Articles tagged with Discovery Research
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
Researchers at UIC have found that HPSE drives antiviral immunity, proliferative signals and cell death, with potential applications in treating dysregulation of the protein in various diseases. This discovery has broad implications for diseases such as cancer, atherosclerosis and autoimmune disorders.
A new research project, funded by £1 million from the Medical Research Council, is investigating whether selective P2X7 receptor blocker drugs can treat patients with secondary brain damage. The study's goal is to reduce the impact of traumatic brain injury on patients and improve their clinical outcomes.
Researchers develop dynamic and intelligent solution to detect malware in Android apps without rooting devices or breaching privacy. The system achieves high accuracy in sensitive behavior detection, promising enhanced smartphone security.
Researchers at RCSI University of Medicine and Health Sciences have discovered a new way to halt excessive inflammation by regulating Arginase-2, a protein that limits inflammatory cytokine production. This breakthrough has the potential to protect the body from tissue damage caused by inflammatory diseases.
Researchers discovered human BCAS3 and C16orf70 as novel autophagic proteins, which accumulate around damaged mitochondria after mitophagy induction. The BCAS3-C16orf70 complex is required for autophagosome formation site recruitment, indicating accessory functions in autophagy machinery.
Adhesions form after inflammation or surgery and can lead to chronic pain, digestive problems, infertility, and life-threatening consequences. Researchers have discovered that macrophages play a key role in their development and have developed a new imaging system to visualize them.
A new AI tool developed at the University of Gothenburg uses deep learning to analyse microscope images, extracting more details and information than traditional methods. The tool, called Deep Track 2.0, simplifies data generation and allows for real-time analysis and customised information retrieval.
A team of researchers from NYU Tandon School of Engineering discovered that popular machine-learning frameworks for protecting sensitive data can be subverted, allowing secret information to be extracted. The study highlights the inadequacy of current privacy checks and warns against relying on untrusted third-party tools.
A new study published in Aquatic Toxicology found that shrimp on the South Coast of England have significantly lower sperm counts due to pollution. The research also discovered a decline in population density and fertility issues among other marine creatures, including humans.
A Chinese-German research team has identified a rice plant variant that can neutralize arsenic toxins, with grains containing less than half the amount of arsenic as conventional rice. The astol1 rice variant also exhibits an elevated content of essential trace element selenium.
The webinar highlights the importance of open data in developing resilience in agriculture and food systems, particularly in the face of climate change, pandemics, and pests. Key experts share insights on harnessing data to create more sustainable and equitable food systems.
Researchers build first model to track travel patterns of shared e-scooter use, capturing built environment variables more precisely. The study finds that tourism, commercial areas, hotels, and public transit stops are predictive of scooter destinations in Washington D.C.
The Genomic Data Commons has become a leading cancer genomics resource with over 84,000 anonymized patient cases and 65 projects contributing to the platform, providing a critical role in advancing precision medicine.
Researchers analyzed over 90,000 Alexa Skills and found significant security gaps, including the ability to publish skills under false identities and circumvent Amazon's security checks. Many Skills lack proper privacy policies, putting users' sensitive information at risk.
Researchers detected radio flares months and years after a star was torn apart by a black hole, contradicting previous expectations. The team observed two delayed flares in a distant galaxy, suggesting that new models may be needed to explain this phenomenon.
Researchers have discovered a new gene-editing technique that allows for the programming of sequential cuts in genes, enabling researchers to better investigate time-sensitive processes like cancer development. The discovery was made by UIC's Bradley Merrill and colleagues using special molecules called 'proGuides',
A new dataset from ATR Brain Information Communication Research Laboratory Group provides insights into Decoded Neurofeedback, a technique that uses AI and brain scanning to modify fear memories and boost confidence. The dataset includes five studies and could lead to new treatments for PTSD, phobias, and anxiety disorders.
A comprehensive genetic study in Qatar identifies genetic associations with 45 clinically relevant traits, shedding new light on the genetic architecture of clinical laboratory tests. The study highlights the importance of further research to define the genetic architecture of diseases in the Middle East region.
The report reviews recent changes in EU research policy, identifies key barriers and enablers for data sharing, and maps the Horizon 2020 dementia research portfolio. Key findings include a need to overcome technical, financial and motivational obstacles to data sharing, as well as involving people with dementia in research design.
