A new study reveals lysine-specific demethylase 1 (LSD1) as a crucial player in oral squamous cell carcinoma (OSCC) initiation. Inhibiting LSD1 in early-stage lesions prevents tumor growth, restores immune function, and halts OSCC progression.
A recent study on Reddit climate change discussions found that only 1 in 25 links are from scientific sources, highlighting the lack of science-based debate on the platform. The study also highlighted the dominance of mass media and social media sources, which often spread misinformation.
Researchers mapped the human sweet taste receptor's 3D structure in unprecedented detail, revealing its binding pocket and shedding light on why people differ in their sensitivity to sweets. This breakthrough could lead to the discovery of new regulators to curb sugar cravings.
Researchers found that individuals with excessive and dependent social media use are more likely to engage with and believe false information. The study suggests that social media addiction may lead to increased susceptibility to misinformation.
A new study reveals the atmosphere can store moisture over extended periods, creating a physical memory effect. This 'memory' allows monsoon systems to flip between two stable states, with severe consequences for regions relying on monsoon rainfall.
GigaScience Press has won the first-ever Crossref Metadata Award, recognizing its efforts in providing high-quality metadata for its journal GigaByte. The award highlights the press's commitment to making research more discoverable and accessible through rich metadata standards.
A study found that losing a parent increases the risk of bullying among female children, adolescents, and those in rural areas. The researchers hope this data informs tailored support for bereaved youth. Effective interventions should address emotional and social dimensions of support, fostering inclusive environments.
Researchers at Texas A&M University and the University of Georgia are working on interventions to impact both canine and human health. The study combines field and laboratory research, treating dogs, measuring clinical outcomes, and studying ecological factors to advance Chagas disease research.
A study published in JAMA Neurology found no evidence supporting a diagnosis of the New Brunswick neurological syndrome of unknown cause, highlighting the need for independent clinical evaluations. The data revealed presence of several neurodegenerative and non-neurodegenerative conditions instead
Paul Mulhausen, MD, will lead the American Geriatrics Society (AGS) in advancing healthcare for older adults. The AGS has elected Mulhausen as its new President following his extensive experience in clinical care, medical education, and policy advocacy.
A new study by Yale University researchers found significant differences in life expectancy among US states and Washington, D.C. over the past century, with some states experiencing dramatic gains while others saw little to no improvement. The study used an age-period-cohort model to analyze mortality trends and found that systemic fac...
Researchers have identified where and when the most aggressive subgroups of childhood brain tumors develop, revealing that they arise from precursor cells of highly specialized nerve cells. The study suggests that genetic changes occur many years before clinical symptoms appear, paving the way for possible early detection methods.
Scientists at Boston Children's Hospital discovered that native nucleosomes contain a physical code governing their role in genome architecture. This insight could lead to new understanding of the maintenance of cellular function and the development of diseases like autoimmunity and cancer.
Researchers developed iron carbide catalysts for deoxygenative C-C coupling of benzyl alcohols, producing bibenzyls and leveraging the Fischer-Tropsch synthesis process. The system promotes radical reaction pathways and accelerates oxygen removal on the catalyst surface.
Researchers identified the thalamocortical pathway as the key area modified during learning, which physically changes links between brain regions. Learning refines the conversation between the thalamus and cortex at a cellular level, making it faster, stronger, and more precise.
A new study reveals that over half of Black and Latina women reported using personal care products with formaldehyde-releasing preservatives, highlighting critical safety gaps in product regulation. The study found that these chemicals are present in a wide range of products, including shampoo, lotions, and eyelash glue.
A new £5 million project will tackle fundamental questions in solar physics by simulating the Sun's radiation and atmospheric conditions. The Solar Atmospheric Modelling Suite (SAMS) aims to build a next-generation modelling tool for the solar atmosphere, capturing its complex dynamics.
A groundbreaking study estimates that only a minuscule fraction of the deep seafloor has been imaged, with less than 0.001% of the ocean floor having visual records. This limited exploration is largely due to high costs and geographical bias in ocean exploration efforts.
A study of 200 mpox social media memes found that 4 in 10 contained misinformation or stigmatized minority groups, despite most promoting awareness and education. The majority of memes were accurate and informative, highlighting the need for responsible online content creation.
Researchers at UiT The Arctic University of Norway discovered Staphylococcus borealis, a previously unknown bacterium resistant to several antibiotic classes. The study found that S. borealis can cause urinary tract infections and inflammation around implants in individuals with weakened immune systems.
