Articles tagged with Animal Research
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
A French study on circadian clocks found that female zebrafish 'set' the clocks of their young before birth, influencing how easily the body adjusts to day/night cycles. Variations in maternal genes may also affect this process.
Researchers at Ohio State University discovered a new mechanism of drug resistance in cancer cells, where growth factors protect tumors from anticancer drugs. They found that inhibiting these growth factors may improve chemotherapy effectiveness and reduce dosage needed.
A study by Cornell University ecologists found that cadmium from abandoned mines is affecting white-tailed ptarmigan birds in Colorado, causing brittle bones and damaged kidneys. The metal is also concentrated in willow plants, which the birds eat, leading to reduced reproductive success.
A team of scientists at Cornell University has discovered a genetic connection between the evolution of plump fruits and vegetables and the growth of human cancer cells. The study identified a single gene called ORFX that plays a key role in plant fruit development, similar to the human oncogene c-H-ras p21.
Researchers at the University of Pennsylvania School Medicine have discovered that the transforming growth factor-beta protein stimulates the development of sclerosis in the kidneys, leading to renal failure in diabetic mice. By neutralizing this protein, the study suggests that kidney disease in diabetes can be prevented.
Researchers at Johns Hopkins Medicine have discovered a compound called C75 that rapidly turns off appetite in mice, causing significant weight loss. The substance works by blocking the production of neuropeptide Y, a key hormone involved in appetite regulation.
Researchers have designed a molecule that selectively inhibits gelatinase enzymes, which help tumors grow and spread. This discovery may lead to new treatments for breast and prostate cancers, as well as other types of cancer and inflammations.
Researchers identified a working 'inhibitory synapse' between brain neurons and hair cells in the cochlea, suggesting a feedback mechanism that wires ears and brain for hearing. This discovery moves researchers closer to understanding human and mammalian hearing development.
Researchers have restored vision in a mouse model of Leber congenital amaurosis, a severe retinal degenerative disease. The treatment, which involves orally administering a chemical compound derived from vitamin A, has shown promising results in restoring visual function.
A new Amazon rainforest field research facility will conduct extensive ecological studies to understand the region's impact on global change. Scientists from around the world will study logging effects, carbon exchanges, and ecosystem cycles.
A new TB drug candidate, PA-824, has been shown to be effective against MDR strains of the bacteria. The compound, developed by PathoGenesis Corporation with assistance from NIAID's Laboratory of Host Defenses, works by preventing MTB from forming an important fatty acid component of its cell walls.
Scientists have created a novel dinucleotide molecule that appears to outlast existing treatments in cells. The integrase inhibitor has the potential to prevent HIV infection by blocking its ability to replicate in non-infected human cells.
Researchers found that tetrahydrocannabinol (THC) promotes tumor growth by impairing the immune system, increasing IL-10 and TGF-beta cytokine production. Marijuana smoke contains higher carcinogenic hydrocarbons than tobacco, posing a potential cancer risk.
Scientists have developed a method to 'knock out' fruit fly genes, allowing researchers to study their functions and identify corresponding human diseases. The technique, also applicable to fixing faulty genes, has the potential to revolutionize gene therapy.
A new 25-minute test distinguishes between different types of schizophrenia by measuring people's response to a sudden loud noise. Early onset schizophrenia has more severe information processing deficits and is less responsive to current treatments.
Scientists have conclusively determined that European Neandertals were top-level carnivores who lived on a diet of mainly hunted animal meat. The team analyzed bone-chemistry and stable-isotope analysis to reconstruct the Neandertal diet, finding that they likely ate almost exclusively meat.
The UCSD Superfund program will conduct projects on 20 toxic contaminants, studying their effects on humans, animals, and the environment. Researchers will use molecular biology and recombinant DNA technology to develop tools for evaluating health risks and minimizing hazardous risks.
Researchers at the University of Pittsburgh Cancer Institute found that triggering an anti-tumor immune response significantly potentiates the effects of the anti-angiogenic drug endostatin. The study showed that half of treated animals experienced complete and permanent regression of tumors, suggesting a highly effective cancer therapy.
Researchers found that blind naked mole-rats disperse from their natal colonies to seek new partners and form new colonies, challenging the assumption that inbreeding is the norm for these eusocial creatures. The study also revealed that outbreeding is the preferred breeding system of choice for mole-rats.
A University at Buffalo study shows that exercise training improves muscle function and protects against injury in aging animals. Regular exercise can help prevent frailty in seniors by strengthening muscles and reducing the risk of injury.
