Research examines data from multiple studies to better understand how obesity impacts kidney transplant patients. Obese patients experience more adverse outcomes, including wound infections and cardiac disease, leading to poorer health outcomes after surgery.
A large, randomized trial found that angiotensin II blockade did not lessen tissue scarring or prevent kidney failure in kidney transplant recipients. The treatment was safe and well-tolerated but showed no benefit in slowing disease progression.
Retaining certain compounds normally excreted by the kidneys can cause insulin resistance in kidney disease patients. Treating mice with a prebiotic reduces these compound levels, preventing insulin resistance and related lipid abnormalities.
A new study found that six months of steroid treatment didn't reduce relapse rates or side effects in children with nephrotic syndrome, challenging previous assumptions about optimal treatment strategies. The research highlights the need for new treatment strategies to prevent frequent relapses in this disease.
Blocking the endothelin receptor reduces cardiovascular risk factors in patients with chronic kidney disease independent of blood pressure. The findings suggest that blocking the receptor may provide heart-related benefits to these patients, who have a higher risk of developing heart problems due to their condition.
A study found that disordered mineral metabolism worsens with progressive chronic kidney disease and is linked to a higher risk of kidney failure among African Americans. Measuring mineral metabolites may be a useful way to determine CKD patient prognosis, while targeting these metabolites could help slow disease progression.
The most severe form of acute kidney injury has seen a significant increase in incidence rates, with deaths associated with the condition also rising. The study highlights the need for further research into the causes behind this trend and potential interventions to reduce its impact.
A study published by UCSF found that acute kidney injuries have doubled over the last decade, from 222 to 533 cases per million people. The total number of deaths associated with acute kidney injury also more than doubled during this time, from 18,000 in 2000 to nearly 39,000 in 2009.
African Americans experience faster progression of chronic kidney disease in later stages compared to other races. Screening for microalbuminuria is cost-effective for African Americans with diabetes or hypertension, improving care and reducing kidney failure risk.
A study found that open heart surgery is safer than angioplasty for dialysis patients with blocked arteries surrounding the heart, with five-year survival rates over 90% without kidney disease but dismal in kidney failure patients. Heart disease is a leading cause of death in kidney failure patients, affecting 30-60%.
A new study reveals that even low levels of preformed donor-specific antibodies can nearly double the risk of antibody-mediated rejection and increase kidney failure by 76%. This finding could help clinicians provide better donor-recipient matches and tailor immunosuppressive therapy.
Recent studies suggest that hypertension and diabetes are more prevalent in black versus white donors, but the risk attributable to donation remains unknown. Individuals with prediabetes can safely donate kidneys without increasing their risk of developing diabetes or kidney failure.
Researchers found that adding fruits and vegetables can reduce metabolic acidosis and preserve kidney function in CKD patients. Poor dietary habits and poverty are also linked to an increased risk of kidney disease, highlighting the need for targeted interventions to address disparities in care.
Researchers have successfully created functional 'organoids' that can carry out kidney functions when implanted into rats. The breakthrough could lead to more options for individuals with kidney failure and better tools for understanding and treating complex kidney diseases.
Researchers have identified a new therapeutic target for diabetic nephropathy, the leading cause of kidney failure, by activating liver x receptor (LXR) to inhibit osteopontin expression. Activation of LXR with a drug named T0901317 improves kidney health and function in diabetic mice.
A study reveals that kidney failure patients have less of the sugar coating on their blood vessels, leading to high levels of its constituents in the blood. This damage may contribute to their increased risk of heart problems.
A single gene variant in donors has been linked to a 69% increased risk for long-term failure of transplanted kidneys. The variant affects the expression of the protein that pumps drugs out of cells, which can be toxic to the kidneys.
Home hemodialysis could enable patients to increase their dialysis frequency, potentially providing a survival benefit. Increased physician and patient education can eliminate barriers to its adoption.
A study found that nearly half of Canadians view financial incentives for deceased kidney donation as acceptable. Lower-income individuals were not more likely to donate for financial gain, according to the researchers. The study suggests that financial incentives may increase donations from both living and deceased donors.
The American Society of Nephrology has identified five recommendations for reducing unnecessary medical interventions, including avoiding routine cancer screening and administering erythropoiesis stimulating agents in chronic kidney disease patients. By implementing these guidelines, healthcare costs can be lowered and patient care imp...
