Researchers at Texas A&M University have made a breakthrough in treating epilepsy by using stem cell-derived neurons to stop seizures and improve cognitive function. The study showed that transplanted human GABAergic neurons formed synapses with host excitatory neurons and were directly involved in controlling seizures.
Researchers at the University of Birmingham have discovered a protein fragment called ?N-JARID2 that regulates skin cell differentiation. The finding holds promise for developing new gene therapies for psoriasis and other skin conditions caused by hyper-proliferation of skin cells.
Since 2012, the number of leprosy cases in Morocco has decreased significantly, with an average annual decline of -16.83%. This improvement is attributed to the implementation of single dose rifampicin chemoprophylaxis, which has helped to interrupt transmission and reduce disability.
A new study by Australian researchers found that pinnipeds quickly react defensively to approaching boats, risking injury and death. The closer the vessel is, the more likely it is for the animals to rush into the sea, triggering a stampede that can be deadly.
Fossilized newborns and egg shells found together in 130-million-year-old Lebanese amber provide the first direct evidence of how tiny insects hatched in deep time. The discovery sheds light on the evolution of the hatching mechanism used by modern green lacewings.
A new study has found that a better understanding of dog body language can reduce the risk of dog bites. Children and parents were trained to correctly interpret dog distress signals, leading to significant improvement in accuracy, particularly among younger children.
A new study reveals how the worm's digestive tract signals the brain when to linger in a plentiful spot. Researchers found that specialized nerve cells detect bacteria and release neurotransmitters to slow down or speed up locomotion.
Physicists at LSU and Penn State develop new mathematical equations that go beyond Einstein's theory of general relativity, showing that black hole singularities do not exist. The theory predicts a funnel to another branch of space-time instead.
Simulations of nuclear fission using quantum-mechanics show that pear-shaped deformation is favored by strong Coulomb repulsion in fragments. This mechanism explains asymmetric fission in several systems and improves predictions for exotic nuclei.
Researchers have discovered strong, long-range social ties that bridge vast gaps in social networks, providing high-bandwidth shortcuts. These 'wormholes' can spread information and ideas, including potentially unhealthy ones, across extreme network distances.
A new report provides guidance on how hospitals can implement universal suicide risk screening of youth in medical settings, using a 3-tiered clinical pathway system. The ASQ tool is used as the first screen, followed by a brief safety assessment and a comprehensive evaluation if necessary.
A new study by USC researchers reveals that a fatty diet can trigger changes in the immune system leading to non-alcoholic steatohepatitis (NASH), a serious form of non-alcoholic fatty liver disease. The study identified a novel type of reparative macrophage that counteracts inflammation, offering potential pathways for future therapies.
A Yale-led team of researchers found that a specific bacterium in the gut triggers an immune response leading to autoimmune disease. A high-fiber diet rich in resistant starch can suppress this response by altering gut bacteria and short-chain fatty acid production.
Researchers at University of Basel discover how Pseudomonas aeruginosa attaches to tissue within seconds and spreads using motile spreaders and virulent stickers. The bacterium exploits a simple business model: settle, grow, expand.
According to a report from UC3M and CODERE, Madrid is the autonomous community that spends the most on the Spanish Christmas Lottery, with an average expenditure of 59.26 euro per inhabitant. More than 90% of residents buy tickets due to habit or social pressure, while only 35% do so for recreational reasons.
A recent NUS study reveals that lower-income households in Singapore use more water to cool down during hot weather, whereas higher-income households rely heavily on air-conditioners, increasing their electricity demand.
Many NHS trusts and health boards have been unable to accurately forecast how Brexit will affect crucial areas such as supply chains, medicines, and workforce. Only a quarter of those that responded were able to disclose their risk assessment related to Brexit, with many citing uncertainty about the government's guidance.
Single-cell RNA-seq technology reveals which genes are active in early embryo cells, offering a snapshot of cellular behavior. Researchers use molecular trackers to monitor individual cells' fate during development, shedding light on organ formation and tissue regeneration.
Studies from Massachusetts General Hospital examine the presence of pediatric areas in EDs and use of telemedicine for pediatric emergency care. An intervention increased the appointment of Pediatric Emergency Care Coordinators in Massachusetts EDs, a key step to improve pediatric emergency care.
Scientists at Stanford University have developed an electrocatalytic mechanism that mimics the mammalian lung's gas exchange process, enabling more efficient conversion of water into hydrogen fuel. The design uses a thin membrane to separate oxygen and hydrogen gases, reducing energy costs and increasing current density rates.
