Researchers found that suppressing CBP function in adult rodents impaired long-term memory, but administering a histone deacetylase inhibitor corrected this defect. This suggests remodeling of chromatin is essential for learning and memory, and may offer new treatment options for cognitive disorders.
SourceScripps Research Institute·JournalNeuron·DateJun 23, 2004
A new study found that the brain's amygdala interacts with memory-related brain regions during emotional memory formation, contributing to its emotional resonance. The researchers discovered a significant correlation between activity in emotion- and memory-related brain regions during emotional memory formation.
Scientists have developed fruit flies with fluorescent genes to study memory formation, discovering that a specific set of neurons, called projection neurons, show increased active connections after learning. The new synaptic activity disappeared within minutes but the flies continued to avoid the odor they associated with the shock.
SourceNIH/National Institute of Neurological Disorders and Stroke·JournalNeuron·DateMay 12, 2004
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A recent study by researchers at the University of North Carolina at Chapel Hill found that a lack of choline during pregnancy can lead to reduced brain cell formation and impaired memory in children. The scientists discovered that choline plays a crucial role in regulating stem cell division, which is essential for brain development.
SourceUniversity of North Carolina at Chapel Hill·JournalJournal of Neurochemistry·DateMar 18, 2004
Researchers discovered that the radish gene encodes a phospholipase-A2 enzyme, which plays a crucial role in anesthesia-resistant memory. The study found this enzyme is also involved in memory formation in chickens and rodents, suggesting a conserved mechanism across animal phyla.
The study reveals a direct activational signal from the synapse to the protein synthesis machinery, enabling neurons to boost protein production rapidly during long-term memory formation and synaptic strengthening. This discovery has significant implications for understanding psychiatric and neurologic diseases, potentially leading to ...
SourceMassachusetts Institute of Technology·JournalCell·DateFeb 5, 2004
A team of researchers has identified an enzyme, protein kinase C, that may play a crucial role in turning fleeting experiences into lasting memories. The study found that this enzyme helps to activate genes that express proteins involved in forming long-term memories.
A UCLA study used fMRI to scan brains while participants learned to associate names with faces, revealing areas of high activity during encoding and retrieval. The findings show that different parts of the hippocampus contribute to memory formation and retrieval in distinct ways.
SourceUniversity of California - Los Angeles·JournalScience·DateJan 23, 2003
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Buszaki's research published in Science and Nature reveals the neural code used by brain cells to communicate, including wave-like bursts that shape connections in the newborn brain. This breakthrough has significant implications for understanding how memories are formed and how the brain develops.
Researchers found that the brain replays and reinforces initial learning events to create cell-to-cell connections for long-term memories. This process, called synaptic reentry reinforcement, may be crucial for maintaining stable information over time.
SourcePrinceton University·JournalScience·DateNov 9, 2000
Researchers found that long-term memories become labile every time they are retrieved, making them susceptible to alteration or disruption. The process of reconsolidation, which involves the generation of new proteins, is necessary to store long-term memories without retrieval.
Researchers found that ERT increased blood flow to areas involved in memory formation, such as the hippocampus and parahippocampal gyrus. The study suggests ERT may lower susceptibility to age-related memory problems and Alzheimer's disease.
SourcePlaceholder·JournalNeurobiology of Aging·DateJun 26, 2000
Scientists at Emory University Health Sciences Center have discovered that the oxytocin gene is necessary for forming social memories, allowing individuals to recognize familiar faces. The study found that mice lacking this gene exhibited social memory deficits, which were restored with oxytocin treatment.
SourceEmory University Health Sciences Center·JournalNature Genetics·DateJun 18, 2000
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Researchers at Cold Spring Harbor Laboratory uncovered a new link in the molecular chain of events thought to underlie learning and memory. Strengthening of nerve cell connections can be largely explained by the movement of AMPA receptors into synapses.
