A new study in mice reveals that the insular cortex plays a crucial role in balancing fear responses, integrating sensory and bodily signals to maintain an adaptive range. The InsCtx function depends on bodily feedback signals, dampening excessive fear-evoked activity and promoting healthy fear regulation.
A study by Katariina Koivusaari found that high cow's milk consumption is associated with a higher risk of developing preclinical type 1 diabetes in genetically predisposed children. The study also linked high-temperature treated infant formula to an increased risk of asthma in children.
Flowering plants dramatically increased Earth's biodiversity and rebuilt entire ecosystems after the dinosaur extinction. Angiosperms' unique features, such as colorful flowers and adaptations for insect pollination, drove their success.
A new paper cautions that slow economic growth may bring challenges, particularly in multicultural democracies like the US, affecting social solidarity, opportunity, inequality, and trust in government. The authors propose a 'guided civic revival' to address these challenges by strengthening democratic institutions, increasing social i...
Researchers from ASHBi at Kyoto University have made a breakthrough discovery on X-chromosome dosage compensation in monkeys. In contrast to mice, both X chromosomes are inactivated in female and male monkey embryos prior to implantation, but not after. This finding provides new insights into human embryonic development and may help ex...
Researchers at Texas A&M University developed a simulation tool to accurately assess the levels of specific marker compounds in organic aerosols. This helps government agencies monitor human-made sources of carbon-based pollutants and develop emission control measures for cleaner air.
The global red and processed meat trade has risen exponentially, leading to a sharp increase in diet-related illnesses, particularly bowel cancer, diabetes, and coronary artery heart disease. Health policies should be integrated with agricultural and trade policies to address this issue.
Researchers at Cornell University have launched scMuscle, a large single-cell database that provides a comprehensive picture of the dynamics of muscle repair. The database houses transcriptomic data from approximately 365,000 cells involved in muscle injury across various ages and experimental conditions.
Researchers at UNC Chapel Hill and UC Davis have discovered how the soil bacterium Pseudomonas aeruginosa uses copper to produce fluopsin C, a broad-spectrum antibiotic. This finding could lead to new treatments for infections caused by this pathogenic bacterium.
A review of anti-aging dietary interventions reveals complex physiological consequences and intriguing similarities across diets. The study suggests a common mechanism involving the inhibition of protein kinase mTOR as a molecular target for increasing health longevity in humans.
Researchers discovered a mechanism of sleep in zebrafish and mice, linking PARP1 protein to signaling the brain for sleep. Six hours of sleep per night is sufficient to reduce DNA damage, highlighting the importance of adequate sleep for efficient DNA repair.
Scientists have determined the near-atomic-scale structure of GPR158, a brain-cell receptor linked to depression and anxiety. The study offers insights into how to block this receptor as a strategy for treating major depressive disorder.
A recent study reveals that child maltreatment is associated with altered oxytocin gene methylation, leading to atypical brain structures and function. This finding suggests a potential biological mechanism for targeting during adolescence to improve the lives of victims of childhood abuse.
A groundbreaking technique allows researchers to study the unique venom production of a wide range of venomous animals, including scorpions, fish, and the platypus. This non-lethal approach provides new insights into how animals produce venom and opens up possibilities for discovering new drugs.
Researchers have developed highly sensitive quantum sensors for the brain that can detect magnetic fields generated when neurons fire. This technology introduces a new method to spot bio-markers of early health problems, such as Alzheimer's disease. The sensors are believed to be more accurate than existing EEG and fMRI scanners.
A comprehensive survey conducted by the Wildlife Conservation Society and partners estimates that 95,000 forest elephants live in Gabon, confirming it as the principal stronghold for this species. The study provides hope for the future of the critically endangered African forest elephant population.
Researchers found that warmer soil releases less carbon, but coarse-textured soils are more vulnerable to climate change. The study's findings highlight the importance of understanding soil types and their impact on carbon storage.
The new quantum microscope uses entangled photons to create interference patterns on the sample, reducing noise levels and increasing sensitivity by over 25%. This allows for high-resolution imaging of transparent cells without damaging them.
A new study by USC researchers uses GANs to generate synthetic neurological data that can be fed into machine-learning algorithms to improve BCI usability. This approach improved BCI training speed by up to 20 times and enabled rapid adaptation to new subjects.
A University of Illinois study examines the transport of aerosolized organic materials from bursting bubbles into the air. The research found that the viscosity and thickness of oil layers control the shape, size, and velocity of resulting bursting jets, with implications for contaminant dispersal and climate modeling.
