Researchers have discovered that a small percentage of drug-resistant cancer cells were already present before treatment, relying on alternative genes for survival. Understanding this mechanism is key to developing new treatments to eliminate both AXL- and EGFR-dependent cells from the start.
A new study suggests that Easter Island's demographic collapse did not occur, but rather experienced steady population growth until European contact. The researchers used Approximate Bayesian Computation to analyze radiocarbon dates and environmental changes, revealing that the islanders' resilience strategies were successful despite a...
Researchers predicted gamma ray bursts from a nearby magnetar and confirmed their prediction, showing periodic windowed behavior. The pattern of bursts was found to be periodic, but not perfectly regular, adding to the mystery of how magnetars produce radio and gamma ray bursts.
A University of Alberta study found that infant boys with a high Bacteroidetes gut bacterial composition scored higher in cognition and language skills. The researchers believe this association may be due to the production of metabolites called sphingolipids, which are instrumental for neuron formation and structure.
Non-alcoholic fatty liver disease affects 25% of the global population, leading to inflammation and fibrosis. Researchers discovered that hepatocyte reprogramming is controlled by molecular switches, resulting in dysfunction.
A diet rich in isoflavone may provide protection against multiple sclerosis-like symptoms when combined with specific gut bacteria that can break down the compound. The study found that mice fed an isoflavone diet had a microbiome similar to healthy individuals, while those without it lacked beneficial bacteria.
In a proof-of-concept study, researchers used DNA base editing in a prenatal mouse model to correct the single base mutation responsible for Hurler syndrome. The treatment demonstrated increased survival and improvement of metabolic, skeletal, and cardiac disease in prenatally treated mice.
Scientists investigate how bacteria develop resistance to silver nanoparticles, identifying a key genetic mutation and differences in motility. The findings suggest that silver nanoparticles may be effective against certain strains of bacteria, but caution is needed to prevent resistance.
A recent study published in the British Journal of Health Psychology found that providing information on the efficacy of COVID-19 vaccines can significantly increase willingness to be vaccinated. The research showed that adults who received information about vaccine effectiveness scored 20% higher on a measure of willingness to be vacc...
Researchers at IMIM-Hospital del Mar and CIBERONC discover a low-toxicity treatment combining chemotherapy and BRAF inhibitors eradicates malignant melanoma by preventing DNA repair. The strategy offers a new therapeutic perspective for patients with BRAF oncogene mutations.
A USC analysis found that ICE violated its own medical care standards in 78% of cases, often ignoring warning signs of critical illness. Many deaths were preceded by delayed or inappropriate care, and researchers recommend improved reporting, independent reviews, and rehabilitation for facilities with recurrent violations.
Researchers have discovered a new set of signals that control the production of goblet cells in the lung, which are often increased in lung diseases. The study found that altering these signals can increase or decrease goblet cell production, offering potential therapeutic avenues for treating conditions like asthma and COPD.
Researchers analyzed a large US COVID-19 dataset to assess clinical severity and identify risk factors for severe illness. The study found that machine learning models can accurately predict SARS-CoV-2 infection severity among US adults.
A Rutgers-led study found that lesbian and gay smokers, particularly bisexual female smokers, prefer menthol cigarettes. The study reveals a preference rate of 54% among bisexual females and 50% among lesbian/gay females compared to the overall smoking population.
MicroED can solve high-resolution crystal structures from sub-micron-sized crystals, aiding small-molecule drugs and transient polymorphs determination. This approach helps guide synthesis strategies and inform production decisions.
A study published in the Journal of the American Medical Association found that PRP injection provides no benefit for patients with debilitating Achilles tendon pain. The researchers recommend against using PRP treatment for these patients due to its lack of effectiveness and potential short-term harm.
A Skoltech team developed a model to assess infection risks for supermarket customers. The composite model incorporates social forces and retail space layout, suggesting that social distancing is the primary factor in reducing infection rates. Filling stores to capacity has little economic sense during the pandemic.
A study by Queen Mary University of London and University of Oxford found that lateral flow tests are 95% effective in detecting Covid-19 when used at the onset of symptoms. The findings support using lateral flow tests as an alternative to PCR testing among symptomatic patients.
Agricultural economist Thomas Daum argues that farm robots could lead to a utopian future with rich fields, diverse crops, and conservation of biodiversity. In contrast, large, tractor-like robots could result in a dystopian scenario with environmental degradation.
The RAPID Trial found that administering a full dose of heparin early to moderately ill hospitalized patients with COVID-19 could reduce the risk of severe disease and death. The study showed a significant reduction in all-cause death with therapeutic heparin compared to low-dose treatment.
