The UT Southwestern-based collaboration aims to speed the transfer of laboratory discoveries to new therapies that improve human health. The initiative will carry out several key functions, including improved design of clinical research studies and expanding outreach efforts to medically underserved communities.
The Johns Hopkins Institute for Clinical and Translational Research (ICTR) aims to speed up the translation of promising research from labs to clinics and eventually to communities. The ICTR will support over 100 faculty members across various schools, enabling them to form relationships with outside organizations and partner with heal...
The NIH is expanding its national clinical and translational research consortium, adding 12 new academic health centers to the existing network. This expansion aims to facilitate collaboration and accelerate the translation of research into real-world treatments.
A new initiative aims to better understand and enhance patient participation in clinical trials. Researchers will use socio-psychological approaches to identify factors influencing patients' decisions to participate. The project has the potential to increase patient accrual rates, leading to faster development of novel treatments.
Dr. Susana Martinez-Conde and her team will record neural activity in the brain's visual areas to understand why images appear stable during fixation. They aim to determine at what level of the brain visual perception becomes stable, shedding light on this critical aspect of our visual experience.
The NCRR has launched a Translational Research Network to facilitate multi-site clinical and translational research among minority institutions. The network will enable researchers to pool resources and expertise, increasing the productivity and impact of individual centers.
Internal medicine faculty report that reduced resident duty hours worsen aspects of patient care, education, and professionalism, while improving residents' well-being. Key clinical faculty also express concerns about increased workload, burnout, and decreased autonomy for residents.
T. Andrew Burrow, MD of Cincinnati Children's Hospital Medical Center received the $75,000 grant to support training of clinicians in biochemical genetics. The award aims to recruit and train physicians in clinical biochemical genetics for metabolic diseases diagnosis and treatment.
A Barrow researcher has received a $120,000 grant to study flicker fusion and its impact on people with epilepsy. The goal is to develop safe brain products that can make artificial lighting appear stable to the brain.
A novel mutation in regulatory protein tropomyosin is associated with muscle weakness and distal limb deformities. The mutation modulates contractile speed and force-generation capacity by affecting myosin-actin kinetics.
The International Committee of Medical Journal Editors (ICMJE) has updated its policy to align with the World Health Organization's Clinical Trials Platform. The revised policy now requires registration in a primary registry that participates in the WHO ICTRP for all trials beginning enrollment on or after July 1, 2008.
A new survey by Duke University Medical Center and Johns Hopkins University found that 41% of clinical trial coordinators have experience disclosing financial conflicts of interest, but many feel uncomfortable doing so. The researchers suggest that additional education and training are needed to address these concerns.
A retrospective analysis found patients taking risedronate (Actonel) had a lower incidence of hip fractures compared to those taking alendronate. The REAL study used a health service utilization database and provided valuable insights into the clinical effectiveness of these osteoporosis treatments.
A University of Missouri study found that negative news stories about clinical trials deter people from participating in medical research. The study analyzed 216 New York Times and 124 Washington Post articles, revealing a significant correlation between negative coverage and decreased willingness to participate.
The NIAID has selected 60 U.S. and international institutions as HIV/AIDS Clinical Trials Units (CTUs) to conduct next-generation research on vaccines, prevention, and treatment. The CTUs will work together with clinical research networks to tackle critical research questions and accelerate progress against the HIV/AIDS pandemic.
The National Institutes of Health has awarded grants to University Hospitals Case Medical Center for expanded HIV treatment development and pioneering advances in Microbicides Trials Network. This includes immunology laboratory funding at Case Western Reserve University School of Medicine and clinical trial research sites in Uganda.
The exclusivity of clinical trial data could jeopardize efforts to create generic versions of life-saving medicines, harming public health. Karin Timmermans warns that data exclusivity can delay generic competition and drive up prices.
A trial comparison found that COX-2 inhibitors like etoricoxib are associated with fewer upper gastrointestinal clinical events in patients with arthritis, compared to traditional NSAIDs like diclofenac. The study suggests that COX-2 inhibitors may be a safer alternative for pain management.
A new NIH-funded program co-directed by the Mailman School faculty will expedite clinical research, transforming how medical discovery is made. The center will centralize core resources for clinical researchers and enhance collaboration among scientific communities.
A new model language has been developed to guide clinical researchers in properly disclosing their financial interests in research, providing guidance on risks and benefits to participants. The language includes specific wording for various types of financial interests, aiming to minimize potential risks to research subjects.
