A new study in Current Biology found that male squid become aggressively after contacting a chemical on female eggs, revealing the first detailed evidence of an aggression-inducing pheromone in any aquatic animal. This discovery challenges previous theories on aggression and highlights the complex communication system of squid.
A new study reveals that early defects in sensory synapses contribute to motor neuron disease progression, suggesting therapeutic strategies targeting spinal synapses may slow or prevent disease progression.
A study published in Neuron reveals that individual differences in amygdala and ventromedial prefrontal cortex function are independently associated with anxiety vulnerability. High trait anxiety individuals show enhanced amygdala response and faster fear acquisition, while vmPFC recruitment is linked to reduced fear responses in fear-...
Cell Press won the PROSE Award for Excellence in Biological & Life Sciences for its 'Article of the Future' format, which offers a personalized reading experience. This award reflects Elsevier's and Cell Press' commitment to evolving scientific publications with new technologies.
A recent survey of US stem cell scientists reveals substantial negative impacts of ongoing policy uncertainty on their work, including changes to science type and quality, delays in new projects, and hindered collaborations.
A new study reveals that BRCA1 mutations regulate cell fate in breast tissue, leading to the formation of aggressive basal-like tumors. Cells with mutant BRCA1 exhibit elevated Slug levels and remain immature, stalled in a premature state of development.
A new method allows for quick and comprehensive characterization of induced pluripotent stem cells (iPS) and embryonic stem cell lines, enabling high-throughput assessment of quality and differentiation efficiency. The approach yields genome-wide reference maps detailing epigenetic and gene expression landscapes.
A new study couples a complex genetic screening technique in humans with functional validation of results in flies to study human disease. The strategy has the potential to be an effective approach for understanding complex disorders, such as Alzheimer's disease.
Cell Alerts offers free, instant access to high-impact research articles from top journals like Cell, Neuron, and Current Biology. The app also features upcoming conference listings, enabling easy browsing on-the-go.
A new study suggests that consuming inorganic nitrate from spinach can improve mitochondrial efficiency, leading to reduced oxygen consumption while exercising. This increase in efficiency may contribute to the known health benefits of fruits and vegetables, particularly leafy greens like spinach.
A new study reveals that estrogen receptors in the liver are critical for maintaining fertility, with dietary protein playing a crucial role. The researchers found that mice on calorie-restricted diets showed reduced reproductive cycles, but those given more protein restored normal function.
A new study reveals complex molecular mechanisms associated with chronic stress and its link to depression. The research found that genetic modifications, such as DNA methylation and histone modifications, play a crucial role in determining susceptibility to depression.
Researchers have identified a complex brain navigation system in migrating monarch butterflies that integrates internal compass, sun compass, and skylight cues to guide their long-distance migrations. The study reveals the integration of seemingly contradictory signals into a consistent neural representation of the environment.
Research reveals erythropoietin (EPO) has contrasting influences on infectious and inflammatory diseases. EPO reduces the ability of the immune system to fight off systemic infections but decreases inflammation in non-infectious conditions.
A new study links an oncometabolite to widespread gene expression alterations in brain cancer and leukemia, promoting tumorigenesis. The research suggests that targeting the metabolic pathway may guide the development of new cancer therapies.
Researchers found that SIK2 suppressed CREB-mediated gene expression after oxygen and glucose deprivation, increasing neuronal survival in mice lacking SIK2. The SIK2-TORC1-CREB signaling pathway may serve as a potential therapeutic target for promoting neuron survival.
Researchers have discovered that cancer can arise rapidly after a single catastrophic event involving tens to hundreds of genomic rearrangements. This phenomenon, known as chromothripsis, is seen in at least two percent of all cancers and up to 25 percent of bone cancers.
Researchers have created a potential method for detecting Alzheimer's disease with a simple blood test using synthetic molecules. The new technology may lead to blood tests for many important diseases if it proves successful.
A compound found in birch bark, betulin, has been shown to lower cholesterol and prevent diet-induced obesity in mice. It works by targeting SREBPs, transcription factors involved in lipid synthesis, and also improves insulin sensitivity.
