Researchers analyzed single-cell transcriptome data to reconstruct communication networks among human preimplantation lineages. They found that signaling crosstalk between tri-lineages is crucial for lineage specification and cell fate regulation during human embryonic development.
New research suggests that the devastating 2021 floods in Germany could have been even more damaging with small shifts in atmospheric conditions. The study found that rainfall characteristics could have lasted longer and spread across larger areas, causing worse flooding downstream.
A recent multinational study found that people diagnosed with dementia are living longer due to advancements in diagnosis and care. The study of over 1.2 million individuals across eight regions revealed a lower risk of death in five regions, primarily attributed to improved prevention and treatment methods.
Researchers investigate whether language alone is sufficient to understand color metaphors and find that hands-on experiences using color unlock deeper conceptual representations in language. ChatGPT generates consistent color associations but struggles with novel metaphors and embodied explanations.
Researchers found that human stem cells can differentiate into bone cells simply by being squeezed through narrow spaces. This discovery could lead to the development of simpler and safer regenerative therapies by using physical signals instead of chemical cues. The study's findings have broader implications, including potential applic...
Researchers at University of California, Riverside, found that symmetrical silicon molecules can be fine-tuned for quantum electron behavior, turning conductivity on or off like a molecular-scale switch. This discovery could lead to ultra-small switches and thermoelectric devices, revolutionizing electronics.
Researchers developed an AI-powered diagnostic approach using quantitative biomarkers and biometrics to rapidly assess neurodivergent disorders. The method has the potential to diagnose autism or ADHD in as little as 15 minutes, providing healthcare providers with additional tools to tailor treatments.
A new study published in Nature Climate Change found that most people are more likely to support climate policies if they see a connection between extreme weather and climate change. Strong support was observed in African and Asian countries, as well as among individuals who attribute extreme weather events to climate change.
A combination of data from the FDA and independent studies confirms 7-OH's strong real-world safety profile, with no confirmed deaths reported despite over half a billion estimated doses consumed nationwide. The analysis also found that 7-OH has a significantly lower risk profile than many other natural compounds currently on the market.
Physicists from Aalto University have measured a transmon qubit coherence time of over a millisecond, surpassing previous records and enabling more complex quantum computations. This breakthrough marks a significant step towards noiseless quantum computing.
A new study by Children's Hospital of Philadelphia researchers found that US children's health is declining across multiple measurements. Chronic illnesses, physical and mental health conditions, and increased mortality rates were observed compared to other high-income nations.
Seeds can achieve speeds up to 29 miles per hour and reach shooting distances of up to 12 meters, propelled by high-pressure explosions. The fruit stem straightens up during ripening, creating an optimal angle for maximum distance.
Researchers developed a new method for selective conversion of epoxides using glutathione S-transferase enzymes, producing pure substances with desired properties. The process is inspired by nature's detoxification mechanism and demonstrates the potential to translate natural reactions into useful syntheses.
Researchers investigated spatial and seasonal variations of polychlorinated biphenyls (PCBs) in the Seto Inland Sea. The study found that dissolved and particulate PCB concentrations peaked in different seasons due to varying environmental conditions.
Dr. Xuyu Qian's pioneering research using MERFISH technology created an unprecedented developmental atlas of the human cerebral cortex, analyzing over 18 million single cells. His work aims to identify mechanisms disrupted in conditions like malformations and autism spectrum disorder.
Dr. Mirko Manchia's groundbreaking research identifies genetic markers predicting treatment response in bipolar patients, enabling precision medicine approaches to transform psychiatric care. He envisions a future where genetic testing becomes routine in psychiatric care.
Researchers developed Group Encoding (GE) to forecast electricity demand using On/Off device status, improving prediction accuracy and efficiency in smart energy operation. The method simplifies complex datasets while retaining key information for optimal energy management.
A UK-led mission plans to recreate artificial solar eclipses in space to study the Sun's atmosphere and shed light on space weather. The MESOM mission would use a mini-satellite and the Moon's shadow to capture unprecedented views of the Sun's corona.
A new study published in JCPP Advances found that watching a ten-minute video can shift how teenagers view themselves by promoting mental well-being. The intervention appeared to have little immediate effect on symptoms of anxiety or depression, but may work best as part of a broader toolkit of services.
A recent survey found that 39% of respondents incorrectly identified all processed foods as unhealthy. However, the Physicians Committee for Responsible Medicine reports that it is not processed plant foods but rather meat consumption associated with an increased risk of type 2 diabetes and cardiovascular disease.
