Seroquel was shown to significantly reduce mean Young Mania Rating Scale (YMRS) total scores in patients with bipolar disorder, with a faster reduction in symptoms compared to placebo. The medication was well-tolerated and had fewer side effects than other treatments like haloperidol.
Researchers at Frankfurt University Medical School have assessed the antiviral potential of five drugs against the SARS coronavirus. Glycyrrhizin, an antiviral agent proven to treat HIV-1 and hepatitis C, is the most active compound in inhibiting replication, with increased nitric oxide synthesis contributing to its effectiveness.
A recent study by Colorado University-led researchers highlights the growing health risks associated with changes in the global nitrogen cycle. The excessive use of nitrogen fertilizers has led to increased crop production in poor nations but poses significant environmental and health concerns for humans worldwide.
A study led by Rory Collins found that statin therapy reduces the risk of primary outcomes for people with diabetes, including cardiac death, non-fatal heart attack, and stroke. The reduction in risk appeared to be greater among diabetic patients who did not have occlusive arterial disease.
Researchers at Johns Hopkins Medicine reveal the crucial last step involved in long term depression, a process thought to underlie learning and memory. By blocking this step, they created a mouse with weakened connections that didn't affect behavior, paving the way for studying GluR2's role in motor skills.
Researchers have developed a smart brick that can monitor a building's temperature, vibration, and movement, providing vital information for firefighters and rescue workers. The device uses sensor fusion, signal processing, and wireless communication to report conditions remotely, enabling improved safety and comfort.
Acer's process creates a micro-porous calcium phosphate coated polymer 'bone' that allows natural bone growth, reducing recovery time to 18 months. The technology, funded by the Navy Small Business Technology Transition program, has shown success in animal testing and tissue cultures.
Researchers have developed a portable CT scanner that enables real-time, on-site analysis of gas hydrates in core samples, revolutionizing the search for alternative energy sources. The innovative system uses a medical CT scanner and reduces its size to analyze hundreds of x-ray scans into one high-resolution image.
A brain imaging study found that negative emotional states can override logical thinking in economic decisions, such as the ultimatum game, where people are offered a portion of $10. The study reveals a complex interplay between emotion and deliberative thought, suggesting that emotions play a primary role in decision-making.
Scientists discover that cellular senescence involves packaging of specific chromosomal regions into heterochromatin, which triggers a 'stop growing' response in cells. The study reveals genes are switched on in proliferating cells but silenced during senescence.
The discovery of Homo sapiens idaltu fossilized skulls in Ethiopia confirms modern humans originated in Africa and predate Middle Eastern remains by 30,000 years. The ancient predecessor's diet included hippopotamus, with stone tool marks suggesting early mortuary practices and possible scavenging.
Researchers at Louisiana Tech University are developing handheld computers to gather real-time data on patients' psychological states. This innovative approach aims to provide more accurate diagnoses and better treatment decisions.
A UK multi-centre randomised trial found that statins reduce the risk of heart attacks, strokes or revascularisation operations by about a third in diabetic patients, irrespective of their cholesterol levels. This could prevent at least 10,000 heart attacks, strokes and revascularisation operations each year worldwide.
A new imaging technique, using second harmonic generation microscopy, allows for the observation of microtubule polarity in living brain tissue. This enables researchers to study neuronal development and repair, as well as neurodegenerative diseases such as Alzheimer's.
Researchers at USC developed an animated health intervention called Carmen's Bright IDEAS to improve social problem-solving skills of mothers caring for kids with cancer. The system uses robotic thespians and AI to engage users in a positive experience, resulting in uniformly positive reviews from clinical trial participants.
A new clinical trial shows that antifungal prophylaxis with itraconazole reduces fungal infection risk in children with chronic granulomatous disease (CGD). The study found a statistically significant reduction in cases, suggesting the addition of itraconazole to treatment regimens.
The International Council for Science (ICSU) has released a report synthesizing over 50 science-based reviews on genetically modified organisms (GMOs) in food and agriculture. The report addresses key questions on the safety, environmental impact, and regulations of GM foods.
Dr. Zhang's research focuses on improving indexing, retrieval, and use of images based on algorithms that rely on the semantics of the images themselves. His recent invention disclosure reveals a novel fuzzy logic-based indexing scheme and user relevance feedback algorithm for content-based image retrieval.
