Researchers have identified a framework to characterize RNA structure-changing small molecule drugs, which could lead to the development of better treatments targeting RNA directly. The study found that molecules binding to RNA rarely affect its function, while those altering its structure have a bigger impact.
A Universitat Rovira i Virgili study found that male gender, religiosity, and physical aggression are factors associated with higher levels of transphobia. The study collected data from 333 adults and found that men exhibit significantly higher levels of transphobic attitudes than women.
The company has announced an expansion of its innovative diamond open access (OA) model, Collective Pathway to Open Publishing, through agreements with Jisc in the UK and CAUL in Australasia. Six new journals will make their 2026 volumes open access without charging authors an article publishing charge.
A new study reveals the Milky Way's southern halo is up to 12% warmer than the northern half due to an internal combustion engine-like effect caused by the Large Magellanic Cloud. The compression of gas in this process heats up, affecting the temperature difference between the two regions.
Researchers found that older cells' inability to react properly to external stimuli is caused by changes in the packaged form of DNA, called chromatin. This alteration leads to incorrect gene expression and production of unwanted proteins.
Research from Oman tackles food freshness, mental health, and public health to improve everyday life. The issue showcases how local studies contribute to global conversations on sustainability and quality of life.
The IOP Publishing Outstanding Reviewer Awards recognize researchers who deliver exceptional peer review reports, showcasing the essential contribution of reviewers to published research quality. The awards honor over 3,500 reviewers from 74 countries, with notable recognition for lower middle-income country contributors.
Researchers using satellite imagery and remote sensing technology have discovered at least 28 large stone circles in the Golan Heights, surrounding Rujm el-Hiri. These findings suggest a widespread architectural tradition integrated into social and economic systems of the proto-historic Levant.
Researchers found that vitamin D supplementation was associated with increased levels of immunoglobulin A and decreased levels of immunoglobulin G, indicating a more balanced immune response. The study also observed changes in immune signaling pathways and increased activity of regulatory immune cells.
Early-stage drug development worldwide has nearly doubled over the past decade, with China's share increasing from 8% to 32%, according to Georgetown University researchers. The number of early-stage programs increased by 82.4% from 10,417 in 2015 to 18,999 in 2024.
A recent study combines two modelling approaches to capture the seismicity associated with land uplift and earthquake swarms in the Phlegraean Fields. The model explains long-term trends in earthquake activity by combining changes in stress within the Earth's crust with friction behaviour of geological faults.
A large randomized trial shows that continuous wearable monitoring reduces time with dangerously low oxygen levels after surgery, leading to improved composite outcomes and safety. The study found a 30-minute reduction in hypoxemia and a significant risk reduction for desaturation events.
Epigenetic modifiers targeting histone acetylation, methylation, and phosphorylation show significant preclinical promise in CRC. Combination strategies and novel degraders offer pathways to overcome resistance, including PROTACs targeting KDM3A/B that eliminate cancer stem cells via Wnt/β-catenin inhibition.
Researchers developed an AI model that analyzes routine pathology slides to predict breast cancer recurrence and chemotherapy benefit. The model was validated in a large clinical trial and demonstrates fast, accessible, and globally scalable diagnostic capabilities.
A study by researchers at Institute of Science Tokyo has identified a key gene, DOCK10, involved in abnormal insulin secretion in insulinomas. The findings pave the way for novel diagnostic biomarkers and treatment options.
Research reveals increased interannual temperature variability over China, with greater summer variability during the Last Interglacial and stronger winter variability during the Last Glacial Maximum. This study provides a critical long-term perspective for understanding future changes in extreme temperature events.
A recent study published in JAMA Oncology suggests that obesity control is a potentially effective strategy for cancer prevention. The research reveals that successful weight management can lead to a significant reduction in the risk of various cancers, making it an underutilized approach in cancer prevention.
Scientists created a room-temperature, zero-power infrared sensor with high sensitivity and fast response time. The device uses a novel asymmetric electrode structure to separate generated electrical charges, enabling clear images without external power.
Early-stage drug development has nearly doubled globally over the past decade, driven by a shift from a US-dominated system to a two-hub structure. This change may have implications for scientific workforce development, investment, and patient access to new therapies.
Researchers developed a copper complex that selectively induces cuproptosis in cancer cells, killing them without harming healthy tissue. The method is 100 times more effective than existing platinum derivatives and can target treatment-resistant cancer cells.
Researchers used AI to identify key characteristics of catalysts and guide their designs, discovering a universal design principle for copper-based single-atom alloy catalysts. The approach uses machine learning to predict catalyst performance and inspire generalizable design principles.
