Researchers at UCSF developed CRISPRa, a modified version of the gene-editing tool that activates appetite-suppressing genes without making cuts to the genome. This approach prevented severe obesity in genetically engineered mice with only one functional copy of certain genes.
A new international study published in Nature found that organic food production requires more land, leading to higher greenhouse gas emissions and deforestation. Organic peas and winter wheat have significantly larger climate impacts than their conventional counterparts.
The discovery of protein DEX-1 in the roundworm C. elegans sheds light on the molecular trigger for structural remodeling in response to stress, allowing animals to better withstand challenging conditions. This research has implications for understanding nematode biology and its impact on parasitic species affecting crops.
Researchers have created a sophisticated genomic model that links DNA variations and gene activity to the risk of brain disorders. The model identifies 321 genes associated with schizophrenia, revealing its primary role as a disorder of neurons rather than other brain cells.
The Translational Genomics Research Institute (TGen) has received a $10,000 grant from PayPal Gives to support the cost of genetic testing for low-income children with rare disorders. The grant will help TGen's Center for Rare Childhood Disorders provide state-of-the-art genetic testing and potentially save the lives of fragile children.
Researchers tracked bat species with unpredictable food sources using miniature sensors, finding that they foraged socially when food was scarce. In contrast, bats with predictable food sources foraged alone. The study suggests that social foraging may be a strategy to exploit ephemeral resources.
Researchers developed genetically modified pigs resistant to classical swine fever virus using CRISPR/Cas9 and RNA interference. These tansgenic pigs can effectively limit CSFV replication and reduce disease severity, with stable transmission to offspring.
A recent study has found that European mountain bird populations have declined by as much as 10% in the 2000s, mainly due to climate change and changes in land use. The decline is particularly worrying for species that only inhabit mountain regions and are unable to live in other environments.
Researchers from Mount Sinai's Icahn School of Medicine published four scientific papers highlighting their work on brain genomics and psychiatric diseases. They analyzed over 2,000 brains to identify non-coding functional genomic elements associated with schizophrenia risk, autism spectrum disorder, and bipolar disorder.
A new study published in the American Journal of Infection Control found that home healthcare workers' beliefs about infection prevention influence their compliance with protocols more than their actual knowledge. The researchers suggest targeting nurse perceptions to improve infection control strategies. Key findings include gaps in k...
Researchers discovered a human protein, RBBP6, that interferes with the Ebola virus replication cycle. By mimicking this protein's function, a small molecule drug could potentially block Ebola virus infection in human cells.
A WSU research team has uncovered previously unknown vulnerabilities in high-performance computer chips, which could be exploited by malicious attacks. The communications system is a critical component of the chip, and its malfunction can have severe consequences.
Tropical Cyclone Owen has intensified over the Gulf of Carpentaria, with NASA's GPM satellite detecting extremely heavy rainfall rates up to 97 mm/h in the Arafura Sea. The storm is expected to continue strengthening and potentially reach Category 4 intensity by Friday.
Researchers at the Francis Crick Institute discovered simple rules that determine the precision of CRISPR/Cas9 genome editing in human cells. By analyzing hundreds of edits, they found predictable patterns behind the technology, allowing for greater precision and efficiency.
Researchers at the University of Arizona have identified the biological process behind pontocerebellar hypoplasia type Ib, a deadly disease affecting infants. They believe their discovery could lead to the development of a drug to stop the disease progression and improve treatment options.
A study at Duke University Medical Center found that weekly whole-body massage improved symptoms of knee osteoarthritis, including pain and mobility, in patients. The treatment maintained its benefits over 52 weeks, suggesting a potential complement to existing treatments.
A new publication by Kazan Federal University reviews ionosphere plasma experiments using artificial heating facilities like SURA, EISCAT-Heater, and HAARP. The study reveals insights into plasma fluctuations, turbulence, and electron acceleration, shedding light on the ionosphere's role as a natural plasma laboratory.
Researchers elucidated the operation mechanism of ferroelectric-HfO2-based transistors and memories, enabling sub-60mV/dec subthreshold slope and high-capacity nonvolatile storage. The study's findings will guide device design for ultralow power operating NCFETs and high-capacity FTJ memories.
Researchers identified two genes, UBR4 and PHLPP1, that correlate with reduced cranial roundness in modern humans carrying Neandertal DNA fragments. These genes are involved in brain development and may have played a role in the evolution of human brain shape.