Researchers at NYU and MIT have created a peptide-based scaffold that supports living nerve cells, enabling the growth of functional synapses. This breakthrough discovery offers new hope for repairing damaged nervous systems, including spinal cord injuries.
Researchers have identified a sequence of amino acids found in fibronectin that accelerates healing of hard-to-treat skin wounds in obese, diabetic mice. The substance completely healed skin puncture wounds in eight days, compared to 20-42 days in untreated diabetic mice.
A study by Cornell University researchers suggests that prenatal cocaine exposure may cause lasting attention dysfunction in children, impacting their ability to focus despite distractions. The findings support the potential long-term effects of cocaine use during pregnancy on children's cognitive development.
Researchers discovered that large female spiders in colonies compete for space by building their webs earlier, using a capitalist technique to pre-empt areas. This strategy allows them to secure private space for egg-laying and reduces conflicts with smaller spiders.
A Yale University study suggests that individuals who quickly escalate their cocaine intake are more likely to become addicted. The research identified a key behavioral feature: excessive craving responses, which correlated with dramatic increases in cocaine intake before abstinence.
Scientists at HSC have successfully reversed fatal pulmonary hypertension in an animal model using an elastase inhibitor, which stops disease progression and restores normal blood vessel function. This breakthrough research may lead to new treatments for other cardiovascular conditions.
Philip Benfey has identified a gene that governs how plant cells proliferate and organize to form root systems. The research, published in Cell, has implications for both biology and bioengineering, including improving crop tolerance to salinity and fertilizer reliance.
Researchers from the University of Toronto and Texas A&M University suggest that a belt of open water near the equator may have supported life during the Snowball Earth era. This region could have provided refuge for early multi-celled animals, enabling them to survive and thrive in the face of extreme climate conditions.
A study published in Radiology found that Gulf War veterans experienced significant brain-cell loss, particularly in the brain stem, right basal ganglia, and left basal ganglia. The loss of functioning brain cells was linked to various symptoms, including joint pain, fatigue, dizziness, and mental confusion.
The study identified metalloproteinase-9 (MMP-9) as a key player in the development of abdominal aortic aneurysms. The researchers found that MMP-9 production was significantly reduced in patients who took doxycycline, suggesting a potential therapeutic strategy for preventing aneurysm expansion.
Researchers train embryonic stem cells into oligodendrocytes, which can rewrap nerve axons and remyelinate damaged spinal cords. The study demonstrates a potential approach to restoring neurological function in patients with conditions such as multiple sclerosis and spinal cord injury.
Chronic alcohol consumption combined with thiamine deficiency may have a synergistic effect on the brain, causing impaired learning, reference memory, and cognitive functions. Thiamine supplementation can exacerbate this effect, and some experts suggest that food supplementation or beer enrichment may be more beneficial.
Researchers studied rhesus macaques from birth to young adulthood, finding that those with high cortisol levels responded more strongly to stress and drank more alcohol as adults. The study's findings suggest early life stress can influence later alcohol consumption and offer a promising biological marker of risk.
Researchers link HIV-protease inhibitors to increased diabetes risk due to impaired glucose storage, prompting reevaluation of screening methods and development of new treatments. Up to 83% of patients on the drugs develop excess belly fat and type 2 diabetes.
Researchers identify a component of Chilean tarantula venom that specifically blocks stretch-activated channels, implicated in various physiological processes. This peptide toxin shows promise in treating conditions such as congestive heart failure, heart attacks, and brain tumors.
The National Toxicology Program (NTP) will review testing recommendations for future studies on DNA-based therapies, dietary supplements, and occupational chemicals. The agenda includes discussion of DNA-derived vaccines, gene therapies, and radio frequency radiation emissions from cellular phones.
Researchers have used new methods to track the evolution of human chromosomes over a 130 million-year period, finding that one chromosome is shared only with chimpanzees. By examining analogous chromosomes in other mammals, scientists can reconstruct how human chromosomes evolved from ancient origins.
Researchers at Oregon State University have discovered a new class of chemicals called 'bruchins' that signal a plant to form a benign tumor, helping prevent insect infestation. The unusual chemical can induce tumor formation even at low levels, with precise effects on the plant.
Researchers found that PKA signaling regulates both alcohol-seeking behavior and sensitivity to alcohol intoxication in mice. Mice with a mutation in the RIIb subunit of PKA drank nearly twice as much 20-percent alcohol solution, while recovering faster from sedative effects.
