The American College of Physicians recommends avoiding cardiac screening in low-risk adults, citing lack of benefits and potential harms. Instead, physicians should focus on treating modifiable risk factors such as smoking, diabetes, and hypertension.
A study published by the American College of Cardiology found that patients undergoing coronary angiogram with radial access had a significantly lower risk of major bleeding and death compared to those with femoral access. The study suggests that the arm should be the preferred approach for most catheter-based heart procedures.
A new study published in Canadian Medical Association Journal suggests that implementing a universal public drug plan could reduce Canada's spending on prescription drugs by $7.3 billion per year, while employers and unions could save an additional $8.2 billion. This cost savings is attributed to economies of scale in price negotiation...
The American Geosciences Institute has selected Emma Reed and Annette Patton as the latest recipients of the $5,000 Harriet Evelyn Wallace Scholarship. Both Master's candidates are using their research to investigate climate variability and environmental stressors in geoscience.
A study published in the Journal of Patient Safety found that redesigned IV medication labels can significantly reduce the risk of medication errors in the operating room. The research used simulated surgical emergency scenarios and showed a higher correct selection rate with redesigned labels compared to standard labels.
Scientists at Children's Hospital/Pitt study discover that restoring HNF4 production can heal damaged liver cells and reverse liver failure in animal models. The gene therapy approach has significant potential for treating patients too sick for transplantation.
A large-scale genetic study of tuberculosis susceptibility has identified a key gene, ASAP1, that affects an individual's ability to fight the infection. The research found that variants of this gene impact susceptibility to TB and may hold clues to designing more effective vaccines for prevention.
A study by the American College of Cardiology found that obese patients with atrial fibrillation who lost at least 10% of their body weight were six times more likely to achieve long-term freedom from the condition. Sustained weight loss was also associated with significant beneficial structural changes in the heart and improved other ...
Los Alamos researchers uncovered how materials develop defects during irradiation, revealing key factors that affect their properties. The studies shed light on defect mobility, grain boundary structure, and interface-sink efficiency, which are crucial for predicting material behavior under extreme environments.
A new report finds that only a small percentage of Africa's wet savannas have potential to produce staple crops while emitting less carbon dioxide. Converting these lands into farmland would release significant greenhouse gases, threatening biodiversity and local food security.
Two major diabetes associations, EASD and ADA, jointly recommend a comprehensive overhaul of medical device safety in Europe and the US. The current regulatory framework is criticized for being too lenient, with a lack of follow-up studies and insufficient public availability of adverse event reports.
Researchers found that exercise significantly improved blood vessel formation around tumors, leading to better oxygenation and reduced tumor growth. Exercise also enhanced the efficacy of chemotherapy drugs, shrinking tumors more effectively than sedentary animals.
A new study reveals the significant economic impact of diabetes globally, with high healthcare costs and lost wages in various countries. The review highlights the burden on individuals, families, and societies, especially in low- and middle-income nations where people with diabetes face limited access to affordable care.
A study by Mayo Clinic Cancer Center reveals the average price of cancer drugs in the US has increased significantly over the years, affecting patient care. The authors recommend six potential solutions to control high drug costs, including allowing Medicare to negotiate prices and implementing value-based pricing.
A new study suggests that integrating solar facilities into urban and suburban environments can generate up to 15,000 terawatt-hours of energy per year. The research found that California has millions of acres of land compatible for photovoltaic and concentrating solar power construction with minimal environmental impact.
The European Menopause and Andropause Society's 10-point guide provides a comprehensive approach to managing menopausal health, emphasizing individual needs and personalized care. The guide covers diagnosis, screening, treatment, and follow-up, aiming to promote health over several decades.
Physicists remotely control magnetic molecules spinning like tops using circularly polarised magnetic field changes. Theoretical findings by Iosif Davidovich Tokman and Vera Il'nichna Pozdnyakova may lead to designing rotating magnetic molecule rotors for powering molecular motors.
A research team found oxygen in the entire thickness of nutrient-poor seafloor areas, contrary to previous beliefs that only surface layers contain oxygen. The findings have significant implications for our understanding of microbial life, geochemical processes, and Earth's interior composition.
By channeling food to large individuals, fish biomass doubles, highlighting the importance of size-dependent efficiency in population growth. This study has significant implications for fisheries management and predator-prey interactions.
Researchers discovered how NORE1A prevents excessive cell proliferation associated with cancer. Overexpressing NORE1A induced cell senescence, whereas removing the protein enhanced cancer-promoting Ras mutations. This study highlights the critical role of NORE1A in regulating tumor growth.
