Articles tagged with Memory Disorders
Researchers discovered how anesthesia, surgery, and intensive care stress alter gene activity in the brain, leading to cognitive impairment and delirium. A new drug, vorinostat, reversed these changes, restoring memory formation and regulating the internal biological clock.
Researchers used real human brain tissue samples to test the underlying mechanisms of deep brain stimulation. They found that brain cells became more synchronized in communicating, similar to memory formation, while altering gene expression across different types of brain cells.
A Phase 2 clinical trial shows that a THC/CBD combination significantly reduces agitation in hospice-eligible people with dementia. The study, conducted across multiple US sites, achieved its primary and key secondary endpoints, demonstrating the efficacy of this treatment approach for end-of-life agitation.
Patients with autoimmune limbic encephalitis experience altered hippocampus size and function, leading to memory loss and apathy. This study reveals a link between hippocampus damage and behavioral changes, shedding light on the condition's effects on cognition and motivation.
A new paper reveals a live concert and lecture series improves emotional well-being, intellectual stimulation, and social interaction among dementia patients. Participants reported high satisfaction and improved mood following sessions.
Researchers at Texas A&M University have found a way to intervene early in traumatic brain injuries using a natural, gut-derived chemical that prevents post-traumatic epilepsy from taking root. The treatment reduced brain inflammation, improved memory and mood, protected brain cells, made seizures both rarer and harder to trigger.
The University of Cincinnati launches the Center for Alzheimer's and Neurodegenerative Diseases Research (CANDR) to improve dementia prevention and treatment outcomes. CANDR aligns with UC's mission to innovate and engage locally while addressing one of the region's most pressing public health challenges.
A digital therapy platform, iACT4CARERS, has been shown to reduce anxiety and depression in dementia carers after three and six months. The study, which involved almost 500 volunteers, found that carers using the platform had lower levels of anxiety and depression compared to those receiving usual care alone.
A study by DZNE shows that smartphone-based memory tests can detect subtle cognitive decline in people with mild cognitive impairment (MCI) more quickly than conventional testing. This approach has the potential to accelerate clinical trials for new dementia drugs and be used in routine care.
Dr. Owen Carmichael received the James W. and Neil Ann Parks Professorship for Dementia Research, Prevention and Treatment at Pennington Biomedical. His work focuses on developing advanced biomedical imaging techniques to better understand Alzheimer's disease and brain aging.
A new preclinical study finds that estrogen loss in the extracellular matrix of the hippocampus may contribute to memory decline and increased risk of Alzheimer's disease in postmenopausal women. The study suggests a possible new treatment approach focused on restoring the brain's supportive environment.
A nine-session weekly group program in rural Spain improved caregiver burden, quality of life, and self-efficacy. Key factors associated with greater burden include personal health problems and extended caregiving hours.
A study by the Sant Pau Research Institute found that placental insufficiency during pregnancy is associated with higher risk of memory alterations years after childbirth. Women with angiogenic imbalance had a higher frequency of memory problems, even after accounting for other clinical factors.
A new Cochrane review of 17 clinical trials found that anti-amyloid Alzheimer's drugs have no significant impact on cognitive decline or dementia severity, but may increase the risk of brain swelling and bleeding. The evidence suggests that these drugs are unlikely to provide clear benefit to patients.
Researchers developed a nasal spray that reversibly reduces brain inflammation, restores cellular power plants, and improves memory. The treatment bypasses the brain's protective shield through intranasal delivery, suppressing chronic inflammation and promoting successful brain aging.
A Georgia State University study found that Alzheimer's affects men's and women's brains differently, with women showing steeper and more widespread decline. The research suggests that brain compensation mechanisms may help maintain cognitive performance in women earlier in the disease.
Researchers discovered subtle changes in the blood can reveal early signs of cognitive decline caused by chemicals produced by gut bacteria. A blood test may one day transform how we detect dementia, potentially identifying people at risk years before symptoms appear.
Long COVID affects quality of life with neuropsychiatric issues like cognitive dysfunction, depression, and memory loss, impacting daily tasks and work. The review highlights the need for standardized diagnosis and treatment to address this chronic condition.
A new study models brain aging and resilience over the lifespan, uncovering individual factors that affect cognition and identifying potential biomarkers of healthy brain aging. Researchers are now incorporating diverse data, including social and lifestyle factors, to create a broader picture of the aging brain.
A new study suggests that a lack of fiber in the diet may impair emotional memory in older adults, linked to cognitive problems and inflammation. The amygdala, responsible for processing fearful experiences, is sensitive to highly processed diets, regardless of fat or sugar content.