A study published in PLOS One suggests that curiosity and interest in lifelong learning can help offset or prevent Alzheimer's disease. Researchers found that state curiosity, which is a momentary feeling of curiosity when asked about specific topics, increased sharply after middle age and continued well into old age. This contrasts wi...
A randomized clinical trial with 30 female participants found that neither hot nor cold water immersion improved muscle recovery from exercise-induced damage. Despite physiological differences between groups, none showed significant improvements in muscle soreness or swelling.
Today's children will endure more climate extremes than any previous generation due to continued greenhouse gas emissions. The study highlights the social injustice of climate change and its impacts, with the most vulnerable children facing almost all, or nearly all, unprecedented exposure to heatwaves in their lifetime.
A randomized controlled trial in Switzerland found that legal access to cannabis decreases problematic consumption, especially among individuals using other substances. After two years, participants showed significant improvements in mental state.
The 4th Annual MPS World Summit brings together over 1,500 international experts to explore advancements in Microphysiological Systems (MPS) research. This event focuses on drug and chemical safety, disease modeling, and regulatory testing.
A new study reveals that SIRT5 promotes BMP9-induced osteogenic differentiation by stabilizing HIF-1α. The research suggests targeting SIRT5 could enhance bone regeneration and is a promising approach for clinical applications.
The study provides an overview of the fruit fly connectome, enabling scientists to intelligently design experiments to investigate individual neurons or circuits. Sex-specific differences were identified between male and female specimens, shedding light on behavioural differences such as egg-laying and mating.
A six-year US longitudinal study suggests that religious and spiritual engagement are associated with better physical health outcomes. The research found no evidence to support the notion that religion or spirituality leads to improved physical well-being.
Xu Zhangrun, a prominent Chinese legal scholar, has received the Human Rights Award from Friedrich-Alexander-Universität Erlangen-Nürnberg for his advocacy of democracy, academic freedom, and freedom of expression. The award is a recognition of his tireless efforts to challenge autocratic injustice in China.
A new research published in Frontiers of Computer Science proposes a Multi-Projection Recurrent (MPR) model for hypernym detection and discovery. The MPR model addresses polysemy by leveraging multiple projection functions, allowing it to handle multiple hypernyms at the same semantic level.
Researchers propose a configuration design method for mega constellations in Low Earth Orbit (LEO) using basic and accompanying satellites. The method considers satellite imaging width, formation flying of subgroup satellites, and global uniform coverage by payloads to optimize constellation configuration. By solving nonlinear optimiza...
STN-DBS treatment modifies the extracellular space (ECS) by increasing hyaluronic acid content, EAAT2 expression, and reducing extracellular glutamate concentration. This study demonstrates that STN-DBS enhances ISF drainage by restoring AQP-4 expression while decreasing α-synuclein levels.
This study finds that teen drivers in older vehicles are more likely to be involved in fatal crashes, highlighting the need for safer vehicles. The study's authors stress the importance of ensuring teens drive newer vehicles equipped with advanced driver assistance technologies.
A new study finds that macrophages, the liver's cleanup specialists, quickly adapt after injury to clear debris and support tissue recovery. The research highlights the dynamic nature of these cells during liver injury and repair, offering promising implications for future therapies.
A 10-year study confirms a one-week course of post-surgery radiotherapy is just as safe and effective as the traditional three-week regimen for early-stage breast cancer patients. This shorter schedule provides similar cancer control without additional long-term side effects.
A meta-analysis reveals significant racial and ethnic disparities in the reporting of race and ethnicity in clinical trials for pharmacotherapy of mental disorders. The study underscores the importance of equitable recruitment and reporting in clinical trials to ensure inclusive representation of diverse populations.
Scientists at the University of Southern California have developed a wearable lactation pad that monitors breast milk for safe levels of acetaminophen. The device provides real-time information, enabling parents to make informed decisions about breastfeeding and medication use, and may also be adapted to detect other drugs and biomarkers.
A study among 2,272 mother-child pairs found that infants whose mothers consumed fresh avocado during pregnancy had a 44% lower risk of developing food allergies at 12 months. Avocado intake was associated with improved maternal and infant health outcomes, including breastfeeding duration and diet quality.
Researchers have developed a synthetic lichen system that enables concrete to heal itself without external intervention. This innovation has far-reaching potential in reducing maintenance costs and extending the longevity of concrete infrastructure.
A new study published in Genes & Diseases journal introduces a novel therapeutic approach for acute myeloid leukemia (AML) using the METTL3 degrader ZW27941. The research team found that ZW27941 exhibited potent anti-leukemic activity and synergistic effects with existing AML therapies.