A blood test that measures ACE2 protein and fragments can track SARS-CoV-2 infection evolution, according to a study. Patients with COVID-19 show reduced full-length ACE2 protein levels and increased lower molecular mass fragments.
A new study published in The Economic Journal found that the presence of adult entertainment establishments in New York City significantly decreases sex crimes. Researchers combined crime data with opening dates of these establishments to find a 13% reduction in sex crimes within one week of opening.
A KAIST research team developed a hydrogel-based flexible brain-machine interface that can detect neural signals for up to six months. The device minimizes foreign body responses by mimicking the properties of surrounding tissues when exposed to body fluids.
A team of scientists at NTU Singapore has developed a way to convert tamarind shells into carbon nanosheets, which can be used as an energy storage material in vehicles. The process is eco-friendly and reduces waste, making it a promising alternative to industrially produced counterparts.
A new study by CNIO researchers has found that blocking the RagC protein's signals can delay the onset of follicular lymphoma in animal models. The strategy may also be effective in treating autoimmune diseases.
A study found that teenagers who have self-harmed five or more times in their life have a significantly higher threshold for pain compared to adolescents that have not. This has clinical potential as an effective test for identifying youths at the highest risk of suicide.
Researchers have developed a new type of nanocarrier that combines photothermal, chemo-therapy, and chemodynamic therapy to target and destroy cancer cells. The nanoclusters, which are responsive to near-infrared light, show a significant inhibitory effect on mouse tumor growth in vivo experiments.
A recent study found that over a quarter of COVID-19 patients still experience symptoms six to eight months after initial diagnosis. Commonly reported symptoms include fatigue and shortness of breath. The study's findings highlight the need for timely healthcare resource planning for post-COVID-19 care.
Researchers at the University of California San Diego have developed a new wearable device that can generate electricity from human sweat, even when the wearer is asleep or sitting still. The device, which requires no physical input from the wearer, collects sweat from the fingertips and converts it into electrical energy.
A new study from American University found that individual trees can help mitigate urban heat, particularly in evening hours. The research showed that neighborhoods with at least half of the area covered by canopy were 1.4 degrees Celsius cooler than those with few trees.
Researchers developed a general theoretical approach to calculate the density of 5G base stations needed to achieve specific network parameters. The model shows that full isolation and mixed frequency regimes have different required densities, with the latter being more efficient but technically challenging.
A novel gene therapy method has shown dramatic improvement in symptoms, motor function, and quality of life for children with AADC deficiency. The treatment involves introducing a benign virus programmed with specific DNA into precisely targeted areas of the brain.
New research reveals that destroying tropical ecosystems leads to reduced soybean income by an average of US$100 per hectare per year due to increased extreme heat. Conservation of the Amazon and Cerrado biomes can prevent this damage, estimated to cost the sector US$3.55 billion annually.
A Cornell University-led team projects that vehicle electrification, driverless cars, and ride sharing could prevent 5,500 premature deaths and save $58 billion annually in the US by 2050. The study also finds that vehicle electrification is the most important piece for carbon mitigations and health benefits.
Jessica Hurley, Assistant Professor at George Mason University, will research the impact of nuclearization on decolonization in India, South Africa, Oceania, and Native North America. Funding from the National Humanities Center will support her book project through September 2022.
A new model of inclusive sustainability emphasizes researchers' life experiences as a source of unique perspectives on socioecological challenges. This approach seeks to address the limitations of traditional conservation methods and promote more effective solutions.
A study of online surveys from five countries reveals that genome editing is generally viewed as beneficial for crops but raises concerns about animal welfare. The research found four distinct groups: strong supporters, supporters, neutrals, and opponents, with 21% strongly supporting the technology.
Researchers found that songbirds can sense sweetness regardless of their primary diets, with the ability emerging early within the songbird radiation. The team identified the molecular basis of this ability and found that it has been conserved in nearly half of all birds living today.
A CU Denver study found that greater trunk flexion can significantly impact stride length, joint movements, and ground reaction forces in runners. The researchers discovered that a larger lean can lead to a shorter stride length and increased leg swings, which may contribute to overuse injuries.
A study from University of Michigan researchers found that electric delivery vehicle charging practices can greatly impact their potential to reduce greenhouse gas emissions. Optimizing charging strategies can lower emissions by up to 37% and protect investment. Charging from a cleaner energy source, such as renewables, is key.
Researchers investigated the impact of EGCG on Tau glycation and its effects on advanced glycation end products in neuroblastoma cells. EGCG was found to inhibit methyl glyoxal-induced Tau glycation and reduce advanced glycation end products formation, while also modulating the localization of AT100 phosphorylated Tau.
