Articles tagged with Organoids
Researchers at Montana State University will study how avian flu viruses impact cells in the chicken intestine to better understand their growth, spread, and propagation. The study aims to find alternative strategies to vaccination, as current vaccines have unclear efficacy and can lead to food safety regulations and trade restrictions.
Scientists at UCSF created a new material that enables more predictable organoid growth, allowing for better study of disease and potential tissue replacement. The dynamic gel, invented by Zev Gartner, mimics the body's soft environment and enables precise 3D printing of stem cells.
Researchers at UC Santa Cruz successfully train brain organoids to balance a virtual pole, demonstrating adaptive learning capabilities. This breakthrough has implications for understanding neurological conditions and developing new tools for studying brain function.
Researchers have developed a new device that can record and stimulate activity across the entire surface of miniature, lab-grown human brain-like tissues, enabling whole-network mapping and manipulation. This breakthrough could improve our understanding of brain development, function, and disease.
Researchers at Johns Hopkins University used lab-grown retinal tissue to discover the cellular mechanisms that shape the foveola, a critical part of the eye responsible for sharp vision. The findings suggest that blue cones convert into red and green cones during early development, rather than migrating to other parts of the retina.
Researchers developed an advanced organoid model for human spinal cord injury and tested a promising regenerative therapy. The treatment triggered neurite growth and reduced scarring in injured organoids, offering validation for its potential to work in humans.
Researchers developed miniature 3D tumor organoid models that closely mimic the human brain, revealing how glioblastoma interacts with surrounding brain cells and immune system. The models identified PTPRZ1 as a key regulator of tumor behavior, which helps determine its aggressiveness.
Researchers created pea-sized mini-stomachs with three main regions, replicating human stomach function and acid secretion. The study models a rare genetic disease, paving the way for personalized treatment and accelerated clinical approval.
The American Association for the Advancement of Science (AAAS) has partnered with Research Networks to publish Computational and Structural Biotechnology Journal, Computational and Structural Biotechnology Reports, and Brain Organoid & Systems Neuroscience Journal as Science Partner Journals. These journals will publish high-quality re...
Dresden researchers have developed a system to test multiple compounds on human pancreatic organoids, identifying 54 compounds that affect pancreas development. These compounds inhibit the GSK3A/B protein and drive progenitor cells to differentiate into functional acinar cells. The ability to generate acinar organoids is valuable for s...
Researchers created lab-grown human nasal tissue to study the defense mechanisms against rhinoviruses. They found that cells in the nasal lining produce interferons, which induce a coordinated antiviral defense, controlling viral replication and reducing damage.
The EMBL-IBEC conference brings together experts to discuss recent breakthroughs in multicellular living systems, including organoids and embryonic development. The event will focus on disease modeling, developmental biology, and regenerative medicine applications.
A Korea University study successfully mimics heart mechanics in organoids using three-dimensional magnetic torque, enhancing cardiac differentiation, maturation, and vascularization. This breakthrough could improve drug safety testing by providing more accurate human-relevant models for cardiotoxicity screening.
A multidisciplinary team of world-leading experts is developing an off-the-shelf engineered product that could address liver failure in millions of patients. The ImPLANT project aims to create synthetic biology-based gene circuits in human induced pluripotent stem cells to drive cell differentiation into all required liver cell types.
Researchers developed a lab-grown model of the prostate gland to study bacterial infections. They found that E. coli targets specific cells and uses a 'lock and key' principle to invade. A sugar molecule called D-mannose blocks this interaction, offering a potential new strategy to prevent and treat prostate infections.
Scientists created three-dimensional pancreatic models to study the development of fluid-filled cavities. They found that low pressure and high cell proliferation rates produce complex, star-shaped lumens. The discovery can help understand organ development and diagnose diseases.
The SPINECRAFT project aims to create a cutting-edge, 4D human spinal cord construct that mirrors the architecture and functionality of the real spinal cord. This platform will enable detailed studies of spinal cord biology and integrate patient-derived cells to recreate disease-specific environments.
Early gastric cancer cells become self-sufficient by producing WNT7B, creating a self-sustaining loop and activating WNT signaling internally. This mechanism is triggered by MAPK signaling activation and has been validated in genetically engineered mouse models and human patient-derived organoids.
Researchers will investigate how HIV and cancer drugs damage brain cells over time, identifying potential early biomarkers of neurotoxicity. They will use human brain organoids grown in the lab to mimic brain physiology.
Dry eye disease affects 5-15% of people, causing symptoms like redness and burning sensation. Researchers generated human tear gland organoids from stem cells to understand the connection between DED and autophagy. They found that disabling autophagy led to cellular disruption, reduced tear protein secretion, and increased cell death.
