Articles tagged with Memory Disorders
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Researchers at UC San Francisco have identified CUL5, a protein that tags tau for elimination, as a key player in preventing the formation of toxic tau protein clumps that can lead to dementia. The study found that neurons with more CUL5 are less vulnerable to Alzheimer's disease.
Scientists at Max Planck Florida Institute for Neuroscience have identified a neural code that allows the brain to track distance traveled without visual cues. This ability is essential for navigation and memory formation, and may offer insight into early navigation problems in Alzheimer's disease.
A new dual-action program combines arts sessions for people with dementia with wellbeing sessions for their carers, helping families rediscover connection and confidence. The program was co-designed with those affected by dementia and has been shown to promote social interaction and reduce isolation.
Researchers at Florida Atlantic University have discovered a potential new treatment for Alzheimer's disease by targeting muscle protein Cathepsin B. The study found that increasing Ctsb in muscle tissue may offer protection against the effects of AD and promote brain cell growth, restoring protein balance and rebalancing brain activity.
Researchers at Virginia Tech found that adjusting molecular processes can improve memory in older subjects. They used CRISPR-dCas13 and CRISPR-dCas9 to target age-related changes in K63 polyubiquitination and IGF2, two genes linked to memory formation.
Researchers have discovered that deep sleep plays a crucial role in controlling cerebrospinal fluid dynamics, which is essential for clearing waste from the brain. During slow-wave sleep, changes in cerebrospinal fluid signals are time-locked to slow brain waves and other neural events.
A new study reveals that astrocytes, a type of glial cell, are responsible for stabilizing memories through repeated engagement. The researchers found that Fos activity in astrocytes only occurs during recall, and that these cells can be activated to produce stable memories.
A new research network aims to detect early signs of dementia through open-source digital tools. Penn State will lead a $39 million grant to advance Alzheimer's detection and reduce the financial, interpersonal, and health impacts of Alzheimer's disease.
A new Finnish study reveals that low labor market participation can indicate early stages of dementia, up to ten years before diagnosis. The research found social markers such as long-term unemployment or living alone may signal onsetting dementia.
A large-scale U.S-based randomized trial shows that intensive lifestyle changes can significantly improve global cognition in older adults at high risk of cognitive decline. The intervention emphasized regular physical activity, healthy diet, cognitive stimulation, and social engagement, leading to clinically meaningful improvements. T...
Researchers at Penn State found that weight fluctuations and changes can lead to faster cognitive decline in older adults. The study analyzed data from 4,304 participants and showed that those with greater variability in weight experienced more rapid cognitive declines.
Researchers at UCSF screened hundreds of industrial dyes to identify those that stick to protein clumps in the brain, a hallmark of dementia. They found 10 sure hits that illuminated tau clumps in animal models and human samples, offering new hope for diagnosis and treatment.
A new study reveals that Alzheimer's progression is characterized by a breakdown of epigenomic stability, leading to compromised compartmentalization and the loss of gene regulation. The research provides insights into the molecular mechanisms driving disease progression and resilience, shedding light on potential new treatments.
A new study from UC Davis found that people with a higher sense of purpose in life were about 28% less likely to develop cognitive impairment and dementia. Purpose helped the brain stay resilient with age, even for those with a genetic risk for Alzheimer's disease.
Dr. David Rubinsztein shares his personal journey from childhood curiosity to discovering autophagy, a natural process that clears toxic proteins causing devastating neurodegenerative diseases. His research has established autophagy upregulation as a viable therapeutic strategy for conditions affecting millions worldwide.
UCSF scientists identified a receptor that enables microglia to engulf and digest amyloid beta plaques, leading to fewer and smaller clumps. This discovery creates an opportunity for new therapies targeting the receptor ADGRG1.
Researchers at USC have developed a new understanding of how the human brain organizes its visual memories by sorting them into categories. The study, published in Advanced Science, used human patient brain recordings and machine learning to decode the category of visual image being recalled from precise neural timing.
A groundbreaking brain imaging study confirms intranasal insulin safely reaches key memory regions in older adults with Alzheimer's. The research reveals differences in uptake among individuals with early cognitive decline, paving the way for personalized treatment approaches.
A global study of 161,981 participants across 40 countries reveals that air pollution, social inequality, and weak democratic institutions accelerate aging. BBAGs, a novel measure of accelerated aging, show that exposure to toxic air, political instability, and economic inequality can age you several years faster.
A US study published in Alzheimer's & Dementia found that 37% of dementia cases could be linked to cardiometabolic diseases, with the strongest connection in the South. Hypertension was the leading cause, accounting for 9.6% of cases.