Researchers have developed monoclonal antibodies effective against several synthetic opioids, including fentanyl and carfentanil. The vaccine could help combat opioid addiction and reduce overdose deaths by blocking the analgesic effects of these potent drugs.
A recent study by an international team of researchers found that soot from road traffic in emerging countries can reach high altitudes and contribute to global warming. The reduction of pollutants from diesel cars has a positive impact on both human health and climate protection.
Research suggests that weakened metabolism of immune T cells, specifically one-carbon metabolism, may contribute to age-related immunity loss. Adding small-molecule compounds that boost T cell performance could potentially restore immune function.
Biofilm researchers at Princeton University have found a new method for removing nasty biofilms, which can cause medical infections and clog equipment. The technique, called capillary peeling, uses water to drive a wedge between the biofilm and surface, allowing for complete removal.
Researchers explore protein tyrosine phosphatases in metabolic diseases to understand diabetes development. They focus on inflammation's role in pancreas and liver cells, aiming to identify new therapeutic approaches targeting PTPs.
Researchers found that collagen fibrils in mammalian tissues become stronger and tougher when repeatedly stretched and relaxed. This discovery has significant implications for understanding tissue mechanics and designing better biocompatible materials for wound healing and tissue growth.
Researchers at Sainsbury Wellcome Centre found that male mice recognize pups through a mixture of pheromones and multisensory cues, but distinct signals trigger infanticide and parental behavior. This discovery advances our understanding of social cue recognition in animals.
Researchers at Nova Southeastern University have identified a genetic marker, NER gene expression levels, to predict early relapse in pediatric acute lymphoblastic leukemia (ALL) patients. This finding has the potential to guide targeted treatment and improve patient outcomes.
Researchers at Rutgers University have developed flexible, durable heating patches that are nearly 70% more efficient than similar patches. These patches use intense pulses of light to fuse silver wires with polyester, reducing energy waste and carbon footprint by selectively heating the human body.
A research study published in Ecology Letters found that plants using a mix of chemical compounds for defense are more effective at deterring insect pests than those relying on single compounds. The type of bouquet matters, with blends having multiple defensive chemicals reducing damage by up to 37%.
Research by Kazan Federal University professor Andreja Istenič Starčič reveals that book publishing in humanities is on the rise, with some countries seeing significant increases. Monographs account for varying percentages of total publications across five European nations, while book chapters dominate in others.
Researchers at Johns Hopkins Medicine found that the molecular underpinnings of necrotizing enterocolitis (NEC) lead to brain injury. They identified TLR4 as the cause and found that HMGB1 is generated in response to TLR4, leading to microglial activation and brain injury.
Researchers found that warmer winters mean more ice on the ground due to increased winter rain, posing challenges for Arctic wildlife and ecosystems. The formation of basal ice can kill plants and starve animals, while rain-on-snow events can lead to avalanches.
Historical records of shark catches in Queensland show a 50-year decline, with large apex sharks decreasing by 74-92%. The average size of sharks has also decreased.
Researchers develop 'implosion fabrication' technique to create nanoscale 3D objects with high resolution and functional materials. The method enables assembly of materials in a low-density scaffold, allowing for easy modification and dense solid formation.
A new study assesses the reliability of CETSA HT for early drug discovery, demonstrating good correlations with other assay formats. The technology highlights different compound responses, providing a better understanding of cellular effects.
A study found that face mask use significantly reduces the likelihood of finding drug-resistant Staphylococcus aureus bacteria in hog farm workers' nasal swabs. Household members of consistent face mask users also showed a significant reduction in bacterial colonization.
Researchers identified a new interaction between the Ebola virus protein VP30 and human host protein RBBP6, which disrupts virus growth. The study provides potential therapeutic targets for treating Ebola virus infections.
Researchers found a predecessor of today's corn plants, still bearing wild ancestor features, was brought to South America from Mexico over 6,500 years ago. Farmers improved the crop in Mexico and the Amazon until it was fully domesticated, challenging previous single-origin theories.
Scientists will investigate soil carbon formation, stabilization, and loss with a £1.8 million grant from the Natural Environment Research Council. The study aims to quantify increases in soil carbon storage that can mitigate climate change and improve global food security.
Researchers from ETH Zurich found that moderate exercise in the evening has a positive effect on deep sleep phases, with participants spending 21.2% of their sleeping time in deep sleep after evening exercise, compared to 19.9% without exercise.
