Researchers have identified a new class of sedatives that could enhance the effectiveness of radiation and immunotherapy treatments for metastatic melanoma, reducing toxic side effects. In animal models, these treatments resulted in improved infiltration of immune cells into tumors, shrinking or eliminating cancerous growths.
Researchers found that forest expansion into savannas has continued amid increasing moisture levels, but with recent deforestation impacting the trend. The study suggests conserving the Amazon-Cerrado transition may help mitigate climate change impacts.
The study generated a valuable resource to aid in predicting drug sensitivity, understanding therapeutic resistance mechanisms, and identifying optimal combination treatment strategies. The dataset includes expression changes in over 200 clinically relevant proteins across more than 300 cell lines after treatment with 168 different com...
GAIN4CROPS project uses nature-inspired approaches to enhance photosynthetic efficiency in sunflowers, promoting climate-resilient crops and sustainable agriculture. The research could lead to decreased land, nitrogen, and water usage, aligning with efforts to conserve biodiversity and reduce environmental impact.
Children and adults produce different types and amounts of antibodies in response to SARS-CoV-2 infection, with children clearing the virus more efficiently. The study found that children produced fewer neutralizing antibodies against the virus's spike protein compared to adults.
Increasing diversity in crop production improves biodiversity and ecosystem services, while maintaining crop yields. Diversification practices like crop rotation, intercropping, and reduced tillage can enhance pollination, pest regulation, and soil fertility.
Researchers at Temple University Health System found that bacterial biofilms in the urinary tract can trigger autoimmune reactions in lupus patients. The study identified a link between chronic bacterial infections and increased frequency of lupus flares, suggesting a potential new approach to controlling flare-ups.
The Arctic Animal Movement Archive provides a global dataset of animal migration patterns, revealing changes in behavior and ecosystem responses to climate change. Studies have found that golden eagles arrive earlier in spring following mild winters, while caribou herds are giving birth earlier in the north.
Researchers analyzed data from the Global Burden of Disease Study 2017 to find a high burden of musculoskeletal disorders across the globe. The team found approximately 1.3 billion prevalent cases and 121,300 deaths due to these conditions.
Researchers found that artificial light pollution affects coral reproduction, causing delayed gametogenesis and unsynchronized gamete release. The study suggests that natural periodic illumination is crucial for cueing spawning synchronicity and the gametogenic process.
Researchers recommend that healthcare providers discuss cannabis use with patients who have chronic pain and are using opioids. This conversation should be routine and judgment-free. The goal is to understand the patient's priorities and develop a plan based on evidence-based information.
Neoleukin Therapeutics announces a novel protein decoy NL-CVX1 that blocks SARS-CoV-2 infection in vitro. The lead molecule is shown to protect hamsters from lethal doses of the virus through intranasal administration. This development demonstrates the potential of de novo protein design technology for addressing biological problems.
Researchers have discovered a new form of calcium carbonate that is soft and absorbent, found in mussel shells. They tested its ability to absorb oils and dyes, finding it highly effective but limited by scalability and cost, for potential use in marine pollution cleanup.
The Trump administration's recent ESA changes have sparked controversy due to their potential impact on economic activity. To address the issue, researchers propose improving consensus and transparency in the ESA language to reduce inconsistencies and promote conservation legitimacy.
Researchers have developed a novel antibody-drug conjugate that selectively recognizes and penetrates pancreatic tumors, reducing tumor size and metastasis. The treatment, which uses MRI-based molecular imaging to monitor its effect, shows promise as a more precise approach than existing treatments.
Researchers from Kanazawa University create a new, high-performance carbon fiber material by chemically modifying Kraft lignin, reducing its weight while maintaining mechanical strength. The resulting composite exhibits almost 3-fold improvement in mechanical strength compared to unmodified Kraft lignin.
Research at the University of Zurich reveals that host genetic differences explain most of the variation in virus community composition. Genetic diversity within species is crucial for immune system function and should be prioritized in agriculture to improve pathogen resistance.
Agricultural emissions alone could exceed the 1.5°C limit by 2050 if left unchecked, according to Tilman. Reducing food production emissions is crucial to keeping the planet livable in its current state, with strategies including more plant-rich diets and easing fertilizer use.
A new study found that COVID-19 is making tinnitus worse in 40% of cases, with internal and external factors contributing to the increase in symptoms. Tinnitus affects an estimated one in eight adults in the UK, and the pandemic has made it more difficult for people to access healthcare support for the condition.
