Researchers have developed a new tissue-engineered vessel made from the patient's own cells, which can replace synthetic grafts used in coronary bypass surgeries. The first human trial showed promising results, with no failures noted during the first five months of use.
Studies identify molecular markers that can predict clinical outcome for patients with non-small cell lung cancer treated with gefitinib. Researchers found subgroups of patients with specific biomarkers, including EGFR gene copy number and Akt activation status, have increased survival rates.
The IDEAL study found that intensive LDL-C lowering therapy in patients with previous myocardial infarction did not significantly reduce primary end points but showed reduced risk of secondary composite endpoints and nonfatal acute MI. No differences were observed in cardiovascular or all-cause mortality.
Two studies by nephrologists at Texas Children's Hospital reveal that mild renal insufficiency is linked to poor outcomes in children with acute decompensated heart failure. Additionally, the research shows that hypertension in children is a silent disease that requires early screening and management.
A two-year study involving over 2,500 heart failure patients found that hospitals that cooperated to deliver proven care and educate patients saw lower death rates and rehospitalization rates. The project used a toolkit of standard admission orders, clinical pathways, and discharge checklists to ensure optimal care.
Researchers found that consuming sugar snacks reduces glucocorticoid levels in rats, which can help alleviate physical and psychological stress. The study suggests that sweets made from natural sugar may be a healthy 'self-medication' option for managing stress.
Researchers used FRET and ALEX techniques to measure protein distances, shedding light on protein folding dynamics. The study aims to understand how proteins fold and unfold, holding key to Alzheimer's disease prevention and treatment.
A Phase 2 trial of denosumab found significant increases in bone mineral density across various sites, including the lumbar spine, total hip, and distal radius. The study suggests denosumab may offer a new approach to treating osteoporosis by targeting RANK Ligand.
Researchers discover GRK5 plays a key role in preventing cell growth and proliferation in blood vessel damage, hinting at alternative therapeutic targets. The study suggests that other cell types, such as epithelial cells or bone marrow derived stem cells, may also contribute to restenosis.
Researchers found that people with nonsystolic heart failure can refill their hearts properly, but struggle with pumping blood during exercise. This challenges conventional wisdom and suggests alternative therapies, such as pacemakers or drugs that enhance blood vessel dilation, may be beneficial for these patients.
A study published in the Mayo Clinic found that women with congestive heart failure are less likely to receive cardiac resynchronization therapy but survive longer after implantation. The study revealed a significant gender bias, with women outperforming men in terms of long-term survival.
A mutation in ankyrin-B gene causes cardiac arrhythmia, leading to sudden death in young people. The disorder disrupts calcium balance in heart muscle cells, making patients vulnerable to arrhythmias.
Researchers have developed an immune-boosting vaccine that combines with surgery and chemotherapy to treat pancreatic cancer. Early results show improved survival rates, surpassing previous studies, and the team hopes to refine the vaccine's targets through further analysis.
Research shows lead may cause additional long-term health problems, disrupting immune cells that fight off pathogens. An estimated 434,000 US children under age 5 have elevated lead levels in their blood.
A randomized feeding study found that diets partially replacing carbohydrates with protein or monounsaturated fat lowered blood pressure and improved serum lipid levels. These findings suggest that macronutrient substitution can further reduce cardiovascular disease risk in the general population.
Researchers at UT Southwestern have developed methods to keep sperm precursor cells from differentiating into sperm, allowing them to freeze and thaw the cells. This breakthrough could lead to alternative sources for embryonic stem cells and enable the development of new male contraceptives. The study's findings also pave the way for g...
A follow-up study to the NSABP Breast Cancer Prevention Trial confirms tamoxifen's effectiveness in reducing invasive and noninvasive breast cancer risk. The study found a 43% reduction in invasive breast cancer risk and a 37% reduction in noninvasive breast cancer risk.
A new variant of retinoic acid receptor beta has been discovered, which may play a role in vitamin A resistance in lung cancer. The variant, RAR-beta-1', was found to be expressed in normal lung cells and sensitive to retinoic acid, but not in resistant or lung cancer cells.
A new study has found that chiropractic care is a cost-effective treatment option for chronic low-back pain, with lower costs and comparable patient outcomes compared to traditional medical care. Chiropractic care resulted in clinically significant improvements in pain and disability reduction for both acute and chronic patients.
A new study by Ohio University's Molly Morris and colleagues found that older female swordtail fish spend more time with asymmetrical males than symmetrical males. This contradicts previous studies suggesting females prefer symmetrical markings as a sign of genetic fitness.
