The researchers developed a new imaging technology that enables the creation of high-resolution 3D images of an entire mouse body, including its peripheral nervous system. The technology allows for the mapping of nerve routes at the subcellular level, providing insights into neural regulation and disease mechanisms.
This review explores the roles of orphan nuclear receptors (ONRs) in metabolic dysfunction-associated steatotic liver disease (MASLD) pathogenesis. ONRs modulate key pathways involved in lipid metabolism, inflammation, and fibrosis, offering novel therapeutic avenues.
A new Ontario study reveals socioeconomic disparities in concussion-related emergency department visits among children and youth. The study found that children from higher socioeconomic status groups had significantly more concussions requiring ED visits compared to those from lower socioeconomic status groups.
A potent and selective RIPK2 inhibitor has been identified through the CMD-OPT model as a potential therapeutic agent for acute liver injury. The compound, RP20, demonstrates excellent kinase specificity and superior therapeutic effects in an APAP-induced ALI model.
A new study published in PLOS One suggests that a parasitic worm can serve as a valuable biomarker for managing blue crab populations in the Chesapeake Bay. The worms, which infest and live on the egg clutches of female blue crabs, have been found to have a wide salinity tolerance and can survive at lower salinities than previously tho...
A new study reveals that global ocean analysis products can achieve centimeter-level accuracy in seafloor positioning, comparable to traditional methods. This innovation could significantly reduce costs and logistical challenges in marine geodetic surveys.
A cross-sectional study found that stronger gun laws were associated with lower overall firearm mortality, particularly for suicide. Policies addressing root causes of violence through economic mobility and social services may also reduce homicides.
Researchers have engineered a monoclonal antibody that blocks allergic reactions against common pollen when applied inside the nose of mice, providing new hope for hay fever sufferers. The treatment, known as a 'molecular shield,' acts immediately and locally at the lining of the nose to prevent IgE antibodies from being activated.
Researchers have developed laser-treated hydrogels with enhanced conductivity, improving interfacial adhesion and nerve-conduction block capabilities. The material exhibits a maximum conductivity of 955 S/cm, meeting essential requirements for next-generation bioelectronic platforms.
A Rutgers-led study reveals that the brain protein cypin helps maintain strong connections between brain cells essential for learning and memory. The discovery has profound implications for treating traumatic brain injuries and diseases like Parkinson's and Alzheimer's.
The EU-wide requirement emphasizes five key steps for successful nature restoration: clear communication, agreed targets, coordinated measures, supportive frameworks, and attractive incentives. Effective implementation is crucial to achieving long-term biodiversity goals and mitigating climate change.
A novel metal-assisted van der Waals epitaxy technique successfully fabricates wafer-scale monolayer MoS2 films and achieves precise substitutional doping with transition metals. The research team demonstrates exceptional electrical properties, including high electron mobility and ultra-low power consumption.
Researchers found that small group professional coaching reduced physician burnout rates by nearly 30%, with participants experiencing significant improvements in work-life balance, self-efficacy, and social support. In contrast, one-on-one coaching resulted in a 13.5% reduction in burnout rates.
Researchers found that adults with autism perceive visual body information similarly to neurotypical adults, challenging long-standing assumptions about social difficulties in ASD. The study used fMRI to compare brain activity patterns in adults with autism and typically developing adults while viewing images of body parts.
Researchers at Scripps Research Institute have developed a new microchip that can reveal how antibodies interact with viruses, allowing for faster and clearer insights into vaccine development. The technology offers a quicker-than-ever method to analyze antibody interactions, enabling scientists to design more effective vaccines.
Polyphenols are multifunctional agents with anti-inflammatory, antioxidant, microbiota-modulating, and neuroprotective properties. The Polyphenols Applications 2025 congress explores novel applications of polyphenols in various fields.
Researchers identify Egr-1 as a key regulator of Treg cell development and function, suggesting it as a promising therapeutic target for autoimmune diseases. The study's findings indicate that activating the Egr-1 gene can help alleviate autoimmune inflammation via Foxp3 expression.
Researchers at Seoul National University have developed a fully biodegradable, high-performance conductive fiber that can be seamlessly integrated into wearable electronics. The fiber system maintains performance during use but vanishes in enzyme-rich or soil environments, leaving no harmful residues behind.
Researchers developed a novel fluorescent probe to visualize AMPA receptors on living brain cells, revealing that new receptors are inserted from inside the cell during long-term potentiation. This breakthrough allows for rapid study of synapse strength and plasticity, shedding light on memory formation and learning.
A new tool helps understand original landscape functioning and supports current land use strategies by generating realistic drone footage of past landscapes. The study uses AI to create photorealistic depictions of the Great Hungarian Plain before water regulations.
