A team of researchers identified the gene Trib1 in mice, which regulates lipid production by the liver. Overexpression of Trib1 decreased blood lipids, while lack of Trib1 increased them. This suggests that TRIB1 is responsible for associations between chromosome 8 and lipid levels.
A new study published in Journal of Consumer Research explores how pride affects consumer self-control decisions. Researchers discovered that pride has two opposing forces: one promotes indulgence and the other facilitates self-control.
A University of Alberta study found that including pharmacists in primary care teams leads to significant drops in blood pressure among patients with Type 2 diabetes. The collaboration enables direct discussion between healthcare professionals, resulting in better medication management and reduced cardiovascular risk.
A study by Johns Hopkins Children's Center found that surgical items left behind during surgeries on children are rare but expensive mistakes, adding 8 days to hospital stays and $36,000 in extra charges. The risk of such errors varies depending on the type of surgery and patient age.
A study found that targeting HDMX overcomes p53 suppression and resistance to selective HDM2 inhibition, restoring tumor suppressor pathway in cancers expressing both proteins. The research enables new therapeutic strategies for human cancer, including those resistant to current treatments.
The KINARM Assessment Station is an objective tool for assessing brain function, capturing subtle deficits not measured by traditional tests. Clinical researchers need this tool to develop better therapies for treating brain injury or disease.
A study of retracted papers found US scientists were responsible for a third of all retractions, with one in three cases linked to data fabrication or falsification. Researchers from Asian nations also contributed significantly to the problem.
A study of 66 surgeons found that duration of surgery and blood loss are associated with increased stress scores, while night duty is linked to lower stress arousal scores. The authors argue that improving working conditions for surgeons, including reducing night duty, can lead to better patient care and reduced errors.
Research into health systems aims to improve healthcare delivery, but lacks clarity due to multiple definitions. The article proposes working definitions for Operational, Implementation, and Health Systems research, which can be used to build on existing research and maximize its impact.
A new analysis of fossilized grass-pollen grains from ancient European lake and sea bottoms has found that C4 grasses existed 14 million years ago, prior to the previously believed Oligocene epoch. This discovery sheds light on the evolution of these highly productive plants.
A study published in JAMA found that using automated external defibrillators (AEDs) in hospital settings does not improve survival rates for patients experiencing cardiac arrest. The analysis, which included over 11,700 hospitalized patients, showed a 15% lower rate of survival among those who received AED treatment.
Researchers found that homeopathic consultations can significantly reduce symptoms of rheumatoid arthritis when combined with conventional treatment. The benefits were attributed to the consultation process, not the remedies used.
Researchers at the Salk Institute found that fisetin slows the onset of motor problems and delays death in three models of Huntington's disease. The study suggests that fisetin may be able to slow down the progression of the disease in humans, improving quality of life for those affected.
A new study reveals that consumers who strongly identify with a brand may experience shame and insecurity when betrayed, leading to negative actions against the brand. Companies can mitigate this by promoting forgiveness, indifference, or effective disengagement.
Researchers found that UV radiation levels varied substantially during winter months at high-altitude ski resorts, with clear skies, noon time, and deviation from the winter solstice being key predictors. Despite this, sun protection behaviors did not consistently increase with elevated UV levels.
Researchers found that brain area V4 is divided into separate regions for different colors and orientations, with distinct processing domains for shape and surface properties. This compartmentalization has significant implications for understanding visual object recognition and attention.
Researchers are developing a manufacturing platform to produce biodegradable frames that mimic nature's fine-grained details, including vasculature. The goal is to grow replacement cardiac tissues for people who have suffered a heart attack, and create better systems for growing and studying cells in the laboratory.
Research review finds that regular physical activity can significantly reduce the risk of developing around two dozen health conditions, including some cancers and dementia. Healthy adults should aim for 150 minutes of moderate intensity exercise per week, with strength-training sessions and balance exercises also recommended.
Researchers have discovered that mesenchymal stem cells from umbilical cord blood can suppress inflammation and attenuate collagen-induced arthritis. The study suggests a new potential therapy for rheumatoid arthritis, which currently has limited long-term drug-free remission options.
Researchers at Virginia Tech have discovered a single P450 enzyme responsible for producing two common plant volatiles that defend against insect attacks. The discovery provides new insights into the biosynthesis of these compounds and offers potential applications in improving crop pest controls.
A national survey found that palliative care for patients with dementia has increased, but gaps in coverage and inadequate insurance coverage remain. Interdisciplinary teams, community partnerships, and education are critical strategies for successful palliative care and reducing caregiver burden.
