Articles tagged with Organoids
Researchers model Baraitser-Winter syndrome using human brain organoids, finding altered actin genes lead to reduced brain growth and smaller size. The study reveals a single mutation in the cytoskeleton causes disruption in early brain development.
Researchers have identified a new immune function of human M cells, which can process and present gluten antigens, suggesting a potential link to celiac disease. This discovery sheds light on gut immunity and may support future research into celiac disease diagnosis or treatment.
A new retinal organoid platform has identified biomarkers for Leber Congenital Amaurosis (LCA) and allows for genetic testing of patients. The platform uses small 3D structures of retinal cells to classify variants of uncertain significance in LCA genes.
Scientists at Penn Vet have identified two genes, Ctnna1 and Bcl2l13, that suppress metastasis in preclinical models of colorectal cancer. These findings could lead to better treatments and therapies for patients with metastatic disease.
Researchers create a simple, automated way of making lung organoids, which could help test early-stage experimental drugs more effectively. The bioreactor produces larger numbers of organoids with fewer manual labor requirements, offering promise for personalized patient treatments.
Researchers found that early brain firings occur in structured patterns without external experiences, suggesting a genetically encoded blueprint. This discovery can help better understand neurodevelopmental disorders and the impact of toxins on the developing brain.
Researchers at Terasaki Institute and Caltech will use stem cell-based models to identify factors influencing early human development. The goal is to gain insights into infertility, pregnancy loss, and developmental disorders.
Scientists at The University of Osaka developed a novel hydrogel that supports the efficient 3D culture of human induced pluripotent stem cells. This new material combines the properties of fibrin and laminin-511, creating a potent, xeno-free scaffold with strong cell adhesion.
New review highlights advances in New Approach Methodologies and tissue engineering, offering powerful tools to study early stages of cancer development. Lab-grown models replicate human body environment, unlocking clues about cancer initiation. These models also support discovery of new biomarkers for earlier detection.
Researchers developed a scalable method to produce human kidney organoids, combining them with pig kidneys outside the body for transplantation. The transplanted organs functioned normally and showed no signs of damage or toxicity.
A team of researchers identified a unique protein signature that can predict which patients are likely to resist standard therapies, paving the way for personalized treatments. By blocking a specific transporter system, they made tumors more sensitive to treatment, suggesting a promising new avenue for treating colorectal cancer.
Researchers developed a new human brain tissue platform called miBrains, integrating all major brain cell types and modeling brain structures, cellular interactions, activity, and pathological features. The models can be customized through gene editing and are derived from individual patients' genomes.
The study introduces a synthetic, animal-free gel that enables the long-term growth of 3D organoids, overcoming limitations of traditional animal-derived gels. The PIC–invasin gel offers robustness, consistency, and potential for widespread use in research and clinical settings.
Organoids are transforming biomedical research with their ability to model complex diseases like cancer, Zika virus infection, and cystic fibrosis. They enable high-throughput drug testing, personalized treatment prediction, and safety assessment.
Researchers at Aarhus University used mini-organs to show that cervical epithelial cells actively detect and combat infections, with uninfected cells becoming immune-active. This discovery opens opportunities for mucosal vaccines and targeted treatments against STIs and infertility.
Researchers have discovered that APOL1 mutations impair mitochondrial function in podocytes, leading to impaired kidney filtering. This finding could explain why inflammation triggers the onset of AMKD in patients, paving the way for targeted treatments.
Tiny organoid models capture the complexity of human tumors, enabling accurate testing of drugs and prediction of treatment responses. These mini-tumors preserve tumor heterogeneity, reflect real patient biology, and provide a platform for personalized cancer vaccines.
Johns Hopkins researchers used machine learning to analyze electric activity of mini-brains grown in a lab, revealing unique firing patterns associated with schizophrenia and bipolar disorder. The study improves accuracy in distinguishing between healthy and unhealthy brain organoids, paving the way for potential diagnostic tests and p...
A USC Stem Cell-led team has successfully generated lab-grown kidney structures, or organoids, that exhibit kidney-like functions such as blood filtration and urine production. The 'assembloids' achieved maturity levels comparable to newborn mouse kidneys, paving the way for developing new therapies for patients awaiting transplant.
The team will study neurons within a brain organoid, a millimeter-sized, three-dimensional structure grown in the lab from adult stem cells, to design smarter and more sustainable artificial intelligence. They aim to replicate complex computations that occur in the human brain to improve AI efficiency.
Researchers have developed a new platform for investigating tumor metastasis using CTC-derived organoids. These organoids provide an in-depth model for analyzing CTC behavior, including interactions with the tumor microenvironment and drug resistance mechanisms.