A new study published in Diabetologia found that type 2 diabetes is associated with a decline in verbal memory and fluency over 5 years in older adults. In contrast to previous research, the study did not find a direct link between brain atrophy and cognitive decline in people with T2D.
Stanford researchers have developed a way to study the firing of individual brain cells using only light, eliminating the need for invasive methods. The new approach measures subtle changes in cell shape when they fire, allowing for a cleaner and simpler way to study the brain.
A study from McMaster University and the Netherlands found that the impairment rating of injured workers significantly differs depending on the edition of the American Medical Association (AMA) guides used. The researchers compared two editions and found that the sixth edition resulted in lower impairment ratings.
A new drug candidate targeting a receptor in sarcoma cancer cells was found to be more than three times more effective than currently available drugs. The compound shrank tumors and hindered their ability to spread in mice and pigs, offering hope for a new treatment option.
Scientists have discovered that irisin, a hormone released by muscles during exercise, directly acts on key regulatory cells that control the breakdown and formation of bone. Treating osteocytes with irisin protected them from age-related death and increased their production of sclerostin, a protein that triggers bone remodeling.
Researchers develop a new technique called Implosion Fabrication, which prints nanomaterials inside shrinking gel to create complex shapes and geometries. This method surpasses previous techniques in terms of material versatility and design complexity.
Scientists have gained a clearer understanding of what happens in the brains of people with Huntington's disease, highlighting the crucial role of glial cells. Glial cell dysfunction is believed to drive neuronal loss and disease progression, leading to motor control problems and cognitive decline.
Researchers discovered two warm Neptunes at the edge of the 'hot Neptune desert' losing their atmospheres at a rapid pace. This supports the idea that hot Neptunes transform into super-Earths, which are more numerous than previously thought. The study used NASA's Hubble Space Telescope to observe the evaporation of these planets.
A study of 100 patients found that linking medication reminders to electronic health records (EHRs) improved adherence among glaucoma patients. The reminders were delivered via text or voice message for three months and were reported useful by 74% of participants.
When parents play with infants, their brain activity mirrors the child's attention patterns, suggesting a neural echo effect. This phenomenon, observed in joint play sessions, highlights how adults respond to and influence their babies' behavior.
Researchers at Princeton University have discovered a virus that can listen in on bacterial conversations and kill diseases like E. coli and cholera. The virus, VP882, uses cross-kingdom communication to take the risk out of its decision-making process.
Researchers have discovered the oldest known plant virus, a 1,000-year-old virus from ancient corncobs at an Ancestral Puebloan ruin in Arizona. The discovery reveals that chrysoviruses can persist in plants for long periods and may confer potential benefits to the plant.
A new study by IHME finds that the average US outpatient visit costs nearly $500, highlighting the high cost of healthcare in the country. The study also estimates that universal health coverage (UHC) for all nations would require a significant increase in admissions and visits, with costs estimated at $576 billion.
Researchers using NASA's Hubble Space Telescope have discovered a medium-sized exoplanet, GJ 3470b, losing mass at a rate 100 times faster than similar planets. The study advances knowledge of planetary evolution and suggests that half of the planet may be gone in a few billion years.
Researchers have discovered a way to create atomic-scale binary logic that powers faster and more energy-efficient electronics. This breakthrough could lead to significant reductions in power consumption and pave the way for sustainable, green technology.
Funding for higher education research and development (R&D) in the US increased by 4.7% to $75.3 billion in FY2017, with federal funding accounting for 53.5% of total expenditures. Basic research accounted for 62% of R&D spending, down from 66% in FY2010.
Researchers at NYU Tandon School of Engineering have developed a machine learning system that pairs artificial neural networks with infrared imaging to control and interpret small-scale chemical reactions. This technique can reduce the decision-making process from one year to weeks, saving tons of chemical waste and energy.
Recent PsychENCODE research provides a better understanding of brain development and neuropsychiatric risks, with critical expression differences in genes identified during early brain development and adolescence. The findings highlight the importance of studying specific cell types and time points in brain development to model disease...
A Polish-German team of physicists has described the dynamic phenomena occurring at the interface between a ferromagnetic metal and a semiconductor, filling the 'thermal' gap in material knowledge. The study used computational models to simulate atomic vibrations and showed that the interface exhibits unique patterns.
Researchers from the University of Gothenburg have developed a new method to improve the use of optical tweezers, allowing for more accurate measurements with less data and faster processing. This breakthrough enables the technique to be used in pharmaceutical research and study systems that are not in equilibrium.