News on early, curiosity-driven science that opens new directions. Covers materials discovery, AI-guided research, pediatric research standards, and energy science.
The article presents a new plate-based image cytometry method to measure endothelial barrier function, which can be adapted for high-throughput and high-content screening. This approach shows promise in addressing the need for efficient pharmacological therapies for acute respiratory distress syndrome (ARDS).
Researchers at Mount Sinai have developed a novel therapy called MS67 that effectively fights acute myeloid leukemia with mixed lineage leukemia rearrangement. The therapy degrades the WDR5 protein, which drives the proliferation of this type of leukemia and other cancers such as pancreatic cancer.
A team of researchers at Bristol's Quantum Engineering and Technology Labs has developed a silicon photonic chip that can protect quantum bits from errors using photons. This breakthrough could lead to the creation of more powerful quantum computers by reducing the fragility of qubits.
Researchers have developed ultra-thin, defect-free superconducting flakes for use in quantum computing. The twist angle of the flakes is used to modulate the maximum supercurrent, creating an extremely sensitive magnetic field sensor. This breakthrough has potential applications in healthcare and mineral exploration.
The BiCIKL project links biodiversity data types and classes across 14 European institutions, creating a Biodiversity Knowledge Hub for seamless access. This initiative streamlines Open Science and FAIR practices, empowering researchers with efficient tools to explore and utilize biodiversity data.
A new study at Ohio State University's Comprehensive Cancer Center is using rapid autopsies to gather biological samples after death to better understand how cancer cells overcome different treatments. This approach has already led to novel findings about drug resistance mechanisms, including the recent approval of a targeted therapy f...
Researchers used extensive 2D and 3D broadband seismic reflection data to visualize and understand the subsurface structures of the Orphan Basin. The study provides context for future assessments of source rock, reservoir, and seal strata in oil and gas exploration.
A team of international researchers has unraveled the inner workings of C5aR2, a key receptor involved in inflammation and COVID-19. The study provides an additional opportunity for therapeutic targeting with new drug molecules to block its activation and inflammation response.
A UCL-led research team has discovered a new gene causing hypertrophic cardiomyopathy, an inherited heart condition. The study found that variants in the ALPK3 gene are responsible for 1-2% of adults with the condition, affecting approximately 1,250-2,500 people in the UK.
The Howard Hughes Medical Institute (HHMI) has invested $300 million in 33 new investigators, who will focus on tackling tough questions in biology and medicine. The scientists, from 21 US institutions, will receive funding over a seven-year term to explore uncharted scientific territory.
Engineering researchers at Ohio State University developed a method to use Starlink satellite signals to accurately locate positions on Earth, similar to GPS. The accuracy of this technique is comparable to or even surpasses that of GPS, with the potential to be used as an alternative navigation system.
Researchers used ALMA to observe distant galaxies and discovered two new, dusty galaxies near original targets, challenging our understanding of early galaxy formation. The discovery suggests that a significant portion of early galaxies may be hidden from view due to cosmic dust.
A new study has identified unique genetic codes in the placenta that could detect pregnancy complications earlier than current tests. The researchers found specific biomarkers in maternal blood that indicate placental health and fetal well-being, allowing for real-time assessment throughout pregnancy.
A team of researchers from IOCB Prague has discovered a new type of nanoparticles capable of safely transporting various types of nucleic acids used for therapeutic purposes into cells. The universal nature of their system sets it apart from existing solutions, allowing for efficient transport of mRNA and other RNA molecules into cells.
Researchers found that Maya rulers altered their cities' structures and alignments to reflect their own desires and authority. Many temples were built on top of existing ones or abandoned altogether, shifting the focus from community ritual to ruler-centric politics.
A new study from Washington University in St. Louis suggests that Mars' small size limits its habitability due to a lack of retained volatiles. Researchers used potassium isotopes to determine the presence and abundance of volatile elements on Mars, finding a correlation between body size and volatile composition.
A study by Umeå University researchers found that a specific light receptor, Opsin 3, plays a crucial role in brain development. The discovery may lead to new possibilities for using targeted light therapy during pregnancy to reduce the risk of neurological disorders in adulthood.
Physicists at the University of Bath have found a way to reveal the forbidden colours of light in twisted nanoparticles, opening up new possibilities for emerging nanotechnologies. This discovery has implications for communications, nanorobotics and ultra-thin optical components.
Scientists have developed a method to produce strigolactones, a group of plant hormones that prevent excessive budding and branching. By combining yeast and bacteria, researchers can synthesize these hormones from microbes, providing a promising alternative to traditional methods.
