Two new papers highlight the risks of dabigatran etexilate (Pradaxa) in cases of closed head injuries, showing a higher mortality rate and increased risk of hemorrhage progression. The studies emphasize the need for effective anticoagulation reversal protocols to improve patient outcomes.
Michel M. Modo and Thomas B. Freeman received the 2013 Bernard Sanberg Memorial Award for Brain Repair for their groundbreaking work in neurorestorative biology, stem cell transplantation, and Parkinson's disease research. The awards recognize their outstanding contributions to advancing neural therapy and brain repair.
Researchers at the University of Pittsburgh School of Medicine found that melatonin injections delayed symptom onset and reduced mortality in a mouse model of ALS. The study suggests that melatonin may be a useful treatment for this devastating disease.
During the April 2011 tornado disaster, neurosurgeons at the University of Alabama at Birmingham Medical Center treated patients with spinal cord injuries, most of which were limited to the thoracic and lumbar regions. The authors highlight the importance of disaster preparedness in treating such injuries.
A nationwide program by the Society of Neurological Surgeons has been shown to retain knowledge and skills acquired by PGY1 residents through hands-on learning. The program, which includes patient care and surgical simulations, has demonstrated significant effectiveness in improving residency experiences and patient outcomes.
Researchers have developed a new solid form of bioactive plasma-based biomaterials that can promote healing at sites of tissue injury. These materials, known as PBMs, are easier to work with, inexpensive to produce, and safe to use.
Researchers at Bonn University Hospital have achieved remarkable results using deep brain stimulation to treat treatment-resistant major depression. In six out of seven patients, symptoms improved considerably and rapidly, with significant improvements observed in anxiety, despondence, listlessness, and joylessness.
Researchers explore the potential of EVs as biomarkers, delivery vehicles, and immune modulatory tools for brain cancer diagnosis, monitoring, and treatment. Extracellular vesicles may provide a way for tumor cells to alter the microenvironment, enabling growth and spread while evading immune responses.
Researchers developed a quick and simple fMRI task to localize critical brain areas governing speech and other functions. The new protocol accurately localized the anterior and posterior language areas of the brain in about 90% of subjects, including patients undergoing surgery for epilepsy or tumors.
A new MRI-guided laser treatment has been found to be safe and effective in treating recurrent glioblastoma, a type of brain tumor. The procedure uses a minimally invasive approach to destroy tumors, with nine out of ten patients showing improved response and survival rates.
Researchers at Penn Medicine developed a personalized brain mapping technique using diffusion tensor imaging (DTI) to preserve language, visual, and motor functions during brain tumor surgeries. This technique improved accuracy and extended survival in some cases, with a median survival time of 21.2 months.
Researchers recommend radiosurgery for treating unruptured AVMs due to its reasonable benefit-to-risk profile. The procedure resulted in AVM obliteration in 62% of patients, with a reduced annual hemorrhage rate compared to left untreated AVMs.
A new study published in BMC Public Health has found that homeless people have a disproportionately higher risk for traumatic brain injuries (TBI) compared to the general population. The study suggests that TBI may be a risk factor for homelessness and could contribute to the chronicity of homelessness.
A Phase II clinical trial found that combining hyperbaric oxygen therapy with normobaric hyperoxia improves neurological recovery in severe traumatic brain injury (TBI) patients. The treatment reduced mortality rates, improved cerebral oxidative metabolism, and lowered intracranial hypertension.
Researchers found a high prevalence of low T3 syndrome before and after surgery, associated with unfavorable clinical outcomes and depressive symptoms. Perioperative low T3 syndrome was linked to a five-fold increased risk of poor outcome.
The updated SEEG technique combines sophisticated imaging data reconstructions and robot-assisted surgery to provide essential information in complex cases of drug-resistant epilepsy. The new workflow reduces procedural error risks and improves accuracy in localizing the epileptogenic zone.
Johns Hopkins researchers have discovered that mesenchymal stem cells derived from human adipose tissue can seek out and destroy glioblastoma cancer cells in the brain. This innovative approach may provide a new tool for accessing difficult-to-reach areas of the brain where cancer cells proliferate.
Surviving patients with ruptured aneurysms have persistent problems in key areas affecting quality of life, including mobility and anxiety/depression. Long-term follow-up care plans are necessary to address these challenges.
A new trial has shown that Deep Brain Stimulation (DBS) can help patients with chronic, severe Anorexia Nervosa achieve improvements in body weight, mood, and anxiety. Four of six patients experienced significant weight gain and simultaneous changes in mood and symptoms related to anorexia.