According to the American Heart Association, only 12% of men and 13% of women had all four health factors at ideal levels. Researchers found that death rates were 55% lower for participants with five to seven health factors at ideal compared to those with no health factors at ideal levels.
Researchers found that injecting a platelet inhibitor directly into the heart through a coronary artery may restore blood flow more effectively than conventional administration after a severe heart attack. In contrast, erythropoietin did not reduce heart damage but may increase it in patients over 70 years old. Additionally, measuring ...
Research by University of Alberta graduate student Scott Persons reveals T.rex's long tail was a key factor in its exceptional speed. The dinosaur's caudofemoralis muscles, attached to upper leg bones, provided the power stroke for fast forward movement.
Researchers found that most melanoma cells can drive disease progression and cannot be cured by targeting rare sub-populations. The study suggests that all melanoma cells have the ability to form tumors and change genes on the fly.
Researchers have identified the origin of olfactory ensheathing cells (OECs), which promote nerve repair in the central nervous system. OECs are derived from neural crest cells, which can be grown in large quantities from adult stem cells.
Researchers at UCI discovered that circadian rhythms directly control PPAR-gamma, a protein essential for lipid metabolism. The discovery could lead to new pharmaceuticals targeting the specific amino acid on PPAR-gamma, offering a singular target for drug development.
Research reveals that teenagers' brains respond differently to drugs than adults, with greater cognitive shortfalls and altered stress responses. Long-term effects of adolescent drug use on brain chemistry are also being explored.
Researchers have identified about a thousand brassinosteroid target genes, revealing molecular links between the steroid and various cellular functions. The study provides the first comprehensive action map for a plant hormone, accelerating basic plant science and crop research.
The American Association of Pharmaceutical Scientists (AAPS) presented several awards to researchers and students for their contributions to the pharmaceutical sciences. The awards included AAPS Presidential Citation, Dr. Rainer Hoffman Product through Science Award, and AAPS Community Service Award among others.
A recent study published in Neurology found that children with autism spectrum disorders (ASD) are unlikely to outgrow handwriting problems into their teenage years. Researchers at the Kennedy Krieger Institute also discovered that perceptual reasoning skills are a key predictor of handwriting performance in adolescents with ASD.
Researchers at Baylor College of Medicine and UT Austin used molecular evolution analysis to identify the source of HIV infections in two criminal cases. They found that a single virus, with up to 75% of infections resulting from a single ancestral strain, could be linked to the infected individuals.
New brain machine technologies show promise in restoring vision, controlling prosthetics with thoughts, and regaining limb function after injury. An artificial retina may restore vision more effectively than existing prosthetics.
Researchers at the University of Missouri discovered a previously unknown level of genetic cross talk between plant proteins that fight off bacterial infections. The study found that certain proteins physically associate, enabling them to communicate danger signals to the cell's nucleus.
Despite a high frequency of cardiac risk factors, many patients presenting with acute heart attacks are not on primary prevention medications. The study found that nearly 400,000 patients present annually with ST-elevated myocardial infarction (STEMI) in the US, highlighting the need for improved preventive care.
A study of 68,505 premenopausal US nurses found a positive association between child/teen abuse and higher incidence of uterine fibroids. The researchers discovered that physical and sexual abuse increased the risk of fibroid tumors by 36% among those with severe cumulative abuse in childhood.
Researchers identified irregular heartbeat in pacemaker recipients as a potential stroke risk factor. Meanwhile, disparities in cardiovascular care persist despite healthcare reform, with African-Americans and those with lower socioeconomic status receiving fewer invasive procedures. Stress tests using exercise electrocardiography and ...
A study by Donald Redelmeier and colleagues found that male teenagers with attention deficit hyperactivity disorder, conduct disorder, or oppositional defiant disorder are more likely to be seriously injured in a road traffic crash. The researchers suggest that practical recommendations, such as avoiding excess speed and using seatbelt...
Researchers found that using erythropoietis-stimulating drugs with Herceptin resulted in reduced effectiveness of the cancer treatment. The study suggests that these drugs may activate similar downstream pathways as trastuzumab, causing antagonism between the two treatments.
Researchers developed a data mining method to identify children with serious lifelong chronic conditions using hospital discharge data. This allows hospitals to improve care quality and reduce costs for these patients.
