Insilico Medicine has developed a highly selective FGFR2/3 dual inhibitor, which maintains efficacy against resistance mutations and demonstrates a more favorable safety profile compared to existing FGFR inhibitors. The compound showed robust antitumor efficacy in gastric cancer mouse models.
Dr. Eric Levine's lab at UConn School of Medicine has been awarded $400,000 to study the genetic pathways of autism spectrum disorders using patient-derived human neurons. The team aims to identify genes and brain cell behavior that may cause these disorders, with potential applications for gene therapy.
A study of older adults found that decline in body mass index, waist circumference, and high-density lipoprotein (HDL) occurred up to a decade before dementia diagnosis. These cardiometabolic changes may provide insights into the potential for early monitoring and intervention.
Researchers have created an immune map for pancreatic cancer, showing why some tumours are more susceptible to macrophage-based therapies. The study identifies potential avenues for improved treatment approaches, including boosting certain cell responses and depleting suppressive immune cells.
Researchers developed a highly sensitive laser gas sensor using a four-prong quartz tuning fork, outperforming traditional sensors in terms of sensitivity and signal-to-noise ratio. The new design improves detection performance for trace gases such as acetylene, enabling applications in industrial production, medical diagnosis, and fir...
A novel mechanism has been discovered whereby a short form of IL-18 generated by caspase-3 cleavage in tumor cells activates natural killer cells to suppress tumor growth, offering new therapeutic opportunities. NK cells play a crucial role in cancer immunotherapy due to their rapid response and broad anti-tumor activity.
A new study suggests that delivering tenecteplase directly into a large brain artery after removing a blood clot can improve stroke survivors' function 90 days later. The treatment, which was tested in 127 patients, showed promising results compared to standard medical care.
Researchers at the University of Liège uncover a mechanism regulating the immune response against parasites, where virtual memory T cells express CD22 to prevent excessive inflammation. This discovery opens new perspectives on controlling immune responses and mitigating autoimmune diseases.
A new method developed by Osaka Metropolitan University accurately predicts housing prices in Osaka City, with neighborhood perception being a key factor. The approach achieves nearly 75% accuracy by combining existing property data with machine-learning-processed street view images.
Researchers from Japan develop a non-contact, millimeter-wave sensor system to monitor respiratory motion during diagnostic X-ray and CT imaging. The system has been validated through extensive testing with healthy volunteers and shows promise for improving diagnostic accuracy and treatment outcomes.
The nTIDE February 2025 report reveals a record-high labor force participation rate for people with disabilities, up 1.7% to 42.0%. Employment-to-population ratio also increased for people with disabilities, returning to all-time highs. In contrast, the employment-to-population ratio for people without disabilities decreased.
Researchers developed a novel biocompatible nanoadhesive for corneal transplantation, showcasing improved cell compatibility and antibacterial performance. The nanoadhesive demonstrates strong adhesive strength and prevents wound infection without causing necrosis.
Researchers found that damaged mitochondria send signals to the nucleus, changing cell fate and causing β-cells to become immature and stop producing insulin. Damage was also observed in human pancreatic islet cells, suggesting potential for treatment using a drug called ISRIB.
A team led by Prof. Woo Young Jang developed a novel fluorescent probe to visualize cancer stem cells in complex samples, offering a new direction for cancer diagnostic imaging. This technology has significant implications for diagnosing and monitoring sarcomas.
A multicenter study found that electronic symptom monitoring improved quality of life, clinical outcomes, and well-being in metastatic cancer patients. The PRO-TECT trial showed significant benefits for patients who reported their symptoms via a home-based electronic monitoring system.
A Texas Tech University laboratory played a key role in identifying a genetic adaptation in bats that could help fight viral diseases. The study found that a gene common in some bat species can reduce the production of SARS-CoV-2 virus by up to 90%, presenting a potential new pathway for combating viral infections.
A new study found that hotter and colder regions on a star's surface can distort our interpretations of planets, particularly when looking at dips in starlight. This distortion can lead to misinterpretation of features such as planet size, temperature, and atmospheric composition.
A new review paper warns of the devastating impacts of a 2.7°C global warming on the Arctic region, including sea-ice-free summers, accelerated melting of glaciers, and widespread permafrost loss. The authors urge individuals to take responsibility for mitigating these changes.
A study found that excessive Tibetan Plateau spring warming was the primary factor driving catastrophic June 2024 heavy rainfall in southern China. The research used the ESM to simulate extreme warm temperatures over the TP and heavy rainfall in S. China, reproducing approximately 55% of the observed anomaly.
Researchers from the University of Liège successfully used frozen semen to produce female bees, offering a new avenue for bee conservation and agriculture. The simple, antibiotic-free protocol allows for the preservation of valuable genetic lines and supports breeding programmes.