Researchers at the University of Michigan School of Public Health found a strong association between bone lead concentrations and increased risk of dementia. The study analyzed data from over 30 years of follow-up and estimated cumulative lifetime exposure to lead using machine learning algorithms.
A new study found that patients with Long COVID have a larger choroid plexus, which tracks with Alzheimer's disease markers and greater dementia risk. The research also suggests that CP alterations may predict long-term cognitive issues in some individuals.
Researchers at EPFL's Brain Mind Institute have discovered that rejuvenating specific engram neurons can restore memory performance in multiple mouse settings. This approach uses a short pulse of genes to 'reprogram' these cells, bringing their functionality back to levels seen in young mice.
Researchers discovered that collaborative care programs improve quality of life, reduce costs, and alleviate caregiver burden for dementia patients. Adding lecanemab to treatment increased healthcare costs but was offset by the savings from collaborative care.
Researchers at UC San Francisco have identified CUL5, a protein that tags tau for elimination, as a key player in preventing the formation of toxic tau protein clumps that can lead to dementia. The study found that neurons with more CUL5 are less vulnerable to Alzheimer's disease.
Scientists at Max Planck Florida Institute for Neuroscience have identified a neural code that allows the brain to track distance traveled without visual cues. This ability is essential for navigation and memory formation, and may offer insight into early navigation problems in Alzheimer's disease.
A new dual-action program combines arts sessions for people with dementia with wellbeing sessions for their carers, helping families rediscover connection and confidence. The program was co-designed with those affected by dementia and has been shown to promote social interaction and reduce isolation.
Researchers at Florida Atlantic University have discovered a potential new treatment for Alzheimer's disease by targeting muscle protein Cathepsin B. The study found that increasing Ctsb in muscle tissue may offer protection against the effects of AD and promote brain cell growth, restoring protein balance and rebalancing brain activity.
Researchers at Virginia Tech found that adjusting molecular processes can improve memory in older subjects. They used CRISPR-dCas13 and CRISPR-dCas9 to target age-related changes in K63 polyubiquitination and IGF2, two genes linked to memory formation.
Researchers have discovered that deep sleep plays a crucial role in controlling cerebrospinal fluid dynamics, which is essential for clearing waste from the brain. During slow-wave sleep, changes in cerebrospinal fluid signals are time-locked to slow brain waves and other neural events.
A new study reveals that astrocytes, a type of glial cell, are responsible for stabilizing memories through repeated engagement. The researchers found that Fos activity in astrocytes only occurs during recall, and that these cells can be activated to produce stable memories.
A new research network aims to detect early signs of dementia through open-source digital tools. Penn State will lead a $39 million grant to advance Alzheimer's detection and reduce the financial, interpersonal, and health impacts of Alzheimer's disease.
A new Finnish study reveals that low labor market participation can indicate early stages of dementia, up to ten years before diagnosis. The research found social markers such as long-term unemployment or living alone may signal onsetting dementia.
A large-scale U.S-based randomized trial shows that intensive lifestyle changes can significantly improve global cognition in older adults at high risk of cognitive decline. The intervention emphasized regular physical activity, healthy diet, cognitive stimulation, and social engagement, leading to clinically meaningful improvements. T...
Researchers at Penn State found that weight fluctuations and changes can lead to faster cognitive decline in older adults. The study analyzed data from 4,304 participants and showed that those with greater variability in weight experienced more rapid cognitive declines.
Researchers at UCSF screened hundreds of industrial dyes to identify those that stick to protein clumps in the brain, a hallmark of dementia. They found 10 sure hits that illuminated tau clumps in animal models and human samples, offering new hope for diagnosis and treatment.
A new study reveals that Alzheimer's progression is characterized by a breakdown of epigenomic stability, leading to compromised compartmentalization and the loss of gene regulation. The research provides insights into the molecular mechanisms driving disease progression and resilience, shedding light on potential new treatments.
A new study from UC Davis found that people with a higher sense of purpose in life were about 28% less likely to develop cognitive impairment and dementia. Purpose helped the brain stay resilient with age, even for those with a genetic risk for Alzheimer's disease.
Dr. David Rubinsztein shares his personal journey from childhood curiosity to discovering autophagy, a natural process that clears toxic proteins causing devastating neurodegenerative diseases. His research has established autophagy upregulation as a viable therapeutic strategy for conditions affecting millions worldwide.
UCSF scientists identified a receptor that enables microglia to engulf and digest amyloid beta plaques, leading to fewer and smaller clumps. This discovery creates an opportunity for new therapies targeting the receptor ADGRG1.