Researchers have identified a simple blood test that accurately detects autoimmune kidney disease and predicts patient outcomes. The test measures antiPLA2R autoantibodies, which are associated with disease severity and remission rates.
A new test can measure an individual's propensity for calcification in their blood, identifying those at increased risk of vascular calcification and potential heart disease. The test may also provide a basis for treatment monitoring in patients who receive calcification inhibitors.
A new study found that patients with common kidney disease IgA nephropathy who have normal kidney function and only minor urinary abnormalities at diagnosis experience remission without special treatments. No patients developed kidney failure over a 20-year follow-up, indicating an excellent prognosis.
A study found that even in the normal range, urinary protein excretion increases diabetics' heart risks. Patients may benefit from cardioprotective medications to mitigate this risk.
A recent study found that waiting to treat cytomegalovirus infections in transplant recipients until they reach a certain threshold is more beneficial than prophylactically treating all recipients. This approach led to less kidney scaring and better long-term organ survival among patients.
A study estimates that approximately 1 in 93 men and 1 in 133 women of middle age may develop kidney failure in their lifetime. People with reduced kidney function face a higher risk, with men facing a 7.51% chance and women a 3.21%.
Cefazolin outperforms vancomycin in preventing hospitalizations and deaths from specific bloodstream infections, a study reveals. The antibiotic was found to be 48% more effective at preventing sepsis.
Researchers found that abnormal proteins and antibodies in blood levels increase according to disease severity. High antibody levels are associated with higher risk of kidney failure and premature death.
Patients under 35 years old and those without private health insurance are more likely to be overlooked when starting dialysis, according to a recent study. The findings highlight the need to address racial and socioeconomic disparities in kidney transplantation.
A study found that rituximab, an immune drug, helped patients with serious kidney disorder idiopathic membranous nephropathy experience remission, even when standard therapies failed. The treatment was safe and well-tolerated, with all patients achieving complete or partial remission over time.
A recent study has questioned the safety and effectiveness of commonly prescribed kidney disease drugs, which may cause unexpected harm to blood vessels. The study found that these drugs did not substantially reduce serum phosphorus levels and may be associated with cardiovascular problems in patients with chronic kidney disease.
Homeless individuals with chronic kidney disease are more likely to develop depression, substance abuse, and kidney failure. They also overuse emergency medical services, leading to increased public costs. Research highlights the need for better healthcare access and support services for homeless patients.
Dr. Rebecca Ruebner's study found that end-stage kidney disease is relatively uncommon in children after liver transplantation, occurring in 2% of patients. However, children who develop end-stage kidney disease have a high mortality rate, highlighting the importance of closely following them for early signs of kidney disease.
A low-carbohydrate high-protein diet has been found to be safe for healthy obese patients' kidney function and fluid balance, unlike a low-fat diet. However, additional studies are needed to evaluate its effects in individuals with pre-existing kidney disease or other health conditions.
A recent study suggests that peritonitis, a common infection in dialysis patients on peritoneal dialysis, may be linked to premature death. Researchers found that patients were more likely to develop peritonitis during the final month before their death, and even six times more so during the 30 days prior to their death.
Obese patients have an increased risk of developing kidney damage, or acute kidney injury, after heart surgery. Oxidative stress associated with obesity plays a role in this increased risk. Acute kidney injury affects 5% to 30% of heart surgery patients.
A minimally invasive procedure called renal denervation disrupts overactive sympathetic nerves, lowering blood pressure in CKD patients with hypertension. The study found no worsening of kidney function, indicating the procedure is safe for those with CKD.
A study found that off-pump coronary artery bypass surgery is likely safer than on-pump surgery for chronic kidney disease patients, cutting down on kidney injuries after heart surgery. CKD patients undergoing on-pump surgery were more than three times as likely to die or need dialysis compared to those who received off-pump surgery.
Children with idiopathic nephrotic syndrome (INS) who do not respond to standard treatments may not benefit from rituximab, according to a recent study. The drug, which targets the immune system, was found to be ineffective in reducing protein excretion in urine after three months of treatment.
A study by the American Society of Nephrology found that hemodiafiltration, a technique to remove additional toxins during dialysis, does not improve patient survival or heart health. However, intense treatments may provide some benefits, particularly for patients who receive higher doses of treatment.
