About The Study: In this unblinded randomized clinical trial, prothrombin complex concentrate had superior hemostatic efficacy and safety advantages to frozen plasma among patients requiring coagulation factor replacement for bleeding during cardiac surgery.
Corresponding Author: To contact the corresponding author, Keyvan Karkouti, MD, email keyvan.karkouti@uhn.ca .
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(doi:10.1001/jama.2025.3501)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Media advisory: This study is being presented at the American College of Cardiology’s Annual Scientific Session.
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