A study of 90 patients with bullous pemphigoid found that nearly half had at least one neurologic disease, including cerebrovascular disease and dementia. The condition was often diagnosed after the neurologic disease, suggesting a potential predisposition.
Researchers used multidimensional scaling to create a graphical plot of amino acid sequence data for all strains of H3N2, predicting the dominant strain with high accuracy. The new method can predict whether a new flu strain will become dominant as little as two weeks after its appearance in GenBank, outperforming current methods.
Researchers at NC State University have developed a sensor that allows engineers to assess scour potential of soils without excavation. The 'in situ scour evaluation probe' (ISEP) measures scour rates and behavior, helping authorities prepare for and minimize impact of natural events.
Research published in PLOS Medicine reveals that prescribed medicines are responsible for over 3% of road traffic crashes in France. The study found that drivers taking level 2 and 3 medicines were at higher risk of being involved in a crash, with a fraction of crashes attributable to these medicines being 3.3%.
Professor Brian Cantor to receive honorary membership for distinguished services in metallurgical education and research. He will also deliver a keynote memorial lecture on Multicomponent High-Entropy Alloys, honoring his late colleague P Ramachandrarao.
Researchers at Yale University used fMRI to identify three distinct 'neural signatures' in children with autism and their unaffected siblings. These patterns, including reduced activity in certain brain regions and enhanced compensatory activity, may help with earlier and more accurate diagnosis of autism spectrum disorder.
Researchers found that overexpressing TRIB1 in the liver decreases lipid production, while lack of Trib1 increases it. This suggests TRIB1 regulates lipid metabolism in the liver.
Research found that mothers who smoked heavily during pregnancy had kids who were more likely to become repeat criminal offenders as adults. The study, which tracked over 4,000 adults from 1959-1966, showed a 30% increased chance of arrest among children whose mothers smoked heavily.
A new study found a 30-40% higher risk of colorectal cancer among men treated with hormone-based therapy for prostate cancer. The study suggests continued routine preventive care, including colorectal cancer screening, is essential during prostate cancer treatment.
A new study finds that consumers are often confused by zero values when comparing products, leading to unexpected choices. The Zero-Comparison Effect reveals how relative differences matter more than absolute ones in decision-making.
University of Illinois researchers developed microsensors that can track individual cells' masses and divisions over time. They found that cells grow faster as they grow heavier, rather than at a fixed rate throughout the cell cycle. The sensors also allow for imaging and tracking of cellular processes in conjunction with changes in mass.
A Tel Aviv University researcher discovered that a consumer's religiosity has a significant impact on their likelihood of choosing particular brands. Secular populations are more prone to defining their self-worth through loyalty to corporate brands, while religious consumers are less likely to display explicit brand preference.
Research found that women with high job strain have a 40% increased risk of cardiovascular disease, including heart attacks and the need for procedures to open blocked arteries. Job insecurity was also associated with risk factors for cardiovascular disease such as high blood pressure, increased cholesterol, and excess body weight.
A new protocol significantly reduced radiation exposure in children undergoing electrophysiology procedures, with a 22% reduction in X-ray machine time and 52% reduction in dose entering the skin. The protocol also showed a 51% reduction in median effective dose, correlating to decreased lifetime cancer risk.
Researchers discovered that connections in the spinal cord regrew spontaneously and extensively after a mild spinal cord injury in primates, restoring 60% of original connections. This finding holds significant promise for developing new treatments for patients with spinal cord injuries.
Researchers at Georgetown University Medical Center discovered neurons in bats' brains that 'shush' irrelevant signals and amplify relevant ones, allowing bats to filter out background noise. This finding may help humans better understand how we process sound in complex environments.
Recently bereaved individuals experience elevated heart rates and potentially harmful heart rhythm changes, increasing the risk of heart attack and sudden cardiac death. These effects tend to normalize within six months.
A Mayo Clinic study found that morbidly obese heart failure patients who underwent bariatric surgery experienced significant improvements in disease symptoms and quality of life. The surgery led to better breathing during exercise and reduced swelling in the legs, even if most patients remained obese after weight loss.
The proportion of adult smokers dropped dramatically from 32.8% to 12.2% over the past three decades, with greater decreases among adults with higher income and education levels. Current smokers were smoking less, with a decrease in average daily cigarette consumption.
A new therapeutic implant has been proven to synchronize and strengthen a fading heart beat, reducing the risk of death by 24% compared to current treatment. The device therapy, called cardiac resynchronization therapy (CRT), also improves quality of life and reduces hospital admissions for worsening heart failure.