A four-year NIH grant will support a study of type 1 diabetes, led by Dr. Shuibing Chen at Weill Cornell Medicine. The researchers will investigate the interplay between genetic and environmental triggers using advanced laboratory and computational tools.
Researchers found distinct effects of single disease-causing gene variants across different brain regions, pointing to hippocampal disruptions as a key factor in cognitive problems beyond seizures. This study provides an early step toward understanding why current treatments often fall short and may help identify new therapies.
USC Stem Cell scientists have developed a blueprint for generating specific kidney cell types on demand, holding immense value for preclinical studies of new therapeutics and congenital kidney diseases. The team successfully created lab-grown proximal tubule cells that can absorb sugar and protein, respond to chemotherapy drugs, and pr...
Cells on the intestinal surface are replaced every few days due to pulling forces that determine which cells are weakest and need to leave. Weakened cells are removed from the intestine due to disrupted tug-of-war behavior, leading to inflammation and disease.
Researchers successfully created functional ureter tissue from pluripotent stem cells, bringing them closer to developing transplantable kidneys that can produce and expel urine. The achievement is a significant step toward next-generation regenerative therapies.
Researchers at the University of Minnesota have developed a groundbreaking process to combine 3D printing, stem cell biology, and lab-grown tissues for spinal cord injury recovery. The method involves creating 3D-printed scaffolds with microscopic channels that promote the growth of new nerve fibers.
Researchers at Texas Biomed have developed a live attenuated vaccine that showed high efficacy in cells and animal models, protecting mice from lethal H5N1. The team identified potential treatment targets using human airway organoids, revealing how bird flu remodels airway cells and causes scar tissue to form.
Researchers have developed a novel method to stimulate and mature human brain organoids using graphene, accelerating disease research and enabling brain-machine interfaces. The approach allows for safe, non-genetic, biocompatible stimulation of neural activity over days to weeks.
Researchers used human stem cell-derived kidney organoids to test the safety of gene editing delivered by AAV, a common tool in clinical trials. The study found that AAV2 caused significant harm to kidney cells through the NFκB pathway, but an existing drug was able to prevent this damage without interfering with gene delivery.
Early-life changes in fAD brain cells have been identified using stem cell-derived brain organoids, revealing key features of Alzheimer's disease. Treatment with Thymosin beta 4 has shown promise in reversing AD-specific changes.
The new book explores organoid bioengineering, using pluripotent and adult stem cells to create models for various organs. It discusses breakthroughs in personalized cancer care and large-scale production protocols supported by advanced tools like 3D printing and genome editing.
Researchers grew a 'whole-brain' organoid with neural tissues and rudimentary blood vessels, opening possibilities for studying neuropsychiatric disorders. The multi-region brain organoid retained a broad range of neuronal cell types and formed electrical activity, allowing for real-time study of neurodevelopmental disorders.
Scientists discovered a precise communication system in the gut, where telocytes deliver signals directly to intestinal stem cells using fine extensions. This finding challenges long-standing assumptions about gut healing and repair, potentially leading to better treatments for conditions like IBD and colon cancer.
Recent advances in biofabrication and biomedical electronics have led to the development of biohybrid-engineered tissue (BHET) platforms, turning passive constructs into intelligent systems. These platforms show promise in diverse applications, including brain organoids and cardiac tissues, blurring the line between biology and machine.
A novel 3D culture method enables self-organization of precursor cell types into functional liver organoids capable of producing essential clotting factors. The breakthrough advances organoid-based therapies, drug testing, and disease modeling for liver diseases, including hemophilia A.
The EVOaware project aims to develop an innovative platform that addresses tumour resistance to therapies by using advanced tissue imaging technologies and integrating genetic screening, lineage tracing, and spatial omics techniques. This platform has the potential to accelerate the discovery and development of new cancer therapies.
Researchers have identified LINC01235 as a crucial regulator of NFIB expression and NOTCH pathway in TNBC, suggesting potential therapeutic targets for this aggressive form of breast cancer. The study provides new insights into the role of non-coding RNAs in cancer progression.
Researchers at Cincinnati Children's Hospital Medical Center have successfully grown liver tissue that can produce its own internal blood vessels. This breakthrough could lead to new treatments for people living with hemophilia and those experiencing acute or chronic liver failure, as the liver organoids can secrete coagulation factors.
Scientists at Tufts University have developed a three-dimensional model to study the regeneration of nerve tissue in the nose, revealing that dormant stem cells play a key role in preserving the sense of smell. The research found that these stem cells actively support the generation of new olfactory neurons.
Scientists have created a vascularized organoid model of hormone-secreting cells in the pancreas, promising to improve diabetes research and cell-based therapies. The model, developed by Max Delbrück Center researchers, contains greater numbers of mature beta cells and secretes more insulin than non-vascularized counterparts.