Elevated uric acid promotes liver damage and disease severity through inflammation, oxidative stress, and metabolic disturbances. Lifestyle interventions, medications, and potential biomarkers are being explored to improve diagnostic efficacy and treatment.
A new study forecasts disruptive Siberian-Arctic heatwaves up to one month in advance by monitoring Arctic stratospheric ozone depletion and Kara Sea ice loss. The model correctly predicted six out of seven major SAH events since 1979.
Dr. Justin Garcia, Kinsey Institute Executive Director, named AAAS Fellow for his distinguished contributions to understanding evolutionary and biocultural foundations of romantic relationships across the lifespan. His work integrates biological, psychological, and social perspectives to examine human intimacy and its impact on public ...
Researchers developed a novel lithium-ion battery anode that stores more than 3500 milliampere-hours per gram, outperforming current graphite-based batteries. The new design, VISiCNT, features a vertically integrated silicon-carbon nanotube structure that maintains performance and stability over hundreds of charge cycles.
NYU faculty Eray Aydil, André Fenton, Anirban Maitra, and Liina Pylkkänen recognized for their groundbreaking work in materials synthesis, neuroscience, cancer research, and language processing. The American Association for the Advancement of Science has selected 449 members as AAAS Fellows this year.
CUNY Graduate Center faculty members Kevin Gardner, David J. Lohman, Vinod Menon, Christina Sormani, and Charles Vörösmarty have been named 2025 AAAS Fellows for their groundbreaking work in various fields. Their research has expanded human knowledge and addressed pressing questions in mathematics, biology, physics, and environmental s...
Researchers found that as systems grow, new functions are added at a slower rate, requiring infrastructure and existing functions to expand. Cities show an exception, where function diversity grows rapidly in smaller cities but slows down in larger ones.
A new set of evidence-based clinical guidelines has been developed to manage recurrent wheezing in infants and toddlers. The guidelines recommend standardized protocols for diagnosing and treating the condition, including laboratory tests and type 2 inflammatory disease testing.
Paul Tesar, a Case Western Reserve University neuroscientist, has been elected as an AAAS Fellow for his distinguished contributions to translational neuroscience. His research has helped elucidate the role of oligodendrocytes in neurological disease and develop regenerative therapies for multiple sclerosis and pediatric leukodystrophies.
Mark Adams, a leading expert in genomics, has been elected an AAAS Fellow for his groundbreaking work in DNA sequencing and genome mapping. His pioneering efforts have laid the foundation for modern precision medicine.
The study developed a novel framework that tracks digital communities over time, analyzing how online groups emerge and disappear. Researchers found that social media interactions can create echo chambers and increase societal polarization.
A joint project between The University of Queensland and the Indian Institute of Technology Delhi has led to the development of an eco-friendly process to convert sugarcane waste into biofuel. PhD candidate Ms Neethu Joshikumar successfully tested a one-pot method using deep eutectic solvent, reducing electricity and time requirements.
Drexel researchers have found that, given the right strain rate, simple liquids can fracture like solid objects. This discovery suggests that viscosity plays a more significant role in the mechanical properties of liquids than previously thought, potentially leading to new possibilities for manipulating liquids in various applications.
Two Baylor University researchers, biologist Dwayne D. Simmons and anthropologist Samuel S. Urlacher, have been elected as AAAS Lifetime Fellows for their distinguished scientific contributions. They were recognized for their research in auditory neuroscience and life history tradeoffs in human physiology.
Researchers developed a holographic data storage approach that combines amplitude, phase, and polarization to store more data in the same space. The new method increases information density while simplifying readout, making it suitable for smaller data centers and faster data processing.
Researchers at Hiroshima University have developed a new experimental method to demonstrate the physical delocalization of individual photons in an interferometer. The study challenges traditional interpretations of quantum mechanics and has significant implications for high-tech sensors and our understanding of reality.
Researchers have identified and overcome metabolic instability as the key barrier to developing ovalicin, a potent relative of fumagillin. Using chem-bio hybrid synthesis, they created metabolically stable drug candidates that worked in animal models of amebiasis.
Professor John Bickle has made significant contributions to the field of philosophy of science and neuroscience, bringing together experts from various disciplines to study the human brain, cognition, and behavior. His work aims to develop new treatments for mental disorders through the isolation of proteins.
Researchers investigated human preferences for robot motion on different household tasks, finding that preferences vary from task to task and should be highly individualized. The study also found that users prefer smoother robot motions than their own movements.
