Articles tagged with Organoids
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
Researchers developed a wire-embedded culturing device for noninvasive signal recording from lollipop-shaped neural spheroids, providing insights into neural circuitry and dynamics. The device supports culture and growth of neural spheroids while facilitating real-time monitoring of interior signals.
Researchers Ana Ivonne Vazquez-Armendariz and Jan Hasenauer are using their prize money to study the functions of scavenger cells in the lungs, combining mathematics and medicine. Their new models aim to understand how these immune cells behave in the lung, potentially unlocking better defense mechanisms.
A team of experts at Cincinnati Children's reports achieving a milestone in growing human liver organoid tissue that faithfully reproduces key zones, nearly doubling rodent survival rate. This breakthrough paves the way for studying human liver biology and disease, accelerating drug development and potentially leading to repair tissues.
Researchers have identified a combination of drugs that prevents enteroviruses from replicating, which could lead to an effective treatment for global health problem. The combination includes pleconaril, AG7404, and mindeudesivir, which shows great potential for finding broad-spectrum treatment methods against enteroviruses.
Researchers successfully assembled a miniaturized human nervous system to reconstitute the ascending sensory pathway, which transmits sensations from the skin to the brain. The new construct promises to accelerate understanding and treatment of chronic pain by allowing for non-invasive modeling and manipulation of the pain pathway.
Researchers at Ohio State University Wexner Medical Center have discovered a new way that neurons act in neurodegeneration by studying human neural organoids from patients with frontotemporal lobar degeneration (FTLD). They found GRAMD1B plays a significant role in managing cholesterol and lipid stores, which are linked to brain diseas...
Researchers have discovered a crucial biological mechanism by studying mouse embryo development, revealing how placenta-derived factors promote the expansion of liver progenitor cells. The study uncovers the role of IL1α in enhancing organoid growth under hypoxic conditions.
Scientists at ISTA create a new brain organoid model that incorporates microglia to study viral infections, such as Rubella, and test the effectiveness of ibuprofen. The results show that microglia play a crucial role in inflammatory reactions and that ibuprofen exerts its protective effects by inhibiting two inflammatory enzymes.
A new study presents a proof-of-concept leptomeningeal neural organoid (LMNO) fusion model to study meninges-brain signaling. The co-culture system of neural organoids fused with fetal leptomeninges from mice demonstrates stability and interface characteristics.
Researchers have successfully developed lab-grown pig retinal organoids, which shared similarities with human retinal organoids. The study offers a promising approach to combatting retinal disease by testing 'human-equivalent' photoreceptors in pigs.
Researchers found that pancreatic cancer cells gain a survival edge by carrying copies of critical cancer genes on circular pieces of DNA outside chromosomes. The discovery highlights the importance of targeting extrachromosomal DNA in treating the disease.
Developing multifunctional bioelectronics for organoid interfacing has overcome conventional electronics' limitations. Flexible and stretchable electronics create organoid/electronics hybrids for chronically stable interfaces, enabling electrophysiological recording and multimodal profiling of single cells within 3D tissues.
Researchers at USC Stem Cell discovered a gene called KCTD20 that suppresses glutamate toxicity, leading to enhanced tau protein clearance. This approach offers a promising therapeutic strategy for patients with tau-related neurodegenerative diseases, including Alzheimer's disease.
BaCell 3D conference to feature original research in organoids and regenerative medicine, published in Stem Cell Reports. The International Society for Stem Cell Research (ISSCR) partners with Stem Cell Reports to promote discoveries with potential to transform regenerative medicine.
Scientists discovered that specific gut cells, BEST4/CA7+ cells, regulate electrolyte and water balance in response to bacterial toxins. These cells greatly increase in number when exposed to interferon-γ, presenting a potential target for therapies.
Dr. Paola Arlotta's groundbreaking research on stem cell-derived brain organoids has redefined human brain development and neurological disease understanding. Her work provides access to the complexities of developing human brains, making her a deserving recipient of the ISSCR Momentum Award.
Researchers from Flinders University applied gene editing to explore the role of enzyme ACE2 in healthy placental development. They found that ACE2 plays a key role in helping cells grow properly and that a genetic variation is linked to major pregnancy complications.
Scientists at German Cancer Research Center develop innovative method for growing individual brain tumors in lab, mimicking original structure and molecular properties. The IPTO model accurately predicts patient response to chemotherapy and other drugs, offering a valuable tool for personalized medicine.
The ISSCR International Symposium will commemorate the 20th anniversary of iPSC discovery, highlighting breakthrough achievements and new research advances. The event aims to celebrate the transformative power of scientific curiosity and its potential to unlock cures for previously untreatable diseases.