Researchers developed organoids from Egyptian fruit bats' respiratory and intestinal tissue, showcasing a significantly higher baseline antiviral immune activity. These organoids demonstrated an exceptionally strong production of type III interferons, which played a crucial role in mucosal antiviral immunity.
The Mayo Clinic has established the world's first biobank of human salivary gland tissue-organoids, which can help researchers find a cure for chronic dry mouth. The biobank contains specimens from 208 donors and has already identified biomarkers for mature, saliva-producing cells.
Scientists have created a comprehensive bat organoid model to study zoonotic viruses, enabling early detection and drug testing for future outbreaks. The platform, comprising diverse bat species and organs, has led to breakthroughs in understanding virus behavior, isolation, and treatment.
Researchers developed a wire-embedded culturing device for noninvasive signal recording from lollipop-shaped neural spheroids, providing insights into neural circuitry and dynamics. The device supports culture and growth of neural spheroids while facilitating real-time monitoring of interior signals.
A world-first clinical trial is being launched in Melbourne, Australia to assess the potential of tumour organoids to predict which chemotherapy drugs will work for newly diagnosed patients with bowel cancer. The trial has the potential to transform current treatment selection practices and improve survival rates and quality of life.
Researchers Ana Ivonne Vazquez-Armendariz and Jan Hasenauer are using their prize money to study the functions of scavenger cells in the lungs, combining mathematics and medicine. Their new models aim to understand how these immune cells behave in the lung, potentially unlocking better defense mechanisms.
A team of experts at Cincinnati Children's reports achieving a milestone in growing human liver organoid tissue that faithfully reproduces key zones, nearly doubling rodent survival rate. This breakthrough paves the way for studying human liver biology and disease, accelerating drug development and potentially leading to repair tissues.
Researchers have identified a combination of drugs that prevents enteroviruses from replicating, which could lead to an effective treatment for global health problem. The combination includes pleconaril, AG7404, and mindeudesivir, which shows great potential for finding broad-spectrum treatment methods against enteroviruses.
Researchers at Ohio State University Wexner Medical Center have discovered a new way that neurons act in neurodegeneration by studying human neural organoids from patients with frontotemporal lobar degeneration (FTLD). They found GRAMD1B plays a significant role in managing cholesterol and lipid stores, which are linked to brain diseas...
Researchers successfully assembled a miniaturized human nervous system to reconstitute the ascending sensory pathway, which transmits sensations from the skin to the brain. The new construct promises to accelerate understanding and treatment of chronic pain by allowing for non-invasive modeling and manipulation of the pain pathway.
Researchers have discovered a crucial biological mechanism by studying mouse embryo development, revealing how placenta-derived factors promote the expansion of liver progenitor cells. The study uncovers the role of IL1α in enhancing organoid growth under hypoxic conditions.
Scientists at ISTA create a new brain organoid model that incorporates microglia to study viral infections, such as Rubella, and test the effectiveness of ibuprofen. The results show that microglia play a crucial role in inflammatory reactions and that ibuprofen exerts its protective effects by inhibiting two inflammatory enzymes.
A new study presents a proof-of-concept leptomeningeal neural organoid (LMNO) fusion model to study meninges-brain signaling. The co-culture system of neural organoids fused with fetal leptomeninges from mice demonstrates stability and interface characteristics.
Researchers have successfully developed lab-grown pig retinal organoids, which shared similarities with human retinal organoids. The study offers a promising approach to combatting retinal disease by testing 'human-equivalent' photoreceptors in pigs.
Researchers found that pancreatic cancer cells gain a survival edge by carrying copies of critical cancer genes on circular pieces of DNA outside chromosomes. The discovery highlights the importance of targeting extrachromosomal DNA in treating the disease.
Developing multifunctional bioelectronics for organoid interfacing has overcome conventional electronics' limitations. Flexible and stretchable electronics create organoid/electronics hybrids for chronically stable interfaces, enabling electrophysiological recording and multimodal profiling of single cells within 3D tissues.
Researchers at USC Stem Cell discovered a gene called KCTD20 that suppresses glutamate toxicity, leading to enhanced tau protein clearance. This approach offers a promising therapeutic strategy for patients with tau-related neurodegenerative diseases, including Alzheimer's disease.
BaCell 3D conference to feature original research in organoids and regenerative medicine, published in Stem Cell Reports. The International Society for Stem Cell Research (ISSCR) partners with Stem Cell Reports to promote discoveries with potential to transform regenerative medicine.
Scientists discovered that specific gut cells, BEST4/CA7+ cells, regulate electrolyte and water balance in response to bacterial toxins. These cells greatly increase in number when exposed to interferon-γ, presenting a potential target for therapies.