Professor Mathias Kläui has received a grant from the European Research Council to develop a new type of magnetic sensor, which will enable recording large numbers of revolutions. The new sensors are expected to be ready for pilot applications within 18 months and offer enormous advantages for industrial users.
Researchers calculate vaccine coverage among exposed populations in California, Arizona, and Illinois as far below 96-99% necessary for herd immunity. The virus's effective reproduction rate is estimated between 3.2-5.8, emphasizing the importance of vaccination to control outbreaks.
Scientists from the Scripps Research Institute have confirmed that ribosome assembly is a potentially fertile new target for anti-cancer drugs. The study highlights the essential function of Casein kinase 1δ (CK1δ) and CK1ε in human ribosome assembly, which are also elevated in several tumor types and neurodegenerative diseases.
Middle-aged adults who show sustained concern for others are more likely to construe their lives as stories of personal redemption. Redemption narratives sustain hope that sacrifices today may produce future dividends, helping generative adults persevere in promoting the well-being of future generations.
The study found bivalirudin to be associated with significantly lower rates of bleeding complications and death, but failed to meet its co-primary composite endpoints. The high prevalence of heart attacks in patients may have diluted the benefits reflected in the rates of death and bleeding.
A new method for making perovskite solar cells has been developed by researchers at Brown University, which involves a room-temperature solvent bath to create perovskite crystals. The technique produces high-quality crystalline films with precise control over thickness across large areas.
New research from the University of Warwick found that zoos and aquariums can increase respondents' understanding of biodiversity and conservation after a visit. The study involved 5,661 respondents at 26 zoos and aquariums worldwide, showing an increase in positive evidence of biodiversity understanding from pre-visit to post-visit.
A recent study by SDSU psychology professor Jean M. Twenge found that Americans are increasingly tolerant of people with different views and lifestyles, including those who identify as LGBTQ+, atheists, and have differing political beliefs. The study, which analyzed data from the General Social Survey, also found a decrease in toleranc...
A new study reveals that El Niño and La Niña conditions can predict the frequency of tornadoes and hail storms in susceptible regions of the United States. Moderate La Niña events lead to more tornadoes and hail storms, while El Niño suppresses both types of storms.
A new study led by Elizabeth Archie found that social interactions directly affect the gut microbiome of wild baboons. Baboons with stronger social bonds have more similar gut bacteria, suggesting physical contact is key to shaping the microbiome.
A new study from the University of British Columbia suggests that Canada can implement universal public drug coverage without increasing taxes. The study estimates that this system would save the Canadian economy $7.3 billion annually by increasing the use of generic drugs and negotiating lower prices with pharmaceutical companies.
Columbia University researchers have identified a unique set of patient-specific T cells that react to donor tissue, increasing in number before rejection but decreasing after acceptance. The study supports combining kidney and bone marrow transplants to reduce organ rejection and potentially eliminate lifelong immunosuppression.
A new study using brain imaging shows that intentional recall can lead to the suppression of competing memories, altering their accessibility. The research found that remembering dynamically changes which aspects of our past remain available, and this mechanism is not limited to specific memory types.
A new study published in Medical Care found that specific health system factors, including prescriptions with a 90-day supply and lower copayments, nearly doubled the likelihood of patients adhering to prescribed heart and diabetes medications. The study examined nearly 130,000 Kaiser Permanente members with diabetes and aged 65 or older.
A new study identifies 15 animal species at the highest risk of extinction due to low conservation opportunities. Researchers estimate that conserving these species would require a significant investment of $1.3 billion annually.
Researchers discovered two seafloor gateways that allow warm ocean water to reach the base of Totten Glacier in East Antarctica. This finding explains the glacier's rapid thinning and raises concerns about sea level rise. The study highlights the importance of understanding the role of oceanic gateways in glacier melting.
A study found that laughter triggers the release of endorphins, encouraging people to make intimate disclosures to strangers. The participants who laughed together shared more personal information than those who didn't.
Scientists have developed a new storage principle and material that enables the reversible storage of 1.8 Li per formula unit, increasing lithium storage density by up to 420 mAh/g. The new system allows for high packing densities and stable operation, making it suitable for energy supply of devices with high power requirements.
The American Diabetes Association and European Association for the Study of Diabetes call for a comprehensive safety overhaul of insulin pumps, including greater access to data from manufacturers and funding for independent clinical trials. This is crucial for healthcare teams to educate patients on preventing errors with these devices.
Researchers at the University of Leeds have discovered a rare African bush that may help treat kidney cancer. The Phyllanthus engleri plant contains a chemical called Englerin A, which activates specific proteins in renal cancer cells, leading to their death.
