Researchers at The Hebrew University of Jerusalem have found that mesenchymal stem cell secretions can help protect mammary cells from stress while increasing milk fat production. This breakthrough could lead to healthier cows and richer, creamier milk without the need for additives or heavy processing.
A study presented at the Endocrine Society's annual meeting found that socially isolated older adults are 34% more likely to have diabetes and 75% more likely to have poor blood sugar control. Social isolation is being recognized as a critical social determinant of health, highlighting its importance in caring for older patients.
A rare ichthyosaur fossil from the Late Triassic period was discovered in western Japan, providing significant insights into ichthyosaur evolution. The fossil's unique characteristics suggest a high swimming ability, offering valuable clues for understanding this marine-adapted reptile.
Scientists at University of South Australia developed a long-acting injectable formulation that delivers levodopa and carbidopa over a week, reducing the need for multiple daily tablets. The biodegradable formulation improves treatment outcomes and patient compliance, offering a potential game-changer for Parkinson's care.
A study found that consuming aspartame, sucralose, glycyrrhizin and added sugars may increase the risk of early puberty in children, especially those with genetic traits. This association was strongest for central precocious puberty, a condition linked to emotional distress and metabolic disorders.
A randomized, placebo-controlled study shows that acupuncture can safely reduce methadone requirements and counteract opioid-induced immune and gut disturbances. Acupuncture was found to lower methadone doses by 20% in 84% of patients, while boosting antiviral gene activity and restoring bile acid balance.
Cancer deaths linked to obesity have increased sharply in the US, especially among women and older adults, with sharp regional disparities. The study highlights the need for targeted public health strategies to address this growing public health crisis.
The LIGO-Virgo-KAGRA Collaboration has detected the merger of two massive black holes, producing a final black hole approximately 225 times the mass of our Sun. The signal presents a challenge to current astrophysical models and requires advanced theoretical tools to interpret.
This study reveals the critical roles of Rho GTPases Cdc42 and RacA in Aspergillus flavus growth, development, and metabolism. The proteins regulate aflatoxin synthesis, pathogenicity, and oxidative balance by controlling morphogenesis, energy metabolism, and fatty acid β-oxidation.
A new study presents preliminary data suggesting that grandparents' exposure to endocrine-disrupting chemicals may impact the age when girls get their first period. The research found that certain chemicals in both mothers and fathers were linked to earlier puberty, with stronger effects seen in granddaughters.
Researchers found that floor video projection with simple and interactive pacer methods improved running patterns and performance in students with neurodevelopmental disorders. The study suggests personalized support based on individual cognitive traits is crucial for enjoyable and safe physical activities.
Researchers developed a highly efficient and stable chainmail catalyst for acidic hydrogen evolution, utilizing cobalt-nickel nano-alloy encapsulated in graphene. The confinement of asymmetric π electronic states on the graphene surface enhances catalytic activity and durability.
Researchers at Kyoto University have characterized quantum advantage by proving an equivalence between its existence and the security of certain cryptographic primitives. This breakthrough implies that when quantum advantage does not exist, many conventional cryptographic primitives are broken, including post-quantum ones.
The study introduces aspartame as an electrolyte additive to improve zinc anode performance, resulting in enhanced corrosion resistance and cycling stability. The self-healing ZnO-based SEI film enables long-cycling and wide-temperature operation of aqueous zinc-ion batteries.
A novel AI-powered application has been developed to diagnose endocrine cancers with speed and accuracy, leveraging advanced deep learning architectures. The tool analyzes diverse medical data, including imaging scans and histopathology images, and demonstrated exceptional diagnostic accuracy in certain validation datasets.
A study of over 7,600 Brazilian women found that early menarche increases risk for metabolic and heart problems, while late menarche may protect against obesity but increase certain heart issues. Understanding age at first period can help doctors identify high-risk patients and guide personalized screening and prevention efforts.
A recent study found that oxytocin levels rise in response to stress-related sleep disruption, helping women experience less mood disturbance the next day. The study suggests oxytocin as a potential biological buffer during periods of hormonal and emotional vulnerability.
A recent study published by The Endocrine Society found that osteoporosis treatment after a fracture can decrease both hospitalization and mortality in people older than 80. Researchers analyzed data from 88,676 patients aged 80 and older who suffered a fracture due to bone deterioration or weakness caused by osteoporosis.
A real-world study of 120 postmenopausal women found that using tirzepatide and menopause hormone therapy simultaneously led to superior total body weight loss percentage compared to using tirzepatide alone. This combined treatment also resulted in a higher percentage of participants achieving at least 20% weight loss.
Research suggests that thyroid hormone treatment can improve gut health in individuals with hypothyroidism, particularly those with autoimmune thyroiditis. The study found a higher prevalence of SIBO in people with hypothyroidism compared to controls, which was mitigated by thyroid medication.
