ...
A team at Japan's National Institutes for Quantum Science and Technology has published a roadmap outlining the societal payoff of quantum technologies in life science. The study highlights three pillars: cell-scale diamond sensors, practical hyperpolarized MRI, and quantum biology, which enable earlier disease detection, faster drug de...
Researchers at QST discovered that controlled gamma-ray mutagenesis can create heat-tolerant nitrogen-fixing bacteria in weeks, shortening development timelines. The method produces robust, climate-ready microbial products for agriculture, food processing, pharmaceuticals, and biofuel production.
Researchers developed a gel-like material that mimics the softness and microstructure of slow-twitch muscle tissue, successfully cultivating cells with genetic and metabolic traits of slow-twitch fibers. The technology has far-reaching implications for regenerative medicine, drug screening, and muscle transplantation therapies.
Researchers at National Institutes for Quantum Science and Technology developed a technique to decompose polytetrafluoroethylene (PTFE) into gaseous products using electron beam irradiation. This process reduces energy required by 50% compared to traditional methods, making large-scale recycling of fluoropolymers more viable.
Research found that approximately 50% of participants with late-life depression and bipolar disorder showed tau accumulation in their brains, compared to only about 15% of healthy controls. The study suggests that neurodegenerative diseases, including Alzheimer's, can initially manifest as psychiatric symptoms.
Researchers found that distinct brain pathways from the orbitofrontal cortex are necessary for experience-based and knowledge-based adaptation. The findings have implications for understanding individual differences in thinking styles and may lead to personalized strategies for improving decision-making skills.
Researchers identified key brain areas, including aVTC and OFC, essential for visual object memory in macaques. Single-neuron recordings revealed top-down regulation and causal information flow between these regions, shedding light on short-term visual object memory mechanisms.
A novel radiotracer, C05-05, enables multi-scale imaging of α-synuclein depositions in living patients with Parkinson's disease and dementia with Lewy bodies. The tracer shows high binding affinity and selectivity to α-synuclein, providing a powerful tool for understanding its role in neurodegeneration.
Researchers demonstrate safety and effectiveness of DREADD-based strategy to suppress epileptic seizures in model monkeys. The treatment, deschloroclozapine (DCZ), can control widespread seizures within minutes without tissue damage or impairment.
Researchers have successfully visualized α-synuclein aggregates in the brains of patients with multiple system atrophy (MSA) using a new positron emission tomography (PET) imaging agent. The agent, 18F-SPAL-T-06, shows high specificity and potential for MSA diagnosis.
Researchers at National Institutes for Quantum Science and Technology found that p62 selectively degrades toxic tau species, preventing neurodegenerative disorders. The study demonstrates the pivotal role of p62 in suppressing abnormal protein aggregates using mouse models of dementia.
Researchers found that Amino LP7 supplements can slow down brain degeneration and reduce the development of dementia in mouse models. The study also showed that Amino LP7 reduces brain inflammation and improves neuronal connectivity, improving brain function.
A recent study used gene-targeting drugs to suppress areas of the brain and then imaged brain activity, revealing how this affects other complex operational networks. The research team found that silencing specific brain regions can cause stimulatory and inhibitory changes in brain activity, which can be identified using fMRI.
A novel neuroimaging technique using bacterial enzymes and inhibitors enables better live visualization of brain circuitry. The technique facilitates in vivo imaging without disrupting the blood-brain barrier, allowing for the detection of undetectable tau protein assemblies in neurodegenerative diseases.
Researchers manipulated dopamine receptors to understand benefit- and cost-based motivation, revealing complementary roles for D1R and D2R. The study sheds light on the neurobiological mechanism of decision-making and has implications for psychiatric disorders.
Researchers develop a novel technique to identify specific neural pathways involved in high-order executive functions, including working memory and decision-making. The study reveals that these functions are controlled by different neural pathways linking specific brain areas.
Researchers develop a non-invasive imaging method to track IDO1 activity, providing a promising alternative to invasive biopsies. The study found that IDO1 status in the mesenteric lymph node is a surrogate marker for cancer-immune set point and predicts immunotherapeutic efficacy.
Researchers found that autophagy and the G2 checkpoint are interrelated processes in pancreatic cancer cells, helping them survive radiotherapy. Inhibiting the G2 checkpoint suppresses tumor growth, suggesting new tools to combat radiation-resistant PDAC cells.
Scientists developed a novel quantum sensor that can detect oxidative stress in organs during MRI scans, which could lead to early diagnosis of diseases like cancer and kidney dysfunction. The sensor uses a ring-shaped sugar-like compound and nitroxide derivatives to identify reduced cell/tissue capacity.