A Chinese research team found strong genetic evidence linking mevalonate kinase gene (MVK) mutations to disseminated superficial actinic porokeratosis (DSAP), a rare skin disorder. MVK mutations were not detected in other clinical subtypes of Porokeratosis, suggesting they may be specific to DSAP patients.
The Euro-26 study examined health, life expectancy, and lifestyles of 26 European cities, identifying major differences within individual urban areas. Key priority areas were found for each city, including depression and anxiety, cancer, and respiratory disease.
Researchers at Scripps Research Institute and Sea Lane Biotechnologies discovered an unusual antibody, C05, that can neutralize various flu viruses by targeting the receptor binding site. The unique antibody uses only a single loop to grab this site, making it potentially useful for developing universal flu vaccines and therapies.
A new study published in Nature Climate Change warns that most coral reefs will be subject to severe degradation if global warming exceeds 2 degrees Celsius. Only a scenario with strong action on mitigating greenhouse-gas emissions and rapid coral adaptation could save two-thirds of coral reefs.
Researchers at MD Anderson Cancer Center have identified a promising therapy for NRAS-mutant melanoma patients. By combining two drugs that inhibit proteins Mek and Cdk4, scientists found that the combination shrinks tumors in genetically engineered mouse models.
Wolfram syndrome is a rare disorder that causes diabetes, hearing and vision loss, nerve cell damage, and early death. Researchers have identified a mechanism related to mutations in the WFS1 gene that affects insulin-secreting beta cells, which could lead to new treatment targets for the disease.
Researchers found 155 regions of DNA with different tag patterns in bees, which were mostly regulatory genes known to affect other genes. The epigenetic marks were reversible and connected to the bees' behavior, with more than half of those regions already identified among the original 155 regions.
Researchers have developed a novel method to attach chemical probes to proteins, allowing them to study the biochemistry of naturally formed proteins. The technique enables scientists to understand the mechanisms behind creating better antibiotics, anti-cancer drugs, biofuels, and other natural products.