A study by The Endocrine Society reveals that children with growth hormone deficiency experience improved overall health and coping mechanisms when their caregivers report reduced stress, anxiety, and depression. Conversely, caregivers' emotional stability is associated with better outcomes for the child.
Researchers found that tirzepatide reduced body weight and body fat by approximately 20% in mice, resulting in a significant reduction of tumor volume. The study suggests that this new anti-obesity drug may have a beneficial impact on breast cancer outcomes.
A small study found that consuming more protein may help prevent muscle loss in adults with obesity taking semaglutide, an anti-obesity medication. The researchers noted that older adults and women may be at higher risk for muscle loss, emphasizing the importance of preserving muscle during weight loss with this medication.
A long-term study of healthy men found that minimally elevated blood sugar levels can lead to declines in sperm movement and erectile function. The study suggests that lifestyle choices and medical interventions can help preserve or revive reproductive health in aging men.
WavyOcean 2.0 is an immersive digital twin platform integrating digital technologies with innovative Earth system research. The platform provides precise data support for policymakers to balance marine conservation with socio-economic development.
Researchers developed a simple model that reproduces deep neural network features, allowing for optimized parameter tuning. The 'folding ruler' model demonstrates how nonlinearity and noise improve network performance, enabling more efficient training without trial-and-error.
A new study reveals that pollutants can trigger nonlinear, unpredictable impacts on biodiversity across land, freshwater, and marine ecosystems. The proposed framework integrates real-time monitoring with predictive modeling to detect early warning signs of ecological tipping points.
New research suggests that driving assistance systems can backfire by making drivers less attentive and increasing hazardous behaviors. The study analyzed data from over 195,000 vehicles and found that different types of warning signals trigger opposite effects on driving behavior.
Researchers found that T-bet expression is crucial for preserving the protective memory response in lung and lymph node memory B cells. Continuous T-bet expression in these cells enables their rapid differentiation into antibody-producing plasma cells upon a second flu virus infection.
The authors successfully endow a double B←N bridged bipyridine-based polymer with mixed conduction by incorporating oligoethylene glycol side chains, resulting in higher conductivity and capacitance. This breakthrough enhances the potential of n-type BNBP-based OMIEC materials for organic electronic devices.
Researchers at the University of Illinois have made a significant breakthrough in laser technology, creating a photopumped lasing from a buried dielectric photonic-crystal surface-emitting laser. This achievement improves upon current laser design and opens new avenues for defense applications.
A new study reveals Shen-Bai-Jie-Du decoction inhibits colorectal tumorigenesis by regulating the TMEM131–TNF signaling pathway-mediated differentiation of immunosuppressive dendritic cells. The findings suggest that SBJDD may help restore tumor microenvironment homeostasis and offer a novel cancer therapy.
A global systematic review found that maternal depression is consistently associated with negative parenting practices across multiple domains. The study highlights the importance of developing effective psychological methods and interventions to improve parent-child relationships and reduce negative behaviors.
This study found that sleep fragmentation-induced testicular damage in T2DM is mediated by melatonin receptor 1a, which activates FGFR1 to suppress TAB1/TAK1 complex. Melatonin and its agonist improved lipid homeostasis, highlighting a promising therapeutic approach for male infertility in T2DM.
A new study led by Mount Sinai researchers discovered that the brain's response to regret is sex-dependent, with female brains more sensitive to sunk costs and regret. The study sheds light on how biological mechanisms underlying depression vulnerabilities differ between sexes.
This issue of Acta Pharmaceutica Sinica B features research on intestinal aging, single-cell RNA sequencing, and cancer treatment. Articles explore therapeutic strategies for reducing frailty, inhibiting colorectal tumorigenesis, and developing preclinical candidates for acute liver injury.
Researchers mapped 176 real-world NFT security incidents and identified critical vulnerabilities across platforms and protocols. A multilayered NFT security reference framework pinpoints common vulnerabilities, assesses detection challenges, and proposes a clear path forward for safeguarding the Web3 ecosystem.
Pusan National University researchers developed a comprehensive issue set for MDA implementation, covering technical, organizational, and environmental challenges. The framework helps manufacturers prioritize issues and address them proactively, enabling efficient and effective data-driven smart manufacturing.
A newly discovered interstellar object named 3I/ATLAS is likely to be the oldest comet ever seen, possibly predating our solar system by more than three billion years. The 'water ice-rich' visitor is travelling on a steep path through the galaxy and may be over seven billion years old.
A new approach for understanding chromatin's 3D structure and its influence on gene regulation has been developed by scientists at Sanford Burnham Prebys. The method measures a genomic region's proximity to the isolated center of a chromatin clump, revealing that surface regions are more active than core regions.