Researchers at USC have developed a new understanding of how the human brain organizes its visual memories by sorting them into categories. The study, published in Advanced Science, used human patient brain recordings and machine learning to decode the category of visual image being recalled from precise neural timing.
A groundbreaking brain imaging study confirms intranasal insulin safely reaches key memory regions in older adults with Alzheimer's. The research reveals differences in uptake among individuals with early cognitive decline, paving the way for personalized treatment approaches.
A global study of 161,981 participants across 40 countries reveals that air pollution, social inequality, and weak democratic institutions accelerate aging. BBAGs, a novel measure of accelerated aging, show that exposure to toxic air, political instability, and economic inequality can age you several years faster.
A US study published in Alzheimer's & Dementia found that 37% of dementia cases could be linked to cardiometabolic diseases, with the strongest connection in the South. Hypertension was the leading cause, accounting for 9.6% of cases.
Researchers mapped dynamic cellular mechanisms of memory formation, storage and update, revealing new insights into encoding experiences in the brain. Memories are stored through biophysical changes in neuronal ensembles, which can be manipulated to induce recall.
A new Stanford Medicine-led study reveals that CAR-T cell therapy causes mild cognitive impairments in cancer patients, independent of other treatments. Researchers identified the cellular mechanism behind this effect and found strategies to reverse it.
Researchers found that patients taking HIV drugs called NRTIs are substantially less likely to develop Alzheimer's disease. The study, led by Jayakrishna Ambati, analyzed data from two large health insurance databases and determined a significant reduction in Alzheimer's risk among patients on NRTIs.
A study published in Alzheimer's & Dementia found that learning one's Alzheimer's risk can decrease negative emotions like depression and anxiety, but also leads to decreased motivation for maintaining healthy lifestyle changes. Researchers emphasize the importance of personalized disclosure processes to sustain healthy behaviors.
Researchers found that even small doses of high-intensity exercise can reduce the risk of dementia and promote healthy brain aging. The study suggests exercising regularly is crucial for preserving brain health, making it a key prevention measure against cognitive decline.
A recent study developed a VR game that combines olfactory stimulation with immersive gameplay to improve cognitive function in older adults. After just 20 minutes of play, participants showed significant improvements in visuospatial rotation and memory tasks.
Research reveals two parallel processes during post-learning sleep: reactivation of initial learning experience and emergence of new neurons encoding future memories. This study highlights the critical role of sleep in maintaining cognitive function and overall well-being.
A new study from the University of Missouri suggests that exercise can improve brain health and mitigate cognitive decline, even when ketone production in the liver is impaired. The research found that endurance exercise can prevent cognitive impairment caused by compromised hepatic ketogenesis.
Researchers at Trinity College Dublin have found that the brain forms memories of cold experiences and uses them to control metabolism. The discovery may lead to new treatments for conditions such as obesity and cancer, which are influenced by thermoregulation and metabolism.
Dr. Rhonda Winegar investigates the effectiveness of music therapy in supporting neurological care, including its ability to reduce anxiety and depression in Alzheimer's patients. Her research also highlights its potential to regulate heart rate and blood pressure, as well as improve motor function in individuals with Parkinson's disease.
Researchers found that SIRT2, a previously unknown enzyme, plays a key role in excessive GABA production associated with Alzheimer's disease. This process leads to brain inflammation and memory impairment. By targeting SIRT2, scientists can selectively block its harmful effects on memory without affecting other brain functions.
A novel brain study uncovers the critical role of the HDAC5 enzyme in regulating gene expression and neuronal activity, which can trigger relapse in individuals with substance use disorders. The study highlights a new molecular target for developing novel treatments to reduce relapse risk.
Researchers at The University of Texas at San Antonio are working on a new AI tool to improve lives after brain injury. They plan to analyze data from 3,000 veterans and develop an interactive dashboard for clinicians to use, providing insights that could revolutionize treatment.
A Baycrest study reveals that sleep actively enhances memory for event sequence, improving recall of everyday experiences. This discovery deepens our understanding of the critical role of sleep in integrating experiences into memory.
A new study published in Brain Medicine found that administering Osanetant shortly after a traumatic event significantly dampens fear expression in female mice. This suggests that targeting fear memory at its roots may be an effective intervention to reduce PTSD-like behaviors.
A new study published in The Journals of Gerontology: Series A found that long-term exposure to high levels of air pollution is associated with lower scores in key cognitive abilities, especially language skills. Exposure to nitrogen dioxide and fine particulate matter was linked to poorer language performance.