Researchers demonstrate noninvasive microscopy scans producing images of diseased tissue at the cellular level, rivaling traditional histopathology methods. The technique uses natural fluorescence and multiphoton microscopy to enable optical biopsies on living animals or humans without surgical intervention.
The discovery of Herto fossils, dated between 100,000 to 300,000 years ago, provides critical evidence for the Out of Africa theory. The fossils demonstrate a transition from primitive African hominids to modern humans, bridging a previously unexplained period in human evolution.
Researchers found that exposure to synthetic cannabinoids can disrupt attention and performance in tasks requiring sustained focus. The study's findings suggest that cannabis users may experience serious long-term attention problems.
A recent study found that CACFP monitors play a crucial role in ensuring program quality and child nutrition. The researchers recommend focusing on top five training needs, including program regulation and record keeping, to improve monitor training.
The USGS collaborated with Alpha DVD to produce a comprehensive educational DVD about Alaska's glaciers. The DVD covers glacier characteristics, climate history, and ecosystems, providing a detailed introduction to this natural process.
The US healthcare system faces a high-performance goal with increasing efficiency and effectiveness. Key steps outlined include public reporting of data on providers, health plans, and demonstrations of new approaches to insurance coverage, technology, and quality standards.
A long-term study of 952 households will investigate how farming strategies change with each generation and the impact of human characteristics on deforestation rates. The research aims to determine whether subsequent generations have a reduced learning curve for forest conservation.
Plant pathologists and experts will discuss Soybean Rust's potential impact on US agriculture, citing significant yield losses and costly fungicide control measures. The symposium will focus on disease management tools, resistant breeding programs, detection methods, and a new USDA Action Plan.
Researchers at UC Riverside have made a breakthrough in single neuron positioning on microelectrodes, enabling the study of brain functions and diseases like dementia. This technology has the potential to benefit public health directly by providing a better understanding of how the brain functions.
A new report emphasizes the importance of subgroup analysis in clinical trials to detect sex differences, which could impact drug efficacy. The study highlights cases where inadequate dosing for women led to ineffective treatment outcomes, underscoring the need for better trial design and statistical analysis.
Researchers found that brain cells recycle synaptic vesicles rapidly through a 'kiss-and-run' process, allowing for efficient communication. This process enables small nerve terminals to get full mileage from their limited set of vesicles, supporting rapid neurotransmitter release.
The Early Detection Initiative aims to identify proteins that signify cancer presence or risk in human blood samples using proteomics techniques. Researchers will analyze data from large groups of individuals with known health histories and behaviors.
Researchers observe differences in jet production and particle energy between Deuteron-Gold and Gold-Gold collisions, hinting at the existence of quark-gluon plasma. These findings open up new avenues for studying the strong nuclear force.
Researchers found that glutamate regulates the movement of bicarbonate and chloride into epithelial cells, controlling mucus transport and water flow. This discovery contributes to understanding how cystic fibrosis is controlled by gland cell membranes and may lead to future therapies for severe forms of the disease.
Researchers at Cardiff University are launching a survey to gather detailed data on commercial and industrial waste arisings in Wales. The survey will question 2,400 businesses across the country, providing valuable insights into waste generation and management practices.
Scientists have identified a new cell type, VENT cells, that migrate to the developing inner ear and mix with epidermal cells, contributing to the formation of complex tissues. The discovery, made by Dr. Paul Sohal, could explain how single cells give rise to distinct systems.
Pelli and Farell's study shows that our visual system relies on the detection of smaller elements - features - to recognize complex objects like words. Despite learning millions of three-letter words, we never learn to recognize them as single features.
Fossilized skulls from Ethiopia's Afar region date back to 160,000 years, showcasing the earliest known fossils of modern humans. The discovery fills a major gap in the human fossil record and supports the theory that modern humans evolved in Africa.
Research suggests that rodents' UV vision helps them detect fresh urine marks, improving localization and social organization. This adaptation may have driven the retention of UV vision in these animals.
Researchers discover that PTEN can be activated by phosphorylation, a process that counterbalances cell growth and suppresses tumor growth. This breakthrough could lead to a new therapy for cancers associated with PTEN gene mutations.
The study shows that aspirin is likely a better choice than ticlopidine for recurrent stroke prevention in African Americans, who face higher stroke risks. Aspirin is readily available and inexpensive, while ticlopidine has serious side effects and is more difficult to use.
Researchers found that a Chinese herbal medicine called gastrodine compound granule significantly improved memory and behavioral scores in patients with mild to moderate vascular dementia. The study showed a 51.43% improvement rate, compared to 52% for the standard medication Duxilâ.