Researchers developed a model that reprograms benign skin cells to express genes associated with aggressive melanoma cells, highlighting the role of tumor cell microenvironment in transformation. The study provides potential therapeutic strategies to inhibit melanoma spread.
A meta-analysis of over 95,000 patients found that aspirin significantly reduces the risk of stroke in women, with a 17% reduction in ischemic stroke and a 24% reduction in hemorrhagic stroke. In contrast, aspirin has no protective effect in men and may even increase the risk of bleeding strokes.
Researchers have discovered a novel bacterial protein azurin that can selectively target and kill cancer cells, while also using electric pulses to deliver a gene therapy that stimulates an immune system attack. Additionally, a small nanoparticle has been developed to reduce side effects of radiation and chemotherapy treatment.
A study of diabetic women found that dobutamine stress echocardiography predicts cardiac death and heart attack. The test's accuracy was shown to be higher than previously thought, allowing doctors to rule out ischemia in more patients, thereby extending their lives.
The study found that taking aspirin reduced the risk of cardiovascular death and death from all causes in postmenopausal women with cardiovascular disease. Women taking 81mg or 325mg of aspirin showed a significant reduction in mortality rates, with no difference between the two doses.
Researchers at Lawrence Livermore National Laboratory used fluorescence resonance energy transfer (FRET) to study the transcription of genes in DNA. They found that the initial and final stages of this process occur simultaneously, contradicting earlier theories that proposed separate processes for these stages.
A new combination treatment for glioblastoma has been found to improve survival rates without negatively affecting patients' quality of life. The study, which involved 573 patients, found no significant differences in six out of seven health-related quality of life measures after three months.
Researchers at St. Jude Children's Research Hospital identified Cbln1 as a key protein maintaining correct synaptic connections in the adult brain. Without Cbln1, synapses weaken and new nerve connections form, disrupting brain function.
Researchers found that replacing carbohydrates with protein and unsaturated fat can lower blood pressure, improve cholesterol levels, and reduce the risk of heart disease. The OmniHeart study suggests that these modifications can be effective in reducing some risk factors and estimated risk for heart disease.
A scholar argues that there is no scientific evidence to suggest people classified as 'overweight' are under direct threat from their body weight. The real causes of health issues are diet, exercise, and genetics, not body fat.
Researchers have found that two genetic conditions, sickle cell trait and a mild version of thalassemia, offer natural protection against malaria but can be rendered ineffective when occurring together. This study of Kenyan children highlights the complexity of genetic interactions in naturally acquired immunity.
The University of Georgia has been selected to conduct a pilot program aimed at increasing educational attainment among Hispanic students. The program will be compared to the practices at the University of Texas at Austin, which has a long history of attracting and retaining students from an established Hispanic community.
A study published in Cancer Research reveals that patients with high levels of the protein BCA2 are less likely to experience breast cancer re-occurrence. Higher levels of BCA2 are associated with positive estrogen receptor status and increased disease-free survival for regional recurrence.
Researchers at Ohio State University found that hamsters exposed to limited daylight before birth exhibited increased depressive symptoms as adults. The study suggests a link between seasonal light exposure, sex, and depression in hamsters, providing potential insight into human seasonal affective disorder.
Researchers found that wheezing prevalence follows distinct patterns by age 6 and stability of lung function is maintained through school years. Children with early wheeze tend to have lower lung function levels but stable rates.
UCLA researchers have developed a new method to monitor the immune system's response to cancer using PET scans. This breakthrough could lead to faster and more effective ways to test immunotherapies and track human responses to cancer treatments.
UCSB researchers have developed a hybrid silicon evanescent laser that could alleviate limitations in microelectronic systems. The laser uses InAlGaAs quantum wells to provide optical amplification and has the potential to enable highly integrated laser sources with intelligent opto-electronic devices.
Researchers found that a 12-minute visit with dogs significantly lowered blood pressure, released less harmful hormones, and reduced anxiety among hospitalized heart failure patients. This study demonstrates the benefits of animal-assisted therapy as an adjunct to medical treatment for these patients.
The project aims to sequence the maize genome to understand more about plant genomes and evolve cereal genomes. Scientists will sequence a maize cultivar called B73, with the goal of identifying new genes responsible for important traits like yield and drought tolerance.
Researchers have discovered a protein, RAR1, critical for response to retinoid treatment, which is resistant to this class of drugs. By triggering RAR1 protein expression in cancer cells, sensitivity can be restored, offering new hope for lung cancer patients.