Researchers at Brown University have created a new type of quasicrystalline superlattice that self-assembles from a single component, exhibiting five-fold symmetry. The discovery provides insight into how these materials can emerge and offers a new rule for forming quasicrystals.
Researchers developed LEAP, a neural network-based system that tracks individual body parts in video footage, enabling the study of animal behavior and neural processes. The tool has great potential outside of neuroscience, automating labor-intensive analysis to study diverse animal locomotor behaviors.
Researchers at Penn State used modeling methods to predict properties of ZIF glasses, combining transparency and metallic glass nonbrittle quality, with potential applications in gas storage and energy, promising breakthroughs in transparent and bendable glass
Agricultural technology is transforming food production, but responsible innovation is crucial to address potential environmental, ethical, and social costs. Researchers argue that policy-makers, funders, and innovators must consider the impacts on farming communities and wider society.
Researchers have developed an ultrasensitive test that detects tau protein clusters, which are associated with Alzheimer's disease and chronic traumatic encephalopathy. The test has been shown to detect the protein in small amounts of brain tissue, making it a major advance for early diagnosis.
A new study published in Environmental Geosciences is the first to predict which oil and gas wells are likely to leak methane. The research used machine learning algorithms to identify characteristics of wells that deviate from vertical drill lines, age, and larger casings as indicators of potential leaks.
A research team led by Heng Huang aims to create a framework for secure and efficient multi-site collaborative big brain data mining. The project addresses computational challenges in analyzing complex brain disorders and genomics data.
A pay-it-forward model increased gonorrhea and chlamydia testing among Chinese gay men, with 54% opting in compared to 6%. The program identified previously untested individuals and may be a promising strategy for integrated HIV/STD testing.
A comprehensive study reveals that p62 protein controls multiple factors involved in melanoma metastasis, indicating a coordinated process. The research also identifies FERMT2 as a marker for poor patient prognosis.
A team of researchers found that vertical land motion is the primary factor behind variations in relative sea level rates along the US East Coast. The study, published in Nature, reveals that land motion explains 75% of the observed variation, with ongoing effects from the last ice age being the largest contributor.
The perception of unfair economic inequality can lead to civic unrest in the US, as seen in Ireland's past protests. In contrast, despite the controversial president and global economic impacts, there are currently no large-scale demonstrations, suggesting that the 'tinder' for protests is ready to ignite
A new report reveals that only 41% of European MPAs are fished less intensely than non-protected waters, while trawling activity is 38% higher inside MPAs. The findings suggest that stronger regulations are needed for MPAs to effectively protect sensitive species and biodiversity.
Connexin43 is a widely distributed gap junction protein involved in myocardium disease and tumor migration. Understanding its role in these processes can provide insight into new therapeutic options for cancer and myocardial disease diagnosis and therapy.
Researchers discovered that couples who pool their finances favor utilitarian purchases that are easier to justify. Individuals using joint bank accounts spent significantly less on hedonic purchases and more on utilitarian products than those spending from separate accounts. This strategy may help people spend money more responsibly.
A team of researchers found that animals switch to more stable gaits during speed-related transitions to minimize unstable dynamic states and reduce the risk of tripping or falling. The study, which examined nine animal models across various species, suggests that gait transitions prioritize stability over energy savings.
A new study by the European Society of Cardiology found that giving birth is associated with a 14% higher risk of heart disease and stroke. Pregnant women are advised to keep weight gain under control and adopt healthy lifestyle habits after pregnancy to reduce the risk of cardiovascular disease.
Researchers at Mount Sinai have discovered a novel combination of drugs that induces the highest rate of proliferation in adult human beta cells, increasing insulin production and potentially treating diabetes. The study found a 5-8% daily growth rate, which is significant progress toward a cure for the disease.
Researchers are using big data and machine learning techniques to optimize sports performance, game-day decision making, and even predict the end of daily fantasy sports. The special issue explores various applications of big data in sports analytics, from pacing strategies in long-distance running to business-side insights.
Researchers found unexpected chemical compositions in 'magic nanoparticles' that display enhanced stability, including Fe6O4 and Ce3O12. The study also reveals oxygen-rich nanoparticles may explain carcinogenicity of oxide nanoparticles.
Loop quantum gravity allows physicists to extend gravitational physics beyond general relativity's limitations, enabling the analysis of black hole interiors. The theory predicts a repulsive force that can overwhelm classical gravity, potentially resolving the information paradox at black holes.
