About The Study: Using metformin plus insulin to treat preexisting type 2 or gestational diabetes diagnosed early in pregnancy did not reduce a composite neonatal adverse outcome in a randomized clinical trial of 794 pregnant adults. The effect of reduction in odds of a large-for-gestational-age infant observed after adding metformin to insulin warrants further investigation.
Authors: Kim A. Boggess, M.D., of the University of North Carolina at Chapel Hill, is the corresponding author.
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(doi:10.1001/jama.2023.22949)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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