Researchers found that different parts of the brain are activated depending on the cause of itching, with allergen-induced itches activating the supplementary motor and posterior parietal areas. Histamine-induced itches, on the other hand, activate a smaller area of the brain, suggesting a compulsion to scratch in those cases.
A study found that elderly women, those with public health insurance, and those who don't visit obstetricians regularly are less likely to receive clinical breast exams and mammogram recommendations. Regular clinical breast exams can detect breast cancer at an early stage, making them comparable to yearly mammograms.
The Parkinson Study Group has received a $200,000 grant from the Parkinson's Disease Foundation to fund innovative programs supporting clinical research. The grant will support retrospective data-mining projects and mentorship for young researchers, aiming to accelerate treatment development.
Researchers tracked brain activity in rats while they tasted water, salt water, and sugar water, finding that a formerly disliked taste became pleasurable when the rats were deprived of salt. This study provides new insights into how the brain processes pleasure and has implications for understanding eating disorders and addiction.
The NIH will provide $54 million over five years to Columbia University Medical Center to establish an Irving Institute for Clinical and Translational Research. This investment will enable the expansion of core resources available to clinical researchers, including biomedical informatics support and biostatistical analysis.
Rockefeller University has been awarded a Clinical and Translational Science Award (CTSA) of over $45 million to enhance its infrastructure for translating scientific discoveries into improved health. The award will support translational researchers and train physician-scientists in clinical research.
The NIH has launched a national consortium to transform clinical research, enabling the development of new treatments more efficiently and quickly. The initiative aims to improve medical care by applying scientific advances to real-world practice, particularly in underserved populations.
The University of Pittsburgh is awarded a $83.5 million NIH grant to establish the Clinical and Translational Science Institute (CTSI), aiming to transform clinical research and improve patient care. The CTSI will foster clinical and translational research, promote access to clinical trials, and develop novel methodologies.
A recent study published in the Journal of Clinical Pharmacology found that short duration of depressive symptoms in teens can make it difficult to distinguish between actual treatment efficacy and placebo effects. This design issue may lead to unnecessary long-term drug therapy for some children, as those who recover quickly from depr...
Researchers found different types of immune response in children with varying levels of infection, including pro-inflammatory and regulatory responses. These findings may help design vaccines to prevent trachoma infection.
Researchers at UC Irvine discovered that a class of drugs called ampakines can reverse age-related memory loss by increasing the production of a naturally occurring protein in the brain. The study showed that even after the drug left the body, its effects on memory formation persisted.
The University of Edinburgh's Wellcome Trust Clinical Research Facility will establish a national database for clinical research training opportunities across Scotland. This initiative aims to enhance the skills of NHS Scotland healthcare teams, particularly those involved in primary care.
The National Institute of Allergy and Infectious Diseases (NIAID) has announced the leadership for its newly restructured HIV/AIDS clinical trials networks. The six networks will focus on high-priority research areas, including developing an effective HIV vaccine and conducting translational research for new drug development.
A study of 23 clinical trials found that weight loss can predict a significant reduction in physical disability in patients with knee osteoarthritis. The research suggests that achieving a moderate weight loss of over 7.6% can lead to at least a moderate clinical effect on physical disability.
Researchers found that the septum can induce rhythmical electrical activity in the hippocampus, reducing epileptic seizures by 86-97 percent. The study suggests a new approach to stopping epilepsy, focusing on inducing theta rhythm generation.
New research suggests targeting affected nerves and spinal cords may provide relief from chronic neuropathic pain. The study found changes in spinal cord neurons after sciatic nerve constriction injury, but the exact mechanisms remain unclear.
The 'brain-chip' from Martinsried allows biophysicists to visualize the influence of pharmaceutical compounds on neural networks. This breakthrough enables a novel test system for brain and drug research, advancing neurochip prosthetics and neurocomputation.
Researchers found that Ritalin increases norepinephrine and suppresses sensory responses in the brain, allowing individuals to focus better. The study provides insights into how the drug produces its paradoxical effects and may lead to more effective treatments for ADHD.
A new analysis of ACT trials found that UC patients in clinical remission had significantly higher rates of employment compared to those not in remission. Patients treated with REMICADE experienced a greater percentage of being employed at weeks 30 and 54, with 20.6% vs 8.3% for non-remitted patients.
