About The Study: In this cohort study, seed amplification assays (SAA) α-syn+ was consistently associated with nucleus basalis of Meynert (NBM) atrophy already during asymptomatic stages. Further, in memory clinic cognitively impaired populations, SAA α-syn+ was associated with NBM atrophy, which partially mediated α-syn–induced attention/executive impairment.
Corresponding Authors: To contact the corresponding authors, email Laura E.M. Wisse, Ph.D. ( laura.wisse@med.lu.se ) and Oskar Hansson, M.D., Ph.D. ( oskar.hansson@med.lu.se ).
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(doi:10.1001/jamaneurol.2024.2713)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Media advisory: This study is being presented at the Alzheimer’s Association International Conference.
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JAMA Neurology