Researchers at the University of Bergen have developed mini-brains that can study disease processes caused by mitochondrial failure, potentially leading to new therapies for epilepsy and other brain disorders. The mini-brains offer a realistic model for exploring complex disease processes and testing treatment strategies.
Researchers compared urine NAA levels in patients with mild and typical Canavan disease, finding lower levels in those with the milder form. This discovery has potential for a rapid and cost-effective way to screen for CD incidence and severity.
A new study from the University of Adelaide has identified key markers that influence how commercial behaviour is perceived by courts, providing practical guidance for consumers, businesses, and legal professionals. The research clarifies the line between legal and illegal conduct in commercial law, highlighting the distinction between...
Researchers estimate that 1.72 billion people were within 50 km of shoreline in 2000, increasing to 2.2 billion by 2020, with the most significant increases occurring nearest the shoreline.
Researchers investigate how perturbed gene expression contributes to neurodegenerative disorders like Alzheimer's. Alternative polyadenylation, a mechanism regulating protein production, is being studied for its potential role in the disease.
A study published in Advanced Science found that ethyl lactate, a nonethanol ingredient in distilled spirits, can ameliorate fatty liver, inflammation, and acute-on-chronic liver injury in alcohol-associated liver disease. Ethyl lactate works by inducing fibroblast growth factor 21, which inhibits abnormal lipid metabolism.
A new database reveals significant gaps in hippo population knowledge, with fragmented populations relying on protected areas. The research calls for coordinated surveys and a centralized spatial database to improve conservation efforts.
The updated recommendations provide a comprehensive framework for healthcare professionals to deliver better care and move closer to ending the HIV epidemic. The guidelines emphasize tailored antiretroviral therapy, effective HIV prevention strategies like pre-exposure prophylaxis, and comprehensive care for people living with HIV.
Princeton engineers create soft plastics with programmed stretchiness and flexibility that are also recyclable and inexpensive. The material's internal structure is controlled to achieve stiffness and stretchiness in different regions of an object.
A new study found that a low omega-6, high omega-3 diet with fish oil supplements significantly reduced prostate cancer cell proliferation in men. The findings suggest that dietary changes could potentially delay or prevent the need for more aggressive treatments.
A team of scientists captured an astonishing image of a gamma-ray flare emanating from the supermassive black hole at the center of galaxy M87. The flare was tens of millions of times larger than the event horizon and lasted about three days, providing crucial insights into particle acceleration near black holes.
A new study reveals that plant-based drinks have lower nutritional quality than cow's milk due to chemical reactions during processing. The heat treatment used in UHT processing alters protein structures, leading to the loss of essential amino acids and increased sugar content.
A recent study found that post-COVID-19 condition (PCC) affects approximately 8.4% of US adults, with significant differences observed across various demographic groups. Currently, 3.6% of adults have PCC, and a notable 2.3% experience activity-limiting PCC.
A social work graduate has published her research on cognitive decline among refugees, finding that those who have experienced trauma are more likely to suffer from mild cognitive impairment. The study highlights the need for interventions that address these gaps in care and promote healthier aging.
A new framework evaluates tsunami risk to seaports and the global port network, estimating potential economic losses in trade caused by port disruptions. The study found that a Manila Trench tsunami could damage up to 15 international seaports under present-day sea-level conditions.
A new screening method combining laser analysis with AI identifies patients with breast cancer in its earliest stage, stage 1a. This non-invasive technique reveals subtle changes in the bloodstream that occur during the initial phases of the disease, outperforming existing early detection strategies.
The CNIC has developed a comprehensive set of genetic tools and mouse lines called iFlpMosaics, enabling accurate investigation of somatic mutations on cellular biology and disease. This toolkit facilitates the study of complex interactions between cells within their microenvironment.
The EUnetHTA 21 project has developed guidelines and templates for joint HTA work at the EU level, tested in pilot assessments, and aims to improve HTA quality and reduce patient access inequalities. The results of the project will inform the implementation of the European HTA Regulation from 2025 onwards.
A new study from the University of Surrey found that multinational enterprises (MNEs) are actively contributing to environmental problems despite claiming to address them. The research team argues that there is an urgent need for MNEs to reassess their innovation strategies to align with the UN Sustainable Development Goals.
Researchers analyzed data from 11,797 adults with advanced solid cancers and found no difference in mortality rates during the shortage period. Prescription rates for cisplatin and carboplatin fell less than three percent overall, with alternative therapies helping mitigate the crisis.