A recent study found that forest fragmentation weakens ecosystem resilience in tropical and temperate forests, while enhancing it in boreal forests. The research used satellite data to quantify the effects of edge density on forest resilience worldwide.
GeniPhys has received FDA clearance for its self-assembling collagen scaffold, Collymer Self-Assembling Scaffold (SAS), which supports cellular infiltration and vascularization. The technology is indicated for various wound types and anchors a growing intellectual property portfolio with nearly 20 issued or pending patents.
Researchers have created a comprehensive geochemical database of igneous zircon and their host rocks to predict the chemical makeup of ancient 'missing' rocks. This approach sheds light on the formation of Earth's Hadean crust through convergent tectonics, offering new insights into primordial crust formation.
A new study from Uppsala University finds that targeted training for healthcare professionals and parents significantly increases skin-to-skin contact between newborns and their parents in the first 48 hours after birth. This leads to improved health benefits for both the baby and parent, with a notable increase in the proportion of ba...
A new study reveals that global ocean analysis products can replace expensive in-situ sound speed measurements for precise seafloor positioning. Global ocean analysis achieves centimeter-level accuracy, comparable to traditional methods, and reduces costs and logistical challenges in marine geodetic surveys.
A new prototype imaging system combines light-emitting diodes (LEDs) with hyperspectral imaging technology to create detailed maps of tissue properties invisible to conventional cameras. The system shows promise for cancer detection during endoscopy, achieving real-time speeds and high-quality data comparable to reference systems.
The Center will develop personalized CRISPR on-demand treatments for children with severe inborn errors of immunity and metabolic disease. The initiative aims to make CRISPR cures more affordable and accessible, building on recent clinical success in treating ultra-rare genetic diseases.
A new study from the University at Albany's Oral Health Workforce Research Center analyzed data on Federally Qualified Health Centers and found that capacity-building steps such as investing in skilled providers and improving infrastructure enable more people to access essential health services. The study identified three leading facto...
Researchers have observed the luminescence of an excited complex formed by two donor molecules, opening possibilities for developing simpler, more efficient OLED devices. The discovery also enables the creation of sensitive sensors capable of detecting low concentrations of explosive substances.
A multinational research team analyzed life history trait data for 1,613 fish species across 14 major rivers worldwide. They found significant variation in life history traits among river systems, strongly associated with key environmental variables.
Wassim Itani is researching the translation potential of secure and efficient software updates in industrial internet of things architectures. The project aims to address critical challenges such as limited computing resources and lack of operational standards in IIoT devices.
A novel clustering method combines instance contrastive learning and swapped contrastive learning for scRNA-seq data, achieving more accurate cell clustering performance. The method projects cell representations to a 2D t-SNE space, forming clear boundaries between clusters.
A new study in iScience journal reveals new insights into the lives of 380-million-year-old lungfish, shedding light on their diet and predatory powers. The research uses high-tech examination of fossilized jawbones to evaluate how multiple species co-existed in a tropical prehistoric ecosystem.
Physicists Björn Birnir and Luiza Angheluta develop a new mathematical model to characterize Lagrangian turbulence, which captures its complex phenomena. The study reveals the presence of a Lagrangian scaling regime and connects three scaling regimes as the turbulent flow evolves.
A Brazilian researcher is studying induced pluripotent stem cells from centenarians to understand cellular resilience in COVID-19 survivors. The study aims to identify key cellular pathways that influence longevity and potentially contribute to therapeutic approaches for age-related diseases.
A new study using data from NASA's Parker Solar Probe confirms the presence of the 'helicity barrier', a previously theorized phenomenon that fundamentally changes how fluctuations dissipate and heat plasma. This discovery sheds light on properties of the solar wind, including its proton-hot electron-cold composition.
A study found that exposure to β-glucan reprograms immune cells in the lungs, causing them to overreact and worsen lung damage. The research suggests that trained immunity in the lungs may have negative consequences in certain contexts.
Gene coexpression analysis reveals optimal markers of cell types and states, providing opportunities for developing novel biomarkers and targeted treatment strategies for glioma patients. Dr. Oldham's work tackles the reproducibility crisis in science, emphasizing data metadata standardization.
Astronomers aim to unlock secrets of the 'Cosmic Dawn' by sending a miniature spacecraft to detect faint signals from hydrogen in early universe. The UK-led CosmoCube mission would observe from far side of Moon, creating a quiet spot to listen for an 'ancient whisper'.
Researchers at University of Queensland have discovered a nanobody to combat two highly lethal viruses with no approved vaccine or cure. The DS90 nanobody can access hard-to-reach areas of the virus to block infection.