The University of Missouri is honoring three distinguished faculty members as 2025 AAAS Fellows. Paul de Figueiredo is being recognized for his contributions to microbiology, while Roman Ganta advances research on tick-borne diseases. Wesley Warren's expertise in genome-scale data analysis has reshaped research across multiple fields.
Researchers from The University of Osaka propose a compact LED design that directly emits circularly polarized light, potentially simplifying optical devices. The new design uses robust inorganic materials and achieves high levels of both efficiency and polarization degree.
A new deep learning model classifies Japanese Sue ware from 3D scans with high accuracy, using three-dimensional point clouds directly. The model achieved an overall accuracy of 93.2%, performing almost perfectly on visually distinct categories, while focusing on regions that may correspond to expert archaeologists' considerations.
Carole LaBonne and Matthew Goldrick are being honored for their groundbreaking research in developmental biology and language science. LaBonne's work on pluripotent embryonic stem cells has significant implications for understanding birth defects, cancer, and regenerative medicine.
A KAIST research team identified the mechanism by which Graphene Oxide exhibits powerful antibacterial effects against bacteria while remaining harmless to human cells. The technology has been applied to consumer products, including a graphene antibacterial toothbrush that has sold over 10 million units.
UT MD Anderson faculty members Theresa Guise and Stephanie Watowich have been elected as AAAS Fellows, honored for their outstanding contributions to science and society. Their research focuses on endocrinology and immunology, with breakthroughs in cancer treatment and patient care.
The study found that AI-enhanced single-shot cine MRI produces better image quality compared to conventional cine MRI, particularly in participants with arrhythmia. The technique demonstrated a 100% success rate for image acquisition, outperforming conventional cine sequences.
The latest SLAS Technology volume showcases how AI, automation, and portable technologies are transforming drug discovery and diagnostics. This advancement enables the development of innovative therapeutic solutions and improved patient care.
Researchers found that adults who followed routine eating patterns lost more weight than those with varied diets. Those who repeated many of the same foods lost an average of 5.9% of their body weight, compared to 4.3%. Greater calorie consistency was also linked to better results.
Researchers identified MIEL1 as an E3 ligase that cooperates with XBAT31 to regulate thermoresponsive growth in plants. MIEL1 blocks XBAT31's auto-ubiquitination and self-degradation, maintaining its protein stability.
Researchers developed a video modeling program to enhance romantic relationship skills in young adults with intellectual and developmental disabilities. The study found that participants significantly improved their decision-making skills across four relationship domains, averaging 76% accuracy after the intervention. The findings high...
Researchers have identified phage W5 as a safe and effective natural virus capable of eliminating harmful Salmonella on various foods and packaging materials. The study establishes a solid foundation for developing novel phage-based disinfectants or preservatives to combat antibiotic resistance and enhance food safety.
The latest volume of SLAS Discovery highlights advances in 3D cell culture and novel technologies for drug discovery. Small molecule cytokine antagonists and a versatile ELISA for PPI inhibitor screening are among the key findings.
Twelve life science startups have been selected for the Innovation AveNEW program at SLAS Europe 2026. The companies will showcase their products and services in a specially designated area on the exhibition floor, engaging with purchasing influencers and decision-makers from over 40 countries.
This issue highlights advancements in drug discovery, synthetic biology, and laboratory digitalization. SLAS Technology emphasizes scientific and technical advances that enable improved biomedical research and development.
Researchers have developed a new class of carbon materials called 'viciazites' that contain carefully controlled configurations of nitrogen groups, enabling low-temperature operation and efficient CO2 capture. The materials outperform untreated carbon fibers in CO2 uptake and desorption at temperatures below 60°C.
A clinical trial found that high-intensity therapy for patients begun within two weeks of a stroke did not improve hand and arm recovery beyond standard care. Despite having access to extra therapy, neither group did better than a cohort who received standard care alone.
The study developed a novel multi-task deep LASSO algorithm that identified six core clinical indicators, establishing four stable MASLD subtypes with distinct characteristics. The classification system enables targeted interventions, prioritizing fibrosis screening and aggressive cardiorenal protection for specific subgroups.
The American Academy of Sleep Medicine has announced the 2026 award recipients for their exceptional contributions to sleep medicine. The award winners are Dr. Susan Redline, Danny Eckert, Dr. Douglas Kirsch, Dr. Beth Malow, and Dr. Robert Stansbury, recognized for their research, education, advocacy, and clinical care.
East China Normal University's Faculty of Education has been selected for the 2025 Shanghai 'International Communication of Chinese Culture' initiative, highlighting the growing importance of academic platforms in facilitating global knowledge exchange. The journal ECNU Review of Education plays a central role in advancing this initiat...