Studies found that sit-down rounds significantly improved patient outcomes, including healthy levels of albumin and hemoglobin, lower hospitalization rates, and reduced mortality. Patients treated at clinics with regular sit-down rounds had better care team communication and were more likely to be white, married, or high school graduates.
A new global approach aims to combat the growing threat of kidney disease by promoting early detection and proper care. This strategy has been shown to be effective in treating kidney disease, particularly when combined with evidence-based guidelines and actual clinical practice.
A new study suggests that iron therapy given to patients with kidney disease may have negative side effects, including exacerbating progressive renal damage. The study found that the level of toxicity depends on the type of iron formula used, highlighting a need for safer alternatives in treatment.
Researchers at SLU School of Medicine discovered a new drug, Cinacalcet, that successfully treated hyperparathyroidism, a common side effect of kidney disease. The treatment works by fooling the parathyroid glands into thinking calcium levels are higher than they actually are.
Researchers found a link between the two diseases, with mutations in HNF-1a protein interfering with PKHD1 gene transcription. This discovery may lead to similar therapeutic approaches for both MODY5 and polycystic kidney disease.
A $3.3 million NIH grant-funded study will compare six-times-per-week overnight home hemodialysis to standard three-times-a-week hemodialysis at dialysis centers. The research aims to determine if the higher dose of dialysis improves patient outcomes, including hospitalization rates and quality of life.
Scientists give mice with damaged kidneys injections of BMP-7 to prevent adynamic bone disorder, a condition causing weakening and distortion of bones. The treatment is shown to be effective in normalizing bone cell counts and structures.
Researchers at UCL's Wolfson Institute for Biomedical Research have developed a new drug to treat enlarged prostate with virtually no hormonal side effects. The treatment can both relax the prostate and prevent its growth, offering a major advance in treating a condition affecting millions of men worldwide.
The demand for kidney transplants is soaring due to type 2 diabetes and hypertension, but the number of available donors is low. Experts at the American Society of Nephrology conference discuss the pros and cons of paid donations, weighing the need to increase the transplant pool against ethical concerns.
Researchers have identified multiple families with a genetic mutation causing gout and kidney failure, developing in teenage years and progressing to end-stage kidney disease by the 40s or 50s. The team hopes to find family members who may be unaware of their condition and develop improved treatment for this rare disease.
Non-directed kidney donations have the potential to save thousands of lives, but raise important ethical considerations. Transplant centers are developing policies to evaluate and allocate these kidneys, addressing issues like allocation and donor expenses.
Researchers found that while black and white Americans have the same amount of early kidney disease, black patients are five times more likely to progress to end-stage renal disease. This disparity may be due to differences in blood pressure control, quality of care, and access to healthcare.
A new study found that 16.5% of non-kidney transplant recipients develop chronic kidney failure, with older age, being a woman, and pre-transplant hepatitis C infection increasing the risk. The risk is higher for those whose kidneys fail after transplant, highlighting the need for better treatment regimens.
A newly discovered protein causes blood clots in the livers of humans with viral hepatitis and mice exposed to corona virus. Blocking this protein may offer a new approach to treating patients with chronic viral hepatitis and potentially SARS.
A 12-month study comparing FOSRENOL and calcium carbonate found that FOSRENOL led to a 'considerably better outcome' on bone histology, with halved rates of patients with osteomalacia, adynamic bone disease, or hyperparathyroidism. This contrasts with the calcium carbonate group, which showed an increase in these conditions.
A recent study has found a direct link between cilia assembly proteins and polycystic kidney disease (PKD), a condition affecting one in every 500 people. The research suggests that stopping cilia formation can cause PKD, providing new insights into the disease's mechanisms.
Research highlights the role of WNK kinases in regulating thiazide-sensitive Na-Cl cotransport, a key mechanism for maintaining electrolyte balance. Additionally, studies investigate the immunomodulatory effects of WNK kinases on pulmonary inflammation and diabetes, shedding light on potential therapeutic targets.
Scientists at Cardiff University have developed a new protein to help manage acute infection and inflammation. The protein has been jointly investigated by Dr Simon Jones and Dr Nicholas Topley for several years, revealing its potential in treating chronic disorders such as rheumatoid arthritis and bacterial peritonitis.
A recent study published in The New England Journal of Medicine found that higher doses of hemodialysis and more permeable artificial kidneys did not improve survival rates for all patients with end-stage kidney disease. However, selected subgroups, such as women and those treated with a more permeable membrane, showed significant impr...