Replacing animal products with plant-based foods, including ultra-processed ones, leads to significant weight loss and improved insulin sensitivity in people with type 1 diabetes. A secondary analysis of a randomized clinical trial found that the vegan group experienced reduced body weight and increased insulin sensitivity.
Researchers identify new group of immune cells driving autoimmune attack on insulin-producing cells in pancreas during cancer immunotherapy. JAK inhibitors, already FDA-approved for psoriasis and arthritis, show potential to prevent and even reverse type 1 diabetes in preclinical models.
A University of Mississippi study found that young adult novels are increasingly featuring older protagonists, with 17-year-olds dominating the genre. This shift may be driven by adult readers influencing the market, making it harder for librarians to recommend books suitable for younger teens.
Dr. Phil Costanzo, a Cal Poly chemistry professor, has been recognized with the Jack Flack Norris Award for his contributions to chemistry education. He co-founded the Macromolecular Alliance for Community Resources & Outreach (MACRO), a joint service committee that provides freely accessible educational resources for polymer chemists.
Researchers have uncovered how PAF triggers esophageal muscle contraction, revealing that non-VDCC channels, particularly Orai1, are key drivers of this process. This finding could lead to more effective treatments for esophageal and gastrointestinal symptoms in allergic conditions.
A new study published in Food & Function found that daily grape consumption improved muscle strength markers in postmenopausal women. The results suggest that incorporating grapes into the diet may offer an easy approach to mitigate sarcopenia, a condition with no effective treatment options.
The study identified a rare genetic alteration associated with high levels of the ADAM10 protein, which plays a role in breaking down beta-amyloid precursor protein. The researchers aim to develop a panel of prognostic biomarkers to differentiate Alzheimer's disease from other types of dementia.
Research suggests that airport radar systems and military operations can inadvertently reveal our existence to potential advanced alien civilizations due to hidden electromagnetic leakage. Worldwide aviation hubs like Heathrow and Gatwick emit signals strong enough to be detected by telescopes up to 200 light-years away.
A study by the University of Eastern Finland found that physical performance is associated with better cognition in people with relapsing-remitting MS. The study measured cognitive function, disability, and physical activity using various tests, revealing a significant link between these factors.
Researchers at UChicago have developed a more sensitive liquid biopsy test that uses RNA to detect the earliest stages of colorectal cancer with 95% accuracy. The test analyzes RNA modification levels in blood samples, which remain stable regardless of sample preparation.
A national review by Northwestern University identifies top dermatologist-recommended skin care ingredients for seven common complaints. Mineral sunscreen and retinoids are among the most effective ingredients, while too many products can irritate skin and worsen concerns.
A study from the University of Bath found a clear gap between expected and actual retirement behavior among younger workers. Those without active workplace pensions or outright home ownership are more responsive to State Pension age reform and adjust their expected retirement age upwards.
The interplay between exosomes and metabolic reprogramming shapes breast cancer progression and resistance. Targeting this axis offers novel diagnostic and therapeutic strategies, including exosome-based liquid biopsy techniques and combination therapies.
A novel self-supervised learning-based domain-specific model, OSPM, was developed to detect malignant and premalignant ocular surface tumors. The model demonstrated robust performance on a large dataset of images from multiple clinical centers.
A research team developed a compact dynamic cantilever magnetometer with a diameter of 22 mm, achieving a magnetic moment sensitivity on the order of 10⁻¹⁷ A·m². This innovation provides strong technical support for frontier research areas like low-dimensional magnetism and quantum states of matter.
A University of Houston engineer has developed a method to create strong and eco-friendly materials from bacterial cellulose, which could replace plastic in various industries. The new material has high tensile strength flexibility, foldability, optical transparency, and long-term mechanical stability.
Diphtheria is still being reported in Europe, with cases higher than before 2020, affecting vulnerable populations like homeless individuals, migrants, and those who use or inject drugs. ECDC recommends tailored public health response measures to protect these groups.
A new Flinders University study has mapped the distribution of killer whales in Australian waters, identifying three key regions with high habitat suitability. The research highlights the need for stronger conservation measures to protect these unique populations as apex predators in the marine ecosystem.
The BD² Integrated Network, a collaborative research model, aims to improve care and outcomes for people with bipolar disorder. The Ottawa Hospital Research Institute will receive $2.3 million to join the network, accelerating recruitment and advancing discovery.
Researchers identified a specific mutation in the cystathionine beta-synthase enzyme that affects its ability to metabolize homocysteine, leading to accumulation and organ damage. The study proposes new potential therapeutic strategies, including drug design and personalized therapies.