Researchers at Hiroshima University have discovered complex interactions between Pseudo-nitzschia groups and other algal species, suggesting salinity has a more significant influence than previously thought. This understanding is crucial for predicting harmful algal blooms, which cause substantial damage to the aquaculture industry.
Researchers propose H-CAP method to capture ultrafast phenomena with large frame numbers, improving spatial resolution. The method enhances high-frequency information, allowing for high-fidelity reconstruction of transient processes.
Researchers found that clot-dissolving medication alteplase improved stroke patients' recovery by more than 50% when given up to 24 hours after the beginning of an ischemic stroke. This breakthrough may provide hope for stroke patients worldwide who may not have access to clot-dissolving medications within the approved time window.
A new $10.8 million multicenter clinical trial will compare hip replacement surgery with simpler internal fixation for minimally displaced femoral neck fractures in patients over 60. The trial aims to improve patient outcomes and inform clinical practice.
During the COVID-19 pandemic, primary care practices in the US experienced declining access to care, while average practice capabilities improved. Integrated practice ownership and accountable care organization participation were associated with better access and capability scores.
Psychologists from the Konstanz Cluster of Excellence use portable EEGs to examine synchronization of brain activity in groups of viewers who watch real video health messages against risky alcohol consumption. The study demonstrates that strong messages lead to increased synchronization of brain waves, a key finding with implications f...
Researchers at Heidelberg University have successfully depicted a faultily 'blocked' spliceosome and reconstructed its recognition and elimination process. This breakthrough provides new insights into the quality control mechanism of the complex molecular machine, shedding light on how cells ensure accurate mRNA production.
A Baylor University study investigates how social media impacts loneliness over time, finding that both active and passive use contribute to increased feelings of loneliness. The research suggests that the quality of digital interactions may not fulfill social needs met in face-to-face communication.
A new study compares the allosteric regulation of Escherichia coli and Mycobacterium tuberculosis cAMP receptor proteins, revealing distinct regulatory mechanisms despite structural resemblance. The findings suggest species-specific control over bacterial gene regulation and have potential implications for drug development.
A new computational model from UC San Diego reveals that drivers charge their vehicles more frequently than assumed, with a tendency to top off at 60% battery. This leads to the estimate that using individual drivers' behavior could triple the size of workplace charging networks, impacting cost and design.
A new approach to constructing physical colors on lithium niobate crystals is presented, utilizing gold ion implantation combined with laser direct writing. The technique enables stable, non-fading coloration on the surface of the crystal, with controlled nanoparticle sizes.
A large-scale study has identified genetic overlaps in 72 long-term health conditions associated with ageing, revealing opportunities for new prevention and treatment strategies. The research also found that specific genes are linked to co-occurring conditions, leading to a more personalized approach to care.
Research finds ELK3 inhibits ferroptosis and proliferation of rheumatoid arthritis fibroblast-like synoviocytes, affecting their biological activity. ELK3's molecular mechanism involves regulating kelch-like ECH-associated protein 1.
Researchers developed a bionic skin that mimics human fingertips to detect static and dynamic pressure, accurately characterizing object shape, hardness, and complex texture. The technology enables tactile-based visualization and reconstruction perception for smart wearable devices, robotic sensing, and virtual reality.
Advances in point-of-care testing and diagnostics are transforming healthcare with faster, more accurate, and accessible solutions. These technologies empower doctors to make timely decisions and improve patient outcomes.
Researchers found that glioblastoma stem cells are co-localized with myeloid-derived suppressor cells, promoting tumor growth and aggressiveness. The study identified key molecules, such as IL-6 and IL-8, that attract and activate MDSCs, providing new potential therapeutic targets.
The American Heart Association reports that Black communities face disproportionately higher risk of heart disease, stroke, and hypertension, leading to poorer survival outcomes. Hands-Only CPR training and heart health education are critical to addressing these disparities and advancing equitable health solutions.
The PREPSOIL project aims to enhance soil literacy among European teachers, promoting innovative examples of soil education. The initiative received over 50 submissions showcasing creative approaches that combined science, humanities, and hands-on activities.
Researchers developed a surface-enhanced Raman scattering optofluidic molecular fingerprint spectroscopy detection system based on a single-beam optical trap. The system aggregates metal nanoparticles to enhance Raman signals, achieving controllable amplification of molecular fingerprints for highly sensitive detection.
A study found that two liver graft preservation methods differ in their effect on gut microbiota composition and function following liver transplantation. The NMP cohort showed enrichment of beneficial gut taxa, while the static cold storage cohort depleted such taxa. Notable differences were observed between the two preservation methods.