A new study has found that chicken pox vaccine is safe and effective for children with chronic kidney disease. The study shows that vaccination can prevent severe complications such as pneumonia and brain inflammation in these patients.
Researchers at Ohio State University successfully tested micro-sized gelatin particles that may deliver therapeutic genes to the glomerulus in the kidneys. The biodegradable particles dissolved quickly enough to pass through the glomerulus within 10 hours, suggesting they could be useful in transferring genes to tissues.
Researchers at Wake Forest have identified a gene responsible for two rare kidney diseases, familial juvenile hyperuricemic nephropathy and medullary cystic kidney disease Type 2. The discovery may lead to early detection and improved treatment options for affected individuals.
A new non-calcium phosphate binder, lanthanum carbonate (Fosrenol), has shown a reduction in mortality and cardiac death among kidney patients on hemodialysis compared to conventional phosphate binders. The study involved 647 patients who received Fosrenol therapy for two years.
A new study found that patients receiving the drug Thymoglobulin had two and half times fewer episodes of acute kidney rejection than those receiving Simulect. The study's findings are significant as they show a potential benefit for up to half of kidney transplants from cadavers.
A landmark study suggests that at-home dialysis therapy can be more flexible and manageable than previously thought. The ADEMEX study found that increasing small solute clearances did not impact patient survival rates, and body size, transport status, and other factors had no measurable effect on outcomes.
The HomeChoice Pediatric dialysis system is designed to meet the special needs of young patients with ESRD, offering a safe and flexible option for administering dialysis at home. The system integrates Baxter's PD Link software, enabling remote monitoring and data analysis.
The ADEMEX study found that increasing small solute clearances through modified dosing doesn't impact patient survival, contrary to current practice. This enables tailored prescriptions for individual patients without sacrificing survival benefits.
The University of North Carolina School of Medicine has received a $5 million federal grant to investigate ANCA vasculitis, a disease causing small blood vessel inflammation. Researchers will explore the cause of the disease and develop better treatments.
Dr. Lee Hartwell has made significant contributions to our understanding of the cell cycle and its role in cancer development. His work with yeast has identified over 50 genes crucial for controlling cellular growth and division.
A large UM study found that mycophenolate mofetil (MMF) reduces the risk of losing a transplanted kidney due to chronic failure better than azathioprine (AZA). MMF protects against kidney loss even when acute rejection prevention effects are eliminated, with nearly 86% of MMF-treated kidneys surviving four years.
Researchers at Yale have discovered new insights into the development of polycystic kidney disease (PKD), a life-threatening genetic disorder affecting millions. The study reveals crucial information about the PKD2 gene's role in normal development and its impact when mutated.
A daily dose of fish oil significantly improves kidney function and reduces the risk of advanced kidney failure in people with IgA nephropathy. Researchers followed 106 study participants for over six years, finding sustained benefits from fish oil supplementation.
Researchers at the University of Toronto found that 74% of adhesive tape specimens were colonized by pathogenic bacteria, which can contribute to serious diseases. Discarding the outer layer of tape significantly reduced bacterial growth, making it a simple way to reduce the risk of hospital infections.
Researchers found that improving kidney function in majority of patients can be achieved by reducing cyclosporine dosage and adding mycophenolate mofetil, potentially slowing kidney deterioration. The study showed an improvement in kidney function in 37 patients over two years.
A recent study has uncovered the role of a gene in regulating vitamin D levels, shedding light on the causes of rare forms of rickets. The research suggests that production of active vitamin D hormone by the kidneys is essential for normal bone health and growth in children, particularly those with kidney failure or aging.
A Wake Forest University study found that US dialysis patients are more likely to miss treatment sessions compared to their European and Asian counterparts. Factors contributing to this discrepancy include differences in dialysis prescription, patient health, medical system eligibility, and patient independence.
A low-protein diet can safely delay dialysis treatment for up to a year in patients with severe chronic renal failure. The diet, rich in fruits and vegetables, provides essential nutrients without side effects.
Researchers at the University of Chicago have discovered a new protein, calgranulin, that can prevent the formation of kidney stones in minute amounts. Calgranulin is present in the kidney and human urine and can stop the growth of calcium oxalate crystals, the major component of kidney stones.
A new test developed by Johns Hopkins researchers uses white blood cells to predict which medications are most effective for each patient with kidney disease. The study found a wide range of responses among patients, suggesting that such tests might assist physicians in developing personalized treatment strategies.
Researchers found that black children are nearly 2.5 times more likely than white children to receive hemodialysis versus peritoneal dialysis. The disparity was observed across different age groups, with younger black children being most likely to opt for hemodialysis.