Articles tagged with Memory Disorders
Researchers mapped 1.65 million cells from 437 aging brains, identifying two distinct paths of cellular change that lead to either Alzheimer's disease or alternative brain aging. These findings offer new insights into the development of Alzheimer's and how it differs from healthy brain aging.
Researchers at Boston University created an AI tool that can determine the cause of dementia using commonly collected patient data, boosting doctor accuracy by 26%. The algorithm identifies 10 types of dementia, including vascular and frontotemporal dementia, to help doctors manage patients more effectively.
A team of neuroscientists at Stanford University discovered that blocking the kynurenine pathway can improve cognitive function in lab mice with Alzheimer’s disease. The study found that drugs that block this pathway improved glucose metabolism, corrected astrocytic performance, and enhanced spatial memory in the mice.
A Cornell University study finds that sleep resets vital brain function by silencing certain parts of the hippocampus, allowing neurons to reset and enable new learning. This mechanism could lead to breakthroughs in boosting memory and erasing negative memories in conditions like Alzheimer's disease and PTSD.
A team of researchers from Penn State has identified HDAC3 as a key contributor to age-related impairments in memory updating. When blocked, older mice performed similarly to their younger counterparts, suggesting potential therapeutic targets for improving cognitive flexibility in old age.
A UCLA researcher identified a compound that effectively jumpstarts the brain's memory circuitry, restoring cognitive functions in mice with Alzheimer's disease symptoms. The molecule, DDL-920, works by targeting specific neurons to enhance gamma oscillations, which are critical for memory and cognition.
A study published in Science Advances found that the quality of synapses, specifically dendritic spine head diameter, predicts episodic memory performance in older adults. Researchers suggest targeting pathways that maintain spine head diameter or synaptic strength may yield greater therapeutic benefits for Alzheimer's disease prevention.
Researchers found that dopamine treatment increased neprilysin levels and reduced beta-amyloid plaques in mouse brains, improving memory function. Long-term L-DOPA treatment also showed improved cognitive performance in mice.
Researchers at Mayo Clinic used AI to analyze electroencephalogram (EEG) tests, identifying subtle brain wave patterns characteristic of cognitive problems like Alzheimer's disease. This technology has the potential to provide healthcare professionals with a more accessible tool for early diagnosis in communities without easy access to...
A novel study finds that monitoring cortical microstructural change in the brain using diffusion weighted MRI scans may help identify individuals at risk for cognitive decline and Alzheimer's disease. Tracking these changes over time could provide precious time for disease-modifying treatments.
Viji Santhakumar, a UCR professor, has been awarded a $3.5 million NIH grant to study brain circuit function and its impact on memory formation and cognitive deficits in diseases like epilepsy and Alzheimer's disease.
α-Synuclein pathology in asymptomatic stages is linked to NBM atrophy, leading to attention/executive impairment. MRI signatures can detect this pathology in memory clinic populations.
Scientists successfully mapped transcriptomes from 1.3 million brain cortex cells to gain molecular insights into Alzheimer's vulnerability and resilience. The resulting atlas holds promise for gene and molecular discovery across pathways affecting brain health.
A recent study published in BMC Psychology found that mild COVID-19 patients experienced significant cognitive impairment, with 11.7% showing memory loss and attention deficits. The study suggests that neuroinflammation due to SARS-CoV-2 infection may be a contributing factor to these long-term effects.
Mayo Clinic scientists have established criteria for a memory-loss syndrome in older adults that specifically impacts the brain's limbic system. The syndrome, called Limbic-predominant Amnestic Neurodegenerative Syndrome (LANS), progresses more slowly and has a better prognosis than Alzheimer's disease.
Researchers created a new cortical surface template called 'OpenNeuro Average' that provides greater accuracy and efficiency in analyzing neuroimaging data. The template is based on the geometric shape of the brain and can be used for studies on cognition, clinical neuroscience, autism, and neurodegenerative diseases.
A six-year longitudinal study found that loneliness has a significant impact on memory, even when social isolation is not present. The research suggests that community programs are needed for older adults who are both socially isolated and lonely, as they face the highest risk of memory impairment.
A study published in The Journal of Neuroscience found that blocking a protein called Activin A can halt dyskinesia symptoms and effectively erase the brain's 'bad memory' response to certain Parkinson's treatments. This could lead to longer-term use of L-DOPA for patients.
A new study published in Nature Communications found that smoking is a key lifestyle factor contributing to cognitive decline among older adults. Non-smokers who engaged in healthy behaviors such as regular exercise, moderate alcohol consumption, and social activity experienced significantly slower cognitive decline compared to smokers.