The new open-access journal aims to increase the accuracy and completeness of evidence available for clinical decision-making. All randomized trials are rigorously peer-reviewed and reported accurately, regardless of outcome.
A study analyzing NINDS-supported clinical trials found a 4600% return on investment and estimated benefits of over $50 billion. The studies improved health outcomes and saved lives, with some trials showing benefits of over $6 billion.
Renowned clinicians call for collaborative effort to revive clinical pharmacology in the UK. The Lancet experts advocate for joint action by medical schools, government bodies, and industry partners to bolster this crucial field.
Researchers at Cedars-Sinai Medical Center have identified the potential benefits of Raloxifene in treating advanced prostate cancer. The study showed that Raloxifene can slow or stop the growth of prostate cancer, offering new hope for patients with androgen-independent disease.
Two Stanford University neurologists warn that clinical trials can be disastrous when a drug with unknown side effects is tested on healthy patients. They advocate for stricter entry criteria to prevent similar mistakes in the future.
Journal of Clinical Densitometry will be published by Elsevier, offering print and electronic publishing services. Members of the International Society for Clinical Densitometry will continue to receive the print edition, and online access will be available through a dedicated website.
Researchers found that sleep-restricted rats showed reduced neurogenesis in the hippocampus after learning a spatial task. However, those who used visual and odor cues to navigate had better performance on the task, suggesting an adaptive strategy to compensate for lack of sleep.
A new clinical trials method is proposed to improve patient care by incorporating Bayesian approaches in trial design. The frequentist statistical method used today is considered too rigid and limits innovation, whereas the Bayesian approach allows for continuous updating based on interim results.
The Fluarix clinical study demonstrated the vaccine's ability to induce protective antibodies, making it a promising tool in bolstering flu vaccine supply. The successful collaboration between academia, industry, and government agencies enabled the rapid development of the vaccine.
A study found that informational campaigns alone may not be enough to increase participation in cancer clinical trials among black and Asian American patients. Lack of awareness about trial costs being covered by insurance is a significant barrier to participation, especially among those with lower incomes and education levels.
A study of lung cancer patients found that those who did not participate in clinical trials were more likely to be African American, female, or over 70. The researchers suggest targeting specific patient subgroups to improve representation in clinical trials.
Long-term Phase 3 data from ACT 1 and ACT 2 trials demonstrate REMICADE's efficacy in achieving clinical response, clinical remission, and mucosal healing in UC patients. Approximately two-thirds of patients treated with REMICADE achieved the primary endpoint of clinical response.
A systematic review of randomized controlled trials and meta-analysis found that melatonin reduced the risk of death at one year by 34%. Melatonin was also shown to have a beneficial effect on sleep patterns in patients. The researchers urge caution in interpreting the clinical usefulness of large doses of melatonin.
Patients with active psoriatic arthritis treated with REMICADE experienced a high degree of sustained clinical improvement in arthritis, including significant reduction in structural damage. The treatment also showed sustained improvement in functional status and quality of life, as measured by the Short Form 36 questionnaire.
The new Clinical Trials Directive has led to differences in the scope of revised legislations across EU member states, with only a few adding provisions for non-commercial trials. The directive also simplifies the conduct of academic clinical trials but poses challenges for future pan-European multi-centre studies.
A clinical trial alert system significantly increased physicians' participation in patient recruitment, doubling the enrollment rate from 2.9 to 6.0 participants per month. The system alerted physicians about ongoing trials when a patient's records met selected criteria, leading to a 10-fold increase in referrals.
The NIH Clinical and Translational Science Awards (CTSAs) program aims to energize clinical and translational science at academic health centers nationwide. The program will foster collaborative approaches, encourage creative research methods, and lead to better patient outcomes through new prevention strategies and treatments.
The university will use the grant to enhance its Clinical Scholars Program, which supports young investigators in a three-year educational and training program. The initiative aims to create an environment for career development of young faculty in clinical research.
A recent brain navigation study found that rats use the medial mammillary nucleus to solve navigational problems, which may be similar to how humans think. The study suggests that a sense of direction is crucial for spatial awareness and athletic performance.
The NHLBI-funded program aims to translate knowledge into clinical practice for treating heart, lung, and blood diseases. It focuses on repairing damaged heart muscle, reducing immune complications, and enhancing adult stem cell interactions.
The study reported a 10.6% rate of stent-related MACE for the control Tecnic group, while the Janus group had a 6.4% rate, with a significant reduction in TLR, and no stent thrombosis occurred