A new study reveals that comb jellies and other ancient animals evolved the ability to control genes from far away, over tens of thousands of DNA letters, around 650-700 million years ago. This discovery sheds light on the fundamental principles of genomic regulation that govern our cells and bodies today.
Small drones combined with free software can calculate and monitor carbon in community forest organisations. The research results show that these measurements are comparable to those derived from field-based measurements.
A meta-analysis of over 140,000 participants found a significant association between excess weight and neurological/neuropsychiatric symptoms in post-COVID-19 condition. The study suggests that maintaining a healthy weight may be crucial in mitigating these symptoms.
Researchers developed an intelligent autonomous robot capable of automating hospital disinfection processes through dual disinfection system, increasing efficiency and precision. The robot's performance was validated through real-world testing, reducing the risk of infection in hospitals.
A portable device can instantly detect dangerous street drugs at extremely low concentrations, highlighting their dangers. The device, being trialled by drug-checking services in the UK, Norway, and New Zealand, allows for cheap and on-the-spot analysis of substances.
Researchers found that NFL players are 3.7 times more likely to suffer a tear of the extensor mechanism during a short rest week than a long rest week or resting less than seven days.
Researchers at MIT have captured the first images of individual atoms freely interacting in space, visualizing never-before-seen quantum phenomena. The technique allows scientists to directly observe correlations among 'bosons' and fermions, shedding light on their behavior and interactions.
A University of California, Riverside-led research team adapted an intervention for childhood obesity prevention to better serve Latina mothers, non-maternal caregivers, and families of low-income backgrounds. The study emphasizes the importance of involving non-maternal caregivers in the adaptation process.
Researchers developed a thermal sensor to measure phonon vibrations at a molecular scale, finding that certain pathways cause destructive interference to reduce heat flow. This discovery could lead to the development of new materials and electronics with improved heat dissipation and efficiency.
A global study reveals a consistent gap in trust toward climate scientists based on political ideology, with right-leaning individuals reporting lower trust. The divide is strongest in wealthier democracies and English-speaking nations.
Researchers have discovered that combining antibiotics with an enzyme called endolysin can protect against infection by resistant bacteria in all bodily organs, including the brain. This breakthrough could lead to a new treatment for meningitis, a life-threatening disease caused by resistant bacteria.
Scientists have discovered a Triassic-era fossil with an elongated jaw structure, similar to modern-day pike and needlefish. The findings suggest that different species independently evolved similar jaws hundreds of millions of years apart, highlighting the universal problem-solving strategies in nature.
A groundbreaking study by Washington University in St. Louis found that eating disorders affect all racial groups equally among college students. The study revealed that up to 13% of respondents showed signs of eating disorders, with bulimia nervosa and binge eating disorder being the most common types.
Researchers explored combining checkpoint blockade therapy with in situ vaccination to improve anti-tumor immunity in colorectal cancer. This innovative approach aims to mitigate adverse effects and enhance treatment effectiveness by targeting immune checkpoints and promoting tumor-specific T cell responses.
A systematic review of 46 clinical studies with 4,113 participants found that automated insulin delivery (AID) systems improved time in target range and reduced elevated glucose values compared to conventional pump therapy. However, low efficacy was observed during periods with very low glucose levels.
A new study suggests that collaborating with human radiologists and using AI for initial screenings can streamline the process, reducing costs by up to 30%. This delegation strategy leverages AI's strengths in identifying low-risk cases while allowing humans to focus on complex or ambiguous ones.
A study of 273,770 individuals with cardiovascular disease found that increasing lipoprotein(a) levels significantly increases the risk of subsequent cardiovascular events. Treatment with high-impact LDL-C lowering therapies may help reduce this risk.
A new study suggests that urban agriculture alone can only feed about one fifth of a city's population, but combining it with near-urban farming can ensure food security for the entire city. Peas are found to be the best crop for maximizing protein and calories while minimizing land requirements in normal climate scenarios.
Researchers developed an artificial interphase using Al-Li/LiF to solve the lithium metal battery's volume expansion issue. The study shows a discharge capacity of 114.3 mAh·g after 300 cycles, demonstrating improved cycle stability and capacity retention.
Researchers identified a genetic mutation in Turkish Pointers that distinguishes their forked nose, linking it to cases of human orofacial clefts. The study suggests that the mutation of PDFGRA gene may be involved in some cases of human orofacial clefts.