A US policy instituted in 2005 has reduced racial disparities in kidney transplantation among children, allowing more kids from diverse backgrounds to receive deceased donor kidneys. The study found that Share 35 has attenuated racial disparities in terms of how likely and how soon children will receive a deceased-donor kidney transplant.
A study found that information on a mandatory Medicare form regarding kidney disease patients' care doesn't accurately reflect the actual care billed by physicians. The report's accuracy varies by patient characteristics and declines over time, emphasizing the need for improved reporting to ensure public health surveillance and planning.
A new study found that 84% of female dialysis patients experienced sexual problems, which are often overlooked by clinicians. The study also highlighted the impact of various factors such as age, education level, and presence of depression on sexual dysfunction in these patients.
A study found that dialysis patients with deteriorating mental health have a higher risk of developing heart problems and dying prematurely. The research suggests that addressing kidney disease patients' mental health may help prevent heart complications and even death.
A recent study by John Gill and colleagues found that the age of a live donor between 18 to 64 years has minimal effect on the survival of transplanted kidneys. This finding suggests that patients over 39 years old may benefit from participating in living donor paired exchange programs or kidney swaps.
Patients with kidney failure have relatively poor physical health. Frequent dialysis does not significantly improve their overall physical capacity compared to conventional dialysis, but it can provide improved quality of life.
A study published by the American Society of Nephrology found that 10% of patients with chronic kidney disease did not experience progressive kidney dysfunction, and 3% demonstrated improved kidney function. The study suggests that some cases of CKD may be reversible, providing hope for patients with this condition.
Most Medicare beneficiaries with kidney failure (64%) participate in Part D coverage, with 72% receiving financial assistance. Those without assistance often opt for more expensive plans due to the need for intensive medication therapy.
A study published by the American Society of Nephrology found that weight-loss surgery is safe for chronic kidney disease patients who are obese, with complication rates below 10%. Maintaining weight loss remains challenging for CKD patients due to limited exercise abilities and eligibility restrictions for kidney transplants.
Researchers identified biomarkers in blood and urine that predict which patients with acute kidney injury (AKI) following heart surgery will experience worsening kidney function. Testing for these markers soon after surgery may help protect patients' kidneys.
Research suggests that daily or nightly dialysis sessions at home or in the clinic may provide more benefits for some patients with kidney failure, improving their health and survival. However, additional research is needed to determine if extended or more frequent treatments are beneficial for all dialysis patients.
A study published in the Clinical Journal of the American Society Nephrology found that adding information on how to treat chronic kidney disease (CKD) patients to kidney test results did not improve care. The study included 22,092 patients with CKD and found no difference in the use of recommended medications between those who receive...
A new study found that patient education classes can improve access to kidney transplant evaluations for blacks and patients living in poor neighborhoods. After implementing a required educational session, 80.4% of patients completed an evaluation within one year, compared to 44.7% before the program.
Researchers at Baylor College of Medicine discover that ROCK1 protein activates mitochondrial fission, leading to diabetic kidney disease. The study reveals a key metabolic pathway involved in the progression of kidney disease in diabetes.
Home-based dialysis treatments for kidney failure are gaining popularity worldwide, particularly in developing countries. The study found a significant increase in peritoneal dialysis patients in these regions, driven by lower costs and easier access to care.
A new study found that patients who quickly stop taking immunosuppressive prednisone after receiving a kidney transplant avoid experiencing serious prednisone-related side effects. The study also showed that rapid discontinuation of prednisone does not jeopardize the long-term survival of patients and their new organs.
A rare kidney disease study reveals how sodium and potassium levels are moderated in the body, shedding light on hypertension and familial high blood pressure disease. Researchers identified novel mutations linked to increased sodium activity and decreased potassium activity, providing a better understanding of this inherited condition.
Upper GI bleeding is common and serious in dialysis patients, with rates 10 times higher than in the general population. The condition can lead to early deaths and substantial negative effects on kidney function.
The FDA has revised labeling guidelines for erythropoiesis-stimulating agent (ESA) drugs in chronic kidney disease patients. These updates aim to minimize the risk of heart-related problems, but critics argue that they may be too conservative and not tailored to individual patient needs.
High levels of TNF receptors in the blood increase diabetes patients' risk of developing kidney problems by three- to five-fold. Measuring blood levels of TNF receptors may help predict which patients' kidneys are in jeopardy, and targeting TNF receptors may help protect them.