A study of 16,000 patients with new cancer diagnoses found that those from higher socioeconomic backgrounds were more likely to use telemedicine in the months following their diagnosis. Higher socioeconomic groups also showed increased utilization of telemedicine services within 30 days of diagnosis during the COVID-19 pandemic.
A recent CDC analysis found that vaccination rates among US hospital personnel stalled after initial uptake, with 30% remaining unvaccinated as of September 2021. The analysis, which included data from over 3.3 million healthcare workers, revealed that vaccine mandates and educational efforts could help improve coverage.
Conservatives believe bodily markets violate human body sanctity, while liberals see them as exploitative. This study found liberals support laws punishing buyers over sellers, whereas conservatives back laws punishing both parties.
Researchers from Peking University developed a new technique using 4D-EELS to measure phonon modes at heterointerfaces, directly observing localized phonon modes for the first time. This breakthrough enables better understanding and control of solid interfaces' properties.
Researchers at Berkeley Lab are developing next-generation materials and systems for thermal energy storage, which could be a viable alternative to batteries. The technology has the potential to reduce demand on the electricity grid from thermal loads and free up resources for other applications.
Researchers discovered that a specialized form of vitamin D can reduce inflammation caused by T cells in lung cells, which may be relevant to severe COVID-19. The study suggests that adding this concentrated intravenous metabolite to existing treatments could help patients recover from COVID infections.
A group of former PCAST members recommend a commission to examine public health agencies, earlier outbreaks, pandemic preparedness, and the U.S. response to COVID-19, aiming to improve future preparedness
Researchers have identified metabolic signatures in blood plasma that can predict a patient's response to chemotherapy and prognosis. This discovery enables physicians to personalize treatment and enhance its efficiency, leading to improved outcomes for patients with gynecologic tumors.
The study tracked nations' progress in meeting basic needs and respecting environmental limits, finding that no country meets both criteria without overconsuming resources. Wealthy countries like the US and UK drive ecological breakdown while poor countries like Bangladesh struggle to meet basic human needs.
CanDIG, a collaboration of computer scientists, AI specialists, clinicians, and geneticists, enables studies needed to address health challenges in Canada. The platform is helping scientists access large-scale genomics data and connect Canada's genomic datasets to those from around the world.
A nationwide observational study published in Circulation found that lower levels of income and education are associated with reduced chances of survival after out-of-hospital cardiac arrest. The study analyzed data from 31,373 cases of OHCA between 2010 and 2017, showing a correlation that was observed in both men and women.
A new article from McGill University researchers advocates for bolstering planetary biosecurity to address potential biological contamination risks from space missions. Early detection and rapid response protocols, informed by knowledge gained from invasion science, are crucial for preventing the spread of alien biological contaminants.
Researchers have developed highly efficient flexible perovskite solar cells by annealing a SnO2 ETL in a rough vacuum at a low temperature, achieving 20.14% efficiency and improved interface connection.
A recent study published in the Journal of Marketing found that brand-to-brand praise can lead to increased consumer engagement and sales for the praiser. The research suggests that this approach is particularly effective for brands that are not traditionally seen as warm or caring, such as for-profit brands.
Researchers have uncovered how a viral RNA changes shape to hijack host proteins, revealing the role of cryogenic electron microscopy in making this discovery possible. The study highlights the emerging power of cryo-EM to visualize multifunctional dynamic RNA structures.
Researchers at Children's National Hospital have successfully developed a personalized T cell immunotherapy that targets and kills unique proteins in individual tumor cells. This approach, combining genetic sequencing and protein identification, offers a promising treatment option for children with hard-to-treat brain tumors.
Researchers studied 4022 dogs fed different diets as puppies to see if it affected allergy and atopy related skin symptoms in adulthood. They found that puppies fed raw tripe, organ meats, and human meal leftovers had fewer allergies and skin issues.
A new virtual histology technology may reduce the need for invasive skin biopsies, providing a biopsy-free solution for rapid diagnosis of malignant skin tumors. The technology uses deep-learning frameworks to transform images of intact skin into detailed, virtually stained images.
Aluminum implantation doping creates defects many layers deeper than the implantation site, affecting conductivity modulation and specific on-resistance. Researchers found that ion implantation defects penetrate up to 20 µm from the active region, requiring processing at least this distance away.
A team of researchers from UC Riverside has discovered how a small molecule called auxin triggers the growth process in plants. By analyzing cell walls, they found that auxin lowers pH levels, causing cells to become acidic and soften, allowing them to expand and grow.