The European Society of Cardiology emphasizes the importance of including heart and cardiovascular health in cancer treatment plans. Recent studies estimate that approximately one-third of patients experience mild toxicities, while 3% develop moderate toxicity. The ESC is launching a new conference to address this growing epidemic.
Scientists at Helmholtz Centre for Infection Research have developed ACTIMOT, a genetic method that amplifies and isolates biosynthetic gene clusters from bacteria to produce new bioactive natural products. The approach enables faster and easier access to previously hidden pharmaceutical potential.
Adult obesity trends in the US have declined for the first time in more than a decade, according to recent data. The South region experienced the largest decreases in body mass index and obesity prevalence, despite also facing high COVID-19 mortality rates among obese individuals.
A team of experts has discovered that the ARID1A gene regulates a critical genetic program for cell migration, with ZIC2 identified as a crucial regulator in this process. This study expands our understanding of craniofacial development and provides valuable insights into the genetic causes of congenital diseases.
A breakthrough in electrochemical CO2 reduction processes has been achieved through ligand engineering of copper nanoclusters. The study reveals that variations in intercluster interactions significantly impact the stability and selectivity of these nanoclusters, leading to more efficient carbon conversion technologies.
Researchers discovered that human SMC protein cohesin twists DNA in a left-handed way by 0.6 turns per step, regulating chromosome function and impacting health. This finding provides essential clues for resolving the molecular mechanism of twisted DNA looping.
Researchers at Osaka Metropolitan University developed a new technique for head and neck reconstruction that achieves 100% success rate in high-risk patients. The pedicled latissimus dorsi flap technique provides a reliable, fast, and minimally invasive option for complex tissue defects.
A team of researchers at USC will receive funding to test a novel approach to slowing age-related cognitive decline, targeting the brain's lymphatic system. The grant aims to delay the onset of Alzheimer's and Parkinson's disease by clearing waste buildup.
Sage has acquired Mary Ann Liebert, Inc., a renowned global media company publishing over 100 peer-reviewed journals in biotechnology and life sciences. The acquisition will enhance the reach and impact of Mary Ann Liebert's content, supporting the global research community.
Adding camrelizumab to neoadjuvant chemotherapy significantly improved pathological complete response in patients with early or locally advanced triple-negative breast cancer. The treatment showed substantial benefits, leading researchers to explore its potential as a neoadjuvant strategy.
Scientists at Monash University have discovered the structure of how LAG-3 interacts with its main ligand, providing a new targeted approach to improve immunotherapy's effectiveness for certain forms of cancer. This breakthrough could lead to the development of blocking LAG-3 therapeutics and further enhance cancer treatment.
Researchers identified 159 genetic studies and 37 key genes linked to reproductive traits such as age at first childbirth, menopause timing, and hormones like FSH and testosterone. Genetic factors play a significant role in broader health outcomes and influencing fertility.
Professor Minh Nguyen and Professor Carsten Sauer have received ERC Consolidator Grants to investigate financialization in Asia and gender-based wage differentials in Europe. Their projects aim to understand the impact of financial markets on working lives and labor market practices.
Researchers have created a novel breeding strategy to rapidly create climate-smart crops that can withstand heat stress. By optimizing carbon partitioning to sinks, they increased yields in staple grain and vegetable crops. The study showed improved fruit quality, sugar content, and yield resilience under heat stress conditions.
Researchers found that rutting calls of Siberian wapiti stags reflect their harem-holding status and individual characteristics. The study suggests that these acoustic displays enable females to assess a male's quality from a distance, while also signaling to rivals whether it's worth challenging him.
A recent study found that diverse research teams in allergy and immunology programs exhibit increased research output due to enhanced creativity and innovation. The study also highlights the importance of depth of expertise and balance within the team.
Researchers have developed a novel strategy for bone defect repair using flat silkworm cocoon fiber scaffolds functionalized with magnesium ions. These innovative materials exhibit enhanced biological performance and simplify scaffold preparation, paving the way for cost-effective and efficient bone regenerative therapies.
A new study from the University of Illinois aims to determine the most effective risk management strategies for the produce supply chain. The researchers found that improved process controls, such as washing, provided a greater reduction in overall risk than additional product testing.
Reproductive justice leaders discuss the need for intersectionality, economic and public health impacts, youth leadership, and state-based solutions to protect reproductive rights. The discussion aims to harness young people's energy and foster intergenerational collaboration.
A new study reveals insights into leveraging allele dosages in sweetpotato breeding practices to improve key agricultural traits. Researchers found that differences in allele dosage significantly impact root weight, plant architecture, and flesh color.
