The PLOS Medicine collection addresses diverse topics in the field of STI prevention, diagnosis, and treatment. Researchers investigate vaccine development, online testing services, healthcare provider perspectives, and antibiotic shortages.
A group of authors from IQWiG has contradicted the American Society of Clinical Oncology's conclusion that MammaPrint can identify patients who do not require chemotherapy. The IQWiG analysis found a statistically significant disadvantage of the test for disease-free survival in certain patient groups.
The Kessler Foundation has received a two-year $150,000 grant from the Hearst Foundations to support a postdoctoral fellow in cognitive rehabilitation research. This funding will enable the fellow to use research tools and innovations created by Foundation scientists while focusing on identifying breakthroughs in cognitive rehabilitation.
Osaka University researchers develop an enzyme-driven approach to sticking biological ink droplets together, enabling the 3D printing of highly complex biological structures with a wide variety of cell types. The method overcomes compatibility problems with sodium alginate and results in high viability rates for cells.
Researchers from A Coruña University reject the glacier refuge theory for Iberian brown bears. They found that the Pleistocene lineage was lost and Holocene bears arrived from an unidentified area, likely France, 5,000 years after colonizing Britain.
A pilot study found that noninvasive brainwave mirroring technology significantly reduced symptoms of post-traumatic stress in military personnel. The treatment, HIRREM, improved insomnia, depressive mood, and anxiety symptoms, with durable effects through six months after use.
A recent study found that opioid prescribing for disabled adults is higher outside of large central metro counties, even after accounting for local economic factors. County-level factors such as household income, unemployment rate, and income inequality also play a significant role in determining opioid prescribing rates.
Researchers develop novel method for selective C-H arylation at room temperature, overcoming harsh reaction conditions. The proposed mechanism involves iridium catalyst activation, arylsilane attack, and oxidation of the intermediate to achieve low-energy reaction.
A University of Hawaii Cancer Center researcher has identified a mechanism that drives cancer cells to move during metastasis. The study defines a signaling hub required for cancer cell movement, which may provide new therapeutic opportunities for brain tumors and other cancers.
People with mild cognitive impairment (MCI) may experience improved memory and thinking ability with regular exercise, according to the American Academy of Neurology. The guideline recommends that doctors recommend exercise as part of an overall approach to managing symptoms.
Researchers at Tokyo Institute of Technology have developed a new technique to determine and visualize the three-dimensional structure of individual dopant atoms in semiconductors, correlated with their electrical activity. This breakthrough could support the development of high-performance devices.
Researchers assess hurricane damage to Caribbean coral reefs, finding severe injury and changes in composition. Despite encouraging signs of recovery, scientists note increased vulnerability due to climate change and stressors.
A new Hybrid-SOEC system with mixed-ion conducting electrolyte allows for water electrolysis to occur at both electrodes, increasing hydrogen production efficiency. The system demands less electricity and exhibits outstanding performance with stability.
A team of researchers has successfully developed a novel method for separating isotopes using a flexible porous material. By exploiting the dynamic change in pore dimensions, they can selectively adsorb and desorb desired gas components, leading to improved separation efficiency and selectivity.
Scientists at Sun Yat-Sen University present advances in controlling the flexibility of MOFs for improved performance. They summarize strategies for designing/synthesizing flexible MOFs with specified structural response and dynamic behavior towards external stimuli.
Researchers at Tufts University have developed a novel preclinical model of postpartum depression, showing the involvement of the HPA axis and specific protein KCC2 in inducing disorder. The study provides empirical evidence that dysregulation of the HPA axis and KCC2 can lead to behaviors mimicking postpartum depression.
Richard Schoen was awarded the Lobachevsky Medal for his work on positive energy in general relativity and a complete solution to the Yamabe problem. The prize is part of Kazan Federal University's efforts to revive a tradition from 1895, with an award amount of $75,000 and recognition as a biennial honor.
Researchers found that CD4+ T effector cells upregulate Mdr1 in response to bile acids, maintaining intestinal homeostasis and limiting oxidative stress. This study provides valuable insights into the interaction between Teff cells and metabolites, potentially leading to new therapeutic agents for inflammatory bowel diseases.
A Michigan State University student examines the impact of grain size and niche breadth on species distribution modeling, finding that relying solely on expert opinions can lead to inaccurate predictions. The research aims to promote more extensive testing and data-driven approaches in conservation.
Researchers at Hokkaido University have shed light on the molecular mechanisms behind ALS by studying the depletion of protein TDP-43. The study found that TDP-43 binds to U6 snRNA, stabilizing it, which leads to its degradation and eventual cell death. This discovery may lead to ways to slow or stop neuronal cell death in ALS patients.