Researchers have identified a conserved mechanism to protect plant vacuoles from rupturing due to cell wall damage. The study found that the molecule ATG8 is relocated to the vacuole membrane upon disruption of the cell wall, helping to maintain pressure balance.
A CABI-led study uses publicly-shared DNA barcodes and citizen science images to detect the establishment of a biological control agent used to tackle Lantana camara. The research found two genetically distinguishable populations of Orphanostigma haemorrhoidalis, one in south-eastern USA and the other widespread in Neotropics.
The Terasaki Institute for Biomedical Innovation has announced the recipients of its inaugural Keith Terasaki Mid-Career Innovation Award. Dr. Liangfang Zhang and Dr. Aydogan Ozcan were recognized for their innovative approaches to translating groundbreaking research into real-world impact.
Researchers used cryo-electron microscopy to determine the atomic structure of collagen assemblies with an unexpected right-handed superhelical twist. This discovery could reshape biomedical research by revealing greater structural diversity in collagen.
The US Department of Energy's Office of Science is now accepting applications for the SCGSR program, providing funding for graduate students to conduct research at national laboratories. The goal of the program is to prepare students for scientific and technical careers critically important to the mission of DOE's Office of Science.
A team of researchers from Lund University analyzed the soft tissue from a 183-million-year-old Jurassic plesiosaur, discovering a mix of smooth and scaly skin. The findings suggest that the long-necked marine reptile used its smooth skin to swim efficiently and its scales for navigating rough seabeds.
Researchers discovered that a network of subcellular structures similar to those responsible for muscle contraction are also present in brain cells. These structures, called contact sites, play a crucial role in transmitting calcium signals that regulate neuronal signaling. The study provides new insights into the molecular mechanisms ...
A new study reveals that microglia can be reprogrammed from a tumor-promoting state to one that strengthens antitumor responses, reducing brain metastases growth and enhancing immunotherapy responses. Researchers identified a key signaling pathway that, when blocked, reverses the protumoral function of microglia.
A new study from Karolinska Institutet found that women with complicated pregnancies and their sisters are at higher risk of cardiovascular disease. Genes and shared environmental factors may contribute to this association.
A recent study by UCLA researchers has discovered high amounts of bis(2,2,6,6-tetramethyl-4-piperidyl) sebacate (BTMPS) in illicitly sold fentanyl. BTMPS is not approved for human consumption and has been linked to serious health effects such as cardiotoxicity and ocular damage.
UD researchers found significant differences in gene expression in adipose tissue, a vital endocrine organ linked to cardiovascular and metabolic diseases. The study identified four genes related to metabolism, calcium handling, and inflammation that warrant further investigation.
This study explores fungal biomass's role in stabilizing carbon in soils, showing a strong correlation between microbial biomass and reactive mineral-associated carbon. Fungal necromass interacts with nanoparticles to further stabilize the carbon after death, proposing a new conceptual model for hypha-mineral interactions.
Mangrove ecosystems in Andaman and Nicobar islands faced significant changes after the 2004 tsunami, with 97% of mangroves lost due to land subsidence and uplift. Local ecological conditions are often overlooked in governance frameworks, leading to failed restoration efforts.
Researchers discover broad active metabolic pathways, autophagy, and antagonistic hormones regulating dinoflagellate cyst dormancy in marine sediments. The study sheds light on the molecular machinery required for maintaining dormancy and viability.
A pilot study will explore whether a ketogenic diet helps stabilize mood symptoms in teens and young adults with bipolar disorder. Preliminary research suggests improvements in mood and executive function among older adults.
Mindy Hildebrand's $20 million gift will support a matching campaign to raise scholarship funds for incoming full-time MBA students, while enhancing leadership development opportunities across all five Texas McCombs MBA programs. The fund will also create personalized, targeted leadership experiences for students.
The study compared the performance of seven AI models with that of 400 humans in comprehension tasks, revealing a significant difference in accuracy. Human accuracy reached 89%, while AI models struggled to achieve more than 70% correct answers.
Naomi Halas' work has pioneered new insights into how light and matter interact at the smallest scales, leading to discoveries in biomedical applications such as cancer therapy and water purification. Her research on plasmonic catalysts could dramatically reduce energy required for chemical reactions.
UCalgary researchers confirm that endovascular thrombectomy (EVT) is not effective for patients with blockages in medium-sized blood vessels. The ESCAPE-MeVO clinical trial found no improvement in outcomes for these patients compared to standard care. EVT was previously shown to improve patient outcomes after large-vessel strokes.
Researchers at Chalmers University of Technology have developed a novel approach to packaging canned tuna, using a water-based solution of amino acid cysteine, which removes up to 35% of accumulated mercury. This technology has the potential to improve food safety and reduce human exposure to mercury via food.