The WVU-led Dolly Sods GPU cluster enables researchers to accelerate computational research in fields like drug development, interstellar phenomena, and biometrics. The cluster will facilitate the analysis of massive datasets and enable real-time processing of signals from satellites in space.
Early symptomatic cases linked to Hunan Market, where live animals were sold, suggesting zoonotic spillover as likely source of COVID-19. The closure of the market and lack of virus screening from animals may hinder understanding of the origin.
Researchers have developed a new electrochemical technique for printing metal objects at the nanoscale, achieving resolutions of up to 25 nanometres in diameter. This technology has vast potential applications in fields like microelectronics, sensor technology, and battery production.
A new AI model has been developed to classify colorectal polyps, demonstrating accuracy and sensitivity at a level comparable to practicing pathologists. The model was tested in a clinical trial involving 15 pathologists, showing significant improvements in accuracy compared to traditional methods.
USP8 activity regulation has been decoded, revealing an autoinhibitory region that interacts with its catalytic region and enhances deubiquitinating activity in Cushing's disease. This discovery could lead to targeted therapy for the condition.
Researchers found a mechanism that regulates cell behavior depending on environment's curvature change, using soft hydrogels to replicate folding patterns in living tissues. The study reveals how curvature governs cell distribution, shape, and density in complex environments.
A new study examines the genetic basis of longevity in Galápagos giant tortoises and finds that these animals have extra copies of genes that may protect against aging and cancer. The creatures' cells respond to stress in ways that could help prevent disease.
Researchers have developed a new strategy to combat the tick-borne Crimean-Congo hemorrhagic fever (CCHF) virus by reconstructing its structure and identifying neutralizing antibodies. The study, published in Science, offers insights for developing therapeutics and vaccines against the virus.
Researchers will investigate brain circuitry, neurochemicals and immune system interactions to understand why people living with HIV are more vulnerable to depression. They aim to identify specific biomarkers of depression and develop better treatments.
A recent study found that B cells can support tissue repair and regeneration after injury by adopting MyD88-dependent regulatory functions and phenotype. This complex mechanism involves the release of pro- and anti-inflammatory molecules, which facilitate healing and reduce inflammation-associated proteins.
A new study published in the Journal of Affective Disorders found that adults with ADHD are four times more likely to experience generalized anxiety disorder. Factors associated with GAD among those with ADHD include being female, having a lower income, and a history of major depressive disorder.
A non-partisan COVID-19 commission could provide a clear-eyed assessment of the US response to the pandemic and recommend steps for improvement. The commission should evaluate public health infrastructure, warnings and origins of the virus, and adequacy of pandemic preparedness.
MIT physicists have observed the Pauli exclusion principle suppressing how a cloud of ultracold, superdense atoms scatter light. The effect, known as Pauli blocking, makes the atoms effectively transparent and invisible to photons.
A new study describes a proof of principle for engineering Gluconobacter oxydans bacteria to extract rare earth elements from ore in a way that meets U.S. environmental standards. The method is more efficient than current thermochemical extraction and refinement methods, with potential to control the resource and meet domestic demand.
A University at Buffalo study explores how social and economic characteristics influence hospital readmissions and health inequity in the US. The research found that patients with lower household income, male gender, or treated in urban hospitals have a higher risk of being readmitted within a month of discharge.
Researchers at Brigham and Women's Hospital discovered that cancer cells can disarmed the immune system by forming nanotubes that pull out mitochondria from immune cells. This new mechanism gives a target to go after, leading to potential new combinations of therapies for improving cancer immunotherapy outcomes.
Researchers find that right-wing parties in Brazil successfully employ descriptive representation to connect with poor voters, nominating less educated candidates. However, they also face challenges due to the unavailability of less educated candidates and potential voter backlash against less capable politicians.
Researchers found that re-identifying individuals from genomic data using public face images is harder than previously thought, with success rates well below idealized settings. They developed a method to alter social media photos and reduce the risk of privacy breaches.
A team of scientists from Tokyo University of Science has developed a machine learning-based tool to predict thermoacoustic oscillations in engines. The tool uses dynamical systems theory and can classify combustion into three states, identifying pressure fluctuations that indicate future combustion oscillations.
Researchers at Arizona State University have developed a new microscopy method that can track 100 single molecules simultaneously in three dimensions. The technique uses surface plasmon resonance (SPR) technology to precisely image molecular binding events and study their dynamic activities in real time.