Researchers have discovered a new diagnostic method for PSP by analyzing protein biomarkers in spinal fluid, which could lead to earlier diagnosis and targeted therapies. The high-throughput technology allows for the measurement of thousands of proteins in a tiny drop of fluid, providing a promising solution for identifying the condition.
Researchers at the University of Birmingham found that people are aware when their brain is filling in gaps with generic information, enabling them to factor in this knowledge when assessing memory accuracy. The study suggests individuals can recognize prototypical memories and distinguish them from accurate ones.
A pilot study found that remote cognitive rehabilitation using TELE-Self-GEN improved memory performance and daily life functionality in individuals with MS. The virtual intervention demonstrated high levels of participant satisfaction and effectiveness.
Researchers have found that the serotonin 2C receptor plays a crucial role in regulating memory in both mice and humans. The study discovered that non-functional mutations of the receptor are associated with memory deficits in humans, and that administering a serotonin analog can improve memory in animal models of Alzheimer's disease.
Researchers identified changes in gene activity underlying cognitive decline in older nematode C. elegans, providing evidence for neuroprotective genes that may preserve cognition later in life. Reducing expression of certain genes improved memory performance in aged animals.
A new study by Dr. Peter Lichtenberg and his team found that early memory loss is linked to excess spending in older adults. The WALLET Study analyzed bank statements to identify financial behaviors associated with excess spending, providing valuable insights into the intersection of financial risk and cognitive decline.
Researchers at MD Anderson Cancer Center have identified a small molecule compound that restores physiological levels of telomerase reverse transcriptase (TERT), reducing cellular senescence and tissue inflammation. TERT restoration also spurred new neuron formation with improved memory and enhanced neuromuscular function.
Researchers at OIST have discovered a novel treatment that effectively reverses the symptoms of Alzheimer's disease in mice. The treatment, PHDP5, targets the dynamin-microtubule interaction and restores communication between neurons inside synapses.
A randomized controlled trial at Ohio State University Wexner Medical Center found that using the SAGE test during routine appointments led to a sixfold increase in early diagnoses. The study demonstrated the effectiveness of this simple, self-administered tool for detecting cognitive impairment.
A recent study revealed that the brain uses a similar neural mechanism to store faces of familiar individuals as it does to remember the value of objects. The striatum tail plays a critical role in this process, responding strongly to familiar faces and weakly to unfamiliar ones.
A recent study by Mass General Brigham researchers found that adults with a family history of Alzheimer's disease on their mother's side had higher amyloid levels in their brains. This suggests that maternal inheritance may play a role in identifying individuals at heightened risk for developing the disease.
A study found that neural balance, measured by the E/I ratio, is associated with brain maturity and better cognitive ability. Research suggests that as children develop, their E/I ratios decrease, leading to improved performance in cognitive tests.
A new study published in JAMA Network Open found that depressive symptoms are linked to subsequent memory decline in older people, and conversely, poorer memory is associated with an increase in depressive symptoms. The researchers suggest that addressing depressive symptoms may help slow down memory decline.
Scientists at Okinawa Institute of Science and Technology identify a positive glutamate-NO-glutamate feedback loop that blocks long-term potentiation and impairs learning and memory. The study suggests that this loop may explain memory loss in stroke patients and potentially offer a solution for treatment.
A new study from Karolinska Institutet found that stress weakens the association between cognitive reserve and improved cognition in memory clinic patients. Cognitive reserve is built through experiences like higher education and social interactions, but high or persistent stress levels can impair these benefits.
A new study finds that individuals with cognitive declines before an Alzheimer's diagnosis experience a significant increase in credit card and mortgage delinquencies. The research, led by Georgetown University, shows that financial outcomes deteriorate consistently over the quarters leading up to diagnosis.
Researchers found that increasing astrocytic mGluR3 levels enhanced memory in older females, while reducing these levels impaired memory in young females. In males, reducing mGluR3 enhanced memory, and increasing the receptor had no effects.
Researchers from Mass General Brigham found that reports of cognitive decline were associated with the accumulation of tau, a hallmark of Alzheimer's disease. The study used imaging to detect levels of tau and amyloid beta in participants who were cognitively unimpaired but at risk for Alzheimer's.
Research from McMaster University found that orienteering exercise can improve spatial memory and delay cognitive decline. Those who ran while orienteering showed greater benefits than those who walked or exercised without navigation. The study suggests that orienteering could be a preventative measure for age-related cognitive decline.
A new study published in Neurology found that people who eat more ultra-processed foods are at a higher risk of developing memory and thinking problems and having a stroke. The study associated increased consumption of ultra-processed foods with a higher risk of cognitive impairment and stroke, particularly among Black participants.