Scientists will conduct live agent testing of masks at Aberdeen Proving Grounds, simulating mustard blistering and nerve gas sarin exposure. The tests aim to establish a maximum penetration rate and fit testing methods for gas masks worn by first responders.
A study by Yale University found that older adults' disability scores worsen by 11.2% for every month of curtailed activity. The association between restricted activity and functional decline differs significantly in risk groups, with adjusted disability scores increasing by 18.7% and 7.5% for low- and intermediate-risk groups, respect...
Researchers have observed a steady decline in atmospheric mercury levels since the mid-1990s, with concentrations remaining relatively constant. The findings highlight the need for further research on the sources of mercury emissions, including both natural and manmade components.
Researchers at NIST have invented composites that can promote re-growth of natural tooth structures efficiently. These bioactive, biocompatible materials can be used to stimulate the repair of defective teeth, minimizing decay under orthodontic braces and potentially in root canal therapy.
Long-term data show effective control of serum phosphate levels, with 71.7% achieving target levels after one year and 68.9% after three years. Low incidence of hypercalcaemia is also maintained throughout the study period.
Researchers at USC created a new tool, eArchivarius, to organize and visualize electronic mail collections. It uses advanced search software to detect important relationships between messages and people, creating vivid and intuitive visual interfaces.
Researchers at NIST are developing tiny lab-on-chip devices to automate material formulation testing, reducing trial-and-error exercises. The project aims to improve paints, shampoos, and other emulsions with real-time image measurement techniques, extending microfluidic system capabilities.
Researchers found a significant reduction in micro-emboli during off-pump coronary bypass surgery compared to traditional pump-assisted procedures. This decrease was associated with lower rates of neurological complications and cognitive decline after surgery.
Researchers are investigating the role of arterial stiffness in hypertension by analyzing the elasticity, strength, and stiffness of rat and calf arteries. They found that hypertensive tissues are stiffer and less responsive to pressure changes.
Researchers create device that measures forces as small as tens of nanonewtons and ties those measurements to larger forces based on the kilogram. The instrument achieves accuracy to a few parts in 10,000 and aims to extend its resolution to piconewtons.
Researchers have developed a method to control the behavior of ultra-cold substances, which could lead to significant advancements in quantum computing and precise time measurements. By manipulating the material's density and vortex patterns, scientists can create unique flow patterns that defy traditional solid or liquid states.
A new study links premenopausal breast cancer to where women were born and lived during early life. Researchers found clustering of cancer patients based on their place of birth and residence at the time of menarche in Western New York's Erie and Niagara counties.
Researchers analyzed lipid levels of HIV patients before and during HAART and found that average total and LDL cholesterol levels remained stable over three years. After initiation, cholesterol levels rose but returned to pre-infection levels after a year. However, triglyceride and HDL levels were higher than in similar-aged men.
A study found that physicians prioritize profits over patient benefits when considering cost savings. More than half of responding physicians believed money saved would go to insurance executives rather than patients or improved services. The study highlights the disconnect between doctor perceptions and long-term societal benefits.
Identical twins who communicated once a month or more lived significantly longer than those with less frequent contact, outliving fraternal twins by nearly two years. Frequent social interaction among identical twins appears to contribute to their longevity.
Researchers found that AIDS-related lymphomas responding well to chemotherapy have high levels of proteins indicating rapid growth and multidrug resistance. The study also showed that suspending antiretroviral therapy during lymphoma treatment is safe and allows for high overall survival.
Researchers discovered that globular proteins can utilize their barrel structure to transport small molecules like ammonia, improving chemical reactions. This process, known as substrate channeling, allows for efficient delivery of reactants and enhances reaction rates.
The device detects cell viability directly and instantly, measuring electrical resistance changes in milliseconds after exposure to a toxic agent. It offers a rapid alternative to traditional fluorescent dye assays for detecting biochemical attacks or monitoring drug toxicity.
A study found that adolescents who see more smoking in movies are more likely to try smoking, with 52% of initiations attributed to movie exposure. Reducing adolescents' exposure to smoking in movies could significantly reduce the number of smokers.
A study of 448 children in New York Head Start preschool programs found that those with high cholesterol at ages 3 and 4 were more likely to have high cholesterol five years later. The study suggests that early intervention and primary prevention can be effective in reducing the risk of coronary heart disease.