Researchers at MPI-CBG have created a patient-specific human liver model consisting of three liver cell types, capturing key aspects of human liver physiology in a dish. The novel model provides a platform to study liver diseases, develop new treatments, and advance personalized medicine.
Researchers model Baraitser-Winter syndrome using human brain organoids, finding altered actin genes lead to reduced brain growth and smaller size. The study reveals a single mutation in the cytoskeleton causes disruption in early brain development.
Researchers have identified a new immune function of human M cells, which can process and present gluten antigens, suggesting a potential link to celiac disease. This discovery sheds light on gut immunity and may support future research into celiac disease diagnosis or treatment.
Scientists at Penn Vet have identified two genes, Ctnna1 and Bcl2l13, that suppress metastasis in preclinical models of colorectal cancer. These findings could lead to better treatments and therapies for patients with metastatic disease.
A new retinal organoid platform has identified biomarkers for Leber Congenital Amaurosis (LCA) and allows for genetic testing of patients. The platform uses small 3D structures of retinal cells to classify variants of uncertain significance in LCA genes.
Researchers create a simple, automated way of making lung organoids, which could help test early-stage experimental drugs more effectively. The bioreactor produces larger numbers of organoids with fewer manual labor requirements, offering promise for personalized patient treatments.
Researchers found that early brain firings occur in structured patterns without external experiences, suggesting a genetically encoded blueprint. This discovery can help better understand neurodevelopmental disorders and the impact of toxins on the developing brain.
Researchers at Terasaki Institute and Caltech will use stem cell-based models to identify factors influencing early human development. The goal is to gain insights into infertility, pregnancy loss, and developmental disorders.
Scientists at The University of Osaka developed a novel hydrogel that supports the efficient 3D culture of human induced pluripotent stem cells. This new material combines the properties of fibrin and laminin-511, creating a potent, xeno-free scaffold with strong cell adhesion.
New review highlights advances in New Approach Methodologies and tissue engineering, offering powerful tools to study early stages of cancer development. Lab-grown models replicate human body environment, unlocking clues about cancer initiation. These models also support discovery of new biomarkers for earlier detection.
Researchers developed a scalable method to produce human kidney organoids, combining them with pig kidneys outside the body for transplantation. The transplanted organs functioned normally and showed no signs of damage or toxicity.
A team of researchers identified a unique protein signature that can predict which patients are likely to resist standard therapies, paving the way for personalized treatments. By blocking a specific transporter system, they made tumors more sensitive to treatment, suggesting a promising new avenue for treating colorectal cancer.
Researchers developed a new human brain tissue platform called miBrains, integrating all major brain cell types and modeling brain structures, cellular interactions, activity, and pathological features. The models can be customized through gene editing and are derived from individual patients' genomes.
The study introduces a synthetic, animal-free gel that enables the long-term growth of 3D organoids, overcoming limitations of traditional animal-derived gels. The PIC–invasin gel offers robustness, consistency, and potential for widespread use in research and clinical settings.
Organoids are transforming biomedical research with their ability to model complex diseases like cancer, Zika virus infection, and cystic fibrosis. They enable high-throughput drug testing, personalized treatment prediction, and safety assessment.
Researchers at Aarhus University used mini-organs to show that cervical epithelial cells actively detect and combat infections, with uninfected cells becoming immune-active. This discovery opens opportunities for mucosal vaccines and targeted treatments against STIs and infertility.
Researchers have discovered that APOL1 mutations impair mitochondrial function in podocytes, leading to impaired kidney filtering. This finding could explain why inflammation triggers the onset of AMKD in patients, paving the way for targeted treatments.
Tiny organoid models capture the complexity of human tumors, enabling accurate testing of drugs and prediction of treatment responses. These mini-tumors preserve tumor heterogeneity, reflect real patient biology, and provide a platform for personalized cancer vaccines.
Johns Hopkins researchers used machine learning to analyze electric activity of mini-brains grown in a lab, revealing unique firing patterns associated with schizophrenia and bipolar disorder. The study improves accuracy in distinguishing between healthy and unhealthy brain organoids, paving the way for potential diagnostic tests and p...
A USC Stem Cell-led team has successfully generated lab-grown kidney structures, or organoids, that exhibit kidney-like functions such as blood filtration and urine production. The 'assembloids' achieved maturity levels comparable to newborn mouse kidneys, paving the way for developing new therapies for patients awaiting transplant.
The team will study neurons within a brain organoid, a millimeter-sized, three-dimensional structure grown in the lab from adult stem cells, to design smarter and more sustainable artificial intelligence. They aim to replicate complex computations that occur in the human brain to improve AI efficiency.