Scientists at the University of Edinburgh have created stem cells that can transform into brain cells and produce dopamine, a key neurotransmitter lost in Parkinson's. The gene-edited cells resisted developing Lewy bodies, a hallmark of Parkinson's disease.
Tropical Cyclone Cilida showed a cloud-covered eye with powerful thunderstorms circling its 18 nautical mile wide center. The storm intensified rapidly by 55 knots in 24 hours due to warm sea surface temperatures and light outside winds.
A group of researchers in India has developed an iron-platinum alloy that can overcome the thermal stability issues limiting its use as a material for future hard disk drives. By tweaking the L10 phase, they achieved a significant enhancement of the transformation rate and reduced the ordering temperature below 300 degrees C.
A recent study published by University of Queensland researchers sheds light on the responses of various species to major climate events. The research found that extreme weather events such as cyclones, droughts, and floods are causing unpredictable changes to ecosystems, leading to population declines and local extinctions.
The transformation of Swedish mining policy has led to widespread resistance and demands for greater state responsibility. The book examines how the withdrawal of state involvement has shifted responsibilities to local administrations and companies.
Researchers found that street-based FSWs with more frequent abusive police interactions had a higher risk of client violence, emphasizing the need for interventions addressing relationships between FSW and police. The study also highlights the importance of decriminalizing sex work to alleviate pressure on these women.
A new study by Boston Medical Center found that patients are less likely to disclose drug use earlier in treatment, but urine drug testing can help identify and engage patients with positive test results. The study suggests developing interventions for patients with positive urine tests to keep them engaged in care.
A study published in Aging Cell found age- and health-related differences in cell-free DNA (cfDNA) packaging, which could be used to determine biological age. The researchers detected well-spaced nucleosomes in younger individuals but less regular patterns in older groups.
A new study reveals major challenges in incorporating traditional knowledge into Atlantic salmon governance in Norway and Finland. The authors argue that unrealistic international expectations and local legitimacy issues hinder the successful integration of Sámi knowledge with science.
Researchers found an ancient mutation in citron that made it 1000 times less acidic, and discovered a key gene called Noemi controlling fruit acidity. This genetic marker provides insights into the domestication of modern citrus varieties.
A recent study published in the Journal of Clinical Oncology found that time to biochemical failure can be used as a surrogate endpoint for locally advanced prostate cancer treatment, reducing overall survival benefit by 6% compared to traditional endpoints. The analysis of NRG-RTOG 9202 clinical trial results showed significant associ...
Researchers have discovered that protein clumps, particularly pα-syn*, recruit enzymes and tau to damage brain cells, leading to mitochondrial destruction. This study provides insight into the molecular mechanisms of Parkinson's disease, shedding light on potential treatment targets.
Researchers at the University of Nebraska-Lincoln have identified a potential Zika vaccine that induces strong T-cell responses and substantial protection without producing antibodies. This breakthrough could be a 'huge leap' for immunology, potentially overcoming the obstacle of antibody-dependent enhancement (ADE) of disease.
A new approach to treating tumors has been discovered by regulating vascularization through a gene that is overexpressed in the tumor vasculature. By targeting the insulin receptor, scientists hope to deliver treatments more accurately and effectively.
A comprehensive review of air pollution effects in children reveals adverse birth outcomes, cognitive and behavioral problems, asthma incidence, and potentially childhood cancer. The study estimates that over 40% of environmental disease burden is borne by children under five.
A genomic duplication in Caucasians could contribute to the high incidence of esophageal adenocarcinoma. Researchers found that African-Americans have a protective genetic variant, GSTT2, which may help prevent cancer. Flavonoids derived from cranberries show promise as a potential chemoprevention agent.
Researchers at Cornell University have developed a low-cost method to capture complete RNA transcription information in single-cell genomics. The new technique, called DART-seq, uses droplet microfluidics to simultaneously analyze multiple genes and identify virus-infected cells.
Scientists have discovered that humpback whales retain tooth germs until late in gestation, a surprising finding that sheds new light on the evolutionary transformation of these marine mammals. This discovery was made possible by advanced CT scanning technology and provides valuable insights into the development of whale anatomy.
Geochemical analysis of fossil teeth reveals that prehistoric horses in coastal Florida lived and died within a small area, suggesting they were relatively sedentary. The study used strontium isotopes to track the animals' wanderings and found no evidence of epic migrations.
Researchers discovered that metformin relaxes the key heart muscle protein titin, allowing the heart to properly fill with blood before pumping it around the body. This reduces blood supply to the rest of the body, leading to shortness of breath with exertion and difficulty exercising.