Researchers at Mayo Clinic developed patient-derived organoid models to study uveal melanoma, a common type of eye cancer. These 3D models accurately represent the disease's genetic and biological characteristics, enabling better understanding and treatment development.
A new AI-powered software, EmbryoNet, can automatically detect defects in animal embryos and link them to underlying signalling pathways. This technology has the potential to replace lengthy animal studies in drug research, speeding up conventional processes while reducing costs significantly.
The KAIST research team developed a highly stretchable microelectrode array to monitor organoids' functions, enabling real-time analysis of their states. The technology showed promise in high-throughput drug screening applications, revealing changes in signal characteristics according to size and identifying potential drug interactions.
A novel patient-derived organoid library of tongue cancer tissue samples reveals new insights into chemoresistance mechanisms, highlighting the importance of autophagy and cholesterol biosynthesis pathways. The research also identifies potential drug targets for overcoming chemotherapy resistance in tongue cancer.
Organoids, derived from stem cells, closely mimic human tissue for biomedical research and drug testing. Standardization is crucial for generating reliable results in organoid construction, requiring approved operating procedures and informed consent from donors.
Researchers have developed a new way to grow organoids using Invasin, a protein produced by bacteria, mimicking the original organ with its variety of cell types. This study provides an affordable, standardized and animal-free alternative to currently used methods.
Researchers at TUM have grown tumor organoids that reproduce the morphological complexity of pancreatic cancer cells in the laboratory. The team used machine learning to categorize the organoids into different phenotypes based on their appearance and behavior, which react differently to treatments.
Researchers used lab-grown organoids from glioblastoma tumors to model patient response to CAR T cell therapy. The organoids accurately reflected the treatment's effect on actual tumors, providing a promising tool for personalized medicine.
Researchers developed a deep-learning model to predict organoid development at an early stage, outperforming human experts in accuracy and speed. The model classifies bright-field images of organoids into three quality categories, indicating their potential for regenerative medicine applications.
A Virginia Tech researcher has received a collaborative grant to improve cancer therapies by developing 3D liver organoids and employing cutting-edge microscopy technology. The project aims to identify the most effective treatments for cancer, enabling better-targeted treatments.
Scientists have developed a new organoid that includes all three key cell types in the pancreas, allowing for a clearer understanding of its early development. The research discovered a new stem cell type that can develop into these cells, and found differences between human and mouse pancreatic development.
Researchers at ISTA used miniature 2D organs and rubbery silicone molds to study morphogen signaling dynamics during spinal cord development. The study found that BMP morphogen signaling gradients emerge quickly, then fade away, only to reappear again, shedding light on the complex process of tissue development.
Researchers developed a platform to produce mature, uniform organoids using a three-dimensional engineered membrane. This breakthrough enables consistent quality and improved efficiency for practical applications in clinical trials and drug development.
Researchers created tiny lab-grown models of human immune systems to study immune function in cancer and predict disease treatment response. The miniature models support longer cell function, allowing processes like antibody formation to occur similar to the human body.
The SpaceX CRS-31 mission to the International Space Station includes studies on in-space manufacturing, cardiac health, and a method for repairing spacecraft damaged by debris. Multiple payloads sponsored by the ISS National Laboratory are bound for the orbiting outpost.
The IGFBP3 protein plays a crucial role in human lung development, and its expression must be reduced for cell differentiation to take place. The study used organoids derived from embryonic lungs to simulate lung development and found that IGFBP3 helps maintain lung epithelial cells in an undifferentiated state.
A team of researchers has developed strategies to identify regulators of intestinal hormone secretion, which could lead to new treatments for metabolic and gut motility disorders. They used human organoids to study the function of 'nutrient sensors' on hormone-producing cells in the gut.
Researchers at EPFL have developed the e-Flower, a flower-shaped 3D microelectrode array that enables real-time recording of neural activity from 3D neural spheroids. This breakthrough technology allows for more accurate and gentle monitoring of brain cells, paving the way for further research on brain organoids.
Researchers created a single cell atlas of prenatal human skin, providing a molecular recipe for building skin. The study also led to the creation of a mini organ model that grows hair, offering insights into scarless skin repair and potential clinical applications in regenerative medicine.
A Korean research team has successfully observed living organoids in real time at a high resolution using holotomography. The technology allows for long-term observation of dynamic changes and precise analysis of organoid responses to drug treatments.
Researchers at Texas Biomedical Research Institute developed a human cell culture model of alveolar macrophages, which helped make a key finding about the role of tumor necrosis factor (TNF) in tuberculosis (TB). The study found that TNF is critical to protect against TB but not other infectious diseases.