Researchers investigated whether music training enhances multisensory processing, particularly sound localization in conductors. The study found that conductors outperformed musically untrained subjects in combining auditory and visual cues.
A combination of brain scanning with a new imaging agent and cerebrospinal fluid analysis has shown promise in predicting Alzheimer's disease. Researchers found low CSF levels of amyloid beta 42 in patients with cognitive impairments, but also detected positive results in cognitively normal subjects.
Researchers at the University of Pittsburgh discovered a brain imaging method to monitor Alzheimer's disease progression non-invasively using Pittsburgh Compound-B. This breakthrough allows for early diagnosis and monitoring of amyloid plaque deposits, which are thought to cause brain cell death.
A new antimalarial combination, CDA, has shown faster time to reduce parasite levels and greater reductions in parasite viability and reproductive ability compared to current treatments. Phase III trials are planned across sub-Saharan Africa to study its safety and efficacy.
A recent Penn State study suggests that increasing the truck driver's hours of service beyond 10 hours leads to a significant rise in the risk of crashes. The most concerning increase occurs within the 9th, 10th, and 11th hours of driving.
Research at Duke University Medical Center found that US heart patients receive blood transfusions 84% more often than Europeans and 38% more often than Asians. The study revealed wide differences in bleeding and transfusion rates among heart patients globally, with the US having significantly higher rates.
Researchers developed a new technique using time-resolved laser-induced fluorescence spectroscopy to identify plaque characteristics that contribute to weakening of the plaque. The technique was found to be 97 percent effective in identifying high-risk lesions, which are more likely to rupture and block blood supply.
A new study has successfully treated 99.1% of children with heart rhythm problems using a 3-D computer-assisted navigation system, reducing radiation dose by nearly half compared to traditional methods. The treatment also resulted in fewer RF applications and improved accuracy in finding specific locations.
Researchers at Thomas Jefferson University discover fullerene nanoparticle reduces organ damage from ionizing radiation by one-half to two-thirds, outperforming current protection methods. The agent also provides specific protection for organs like the kidney and nervous system.
Researchers at OHSU found that mice consuming fewer calories experienced a boost in essential neurochemical glutamate, which reversed a Parkinson's-induced drop. The study suggests dietary restriction may be beneficial in early-stage Parkinson's disease.
Researchers have discovered a key process underlying CML progression and identified an agent that can block it. Forskolin restores normal cell functioning in Gleevec-resistant cells, offering new treatment options for patients with advanced or resistant disease.
Researchers found that pursuing a goal can liberate people to pursue another, incompatible goal. Making plans for a goal also leads to the immediate satisfaction of conflicting desires. The study aims to address the behavior of individuals holding multiple goals.
A 'Perception' gene tracked by scientists suggests regulation of this gene played a crucial role in the evolution of modern humans' mental capacity. The gene, prodynorphin, is implicated in pain perception, social attachment, learning and memory.
Researchers found that when consumers identified a celebrity from their voice, there was no tie between the consumer's feeling for the celebrity and the brand. However, this changed when a consumer could not identify the celebrity, resulting in a definite effect on brand attitude.
A study found that low VO2max levels are a significant predictor of long-term mortality in patients with coronary artery disease. Patients with a VO2max below 18 ml/kg/min had a high risk of dying within 10 years, even after adjusting for age and other factors.
A novel proteasome inhibitor, NPI-0052, has been found to block cancer cells' proteasomes, leading to cell death. The compound is distinct from existing therapies like bortezomib and shows promise in preclinical studies.
Researchers from Yale University found that consumers tend to take risks with subsequent decisions when things are going well. Conversely, they opt for reliable options when the evening is off to a bad start. The study suggests that this pattern of choices applies to various goals including enjoyment and health.
A study by Lalwani and Monroe found that frequently fluctuating prices cause consumers to perceive a product's average price as lower than when the price is reduced by a larger amount but less often. This suggests that frequent discounts may be more effective in driving sales.
A Cornell University study reveals that child-headed households in Namibia often rely on their youthful social networks for support, highlighting the need for young Africans to be trained as social supports. The study of over 200 children found that 60% turn to other youths for help and advice, with many facing suicidal thoughts.
A systematic review and meta-analysis found that longer breastfeeding reduced a child's risk of coeliac disease by 52%. Infants breastfed regularly had lower risk when first introduced to gluten, suggesting reduced exposure or gut health benefits.