Researchers found that mice with a missing gene for Protein Kinase A drank twice as much alcohol and recovered in about 65 minutes from intoxication. The study suggests PKA may play a role in regulating voluntary consumption of alcohol and sensitivity to its effects.
A new study contradicts the long-held assumption that the Helicobacter pylori bacterium has been with humans forever. Researchers analyzed DNA from over 500 strains from five continents and found that strains from Peru resemble those from Spain, not those from eastern Asia.
A team of researchers has discovered two nearly complete fossil skulls from the Dmanisi site in Georgia, which may represent the first hominid species to migrate out of Africa. The fossils show clear signs of African ancestry and are dated to around 1.7 million years old.
Research suggests that high levels of environmental endotoxin in homes with sensitive children may drive the immune system to produce cytokines that inhibit processes leading to asthma. Conversely, homes with children who are not sensitized to common allergens have significantly higher endotoxin levels.
The JDF Center aims to develop new gene therapy techniques to increase islet cell supply for transplantation and protect transplanted cells from immune system attack. The center will focus on making islet cell transplants viable for young patients with Type 1 Diabetes.
Researchers have found nearly complete fossil cranium and skullcap in Dmanisi, Georgia, dating back to 1.7 million years ago. The discovery suggests early human species may have left Africa earlier than previously thought, with the possibility that they were driven by appetite for more protein.
Researchers at Northwestern University have successfully cloned a gene called Prestin, which codes for a protein that plays a critical role in the functioning of outer hair cells. The discovery could hold promise for treating hearing disorders and developing new biocompatible motors for nanotechnology applications.
A study of 589 10-year-olds found that those exposed to tobacco in the womb were more likely to experiment with tobacco. Peer tobacco use, child delinquency, maternal depression, and child depression were also significant predictors of tobacco experimentation.
Researchers have developed a novel diagnostic technique to directly detect prions in the cerebrospinal fluid, which is easily accessible for diagnostic purposes. This breakthrough method uses dual-color scanning for intensely fluorescent targets to identify single prion particles with high sensitivity.
Researchers discovered toxic alkenylbenzenes in tobacco smoke, which can cause cancer and lung disease in humans. The compounds are more likely to affect health when filtered cigarettes' ventilation holes are blocked.
Researchers found that hamsters use day length information to anticipate winter, and this memory is retained for a season. The study suggests that the hamsters' brain processes seasonal changes in daylight to adjust reproductive cycles.
Research finds that people typically focus on lower facial expressions when interacting with others, but these can be misleading. Studying brain activity, researchers discovered that the upper face is more closely tied to a person's true emotional state.
Researchers at San Francisco State University discovered that blister beetle larvae mimic female bees as part of a three-step strategy to infiltrate and parasitize the bee's nest. The larvae use cooperative behavior to lure male bees into pseudocopulation, which then transport them to multiple females.
Researchers test new fragrances to bait coyotes into consuming birth control drugs, aiming to reduce attacks on livestock and wildlife. The approach aims to decrease the need for lethal methods like shooting, which have cost farmers millions in lost earnings.
Scientists found that even in desolate areas, protected plants like seeds, spores, and root balls could sprout new life. The standing dead trees and debris acted as 'lifeboats' for plants and animals, adding complexity to the recovering ecosystem.
Researchers from MGH discover that a protein called SDF-1 not only attracts but also repels T cells at high concentrations. This finding opens up potential new ways to manipulate the immune system for treatment of autoimmune diseases and organ transplantation.
The UC Berkeley team has developed a set of principles that apply to animal locomotion of all kinds, from running to flying. Their research has led to breakthroughs in robot design, ergonomics, and even computer animation, with potential applications in fields like engineering and Pixar Animation Studios.
Researchers found that inhibiting triglyceride synthesis, a key step in fat regulation, results in obesity resistance in mice. The study suggests that blocking DGAT-mediated triglyceride synthesis may be a potential strategy for treating obesity.
Researchers at Vanderbilt University have designed and constructed a small robotic 'bug' that can scuttle more than half a mile on a single battery charge. The robot, which is about three inches long and weighs two ounces, uses an unusual material called piezoelectric ceramic to achieve its motion.
Researchers at the University of Illinois have developed a new membrane filtration system that enhances the nutritional value of coproducts, including gluten meal and gluten feed. This could lead to increased demand for corn and make ethanol production more profitable.
Researchers at HHMI discovered that crossing two related mouse species results in abnormalities in gene imprinting and growth abnormalities in hybrid offspring. The study found that disruptions in growth contribute to speciation by reflecting a rapidly evolving divergence between species.