The Dream Team of University of Houston students developed a comprehensive 10-year energy plan to address energy poverty in Egypt and Turkey. Their interdisciplinary approach prioritized renewable energy technologies, resulting in $5,000 prize money and recognition for their sustainability and economic feasibility.
A research team from the Istituto Italiano di Tecnologia has identified a key brain mechanism that modulates how animals react to others' emotions. This finding provides new insights into psychiatric conditions such as PTSD, autism, and schizophrenia.
Researchers developed a solar-powered plasma water generator to enhance seed germination. The system produced plasma-activated water that modified the chemical environment for seed development, leading to a 135% increase in germination rates for spinach seeds stored for 23 years.
Researchers discovered that serine inhibits the cell wall remodeling necessary for Clostridium perfringens to form spores, preventing food poisoning. The study provides insights into the underlying mechanism of spore formation and may lead to new strategies for preventing foodborne illnesses.
A recent study found that multiple phage species can coexist stably on a genetically uniform strain of E. coli in the human gut. The researchers discovered that each phage species prefers slower or faster growing cells, allowing them to find a separate niche and maintain stable coexistence.
Researchers at Washington University in St. Louis are developing vaccines to target misfolded proteins in the brain, with a focus on preventing inflammation and using peptide nanofibers. The goal is to prevent dementia by training the immune system against amyloid beta and tau proteins.
The discovery of ferroptosis has renewed interest in non-apoptotic cell death mechanisms. While initially studied in cancer, ferroptosis is increasingly implicated in various diseases, including liver injury. However, the liver's robust antioxidant defenses question its widespread applicability.
Insilico Medicine has received its first clinical milestone payment of $10 million from Exelixis for XL309, a selective USP1 inhibitor discovered with the company's AI platform. The drug is being developed for advanced solid tumors and has shown efficacy in preclinical studies.
The PATINA study demonstrates that palbociclib improves progression-free survival (PFS) in patients with HR+, HER2+ metastatic breast cancer, with a median PFS of 44.3 months. This represents an extension in median PFS of over 15 months compared to anti-HER2 therapy and endocrine therapy alone.
A new UC Berkeley study analyzed over 60,000 animal observations and found no conclusive evidence of inequity aversion in non-human species. However, the researchers suggest that some animals may exhibit disappointment or social protest when their expectations are not met.
A large US study found a strong association between long-term air pollution exposure and an increased risk of blood clots in deep veins, also known as venous thromboembolism. Participants with higher exposure to particulate matter, oxides of nitrogen, and nitrogen dioxide had a significantly increased risk of developing these conditions.
Artificial intelligence is enhancing breast cancer risk prediction through mammographic analysis, uncovering key features that predict breast cancer risk. These AI-generated features may inform personalized screening strategies, such as more frequent or less frequent screenings for women at high or low risk of breast cancer.
Researchers at Salk Institute establish a novel framework for the relationship between nutrition and cell identity. They found that a nutritional switch from acetate to citrate plays a key role in determining T cell fates, shifting them from active effector cells to exhausted cells.
A randomized study found that active monitoring for low-risk ductal carcinoma in situ did not increase invasive cancer risk compared to guideline-concordant care. Women on active monitoring had comparable rates of disease recurrence and survival.
Researchers argue that the seasonal time change provides a natural experiment to adapt work activity to morning light, allowing extra daytime leisure in summer. Despite BSS calls for an end to the time change, polls show majority support for summer time over winter time.
The complimentary CME/CE course, offered in support of the 2022 White House Conference on Hunger, Nutrition and Health, has reported significant improvements in clinicians' knowledge, confidence, and practice of lifestyle medicine. Over 53,000 clinicians have registered for the course so far.
PeerJ's new Open Advances in Plant Science journal eliminates financial barriers to publication and dissemination, making high-impact research accessible to all. The journal addresses critical questions in plant science through peer-review reports and Impact Statements highlighting its Global Challenges.
Longidaza significantly reduced exertional desaturation and dyspnea, as well as improved distance walked during the six-minute walk test. The drug's effects on exercise tolerance were sustained for over 100 days after treatment.
A digital dialogic approach helped Chinese college students develop a stronger sense of global awareness by critically examining competing media narratives during COVID-19. The study found that this online approach encouraged critical thinking, media literacy, and bridged ideological divides.
A copper-containing, electrically conducting, two-dimensional metal–organic framework has been developed for the highly selective detection of nitric oxide. The material detects NO at room temperature with high sensitivity and selectivity, making it suitable for air quality monitoring and medical applications.