A multidisciplinary organization has reached consensus on guidelines for performing, interpreting, and reporting MR defecography. The consensus templates aim to standardize care for patients with evacuation disorders of the pelvic floor.
Researchers have discovered six new species of glass sponges and two previously unknown species in the waters off New Zealand, revealing a more diverse ecosystem than previously thought. The findings provide important data for protecting these unique habitats from deep-sea mining and fishing.
Researchers at City University of Hong Kong discovered a way to steer the spreading direction of liquids on a surface inspired by the Araucaria leaf. By adjusting the surface tension, they can control the liquid flow direction, with implications for fluidics design and heat transfer enhancement.
Research reveals that dopamine levels increase with stressful stimuli, rewriting the 'pleasure molecule' narrative, and suggesting new treatment approaches for psychiatric diseases and addiction. The discovery has significant implications for understanding dopamine's role in behavior and developing evidence-based treatments.
Researchers have discovered a new species of otter in Germany that dates back to 11.4 million years ago. The Vishnu otter genus was previously known only from Asia and Africa, but this finding suggests they also occurred in Europe.
Researchers have discovered a new technique to locate the diffusion wake's signal in the quark-gluon plasma, a subatomic soup that flowed like a friction-free fluid after the Big Bang. This breakthrough may help scientists understand how matter emerged from this perfect fluid.
A team of researchers has discovered a new species of giant penguin, named Kairuku waewaeroa, in the North Island of New Zealand. The fossil, estimated to be between 27.3 and 34.6 million years old, was found by school children on a fossil hunting field trip in 2006.
A team of NTU Singapore scientists developed a predictive computer model called NSGA-II, which proposed strategies to reduce COVID-19 infections and deaths by an average of 72%. The model recommended timely and country-specific advice on interventions such as home quarantines and social distancing measures.
A study on Antarctic jellyfish was conducted using footage from an amateur nature video. The research team identified 12 species, with two likely representing undescribed species. A machine learning training set for video annotation was also developed.
A University of Queensland-led study reveals that hot spot volcanoes do not produce 'pristine' magma from the melting mantle but instead filter a different melt to the surface. This new information supports the notion that detection of magma at the crust-mantle boundary could indicate an upcoming eruption.
Scientists have discovered a two-dimensional type I superionic conductor with high ionic conductivity and low thermal conductivity, making it a promising material for batteries, fuel cells, thermoelectrics, and environmental cleanup applications.
A nearly $2 million NSF grant will accelerate the hunt for low-frequency gravitational waves using high-precision timing observations of exotic stars called millisecond pulsars. WVU's Maura McLaughlin is principal investigator on the project, which aims to discover new types of gravitational waves and expand the IPTA's reach globally.
The Center for Research on Programmable Plant Systems (CROPPS) aims to integrate plant sciences, engineering, and computer science to improve crop efficiency and sustainability. Researchers will engineer plants that can detect environmental changes and respond to digital signals, leading to more efficient water and nutrient delivery.
Researchers at University of Illinois Chicago found a potential direct connection between neurodegenerative diseases, such as Alzheimer's disease, amyotrophic lateral sclerosis (ALS), glaucoma, and herpesvirus. The study suggests OPTN protein restricts HSV-1 virus spread in cells.
Researchers used a groundbreaking technique to study silicon crystals and neutron particles, revealing new information about a possible fifth force of nature. The study achieved fourfold improvement in precision measurement of the silicon crystal structure factor.
Researchers at Vanderbilt University Medical Center have identified a new antibacterial mechanism where immune cells cooperate to capture and 'eat' bacteria. This cooperation enhances the killing power of macrophages, increasing phagocytosis of bacterial pathogens, including antibiotic-resistant staph
A new study published in Science identifies a specific molecule, C1q, that plays a key role in the long-term effects of traumatic brain injury. The researchers found that an antibody treatment could prevent the development of negative outcomes such as sleep disruption and inflammation.
Researchers at UVA Health System have made a groundbreaking discovery about cells' 'batteries,' revealing how they sense problems and perform quality control on mitochondrial function. This finding could lead to better treatments for non-communicable diseases, which are estimated to cause 71% of all deaths.
The National Institute on Aging has expanded its network of cutting-edge Alzheimer's disease and related dementias centers, with two new centers in North Carolina and Texas. The Duke/University of North Carolina ADRC will focus on understanding age-related changes across the lifespan and identifying disparities in dementia among differ...
Researchers at Stanford University have overcome a key obstacle in phase-change memory technology, enabling faster and more energy-efficient data storage. By using a thermally insulating flexible substrate, they reduced power consumption by a factor of 10 on flexible substrates and 100 on rigid silicon.