Researchers developed a co-crosslinked hydrogel combining the rapid filling properties of hyaluronic acid (HA) with the collagen-stimulating abilities of silk fibroin. The HA-SF hydrogel promotes tissue adhesion, stimulates collagen regeneration, and achieves combined volume restoration and anti-aging via fibroblast activation.
Researchers developed a ternary composite electrolyte additive system PAFE to address lithium metal battery stability issues. The system enables stable cycling at 4.7V, reducing activation energy and suppressing dendrite growth.
Heterometallic nanosheets with defined structures can be synthesized in a single-phase reaction, enabling their use as coatings, electronic devices, and catalysts. The discovery paves the way for mass-producing these nanomaterials using printing technology.
Researchers from Université Laval designed an ultra-fast and greener optical chip that can transfer massive amounts of data at speeds of 1,000 gigabits per second while reducing energy consumption. This innovation uses the phase of light to add a new dimension to the signal, reaching unprecedented performance levels.
Researchers developed an AI system that enables a four-legged robot to adapt its gait to different terrain, just like animals. The robot learned to switch gaits on the fly and navigate uneven surfaces without any alterations to the system itself, overcoming previous limitations around adaptability.
A recent Northwestern University study analyzed brain tissue from 174 donated brains, including some from former amateur football players. The researchers found no elevated levels of phosphorylated tau (p-tau) protein in the CA2 region of the hippocampus, which is often associated with CTE and normal aging.
A new Europe-focused study finds that polyethylene (PE) packaging has lower life cycle global warming potential (GWP) than paper, metals, and glass in most applications. The research highlights the benefits of PE-based packaging in reducing greenhouse gas emissions and packaging weight.
The study highlights CCUS-EOR as a critical pathway for global carbon emission reduction, with cumulative CO2 sequestration of over 400 million tons. The proposed two-stage process optimizes dual objectives of enhanced oil production and carbon reduction.
The European Centre for Disease Prevention and Control warns of an increased risk of Vibrio infections throughout the summer season due to rising sea surface temperatures. Several northern countries bordering the Baltic Sea have reported increases in recent years, with serious infections possible through foodborne or skin contact.
Researchers unveiled a graphene-based chip that films reactions with nanosecond resolution, capturing elusive intermediates in the Morita-Baylis-Hillman reaction. The electric field applied accelerated the reaction, achieving a turnover frequency of 5,000 reactions per second.
Researchers discovered how the genome uses competition between proteins to prevent rogue retrotransposon LINE1 from causing damage. The team found that a modified protein NRBP2 marks and disposes of another protein NRBP1, which is no longer functional due to mutations.
Researchers at Hokkaido University developed a new recipe for muscle-like gel polymers, which exhibit rapid self-strengthening due to mechanophores with weak bonds. The innovative design enables the creation of thermostable materials with improved stability and potential applications in biological fields.
Researchers developed a non-invasive questionnaire to identify children at risk of maltreatment, highlighting seven behavioral problem areas linked to maltreatment. The study found critical timing patterns and type of abuse matters, offering a more comprehensive approach to support maltreated children.
The new agreement provides unlimited opportunities for open access publishing in JMIR's journals, eliminating article processing charges and streamlining the publication process. This partnership underscores TU/e's commitment to advancing open science and increasing research impact.
Researchers have found extensive, previously unmapped flat surfaces beneath a 3,500 km stretch of the East Antarctic coastline, which were formed by large rivers after East Antarctica and Australia broke apart. These surfaces may currently be regulating the rate of ice loss from the East Antarctic Ice Sheet.
A new study reveals how variations in the stratospheric polar vortex affect where and when extreme cold hits, with a focus on the northwestern US. The research finds two distinct patterns that steer Arctic air into different areas, leading to colder winters in regions like Montana and Texas.
Researchers design polymer blends to accelerate battery development and identify key temperature thresholds for stability. The study validates a model predicting behavior at different temperatures, enabling more efficient materials design.
Researchers found that cultural heritage forms the foundation of community identity, nurturing a sense of place and continuity. Trust, emotional attachment, and social ties are also crucial for building resilient communities that can unite in times of crisis.
Researchers have identified RG7388 as exhibiting promising antiviral activity against Severe Fever with Thrombocytopenia Syndrome Virus (SFTSV), a tick-borne pathogen with a high mortality rate. The study found that RG7388 can inhibit virus replication by enhancing cells' sensitivity to apoptotic stimulation signals.
A recent study by Tarang Parekh reveals that 80% of US adults show signs of CKM syndrome, which increases the risk for cardiovascular disease. The condition progresses in stages, with stage 4 being the most dire, characterized by clinical CVD diagnoses such as heart failure and kidney failure.