Researchers found that when people visually estimate object size, they consider the surrounding context and distance from the observer, rescaling sizes before estimating variance. This ability allows for quick estimation of statistical characteristics of multiple objects.
A team of researchers found that protein imbalance leads to cataract formation by causing proteins to clump together and become cloudy. The study provides new insights into the causes of this common eye ailment, which may lead to the development of new treatment methods.
A new five-year study of over 100,000 people in Wales found that those from deprived backgrounds have worse asthma outcomes, including higher hospital admissions and risk of death. The study highlights the need for targeted health education strategies to improve asthma management in these communities.
Research by Cornell University's ILR School found that collaborating with a star employee reduces non-star employees' credit and gains in professional status during successful collaborations. However, it can mitigate or outweigh the loss of professional status associated with collaborative failure.
A new tool using machine learning predictive modeling has been developed to predict the success of extubating ICU patients on intensive mechanical ventilation. The study analyzed data from over 1,000 patients and showed a significant reduction in reintubation rate from 9% to 1%.
Researchers discovered that transparent materials are perceived as flatter than actual thickness, contrary to metallic or glossy surfaces. The study used a computational model to predict image cues contributing to judgment errors and identified regional variations in local luminance contrast as the key factor.
Researchers successfully localized a non-repeating fast radio burst (FRB) using a novel processing system and supercomputer. The breakthrough identified the source location as a galaxy about 3.6 billion light-years away, providing valuable insights into FRBs and their possible causes.
Researchers found that some coronaviruses can incorporate host genes, such as CD200, to prevent excessive inflammation and prolong infection duration. This evolutionary strategy allows viruses to multiply and spread more effectively.
Researchers from Japan Advanced Institute of Science and Technology have developed a protocol that combines random sampling, high-throughput experimentation, and data science to identify synergistic catalyst combinations. The study identified 51 out of 300 catalysts as effective in the oxidative coupling of methane reaction.
Researchers at Lund University discovered distinct strategies among fungi species, including the 'soldier' that grows forcefully, the 'marathon runner' that sends out lone fighters, and the 'snake' that weaves around obstacles. The study provides new insights into fungal behavior and its potential applications in agriculture.
The February edition of SLAS Discovery explores the use of hit discovery methodologies and technologies in both small molecule and large molecule drug discovery. The issue features nine articles of original research, including those on high-throughput screening, mass spectrometry, and AI-driven screening.
Researchers found that desire for self-control is influenced by societal demands and internal motivations, with individuals low in trait self-control expressing greater DSC. Desire for self-control hinges on sense of necessity to accomplish current goals, leading to increased willingness to enroll in training.
The analysis of over 4,000 studies reveals a positive correlation between data availability and data use in biodiversity research. Data integration enables global synthesis and research across multiple taxonomies, facilitating research at various scales.
Scientists have discovered a way to create materials that can snap and reset themselves, moving without the need for motors or external power. This breakthrough could enable future military robots to operate independently, reducing reliance on batteries and motors.
Researchers developed an agent-based model to analyze the priority rule in science, finding that excessive rewards for priority can lead to lower-quality research. However, reforms like scoop protection can help mitigate this issue. To further improve science, measures like preregistration and criticism of research plans can encourage ...
Researchers have found that three ozone-depleting hydrochlorofluorocarbons are being emitted globally, including one recently discovered. The majority of these emissions originate from Asia and southeastern France, suggesting a link to the fluorocarbon industry.
Researchers developed an AI that accurately identifies places with insufficient or out-of-service stations. The tool is particularly effective in micropolitan areas, where population growth may lead to infrastructure issues.
A literature review on cycad leaf nutrition highlights inconsistencies in data collection and analysis methods, emphasizing the need for more research to effectively manage and conserve these plant species. The study recommends considering factors such as seasonal variations, insect herbivory, and soil nutrient concentrations.
A study found that male authors, those employed at prestigious institutions, and those affiliated with STEM disciplines are more likely to author open access articles. The study analyzed characteristics of 182,320 open access authors across the US from 2014-2018.
Researchers discovered a gene that shows butterflies and flowers independently evolved to make the same chemical compound for different purposes. Male butterflies use this pheromone to repulse competitors and attract females only once.
Researchers at Northwestern University have created data-driven movies of how RNA folds in the cell, revealing unexpected mechanisms and dynamics. These findings could lead to breakthroughs in understanding and treating RNA-related diseases.