Researchers at the National Institutes of Health (NIH) have discovered a gene called Prkar2a in mice that influences their eating habits and motivation to exercise. The study found that mice lacking this gene consumed less high-fat food and drank less sugar solution than those with the gene, while also being more inclined to exercise.
A massive database tracking Arctic animal movements since 1991 reveals significant changes in behavior due to climate change. Golden eagles migrate sooner, caribou give birth earlier, and herbivores struggle to find food as temperatures rise.
Researchers outline the benefits of tropical fruits in terms of nutrition and discuss barriers to scaling up supply. Smallholder farmers and marginalized groups can benefit from tree-sourced food sources, which can also provide ecosystem services like carbon sequestration.
Researchers discovered that clonal hematopoiesis, a phenomenon where non-cancer DNA mutations are present in blood plasma, is confounding prostate cancer liquid biopsy results. This can lead to false positives and incorrect treatment for patients undergoing liquid biopsies.
A multidisciplinary team will assess the significance of marine life to human societies during the last two millennia. The 4-OCEANS project aims to understand the consequences of marine resource exploitation for societal development, with a focus on informing the UN's Sustainable Development Goals and the Decade for the Oceans.
Researchers uncovered the SARS-CoV-2 genome's 'origami' structure, revealing long-distance RNA interactions critical for replication. This discovery could lead to targeted therapeutics and inform new treatments for COVID-19.
Researchers investigated changes in rates and risk factors for vision-threatening eye infections related to IV drug use. Over a decade, US hospitalizations for these infections increased, with notable risks among young adults and those with underlying health conditions.
New Penn State research reveals disparities in physical activity between men and women, with women more likely to feel uncomfortable using campus recreation facilities. The study suggests that design changes, social environments, and policies can help create welcoming spaces for all students.
Researchers found that antiangiogenic therapy can increase the invasiveness of kidney tumors and induce a poor prognosis. A new biomarker, ALDH1A3, has been identified to predict patient response to treatment.
A new study from the University of Eastern Finland shows that physical activity and dietary counselling significantly reduces insulin resistance in normal-weight children, preventing type 2 diabetes. The intervention also boosts metabolism in skeletal muscles, adipose tissue, and the liver.
Researchers found a significant increase in cancer survival rates among Medicaid expansion states compared to non-expansion states. The study analyzed data from breast, colorectal, and lung cancer patients and discovered improved survival outcomes following the expansion of healthcare coverage.
A new study published in BMC Medicine reveals that informal carers provide more than half of total care costs in the UK, Ireland, and US during the last three months of life. The research emphasizes the need for improved integration and support for community palliative care services to enhance care quality and reduce burden on caregivers.
A new study shows that water striders modify their leg movements to jump safely, depending on their body weight and experience. Female water striders with added weight adjust their midleg movement speed and male striders don't show similar adjustments.
A vast majority of doctors and parents believe genomic sequencing is beneficial for managing care in infants with diseases of unknown origin. The test reveals genetic variations responsible for the child's disease, even if results are negative.
Females in this primate species mature faster after a new male arrives, with some maturing earlier than expected. The researchers observed that these females were previously suppressed from maturing due to their fathers' presence.
Researchers at UNC-Chapel Hill have linked quick flashes of light to growing satellite and space debris, providing a potential explanation for mysterious night sky phenomena. The study's findings may help reduce false alarms in astronomical surveys and improve data accuracy.
A leading ethicist suggests paying people to get the COVID-19 jab to achieve widespread coverage and stamp out infection. The proposal aims to boost vaccination uptake when voluntary schemes prove insufficient, considering financial or 'payment in kind' incentives.
A screening program for COVID-19 in asymptomatic cancer patients prior to each cycle of anticancer therapy was implemented at a UAE hospital. The study found the program's effectiveness in detecting COVID-19 cases among these patients.
The use of brain magnetic stimulation (rTMS) has shown promise in treating depression, PTSD, and cognitive issues in military populations, but the effectiveness remains unclear. A review of nine clinical trials found mixed results, with some studies showing improvement while others found no benefit.
Researchers discovered diverse microbes in Chile's Atacama Desert clay layers, which could indicate the presence of microorganisms on Mars. The study provides a guide for searching for life on the red planet, informing where to look and which instruments to use.
Research reveals that crops adapted to pre-industrial environments, like corn and sorghum, cannot efficiently utilize elevated CO2 levels. Experts propose engineering these plants to optimize resource allocation, potentially boosting productivity in a future with rising CO2 concentrations.