Researchers have developed a new platform for investigating tumor metastasis using CTC-derived organoids. These organoids provide an in-depth model for analyzing CTC behavior, including interactions with the tumor microenvironment and drug resistance mechanisms.
A four-year NIH grant will support a study of type 1 diabetes, led by Dr. Shuibing Chen at Weill Cornell Medicine. The researchers will investigate the interplay between genetic and environmental triggers using advanced laboratory and computational tools.
Researchers found distinct effects of single disease-causing gene variants across different brain regions, pointing to hippocampal disruptions as a key factor in cognitive problems beyond seizures. This study provides an early step toward understanding why current treatments often fall short and may help identify new therapies.
Cells on the intestinal surface are replaced every few days due to pulling forces that determine which cells are weakest and need to leave. Weakened cells are removed from the intestine due to disrupted tug-of-war behavior, leading to inflammation and disease.
USC Stem Cell scientists have developed a blueprint for generating specific kidney cell types on demand, holding immense value for preclinical studies of new therapeutics and congenital kidney diseases. The team successfully created lab-grown proximal tubule cells that can absorb sugar and protein, respond to chemotherapy drugs, and pr...
Researchers successfully created functional ureter tissue from pluripotent stem cells, bringing them closer to developing transplantable kidneys that can produce and expel urine. The achievement is a significant step toward next-generation regenerative therapies.
Researchers at the University of Minnesota have developed a groundbreaking process to combine 3D printing, stem cell biology, and lab-grown tissues for spinal cord injury recovery. The method involves creating 3D-printed scaffolds with microscopic channels that promote the growth of new nerve fibers.
Researchers at Texas Biomed have developed a live attenuated vaccine that showed high efficacy in cells and animal models, protecting mice from lethal H5N1. The team identified potential treatment targets using human airway organoids, revealing how bird flu remodels airway cells and causes scar tissue to form.
Researchers have developed a novel method to stimulate and mature human brain organoids using graphene, accelerating disease research and enabling brain-machine interfaces. The approach allows for safe, non-genetic, biocompatible stimulation of neural activity over days to weeks.
Researchers used human stem cell-derived kidney organoids to test the safety of gene editing delivered by AAV, a common tool in clinical trials. The study found that AAV2 caused significant harm to kidney cells through the NFκB pathway, but an existing drug was able to prevent this damage without interfering with gene delivery.
Early-life changes in fAD brain cells have been identified using stem cell-derived brain organoids, revealing key features of Alzheimer's disease. Treatment with Thymosin beta 4 has shown promise in reversing AD-specific changes.
The new book explores organoid bioengineering, using pluripotent and adult stem cells to create models for various organs. It discusses breakthroughs in personalized cancer care and large-scale production protocols supported by advanced tools like 3D printing and genome editing.
Researchers grew a 'whole-brain' organoid with neural tissues and rudimentary blood vessels, opening possibilities for studying neuropsychiatric disorders. The multi-region brain organoid retained a broad range of neuronal cell types and formed electrical activity, allowing for real-time study of neurodevelopmental disorders.
Scientists discovered a precise communication system in the gut, where telocytes deliver signals directly to intestinal stem cells using fine extensions. This finding challenges long-standing assumptions about gut healing and repair, potentially leading to better treatments for conditions like IBD and colon cancer.
Recent advances in biofabrication and biomedical electronics have led to the development of biohybrid-engineered tissue (BHET) platforms, turning passive constructs into intelligent systems. These platforms show promise in diverse applications, including brain organoids and cardiac tissues, blurring the line between biology and machine.
A novel 3D culture method enables self-organization of precursor cell types into functional liver organoids capable of producing essential clotting factors. The breakthrough advances organoid-based therapies, drug testing, and disease modeling for liver diseases, including hemophilia A.
The EVOaware project aims to develop an innovative platform that addresses tumour resistance to therapies by using advanced tissue imaging technologies and integrating genetic screening, lineage tracing, and spatial omics techniques. This platform has the potential to accelerate the discovery and development of new cancer therapies.
Researchers have identified LINC01235 as a crucial regulator of NFIB expression and NOTCH pathway in TNBC, suggesting potential therapeutic targets for this aggressive form of breast cancer. The study provides new insights into the role of non-coding RNAs in cancer progression.
Researchers at Cincinnati Children's Hospital Medical Center have successfully grown liver tissue that can produce its own internal blood vessels. This breakthrough could lead to new treatments for people living with hemophilia and those experiencing acute or chronic liver failure, as the liver organoids can secrete coagulation factors.