Researchers mapped dynamic cellular mechanisms of memory formation, storage and update, revealing new insights into encoding experiences in the brain. Memories are stored through biophysical changes in neuronal ensembles, which can be manipulated to induce recall.
A new Stanford Medicine-led study reveals that CAR-T cell therapy causes mild cognitive impairments in cancer patients, independent of other treatments. Researchers identified the cellular mechanism behind this effect and found strategies to reverse it.
Researchers found that patients taking HIV drugs called NRTIs are substantially less likely to develop Alzheimer's disease. The study, led by Jayakrishna Ambati, analyzed data from two large health insurance databases and determined a significant reduction in Alzheimer's risk among patients on NRTIs.
A study published in Alzheimer's & Dementia found that learning one's Alzheimer's risk can decrease negative emotions like depression and anxiety, but also leads to decreased motivation for maintaining healthy lifestyle changes. Researchers emphasize the importance of personalized disclosure processes to sustain healthy behaviors.
Researchers found that even small doses of high-intensity exercise can reduce the risk of dementia and promote healthy brain aging. The study suggests exercising regularly is crucial for preserving brain health, making it a key prevention measure against cognitive decline.
A recent study developed a VR game that combines olfactory stimulation with immersive gameplay to improve cognitive function in older adults. After just 20 minutes of play, participants showed significant improvements in visuospatial rotation and memory tasks.
Research reveals two parallel processes during post-learning sleep: reactivation of initial learning experience and emergence of new neurons encoding future memories. This study highlights the critical role of sleep in maintaining cognitive function and overall well-being.
A new study from the University of Missouri suggests that exercise can improve brain health and mitigate cognitive decline, even when ketone production in the liver is impaired. The research found that endurance exercise can prevent cognitive impairment caused by compromised hepatic ketogenesis.
Researchers at Trinity College Dublin have found that the brain forms memories of cold experiences and uses them to control metabolism. The discovery may lead to new treatments for conditions such as obesity and cancer, which are influenced by thermoregulation and metabolism.
Dr. Rhonda Winegar investigates the effectiveness of music therapy in supporting neurological care, including its ability to reduce anxiety and depression in Alzheimer's patients. Her research also highlights its potential to regulate heart rate and blood pressure, as well as improve motor function in individuals with Parkinson's disease.
Researchers found that SIRT2, a previously unknown enzyme, plays a key role in excessive GABA production associated with Alzheimer's disease. This process leads to brain inflammation and memory impairment. By targeting SIRT2, scientists can selectively block its harmful effects on memory without affecting other brain functions.
Researchers at The University of Texas at San Antonio are working on a new AI tool to improve lives after brain injury. They plan to analyze data from 3,000 veterans and develop an interactive dashboard for clinicians to use, providing insights that could revolutionize treatment.
A Baycrest study reveals that sleep actively enhances memory for event sequence, improving recall of everyday experiences. This discovery deepens our understanding of the critical role of sleep in integrating experiences into memory.
A novel brain study uncovers the critical role of the HDAC5 enzyme in regulating gene expression and neuronal activity, which can trigger relapse in individuals with substance use disorders. The study highlights a new molecular target for developing novel treatments to reduce relapse risk.
A new study published in Brain Medicine found that administering Osanetant shortly after a traumatic event significantly dampens fear expression in female mice. This suggests that targeting fear memory at its roots may be an effective intervention to reduce PTSD-like behaviors.
A new study published in The Journals of Gerontology: Series A found that long-term exposure to high levels of air pollution is associated with lower scores in key cognitive abilities, especially language skills. Exposure to nitrogen dioxide and fine particulate matter was linked to poorer language performance.
A pilot study in western Sweden found that 5.5% of fourth-grade students had fetal alcohol spectrum disorders (FASD), including severe cases like fetal alcohol syndrome (FAS). The study's lead author suggests that the results may indicate a higher prevalence in Sweden compared to other European countries.
A new study published in PLOS Digital Health found that older drivers with GPS navigation systems tend to drive more frequently, suggesting these tools help maintain driving mobility. The research reveals that using GPS can alleviate spatial orientation difficulties and support older adults' independence on the roads.
A new study by UCL researchers found that people with visual Alzheimer's disease have a unique distribution of proteins and markers in their brain, leading to symptoms such as reading difficulties. In contrast, those with memory-led Alzheimer's disease have different protein patterns, resulting in symptoms like memory loss.
Cognitive neuroscientists are using VR to develop innovative ways to assess cognitive decline, particularly in identifying age-related differences in spatial memory navigation. The study found significant impacts on memory performance due to the build-up of Alzheimer's proteins in the brain.