A study published in Neurosurgery found that patients undergoing cerebral angiography and neurointerventional procedures are at a very low risk of infection, even without preventive antibiotics. The authors suggest that the minimally invasive nature and short duration of these procedures may contribute to this low risk.
Researchers describe the use of 5-aminolevulinic acid (5-ALA) fluorescence to guide resection of recurrent glioblastoma multiforme, revealing a pathway of tumor spread through brain regions inaccessible to MRI. This technique increases the success of achieving maximum resection.
Researchers are using engineering control theory to create complex brain models that can simulate neurological diseases. By simplifying these models and fusing them with real system measurements, they aim to develop more accurate treatments for conditions such as epilepsy and Parkinson's disease.
A consortium of top researchers has made significant progress in understanding and treating Rasmussen encephalitis, a rare neurological disease. The RE Children's Project has raised funds to study the disease tissue and search for genetic links.
A recent study found that 25% of hospital readmissions for spine surgery patients were not due to true quality-of-care issues. Planned readmissions, unrelated surgeries, and rescheduled procedures were among the cases not counted against hospitals. The study suggests modifying the calculation method to make it more clinically relevant.
A large study found that two-thirds of eligible patients experience significant and lasting benefits from deep brain stimulation (DBS) for neuropathic pain. Benefits vary by cause, with improved outcomes seen in patients with amputation and stroke. Continued improvement is observed with longer follow-up.
A study published in Neurosurgery found that subcortical damage during awake craniotomy for brain tumor surgery can lead to worsening neurological deficits. The researchers analyzed data from 241 patients and found that 36 developed new neurological abnormalities while the surgeon was operating in the subcortex.
A recent study published in Neurosurgery found that pregnancy and delivery do not increase the risk of brain aneurysm rupture. In fact, women with unruptured aneurysms have a high rate of cesarean deliveries, which may be unnecessary. The study also suggests that prompt treatment after rupture can help decrease poor outcomes.
Researchers confirm the value of the Pipeline embolization device in treating difficult-to-reach brain aneurysms. The study showed that the device is a safe and effective tool for patients, with 68% achieving complete occlusion of their aneurysm.
A team of researchers at Yale University has identified four new genetic suspects linked to the origins and treatment of meningiomas. The study found that tumors mutated with these genes tend to be located in different areas of the brain, indicating their likelihood of becoming malignant.
A new robot technology called RP-7 enables remote presence in programming brain and spine stimulators, allowing non-expert nurses to be guided by specialists. The study found no significant difference in accuracy or clinical outcomes between remote-presence and conventional programming.
Researchers identified ELTD1 as a promising biomarker for diagnosing gliomas, particularly high-grade glioblastoma multiforme (GBM). Studies found that ELTD1 levels were strongly associated with glioma development and prognosis.
A study published in Neurology found that smoking and poor blood pressure and cholesterol levels significantly increase the risk of death for patients who have survived subarachnoid hemorrhage. The research, which followed over 64,000 Finns, revealed that lifestyle changes can help prevent early deaths among SAH survivors.
A new tool has been developed to help brain surgeons diagnose cancer and detect tumor boundaries more accurately. The tool uses mass spectrometry analysis to analyze brain tissue and produces a color-coded image revealing the nature and concentration of tumor cells.
Researchers developed a system using depth-sensing cameras and algorithms to recognize hand gestures as commands for medical image manipulation. The system reduced false positives from 20.8% to 2.3% and achieved a mean accuracy of 93%, improving surgery efficiency and reducing infection risk.
Researchers found a significant link between climate and infant brain infections, with rainfall affecting the number of hydrocephalus cases. The study suggests that environmental conditions can quench bacterial infections, making some cases potentially preventable if understood better.
A study by USF and VA researchers found that traumatic brain injury leads to progressive brain deterioration, causing elevated inflammation and suppressed cell regeneration. Therapeutic intervention can still help prevent cell death in the chronic stage of TBI.
A new study questions the need for routinely obtaining repeated CT scans in patients with mild head trauma, suggesting that it is unnecessary when patients are unchanged or improving neurologically. The study found that only two patients had a change in treatment based solely on routine repeated CT scans.
The January issue of Neurosurgical Focus explores the science of neurosurgical practice, shifting priorities from medical discoveries to patient safety, quality of care, and economic implications. Professional societies have launched a national practice data collection platform, N2QOD, to advance quality and outcomes.
The use of virtual reality (VR) and robotic technologies is expanding in neurosurgery, providing opportunities for training, planning, and performance. However, significant technical and economic challenges must be overcome before these technologies become widely used.
Researchers found that transplanting neural stem cells into mice with familial ALS slowed disease onset and progression, improved motor function, and extended survival. The study suggests targeting detrimental roles played by non-neuronal cells to develop more effective therapeutics.