A new analytical method reveals overlooked species at risk of extinction, providing a valuable layer of insight for conservationists. The dual-role approach captures both predator and prey interactions, identifying keystone species and vulnerabilities.
A sweeping national study by ICAMH at Hebrew University found substantial increases in substance use, behavioral addictions, and mental health disorders in Israel since the October 7, 2023 attacks. Younger, secular populations were most at risk, with sociodemographic disparities evident across repeated samples.
UVA engineer Nick Vecchiarello is using a $600,000 grant to develop customized molecularly engineered surfaces for purifying protein-based drugs. The technology has the potential to reduce waste and failed batches, saving manufacturers millions of dollars while making treatments more affordable.
Researchers at KIT have developed a new AI method that generates high-resolution precipitation maps from low-resolution data, offering improved assessments of regional climate risks and disaster control. The model provides physically plausible precipitation maps with statistical uncertainty, applicable to diverse climatic conditions.
A new breast scan system combines photoacoustic and ultrasound imaging to produce clear 3D images of common breast cancer subtypes. The system, called OneTouch-PAT, takes less than a minute to complete and excels at detecting suspicious lesions in women with dense breast tissue.
A novel formulation and delivery approach for the NeoVax personalized cancer vaccine improved immune responses in patients with melanoma. The updated vaccine demonstrated strong vaccine-specific immune responses and cytotoxic responses by special T cells called CD-8+ T cells.
Japan is set to host a global summit on microbiome medicine and fermentation science, featuring pioneering research and collaboration among industry leaders. The event aims to promote personalized nutrition, microbial diagnostics, and next-generation therapeutics.
Researchers at Tohoku University developed a new framework for simulating nonlinear quantum dynamics, making it easier to understand and study complex quantum systems. The method uses time-evolution data to extract nonlinear response functions without requiring explicit multipoint correlations.
Scientists studying ant plants in Fiji have discovered a way for the plant to keep the peace among conflicting ants by providing separate chambers. The new research reveals that compartmentalization is an effective evolutionary strategy to mitigate conflicts, allowing the host plant to benefit from multiple symbiotic relationships.
Researchers have discovered an anomalous low-field quantum oscillation at ultraclean LaAlO₃/SrTiO₃ (LAO/STO) oxide interfaces, revealing evidence of time-reversal symmetry-protected transport. The findings provide a new platform for designing and engineering novel quantum states.
A University of Portsmouth student has discovered a new species of prehistoric mammal, Novaculadon mirabilis, dating back 145 million years. The fossilized jaw features distinctive teeth and provides insights into early mammals that lived alongside dinosaurs.
Researchers developed a wireless implantable drug delivery system that enables anticancer drugs to penetrate deep into solid tumors without harming surrounding healthy tissue. The Dual-Phoretic Wireless Drug Delivery System achieved over four times greater drug delivery efficiency than standard injection methods and reduced tumor volum...
The discovery sheds light on the complex connections between ancient Maya and central Mexican civilizations. Archaeologists found artifacts indicating early contact between the two regions around AD 350.
A research team led by Associate Professor Michinao Hashimoto from SUTD developed a novel 3D printing method that turns biodegradable materials into electrically conductive structures. The breakthrough enables the formation of sharp, well-defined 3D structures with high filler content, suitable for applications such as flexible circuit...
An international team has uncovered a new mechanism by which mitochondria and peroxisomes work together to defend against oxidative stress, maintaining cellular health. This discovery challenges the long-standing idea that cellular defense is confined within individual compartments.
Yen-Ling Kuo, a UVA computer scientist, has been awarded the NSF CAREER Award to help robots understand and respond to human behavior. Her research focuses on building AI systems that can reason, communicate, and collaborate like humans, enabling robots to support people in various settings.
A research team from the University of Münster has developed a new way to produce spin waveguides, allowing for large networks capable of processing information efficiently. The team created the largest spin waveguide network to date, with precise control over properties such as wavelength and reflection.
John Ohab joins ITV's Executive Board bringing scientific expertise and strategic insight from his roles at the National Human Genome Research Institute and U.S. Naval Research Laboratory. His appointment strengthens the region's innovation voice and amplifies connections to the national research ecosystem.
Higher anticholinergic exposure accelerates decline in gait speed and grip strength in older adults, affecting healthy aging. The study suggests minimizing anticholinergic medications is crucial for maintaining physical function.
Researchers from KIMS have developed a biosensor capable of detecting trace amounts of cancer cell DNA in the bloodstream with high sensitivity. The biosensor uses light signals and AI-based analysis to diagnose cancer early without complex testing procedures.