Researchers analyzed 1.4 million field observations and 73,000 museum records to find a strong correlation between species abundance in nature and their presence in museum collections. This method enables scientists to study species decline and estimate past abundances, providing insights into conservation efforts.
Researchers found that the gene TCF-1 regulates specific Treg cells, leading to more severe and inflammatory colon cancers. Without TCF-1, these cells become activated and gain a gut-homing feature, resulting in harsher cancer outcomes.
The Vilcek Foundation has awarded four prizes worth $250,000 to foreign-born scientists in the United States. The prizes recognize outstanding career contributions to biomedical science and innovative research. This year's recipients include Vishva M. Dixit, Markita del Carpio Landry, Hani Goodarzi, and Harris Wang.
Researchers discovered a distinct difference in gene expression in women who underwent preterm labor compared to those at full term. The findings suggest new directions for studying preterm labor and potentially effective treatments.
The GPGD database contains records for 903 herb species, including DNA barcodes, organelle genomes, and whole genomes. It provides essential resources for species identification, biosynthetic pathway decomposition, and molecular-assisted breeding analysis.
Researchers have developed a stable perovskite nanocrystal material for LEDs, enabling bright and long-lasting light sources. The new material is made using a metal-organic framework structure, which keeps the nanocrystals separate and prevents degradation.
A team of researchers from Boston College has created a new metallic specimen where electron motion flows in a fluid-like manner, fundamentally changing particle-like to hydrodynamic dynamics. The discovery confirms theoretical predictions and opens up new possibilities for material exploration and potential applications.
MUSC Hollings Cancer Center researchers discovered a novel mechanism showing how a certain gene mutation can allow tumors to evade detection by the immune system in colorectal cancer patients. The study found that APC mutations lead to increased levels of PD-L1, which allows tumors to evade T-cell function and increase immunosuppression.
A new analysis platform developed by Ohio State University scientists combines genetics and phytochemical data to improve the health benefits of apples. The platform has potential to reduce breeding time and enable data-driven assessments of how to boost apple nutrition.
A study by Anglia Ruskin University found that weaker internal connections between the brain and organs are linked to negative body image. Adults with less efficient brains at detecting internal messages are more likely to experience body shame and weight preoccupation.
The University of Texas at San Antonio's Center for Innovative Drug Discovery (CIDD) has received a $3.2 million grant to develop strategies targeting cancer-related proteins considered 'undruggable'. The Proteolysis-Targeting Chimeras (PROTAC) platform aims to promote degradation of targeted cancer proteins and kill cancer cells.
Scientists have discovered that geckos use their tails to recover from head-first crashes into rainforest trees, with implications for the design of agile robots. This versatile behavior allows geckos to stabilize themselves after impact and maintain control during gliding maneuvers.
Researchers at McGill University have developed a new way to track genetically modified animals using artificial transgenes. The discovery provides a powerful tool for locating and managing escaped or released GM animals.
A new study highlights the need for a national policy to protect submerged Indigenous sites, which are at risk due to climate change, dredging, and seabed mining. Archaeological discoveries off the Pilbara coastline in Western Australia have uncovered ancient stone tools, rock art, and engravings dating back over 7,000 years.
Scientists at the University of Kent have developed a mathematical formula that describes the shape of any bird's egg in nature. The formula is based on four parameters and can be applied across multiple disciplines, including food research, mechanical engineering, and agriculture.
West Virginia University engineers are working on a $750,000 award from NASA to improve data transfer efficiency during space exploration. The team is developing AI-based algorithms that can compress data while retaining maximum information content, which could enable more efficient NASA missions and sustain Earth and solar observations.
A new preclinical study validates the spleen's role in cardiac healing and suggests targeting S1P as a potential treatment for heart failure. The study discovered interactions between S1P and the heart during transition from acute to chronic heart failure.
A new study by Tufts University researchers identifies a high risk of forced labor in US fruits and vegetables, with most food-country combinations coded as high risk. The study's findings highlight the need for policymakers, farmers, and food companies to address systemic issues in food supply chains.
Researchers describe two new species of fossil ctenophores from Utah with preserved nervous systems and up to 24 comb rows. These findings suggest that Cambrian ctenophores had more complex nervous systems than living species, with specific nerve tracks along the body and a ring around the mouth.
A new catalyst and microchannel reactors improve efficiency and cost in converting alcohol into jet fuel. The process reduces complexity, improves efficiency, and lowers capital costs for renewable energy production.
Researchers have discovered three new species of ancient mammals in North America, hinting at rapid evolution following the mass extinction of dinosaurs. The creatures, which include the 'Hobbit'-named Beornus honeyi, differ from earlier known mammals and suggest that mammals diversified more rapidly than previously thought.