RecensMedical Inc., a UNIST startup, has received 1 billion KRW investment and 2 billion KRW financial guarantees from KIBO to develop rapid cooling anesthesia for various medical applications. The funding supports the company's growth as the first venture startup in Ulsan.
A recent study from New Zealand found no consistent association between childhood lead exposure and adult criminal behavior, challenging previous research on the topic. Despite well-documented effects of lead on brain development, researchers did not detect a dose-response relationship between higher childhood blood levels and increase...
Satellite imaging from NOAA's GOES-16 satellite reveals holiday travelers facing wet and snowy weather on both coasts. A large area of clouds associated with a frontal system is forecast to bring rain and snow across the US, with heavy rainfall and flooding predicted in the lower Mississippi and Tennessee Valleys.
A new study from Harvard T.H. Chan School of Public Health found that short-term exposure to fine particulate air pollution and ozone is linked to a higher risk of premature death among the elderly in the US, particularly those who are low-income, female, or Black.
Research on the mangrove killifish found a remarkable amount of genetic diversity across different lineages, contradicting expectations. The fish's ability to fertilize itself and its eggs suggests a complex behavior that allows it to adapt to changing environments.
Researchers at UMass Amherst, in collaboration with teams from Carnegie Mellon and Columbia universities, aim to predict regional flu outbreaks. By combining forecasting models and past performance data, they hope to provide better information for decision-makers.
Researchers at Max Planck Institute found reduced FoxO3 activity reprograms connective tissue cells, leading to pulmonary fibrosis. Boosting FoxO3 activity halted disease progression in mice, offering a potential treatment pathway.
Researchers analyzed Okinawan textile Basho-fu using Scanning Electron Microscopes and X-ray diffraction to compare traditional and laboratory production processes. They found that traditional degumming is milder than laboratory methods, retaining more air voids and breathability.
Distinguished Professor Sang Il Seok at UNIST received the 2017 Korea Scientists Award for his outstanding contributions to energy sector through manufacturing high-efficient halide perovskite solar cells. His research has been recognized worldwide and cited over 5,000 times in prestigious scientific journals.
A record-breaking cold event in Eastern China in 2016 was found to be less likely due to human influences, with anthropogenic forcings estimated to have reduced the likelihood by about 2/3.
Researchers at Osaka University developed a technique called lexical acquisition through implicit confirmation to enable AI to learn words in the flow of dialogue. This method allows computers to acquire knowledge about unknown words during conversations with humans, making them smarter and more responsive.
Researchers at Nagoya University have developed a novel medical device that can efficiently capture extracellular vesicles in urine, potentially leading to early diagnosis of cancer. The device surpasses existing methods and shows promise for non-invasive testing, including a simple urine test.
Research published in eNeuro reveals that fragile X syndrome affects the development of sound-processing neurons in the brainstem. The study found reduced cell sizes in mice with FXS, indicating a role for FMRP in auditory system development.
Researchers at Osaka University have created a new thermoelectric material (ytterbium silicide) with an improved power factor at room temperature. The material's unique layered structure suppresses heat conduction, preserving the temperature gradient and enabling efficient power generation.
Researchers from MSU have created a basis for highly sensitive gas sensors that can detect toxic and non-toxic gases in air at room temperature. The sensors use porous silicon nanowire arrays, which exhibit reversible charging and discharging of Pb-centers, making them reusable and suitable for environmental monitoring and control.
A UNIST professor has been awarded for his work on a patch that can regenerate damaged spinal cords, with the aim of preventing further progression of damages and optimizing neurogeneration. The patch is currently in Phase III clinical trials and contains FDA-approved materials, showing promising therapeutic effectiveness.
Hermaphrodite worms live up to two weeks longer on dietary restriction, while males show no change despite genetic mutations in a key sex-determination pathway. The study suggests hermaphrodites have evolved to conserve energy until favorable conditions return.
Researchers have developed a simple and efficient criterion to identify potential topological insulators, leveraging atomic number and Pauling electronegativity. This approach enables ready screening of candidate materials, reducing the need for detailed electronic structure calculations.
Researchers developed a high-resolution mass spectrometry imaging system capable of analyzing live biological samples at a resolution of several micrometers. The system uses femtosecond lasers and plasma jets to ionize biomolecules, allowing for accurate analysis without chemical pretreatment.
The 30th Annual Legislative Update reports that over 20 states have enacted laws increasing access to healthcare provided by APRNs, with full practice authority now granted in 25 states. This expansion aims to improve access to high-quality, cost-effective healthcare nationwide.