SourceCold Spring Harbor Laboratory·JournalScience·DateMar 22, 2000
Researchers found that exercise increases the growth of new nerve cells and improves long-term memory in adult mice. Mice exercising for one month showed a significant improvement in memory skills, with better recall times and increased neural activity compared to sedentary mice.
SourceHoward Hughes Medical Institute·JournalProceedings of the National Academy of Sciences·DateNov 8, 1999
Researchers discover that exposure to novel environments stimulates the zif-268 gene during sleep, which may help consolidate memories. During REM sleep, this gene is reactivated in rats that explored new environments, suggesting a crucial role in memory processing.
SourceCold Spring Harbor Laboratory·JournalLearning & Memory·DateOct 22, 1999
Researchers found that adult monkeys have new neurons added to their cerebral cortex, reversing a dogma nearly a century old. This discovery suggests new ways of explaining how the mind accomplishes basic functions, such as problem-solving and learning.
Researchers at Max Planck Institute discover key molecule for LTP, a crucial process for learning and memory. The finding sparks new discussion on the role of LTP in memory formation, as mice lacking LTP showed no abnormal learning behavior.
SourceMax-Planck-Gesellschaft·JournalScience·DateJun 11, 1999
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Researchers at NYU School of Medicine have developed a method to measure anatomical changes in the entorhinal cortex, a key memory center in the brain. This technique uses MRI scans and reveals that patients with very mild Alzheimer's disease show significant shrinkage in this area compared to healthy volunteers.
SourceNYU Langone Health / NYU Grossman School of Medicine·JournalThe Lancet·DateJan 1, 1999
Researchers at Stanford and Harvard have identified specific brain regions responsible for predicting memory recall. Neural activity in the medial temporal lobe system, particularly the parahippocampal cortex, was found to predict whether a person would later remember a photograph or word.
Research at Washington University in St. Louis uses fMRI to capture images of specific memories as they are formed within the brain. The study found that increased activity in certain brain structures predicts whether information will be retained or forgotten.
SourceWashington University in St. Louis·JournalScience·DateAug 21, 1998
Researchers used fMRI to capture brain activity during verbal tasks, revealing specific structures involved in memory formation. The study found that increased activity in the left frontal and temporal lobes can predict whether participants will remember a word seen in the scanner.
SourceMassachusetts General Hospital·JournalScience·DateAug 20, 1998
Scientists have created a synthetic peptide that blocks the formation of amyloid plaques in the brain, destroying existing plaques and preventing nerve cell death. This breakthrough may lead to a new therapy for Alzheimer's disease and other diseases caused by defective protein folding.
SourceNYU Langone Health / NYU Grossman School of Medicine·JournalNature Medicine·DateJun 29, 1998
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Researchers found that choline supplementation during pregnancy led to increased memory capability in offspring, as brain circuits were primed to learn and retain new information. This finding has implications for pregnant women and their children, potentially leading to the development of dietary supplements to enhance memory function.
SourceDuke University Medical Center·JournalNeurophysiology·DateApr 7, 1998
A study by University of Washington professors Virginia Berninger and Robert Abbott found that handwriting instruction, combined with composition practice, significantly improved writing accuracy and quality in first-graders. The research also showed a direct carry-over from handwriting to compositional skills throughout the elementary...
SourceUniversity of Washington·JournalJournal of Educational Psychology·DateJan 29, 1998
Researchers at Oregon Health & Science University shed light on the molecular mechanisms underlying long-term potentiation, a key process for memory formation. The study reveals that CaM-KII plays a critical role in this process, enabling persistent changes in synaptic strength and storage of information.
SourceOregon Health & Science University·JournalScience·DateJun 25, 1997
Researchers found that a low-fat diet had no impact on memory loss in old mice, contrary to earlier studies suggesting a correlation between healthy eating and cognitive preservation. The study's findings add weight to theories suggesting that certain genes or stress hormones may contribute to age-related memory decline.