A new study from the University of California, Davis, found that France's Appellation d'Origine Contrôlée (AOC) system led to a significant increase in market value for French wines. The AOC system created production standards and mandatory tasting requirements, allowing wine growers to improve quality and be rewarded for it.
Research suggests that telomere shortening drives intestinal inflammation in inflammatory bowel disease (IBD). Telomere erosion is positively associated with disease severity and may underlie disease recurrence.
The new MaxDIA software provides a computational workflow for data-independent acquisition proteomics, combining library-based and library-free approaches. This enables highly sensitive and accurate data analysis for thousands of proteins, opening up new possibilities for medical applications in personalized medicine.
Kuo-Chu Chang is developing a knowledge graph-based information sharing system with the US Department of Navy. The project aims to improve communication and collaboration among teams.
A novel screening method using untargeted metabolomics profiling can improve the diagnostic rate for inborn errors of metabolism in newborns, identifying many more disorders than traditional methods. This approach offers a faster, more efficient, and less expensive diagnostic journey for individuals with rare metabolic disorders.
A new study by Duke University finds that dogs have developed complex cognitive abilities similar to human babies after 14,000 years of domestication. The research tested dog and wolf puppies, revealing that dogs can intuitively understand human gestures and social cues.
Younger athletes are at greater risk of atrial fibrillation than older athletes, with a 3.6 times higher likelihood. Mixed sports athletes also have a higher risk compared to endurance sport athletes. The study suggests that athletes face significantly greater risk of developing atrial fibrillation.
Researchers at Tel Aviv University have developed a groundbreaking technology that restores tactile sensation via an electric current transmitted from a healthy nerve. The sensor, implanted on a damaged nerve, recreates the feeling of touch without requiring an external power source.
A recent study in Annals of Internal Medicine suggests that mandatory COVID-19 vaccination for healthcare workers is strongly justified due to the higher mortality rate of SARS-CoV-2 compared to influenza. The authors propose strategies to increase employee acceptance and overcome vaccine hesitancy, emphasizing the importance of protec...
Researchers found that coastal communities in San Mateo County are at risk of financial instability from flooding, with lower-income households disproportionately affected. The study's new methodology aims to provide a human-centered approach to risk assessment, focusing on the residents most likely to lose their livelihoods when water...
A new study found that nearly 75 percent of research on relationship beginnings focused on romance between strangers, while only eight percent examined friendships-to-romance transitions. The study analyzed data from over 1,900 university students and crowdsourced adults, finding a strong correlation between friends-first initiation an...
Coastal ecosystems worldwide are estimated to have a significant impact on the global economy, with countries like Australia and Indonesia storing large amounts of carbon. The study found that these countries generate annual welfare gains of around $26.4 billion from reduced climate change costs, while other nations like India and Chin...
A team of UT Austin statisticians have developed a new method to model how the brain learns language over time, with potential applications in clinical practice and other areas of neuroscience research. They found that good learners process audio information faster than bad learners when deciding on tonal differences.
A new study published in PNAS has identified a protein called AXL as a crucial player in hypoxia, which promotes cancer progression and resistance to treatment. By blocking the action of this protein, researchers observed improved recovery of blood vessels and revitalization of the tumour's immune environment.
Researchers at University of California San Diego School of Medicine developed a new AI methodology to hunt for disease targets and predict drug success. The approach, which uses machine learning to analyze big data, was tested in a Phase '0' clinical trial and showed high accuracy across diverse IBD patient cohorts.
Scientists have discovered a novel way to classify magnetized plasmas, which could lead to advances in harvesting fusion energy on Earth. The discovery reveals that a magnetized plasma has 10 unique phases, with transitions between them supporting localized wave excitations.
Researchers from NICT demonstrated a world record 319 Tb/s long-haul transmission of wideband S, C and L-bands signal using 552 PDM-16QAM channels in a 4-core optical fiber. The system enabled transmission distance over 3,001 km with both erbium and thulium doped-fiber amplifiers and distributed Raman amplification.
Researchers have identified distinct metabolic phenotypes in hepatocellular carcinoma subtypes, providing insights into precise personalized treatment options. The study revealed a poor prognosis subtype strongly correlated with immune pathway up-regulation and unsaturated fatty acid accumulation.
A third of teens and young adults reported worsening mental health during the pandemic, with disruptions in social connections a major factor. The study found that those with higher socioeconomic status, lower closeness to friends and family, or older age were more likely to experience worsened mood and anxiety.