A clinical trial by UCSF researchers found that hospital MRIs are better at predicting long-term outcomes for people with mild traumatic brain injuries than CT scans. The study revealed detectable spots on MRI scans called focal lesions, which helped doctors predict persistent neurological problems in patients with 'normal' CT scans.
A new study reveals that mini-strokes result in prolonged periods of brain damage and cognitive impairment, with neurons being lost due to delayed processes. The research suggests a longer therapeutic window to protect cells after these tiny strokes, potentially extending to days and weeks after the initial injury.
Research demonstrates that immune system's natural killer cells can kill off virus-infected tumor cells, rendering glioblastoma virotherapy less effective. The study suggests temporarily suppressing the immune system may counteract this response and enhance therapy.
The Pipeline embolization device shows encouraging results in patients with certain types of difficult-to-treat brain aneurysms, including a 68% complete blockage rate. However, the data also show substantial risks, including major complications and fatal bleeding, particularly for aneurysms in specific locations.
Researchers at Barrow Neurological Institute found that a ketogenic diet significantly enhances the anti-tumor effect of radiation, leading to improved survival rates for mice with malignant gliomas. The study suggests that the diet could be used as an adjuvant therapy without FDA approval.
A new study published in CMAJ found that rules limiting aggression in ice hockey, such as bodychecking, can significantly reduce injuries among young players, including serious brain and spine injuries. The study suggests that interventions based on rule changes showed the greatest likelihood of making ice hockey safer for youth.
New research reveals higher concussion incidence rates in female hockey players compared to males, emphasizing the need for reevaluation of concussion definition. Advanced imaging techniques and neuropsychological assessments were used to track changes in brain function over an entire season.
A higher density of neurologists and neurosurgeons in the US is associated with a decreased risk of death from stroke, according to a new study. The study found that an increase of one neuroscience provider per million population was linked to 0.38 fewer deaths from stroke per million population.
A new study found a four-fold increase in breast cancer incidence among women with neurofibromatosis-1, prompting recommendations for earlier screening. The researchers suggest annual manual breast exams and mammograms beginning at age 40 for this high-risk population.
Pituitary centers of excellence could provide optimal clinical management for patients with pituitary tumors, highlighting the importance of multidisciplinary collaborative environments. The proposal suggests three key missions: comprehensive patient care, residency training, and research contributions.
A new study found that rapid tumor growth in pregnant women with meningiomas is linked to blood flow changes, not hormonal fluctuations. Most of the tumors showed an unusual 'hypervascular' pattern and high edema rates.
Researchers have developed a novel test that measures proteins from nerve damage deposited in blood and spinal fluid to predict the rate of progression in ALS. The test shows promise in identifying patients at most risk for rapid progression, who may be offered new therapies being developed or tested.
A new Johns Hopkins research suggests that uninsured brain cancer patients are twice as likely to die in the hospital after undergoing surgery to remove a tumor. Despite this, patients with government-subsidized insurance through Medicaid had survival rates closer to those with private insurance.
A study published in Neurosurgery found that limiting neurosurgery residents' work hours hasn't decreased complication rates, but actually increased them in teaching hospitals. Complication rates remained stable in non-teaching hospitals.
A recent study in Neurosurgical Focus highlights the importance of preoperative, intraoperative, and postoperative processes in reducing neurosurgery-related adverse events. The authors propose a national registry for outcome data and monitoring, as well as standardization of specialized equipment and evidence-based guidelines.
A recent Johns Hopkins study found that repeated surgeries to remove glioblastomas, the most aggressive brain tumors, can increase median survival time from 14 months to 26.6 months. This may be due to increased efficacy of radiation and chemotherapy with each successive surgery.
A new analysis from the University of Pittsburgh Graduate School of Public Health found substantial local variation in health care spending within large geographic regions. The study reveals that many low-spending hospitals are located within high-spending areas, and vice versa.
Extradural brain stimulation has been shown to be safe and effective in improving movement disorder symptoms for patients with Parkinson's disease. The technique, called EMCS, provides a less-invasive alternative to electrical deep brain stimulation (DBS) and led to small but significant improvements in voluntary movement control.
A joint UMCP and UMB research project has been awarded a new $2 million grant to continue developing a small robot that could aid neurosurgeons in removing difficult-to-reach brain tumors. The robot, called MINIR-II, is fully MRI-compatible and will be controlled by the physician, with targeting information obtained from real-time MRI.
A study of 38 premature babies from low-income families found a higher risk of brain bleeds, fewer follow-up appointments, and more ER visits compared to those from higher-income families. The findings highlight the critical need for better identification of high-risk pregnancies and reduction of premature births.