Organoids are miniature organs that capture specific organ structures and functions. They have been shown to shed light on genetic cell fates in various diseases, including infectious diseases, metabolic disorders, and malignancies.
Researchers found inhibiting ACMSD increases NAD+ levels, reducing inflammation and fibrosis in mouse models of MASLD/MASH. Boosting NAD+ production could protect against severe liver damage and cirrhosis.
Researchers from the Hubrecht Institute found that tuft cells can proliferate and generate new epithelial cell types, restoring damaged gut tissue. This discovery may have important implications for regenerative medicine.
Researchers have developed a lab-grown spine model that can test the effects of valproic acid on fetal development. The study found that co-treatment with Rapamycin can prevent the negative effects of valproic acid, enabling women to take life-saving medication while having healthy children.
Researchers at University of California - San Diego have discovered that Crohn's disease consists of two distinct molecular subtypes, each exhibiting unique patterns of genetic mutation and cellular phenotypes. This finding could lead to more effective management strategies, with therapies tailored to specific subtypes.
Researchers at UCLA Health Jonsson Comprehensive Cancer Center developed a biobank of 294 samples from 126 patients with 25 different subtypes of bone and soft tissue sarcoma. The team created tumor organoids that retained key characteristics of the original tumors, which were then subjected to high-throughput drug screening. They iden...
The Harvard team successfully recreated the satellite cell niche using 3D organoid culture techniques, generating stem cells that closely resemble native adult stem cells. These cells can engraft, repopulate the stem cell niche, persist long-term, and regenerate muscle after repeated injury.
Researchers at Heidelberg University developed a novel technique to create more complex organoids by controlling the release of growth factors and signaling molecules. This breakthrough enables the formation of realistic cell mixes, mimicking natural tissues and opening up new possibilities for engineering improved cellular complexity.
Holotomography offers a promising approach to biomedical research, providing high-resolution images of live cells and tissues at the organelle level. The KAIST research team has developed core technologies and demonstrated its applications in various fields, including regenerative medicine and cancer research.
Researchers found that Chlamydia bacteria can persist in the intestines of humans, where they form a permanent reservoir and evade antibiotic treatment. The bacteria preferentially infect the inner cell layer of intestinal organoids, but not the outer epithelial layer.
A study published in Nature Communications implicates the gene CHCHD2 in Huntington's disease progression and identifies it as a potential therapeutic target. The researchers found that mutations in the HTT gene affect CHCHD2, which is involved in maintaining mitochondrial function.
Researchers have successfully infected gastrointestinal epithelial cells with Chlamydia trachomatis using lab-grown human organoids. This finding supports the theory that Chlamydia can form a reservoir in the human gut, highlighting the importance of further investigation into this potential reservoir.
A study of over 900 children with autism spectrum disorder found that brain overgrowth is associated with increased social and communication symptoms. The research used MRI brain images and mini-brain experiments to show that enlarged brains are linked to altered Ndel1 enzyme activity, potentially affecting brain development.
Organoids models provide a comprehensive understanding of gastrointestinal disease etiology, highlighting complex interactions between genetic predisposition and gut microbiota. The review demonstrates the application of organoid models from bench to clinic for simulating host-microbial interactions and developing treatment strategies.
Researchers found anomalies in embryonic development of individuals with spinal muscular atrophy (SMA), which could lead to new treatment options. These abnormalities were recreated in laboratory-grown tissue cultures called organoids, revealing key insights into the disease's progression.
Human lung organoids can form lifelike models for tuberculosis infection, enabling the testing of anti-tuberculosis drugs. These models may also facilitate the development of host-directed therapies.
Researchers found that epalrestat increased sensitivity of non-small cell lung cancer tumors to chemotherapy, making it more effective. The study used patient-derived tumor organoids and found that overexpression of AKR1B10 was linked to drug resistance.
Bioethicist Insoo Hyun argues that advances in organoids and embryonic models strengthen rather than weaken the concept of human individuality. Current technologies are unable to replicate sentience, a crucial aspect of personhood, until major innovations are made.
Researchers at IBEC successfully generated kidney organoids with a complex vascular system, a breakthrough that could revolutionize disease modeling and drug screening. This achievement was made possible by combining 3D kidney organoids with endothelial organoids in a process that mimics the development of human kidneys.
Researchers from IBEC investigated how mechanical properties of colorectal cancer stem cells influence metastasis. Cells expressing LGR5 protein exhibit softer, less sticky properties and better adhere to blood vessel walls.