Researchers have discovered that breastfed babies have nearly twice as many regulatory T cells, which control the immune response and reduce inflammation. The study found that specific bacteria support these cells' function, emphasizing the importance of breastfeeding.
A new study published in PLOS Medicine found a significant inverse association between physical activity and the occurrence of cardiovascular disease, with participants in highest quartiles showing substantial risk reduction. The study used data from 90,211 UK Biobank participants and found no threshold for this association.
Scientists discovered molecular basis for how shapeshifting immune system protein XCL1 evolved, outlining principles for designing metamorphic proteins as transformers. These principles can be used to develop biosensors, build nanoscale machines, and even create therapeutics.
Researchers have developed a new statistical method called Sum-Share that exponentially increases the ability to discover genetic insights. The method uses summary-level data from multiple sites to generate significant insights, outperforming existing methods in detecting genetic variations associated with cardiovascular conditions.
Cell Press launches a new initiative to promote inclusion and diversity in research, allowing authors to share their efforts in paper statements. The pilot program will track progress and provide data for benchmarking goals, aiming to increase diversity and monitor outcomes.
Researchers update current research focus from 'immune-centric-only' view to better understand autoimmune diseases like type 1 diabetes and multiple sclerosis. The study identifies common gene expression changes at target tissues, highlighting the importance of studying both immune system and target tissues.
A new data-driven global climate model projects significant urban heat stress and reduced relative humidity in cities by the end of this century. The study's findings emphasize the need for local urban climate projections to support city planners' adaptation strategies, such as green infrastructure interventions.
Researchers from St Petersburg University have discovered a complex of rocks forming an ancient island arc in the Songkultau Mountains of Kyrgyzstan, dated to around 500 million years ago. The finding provides valuable insights into the geological history of Central Asia and has implications for understanding large ore deposits.
Study uses machine learning to map brain regions activated by music and finds distinct patterns for happy and sad music. Emotions evoked by films and music rely on different brain mechanisms, with films activating deeper emotion-regulating regions not seen in music.
The January issue of SLAS Discovery features the cover article 'Cryo-EM: The Resolution Revolution and Drug Discovery', which explores how Cryo-EM is influencing drug discovery projects. The journal also includes 13 articles on original research topics, such as high-throughput screening methods and protein-ligand interactions.
The Nobel Prize in Physiology or Medicine was awarded to researchers who discovered the hepatitis C virus (HCV). The discovery was made possible by the perseverance and determination of thousands of scientists worldwide. Their work has paved the way for future research into HCV and potential cures.
Researchers from Universidad Carlos III de Madrid and UNED used big data and physics research to analyze Beethoven's metronomic marks. The study found that conductors tend to play slower than indicated, with a systematic deviation, which could be explained by the composer reading the metronome incorrectly.
A new permafrost thermal stability map for the Tibetan Plateau has been created with high accuracy, using a combination of ground observation data and remote sensing big data. The map divides the permafrost into five zones, providing critical information for engineering planning and water resource management in the region.
A research consortium has analyzed frequency fluctuations in 12 synchronous grid areas across three continents, revealing that bigger grids are more stable. The study used a new measurement technology and a portable GPS-synchronized recorder to collect high-resolution data.
A Clemson University researcher has discovered a new parasitic worm that negatively affects reproduction in the Caribbean spiny lobster. The worm, named Carcinonemertes conanobrieni, is believed to be the first of its kind to infect this species in the Caribbean and western Atlantic Ocean.
Researchers at Tohoku University have discovered a mantle plume beneath central Greenland that melts the ice from below, bolstering understanding of volcanic activities and global sea-level rising.
Researchers conducted the first-ever census of creosotes in a 135-square-mile conservation site in Nevada's Mojave Desert, counting over 23 million plants. The study discovered trends about how landscape features influence plant growth, including the impact of slope direction and soil age on creosote volume.
Researchers at Case Western Reserve University have discovered a new pathway in Alzheimer's disease that could lead to earlier and more effective treatments. The Drp1-HK1-NLRP3 pathway plays a key role in disrupting normal brain cell function, leading to cognitive deficits and degeneration of white matter.
The NCCU project aims to apply evidence-based findings into real-world applications, addressing health disparities in underserved communities. Community advisory boards and focus groups will be formed to engage communities and support mentoring and networking efforts.
Researchers use ultra-bright X-rays to measure ion velocity and concentration, providing unprecedented insight into battery performance. The breakthrough discovery opens doors to optimizing battery designs for specific uses.