A new study from USC Dornsife's Brain and Creativity Institute found that nostalgic music engages the brain's default mode network linked to memory and self-reflection, as well as its reward circuitry. This discovery could support emotional well-being and cognitive function in individuals with memory impairments.
Research published in JAMA Network Open found that college graduates experienced faster cognitive decline after a stroke compared to those with less education. The study highlights the importance of identifying patients at high risk for post-stroke cognitive decline to target future interventions.
Groundbreaking research from the University of South Australia shows that any form of exercise can significantly boost brain function and memory across children, adults, and older adults. Regular exercise improves general cognition, memory, and executive function in both healthy individuals and those with clinical conditions.
Mass General Brigham researchers developed an olfactory test, where participants sniff odor labels on a card, to assess cognitive impairment. The test showed promise as a tool for identifying risk of cognitive decline and was found to be successful at home.
Researchers at WashU Medicine have found that rejuvenating the network of vessels outside the brain can improve memory in old mice. The study lays the groundwork for developing therapies to overcome the challenges faced by conventional medications, which struggle to reach the brain due to the blood-brain barrier.
Researchers at WVU have discovered a way to fine-tune zinc activity to improve messaging in the brain, with potential applications for treating conditions such as autism, schizophrenia and Alzheimer's disease. The study identified new compounds that can selectively change synaptic connections by modulating zinc levels.
Researchers have discovered a blood test that can identify patients with a sleep disorder who are most likely to develop Dementia with Lewy Bodies. The blood test analyzes two proteins in the blood associated with Alzheimer's disease and predicted dementia risk in almost 90% of patients, four years before symptoms appeared.
A recent study published in Molecular Psychiatry suggests that poor sleep quality among older adults disrupts the brain's glymphatic system, leading to memory decline. The research team found that deactivation of the restorative glymphatic system negatively impacts normal brain function and cognitive health.
A new brain-mapping technique identified memory-related brain cells vulnerable to protein buildup, a key factor in Alzheimer's disease. The study found that certain cell types in the hippocampus and cortex were more affected by tau buildup.
Researchers found that high-fat diets caused significant changes in the brains of aged rats, including inflammatory markers and impaired memory functions, even after only three days. The study suggests that aging and diet-related inflammation may be key factors contributing to age-related memory decline.
A study of nearly 900 postmenopausal women found an association between perimenopausal symptom burden and later cognitive function and behavioral impairment. Women with higher menopausal symptom burdens were more likely to experience poorer cognitive function and mild behavioral impairments, both markers of dementia.
Researchers discovered that females' dormant X chromosome reactivates in late life, expressing genes related to brain development and cognitive health. This phenomenon may explain why women outlive men and retain their cognitive abilities longer.
Research reveals nearly 10% of individuals with disabilities misused prescription drugs in the past year, compared to 4.4% without disabilities. Young adults and those with cognitive disabilities are particularly vulnerable to prescription drug misuse.
Studies have consistently shown that 40Hz gamma stimulation can improve cognitive function and reduce Alzheimer's pathology in mice. In human clinical trials, participants exposed to 40Hz light and sound experienced significant slowing of brain atrophy and improvements on some cognitive measures compared to untreated controls.
Research team develops novel method to exploit frictionless sliding for improved memory performance and energy efficiency. The new technology enables unprecedentedly efficient data read/write operations while consuming significantly less energy.
A study published in the Journal of Neurosurgery found that surgery can alleviate psychiatric distress and improve cognitive function in patients with Chiari Malformation type 1. Nearly 90% of patients showed improvements in cognitive function or psychiatric symptoms, with many reporting a significant reduction in brain fog.
Researchers found that a rare genetic syndrome causes different damage mechanisms in male and female brains, affecting neurogenesis and energy production. The study suggests that the ADNP protein plays a crucial role in brain development and aging, with distinct functions in males and females.
Kei Igarashi, a UC Irvine School of Medicine associate professor, has been awarded the Inoue Prize for Science for his discovery of brain mechanisms governing object memory and their deterioration in dementia. His work offers new hope for treating Alzheimer's disease by identifying potential targets for therapeutic intervention.
A study by University of Queensland researchers found nearly 70% of suspected frontotemporal dementia patients did not have the disease. Misinterpretation of brain scans and cognitive tests led to many incorrect diagnoses, highlighting the need for careful interpretation.
Researchers have uncovered a mitochondrial process that supports brain cells critical for learning, memory, and social recognition. The study reveals the critical role of the mitochondrial calcium uniporter in enabling neurons to strengthen connections through synaptic plasticity.