About The Study: This genetic association study including 39,000 participants with clinically diagnosed Alzheimer disease (AD) and 401,000 control participants without AD found novel genetic associations between high high-density lipoprotein (HDL) cholesterol concentrations and high systolic blood pressure with higher risk of AD. These findings may inspire new drug targeting and improved prevention implementation.
Authors: Ruth Frikke-Schmidt, M.D., D.M.Sc., Ph.D., of Copenhagen University Hospital–Rigshospitalet in Copenhagen, is the corresponding author.
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(doi:10.1001/jamanetworkopen.2023.13734)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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