A new study followed 283 older adults with no memory or thinking problems to examine the factors leading to stopping driving. The research found that female participants were more likely to stop driving than male participants, as well as those who developed cognitive impairment and performed worse on cognitive tests.
Researchers found that exercise increased neuron growth in the hippocampus, rewiring neural circuits to help mice forget strong, traumatic memories. This approach may offer new treatments for PTSD and drug addiction.
Judges and physicians hold vastly different opinions on appointing legal guardians for people with dementia. Cognitive and neuropsychiatric symptoms, such as memory impairment and impulsivity, are evaluated differently by medical and legal professionals. Research emphasizes the need for consistency in assessments to ensure equal treatm...
Researchers found that repetitive practice leads to changes in working memory circuits, making them more stable and refined. The study's findings have implications for addressing memory-related disorders.
Researchers at UCLA Health discovered a novel, energy-efficient mechanism of working memory that reduces metabolic cost even during sleep. The discovery is published in Nature Communications and may provide an early diagnostic for Alzheimer's disease and related dementia.
The study suggests that memory plays a pivotal role in shaping consciousness, contrasting the idea that computer-based Information Theory provides a sufficient framework for understanding neural memory. The researchers propose a novel perspective that memory underpins consciousness, introducing the concept of a "brain cloud" to illustr...
Researchers found that ketogenic diets reduced plasma levels of total Tau in females, mitigated elevations in plasma lipids, and improved circulating lipids. However, neither continuous nor intermittent ketogenic diets improved measures of cognitive or motor behavior in the TgF344-AD rat model.
Researchers investigate how early-stage Alzheimer's disease affects memory formation by examining synaptic connections and amyloid beta. The study aims to understand the role of NMDA receptors in synaptic plasticity and how they might be hijacked by amyloid beta, leading to memory dysfunction.
Researchers found that geraniol reduces oxidative stress and neuroinflammation-mediated cognitive impairment in a mouse aging model. Geraniol treatment improved spatial learning and memory by enhancing anti-oxidant and anti-inflammatory effects.
A new platform called TurboID has been developed to identify regulatory mechanisms driving dendritic translation, a process crucial for memory formation. The study reveals the role of micropeptides in protein synthesis and their potential link to intellectual disabilities like Fragile X syndrome.
A study published in Brain, Behavior, and Immunity found that normal levels of interferon-β are required for normal memory function, and its absence changes nerve cell components in a sex-dependent fashion. The research also showed that higher or lower than normal levels of interferon-β affect the brain in a sex-dependent manner.
A blended antioxidant supplement improved spatial learning ability and short-term memory in supplement-treated aged mice. The discovery suggests that the supplements may also prevent age-related cognitive decline in humans and mitigate muscle frailty.
Researchers developed an app to detect mild cognitive impairment, a potential indicator of Alzheimer's disease. The study used data from 199 older adults and found that the app detected MCI with high accuracy, comparable to in-clinic assessments.
Researchers have identified two sex-specific blood biomarkers linked to faster memory decline in middle age, specifically higher HbA1c and plasma insulin levels in women. The findings provide valuable insights into the etiology of dementia and may aid in the development of prevention and treatment strategies.
Researchers have identified PDE4B as a potential target for treating Alzheimer's disease, where reducing its activity shows promise in improving memory and glucose metabolism. The study suggests that this approach may also protect against other forms of dementia, such as Huntington's disease.
A new study found that a viral infection can cause cognitive impairments by damaging the blood-brain barrier, leading to memory loss and learning difficulties. Researchers developed a gene therapy that stimulated the Wnt/beta-catenin pathway to prevent this damage and improve cognitive function in mice infected with SARS-CoV-2.
A ketogenic diet significantly delays early stages of Alzheimer's-related memory loss in mice, according to a new study published in Communications Biology. The molecule beta-hydroxybutyrate (BHB) is found to play a pivotal role in preventing this decline, improving synaptic function and memory formation.
Aging brains exhibit reduced selectivity for both category and individual items, suggesting multiple mechanisms drive age-related neural dedifferentiation. This finding may lead to a reevaluation of age-related neural processes and their relationship with memory performance.
Researchers used single-cell RNA sequencing to analyze the effects of APC treatment on AD transgenic mice, revealing alterations in glial cells and upregulated genes associated with AD progression. APC treatment downregulates inflammatory processes and recovers nervous system functions.
A recent study by Boston Children's Hospital researchers found that activity in the dentate gyrus helps keep us focused on our environment when our mind wanders. This neural activity also aids in forming memories.
The Federation of European Neuroscience Societies is open to media registration for its 2024 event. Journalists can access the latest research discoveries in neuroscience fields such as dementia, addiction and depression.