The American College of Physicians recommends against routine cardiac screening for low-risk adults, citing insufficient evidence and potential harms. Instead, physicians should focus on mitigating cardiovascular risk through treating modifiable factors like smoking and hypertension.
A new study shows that years of running are closely linked to atrial fibrillation risk in runners, suggesting physicians should consider this when assessing older patients with endurance sports history. Meanwhile, a school-based program aimed at educating children about heart disease prevention may improve their parents' cardiovascular...
Researchers identified patients who donated their body to medical research and had undergone multiple MRI exams. Brain tissue samples showed measurable quantities of gadolinium deposited in the brain tissue of exposed patients, but no specific symptoms or diseases were linked to this finding.
Researchers have developed spherical nucleic acids that can selectively trigger the immune response, potentially treating a range of diseases including psoriasis, lupus, rheumatoid arthritis, lymphoma, bladder cancer, and prostate cancer. SNAs are nontoxic, potent, and efficiently deliver nucleic acids into cells via the endosome.
Researchers developed a new technique to compare human milk and rhesus macaque monkey milk proteomes. The study identified 524 human milk proteins and 518 in macaque milk, revealing 88 common proteins at different levels. Human milk contains higher levels of proteins aiding fat digestion and increasing iron absorption.
Scientists use advanced omics technologies to analyze the effects of substances on human cells, revealing potential health risks at very low concentrations. The study identifies changes in protein patterns and metabolism at non-toxic levels, which could inform the development of new risk assessment methods.
University of Illinois scientists have engineered a 'jailbreaking' yeast that increases wine's health benefits and reduces toxic byproducts. The new technology allows for precise metabolic engineering, enabling the addition of bioactive compounds from other foods and improving malolactic fermentation.
A recent study has identified a group of gene variants that may contribute to sporadic motor neurone disease, a devastating condition affecting thousands of Australians. Researchers sequenced the protein-coding genes of 44 MND-affected individuals and their parents, finding rare genetic changes in two-fifths of cases.
A study published in Nature Reviews Immunology reveals a 'window of vulnerability' for sexually transmitted infections (STIs) to infect the female reproductive tract. The researchers found that hormonal changes during the menstrual cycle create an optimal environment for implantation, which also increases susceptibility to STIs.
The SAPIEN transcatheter heart valve is a feasible option for high-risk patients with severe aortic stenosis, but valve leakage remains a significant issue. At five years, death and stroke rates were equivalent to open-heart surgery, but rehospitalization rates and functional outcomes differed.
A rare Caribbean coral species has been successfully bred and raised in the lab, providing a rare glimpse into its procreation process. The research could aid future conservation efforts by increasing genetic diversity and helping populations adapt to climate change.
The SAPIEN 3 heart valve demonstrated lower death, stroke, and paravalvular leak rates than earlier generation devices in high-risk patients. In intermediate-risk patients, the device showed encouraging results, with a reduced rate of major vascular complications and fewer instances of heart attacks and annular rupture.
A new brain shield device has shown improved in-hospital safety outcomes, including lower rates of major adverse cardiovascular and cerebrovascular events. The device also demonstrated benefits for patients' cognitive scores at discharge, with better performance on neurocognitive tests.
Research shows that CT scans paired with standard care lead to more accurate diagnoses of coronary artery disease, altering follow-up testing and treatments. This results in a lower incidence of heart attacks among patients receiving the test compared to those receiving usual care.
Researchers found that bat activity was lower in street-lit areas than dark locations with similar habitat. Only Leisler's bat showed a positive association with street lighting, highlighting the need to reconsider urban planning strategies.
Researchers found that TAVR improves survival rates and quality of life for elderly patients with severe aortic stenosis. The study compared five-year outcomes of TAVR with standard therapy, showing significant benefits in the TAVR group.
The study found that Bendavia did not prevent irreversible injury to the heart but showed a trend towards improved heart pumping function. The drug is well-tolerated but lacks significant benefits in reducing scarring from angioplasty after a heart attack.
A new device called TriGuard has been tested in a multicenter trial to protect the brain during heart-valve replacement procedures. The results show that patients with protection had fewer ischemic brain lesions and improvements in cognitive function, including short-term memory and delayed memory.
A recent survey of 236 cardiologists found significant gaps in their knowledge about heart-healthy diets, with only 13.5% feeling adequately trained to discuss nutrition with patients. Dark chocolate was also shown to have health benefits in sedentary older adults, improving energy levels and exercise stamina.
Research by Queensland University of Technology highlights the difficulties faced by police during death investigations, including emotional re-traumatization of bereaved families. Junior officers are often tasked with gathering evidence while comforting family members, leading to concerns about their preparation and cultural competence.