Barbara Hammer and her team will explore new technologies for secure drinking water supply in cities with the help of 10 million euros from the European Research Council. They are developing controllable artificial intelligence to detect factors putting strain on the system, enabling operators to make informed decisions.
A recent Finnish study found that subarachnoid hemorrhage is the 12th most common cause of death in middle-aged women and exceeds deaths from car crashes or cerebral infarctions. The disease can be largely prevented through healthy lifestyles, including not smoking and preventing high blood pressure.
The University of Texas at El Paso has received a $1.18 million grant from the National Science Foundation to study abiotic carbon dioxide (CO2) dynamics in dryland systems through irrigated pecan orchards. The project aims to understand the conditions that enhance CO2 production and develop methods to model and predict its impact.
A three-year study published in 'Alzheimer's & Dementia' shows that a multinutrient formulation can significantly slow the deterioration of cognitive performance and brain atrophy in early Alzheimer's patients. Patients who received the nutrient drink suffered between 40-70% less cognitive impairment than those in the control group.
Researchers establish objective standards for defining and identifying binary tropical cyclones (BTCs), which can bring extreme precipitation and cause serious disasters. The study analyzed two best-track datasets and provides a main standard for defining BTCs, based on separation distance and coexistence time.
Researchers at EPFL's LANES laboratory have created a revolutionary circuit that combines logic operations and data storage into a single architecture, reducing energy losses and increasing efficiency. This breakthrough technology uses a 2D material called MoS2 to enable smaller, more powerful devices with improved performance.
Researchers have discovered a potential broad-spectrum anti-viral drug target by identifying how encapsulated viruses hijack the protein manufacturing and distribution pathways in cells. This approach offers an attractive alternative to developing individual drugs for each virus, with the same compound targeting multiple viruses.
A new global analysis has revealed that poor nutrition in school years may have created a 20cm height gap across nations. The study assessed the height and weight of over 65 million children aged five to 19 years old in 193 countries, finding an eight-year growth gap for girls and six-year growth gap for boys.
The global food system accounts for nearly a third of total greenhouse gas emissions, with land clearing and deforestation, fertilizer use, and fossil fuel combustion major contributors. Reducing food system-related emissions is crucial to meeting the 1.5°C warming target
Researchers used a large-scale data archive of animal movement studies to find surprising patterns and associations between climate change and the behavior of golden eagles, bears, caribou, moose, and wolves. The study demonstrates the feasibility and importance of studying animal ecology on extremely large scales.
Researchers found that particulate matter (PM2.5) is overestimated in winter and ozone (O3) is underestimated in urban areas compared to suburban areas across all of China. This highlights the need for more data outside urban areas to accurately assess air pollution impacts on ecosystem functions.
A new study published in Science finds that greenhouse gas emissions from the global food system could lead to a 1.5°C temperature increase by mid-century and 2°C by the end of the century. Transforming farming practices, eating habits, and reducing food waste are crucial to achieving climate goals.
Researchers analyzed genome-wide data spanning 6,000 years in eastern Eurasian Steppe, revealing a spectacular level of genetic diversity among Xiongnu and Mongol populations. The study found no evidence for lactase persistence, challenging current medical models.
Researchers repurpose an antirheumatic gold drug, auranofin (AUR), to revive the potency of 'last-resort' antibiotics against multi-drug resistant superbugs. The combination therapy shows promising results in eradicating multidrug-resistant bacteria in animal models.
The study explores the rise of click-and-collect services and examines their most appropriate settings. It finds that different formats address fundamentally different shopper needs, resulting in vastly different performance outcomes.
Researchers discovered a two-layer buckled honeycomb structure of blue phosphorene with extremely stable metallic properties, promising applications in nano- and optoelectronics.
A leukemia patient remained asymptomatic and infectious for at least 70 days with SARS-CoV-2, setting a new record for longest shedding duration. The patient's compromised immune system prevented antibody production, allowing the virus to persist.
Researchers developed a geometric network model to study the multiscale organization of the brain, finding that layers at different resolutions exhibit self-similar structure and efficient decentralized communication. This discovery has implications for understanding brain functioning and may lead to advanced tools for brain simulation.
A study published in the European Journal of Preventive Cardiology found that mothers' cardiovascular health significantly affects their children's risk of developing heart disease. Offspring of mothers with ideal cardiovascular health lived nine more years without cardiovascular disease compared to those with poor health.
Researchers analyzed data from 665 older adults to find trends in end-of-life symptoms. The study found that rates decreased for certain symptoms, such as difficulty sleeping and shortness of breath, while others increased or remained stable.