Researchers have developed a novel technique called Comparative Physicochemical Profiling to identify characteristic patterns in substrate proteins recognized by the gamma-secretase enzyme. This approach has been combined with explainable artificial intelligence to render visible the features that are characteristic for substrates of g...
A new study from Karolinska Institutet has found that women with premenstrual symptoms are at a higher risk of developing cardiovascular disease. The study, which followed over 99,000 women for up to 22 years, revealed a significant link between premenstrual symptoms and an increased risk of heart rhythm disorders and stroke.
Researchers have developed a novel electrified catalysis strategy that removes more CO2 and CH4 from the atmosphere than it emits, resulting in net-negative greenhouse gas emissions. The process converts these compounds into syngas with an impressive energy utilization rate of 80%.
Researchers developed a novel technique to create transient nanopores in cell membranes mechanically, achieving high-efficiency intracellular delivery with minimal cell damage. The method uses stainless steel filters and viscoelastic fluids, offering a promising alternative to conventional transfection methods.
Heart attacks often don't follow a Hollywood script, says UTA expert Ann Eckhardt. Symptoms can be complex and mild, with discomfort or pressure rather than pain. This misperception leads to delayed medical attention, increasing the risk of negative consequences.
Researchers at Mass General Brigham found that targeted radiation was successful in treating patients with brain metastases, resulting in a lower neurological death rate and reduced need for subsequent whole brain radiation. This study supports personalized treatment approaches to maintain quality of life while managing brain metastases.
This study proposes a comprehensive framework for typhoon disaster knowledge services, utilizing large language models to construct structured knowledge graphs and develop intelligent question-answering systems. The proposed system achieves high accuracy in concept, entity, attribute, and relation extraction, providing seamless convers...
A longitudinal cohort study found that recreational cannabis legalization was associated with increased cannabis and electronic nicotine delivery systems use, but not a significant increase in cigarette use. The study suggests that commercialization policy should be closely monitored as retail cannabis expands.
A study by autistic researchers reveals the challenges of navigating nonverbal cues, including body language, facial expressions, and tone of voice. Autistic adults often struggle to process these signals in real-time, leading to misunderstandings and social anxiety.
Researchers developed a novel DPG suspension with enhanced thermal stability and plugging efficiency, outperforming traditional CO2-responsive gels. The modified particles demonstrated significant irreversible swelling and improved thermal stability, achieving high plugging efficiencies even at 100°C.
Researchers demonstrated R-STDP synaptic plasticity in a single ferroelectric floating-gate device, enabling SNN to simulate robotic capture tasks with excellent performance. The network achieved a success rate up to 85.5% in dynamic capturing tasks.
Researchers employed SU(3) flavor symmetry theory and final-state re-scattering to predict larger CP violation effects in charmed baryon decays. The study suggests a matter-antimatter asymmetry of one-thousandth, exceeding prior estimates.
Recent studies reveal disparities in access to hepatitis C treatment for children and recently pregnant women, with significant racial and geographic disparities. The studies highlight the need for targeted resources to reach these vulnerable populations.
A team of researchers are studying the reproductive traits of Japanese tree frogs living in Fukushima Prefecture, Japan, to understand how radiation affects their survival. Their findings suggest that radiation can disrupt genetic pathways associated with sperm motility, potentially altering reproductive success.
Chronic health issues may emerge from long-term obesity in young adults, leading to epigenetic alterations, telomere attrition, and impaired nutrient sensing. The study found a significant association between long-term obesity and accelerated biological aging, highlighting the importance of addressing obesity early on.
Dr. Erin M. Schuman's groundbreaking research reveals that proteins critical for neuron communication are produced locally at synapses, overturning previous beliefs about protein synthesis. Her discovery is influencing the field of neuroscience, focusing on individual synapses rather than whole neurons.
A novel dual-enzyme-driven cascade reaction system significantly enhances catalytic therapy in tumors. Researchers developed this approach to refine single-atom catalytic kinetics, leading to improved cancer treatment outcomes.
A Johns Hopkins study identifies over 200 types of misfolded proteins associated with age-related cognitive decline in rats. The findings suggest that these proteins may contribute to Alzheimer's and dementia beyond just the previously known A-beta and tau amyloids.
Researchers solved a long-standing climate mystery by combining geological evidence with climate model simulations. They found that speleothem δ18O records reflect precipitation signals from multiple seasons, not just summer monsoon season.
Researchers at Duke University Medical Center discovered stress-induced regenerative capabilities in human ankle cartilage, which shares similarities with salamander's ability to regenerate severed limbs. This finding provides a new potential framework for joint repair and may lead to optimizing innate restorative function.