Researchers found that young male songbirds can overcome their genetic predisposition to sing like their fathers with enriched early experience. The study used Bengalese finches and found that exposure to a computerized tutor or live adult males reduced the genetic contribution to complex behaviors like birdsong.
A large study found that short-term exposure to air pollution at levels below current standards was associated with a higher risk of death in Medicare patients. Daily increases in fine particulate matter and ozone were linked to increased mortality rates, even when levels were below the national air quality standards.
Microgrids in Alaska provide electricity for over 200 communities, generating more than 2 million hours of operating experience annually. Renewable energy sources reduce energy costs and improve resilience in the face of grid failures or sabotage.
A meta-analysis of 33 clinical trials found no association between calcium and vitamin D supplements and a lower risk of fractures in older adults. The study included over 51,000 community-dwelling adults aged 50+, but the results do not support routine use of these supplements for fracture prevention.
Research reveals that genetic diversity impacts learned birdsong tempo, with heritable contributions explaining up to 55% of variability. The quality of instruction also plays a role in shaping the relationship between genes and song tempo.
Researchers found high methane concentrations in groundwater near a 1965 gas well blowout site in the Netherlands, suggesting ongoing methane leakage from the reservoir. Methane oxidation reduced isotope concentrations with increasing distance from the blowout site.
Compound I, a non-nucleoside reverse transcriptase inhibitor, exhibited synergistic properties and suppressed viral loads in HIV-1-infected humanized mice. The compound sustained plasma drug concentrations and effectiveness for approximately 3 weeks in mice, suggesting potential in pre-exposure treatments.
Researchers found that Wolbachia-infected mosquitoes exhibited reduced dengue virus transmission potential by up to 50% compared to uninfected mosquitoes. Laboratory conditions underestimated this effect, suggesting improved vaccines and disease management approaches are needed.
Researchers found that team-based care with medication titration by a nonphysician clinician and physician leads to significant reductions in systolic blood pressure. Multilevel strategies without team-based care also show promise, reducing systolic blood pressure by 5 mm Hg.
New research from MIT suggests the EPA's legislation may have saved over 100,000 lives annually from 2000 to 2010 through a dramatic decline in atmospheric organic aerosol. The study found that human behaviors, such as vehicle emissions and residential burning, likely drove this change.
Scientists have made breakthroughs in understanding the early stages of CAVD by studying pig valves and creating a lab model. They found that certain sugar molecules called glycosaminoglycans (GAGs) can increase blood vessel growth, but also trap low-density lipoprotein (LDL) molecules.
A study of 20,000 tree species observations in the European Alps found that climate change has led to a decline in elevation gradients of leaf-out dates from 34 days to 22 days between 1960 and 2016. This shift is likely due to increased late spring and winter temperatures.
Gene expression in specific cells and regions provides a more precise, neuroprotective approach than traditional treatments for neurological diseases. Increasing cholesterol synthesis gene expression in astrocytes of the spinal cord can repair nerves affected by walking in multiple sclerosis patients.
Declining organic aerosol in the US reduces premature deaths and saves lives, with a 40% decrease in anthropogenic sources since 1990.
A University of Colorado Boulder-led study confirms that climate factors limit species expansion in stressful environments, but interactions with other species play a crucial role in shaping range limits. The researchers found that stress impacts plant growth, survival, reproduction, and germination, which drives the pattern.
Scientists have identified the world's first hybrid bird species in the Amazon rainforest, created by the mating of two distinct species. The golden-crowned manakin boasts unique yellow crown feathers and an intermediate keratin structure, setting it apart from its parental species.
Researchers at Ruhr-University Bochum investigate the brain area responsible for storing odours as long-term memories. They found that the piriform cortex is involved, but only works in interaction with other areas, and requires instruction from the orbitofrontal cortex to establish long-term memory.
Lobachevsky University scientists find that moderate temperature increase induces small electrical responses in plant leaves. These responses are observed even at lower temperatures, suggesting a possible natural occurrence under field conditions. The research opens prospects for controlling plant resistance to high temperatures by reg...
Researchers at UCI applied new methods to analyze complex mutations in the fruit fly genome, revealing extensive genetic variation previously undetected. The study's findings suggest that human genomes may harbor even more medically and agriculturally important genetic variation.
Researchers found a direct link between symptom severity and treatment outcomes in patients with isolated dystonia, using deep brain stimulation. Brain activity patterns reveal disease severity, and oscillatory brain activity in the 'theta band' is associated with dystonic symptoms.