A new report reveals a key mechanism linking cellular energy state with whole-body energy state, optimizing fat absorption. Researchers found that the AMPK-SRC-2 pathway plays a crucial role in regulating fat uptake and storage.
A large collaborative study has identified 64 new genetic variants associated with adult height, providing insight into the complex trait. The research suggests that genotyping arrays with rare and uncommon single-nucleotide polymorphisms can capture new signals and disease variants.
A new study in mice suggests that exercise turns on a genetic program that leads the heart to grow as heart muscle cells divide. Researchers identified a key transcription factor involved in this process, which may have clinical implications for those with heart failure or other conditions.
A new study found that mice sired by fathers on a low-protein diet exhibit changes in metabolic genes, passed down via the sperm, and associated with improved cholesterol metabolism. This suggests transgenerational reprogramming of metabolism, challenging traditional views on the impact of parental nutrition.
A new study reveals how tau protein disrupts neuronal communication at synapses before obvious neuron damage, leading to early memory deficits and impaired synaptic function. The research identifies aberrant mislocalization of tau proteins in dendritic spines as a key mechanism driving disease progression.
A study of 14 years of observation of Kanyawara chimpanzees found that females tend to play with sticks more often than males and occasionally treat them like mother chimps caring for infants. This suggests a possible link between biological predilections and sex-stereotyped socialization in object play.
A new study finds that dendritic cells play a key role in amplifying autoimmune disease, specifically systemic lupus erythematosus (SLE). The research suggests that depleting dendritic cells may be a potential therapeutic strategy for treating SLE and potentially other autoimmune diseases.
A new study on a woman without an amygdala, a key structure in generating fear reactions, reveals that humans also lack this function. Despite encountering traumatic events, she experiences little to no fear, while still feeling other emotions like happiness and sadness.
Researchers found that Duchenne muscular dystrophy symptoms emerge when skeletal muscle stem cells can no longer keep up with repairs, leading to progressive muscle weakening and respiratory failure. Successful treatments targeting muscle stem cells may alleviate symptoms and offer new hope for managing the disease.
A new study reveals that ER stress can lead to the destruction of a protein that regulates calcium signaling in neurons, causing brain damage similar to neurodegenerative diseases. The researchers found that a protective chaperone protein helps maintain the interaction between this protein and calcium signaling.
A new study identifies a previously unrecognized mutation in the valosin-containing protein (VCP) gene, which causes an inherited form of amyotrophic lateral sclerosis (ALS). The research provides new insight into the disease's underlying pathology and validates the exome sequencing technique for identifying genetic causes.
Researchers have identified genetic mutations associated with elevated PSA levels in men diagnosed with prostate cancer, offering potential new biomarkers for disease monitoring. The study's findings suggest that sequencing of selected mitochondrial regions could provide valuable information for prognosis.
A study published in the American Journal of Human Genetics reveals a genetic alteration, MAP3K1, responsible for disorders of sex determination (DSD). The discovery provides insight into the cause of DSDs and contributes to better management, including the importance of removing gonads early to prevent cancer.
Scientists created a 3D map of the fruit fly brain's neural networks, revealing 41 local processing units, 6 hubs, and 58 tracts. The breakthrough enables researchers to analyze how the brain processes information and control behaviors.
A new study reveals how diabetes disrupts brain cholesterol synthesis, leading to neurologic complications such as depression and increased Alzheimer's disease risk. Insulin therapy restores normal cholesterol production in the brain.
A study published in Cell Metabolism found that a protein called Angiopoietin-like protein 4 (Angptl4) protects against the severe inflammatory response caused by high levels of saturated fat. Mice deficient in this protein showed massive lymph node expansion and died after consuming a diet high in saturated fats.
Researchers have found that the HIV virus triggers an immune response in CD4 T cells due to incomplete reverse transcription, leading to cell death. The study's findings suggest that targeting the cell sensor responsible for this response could lead to new treatment strategies.
Researchers have developed a method to estimate human age from blood samples, which could be used to identify missing persons or solve crimes. The technique is based on the analysis of T cell receptors and has been shown to be highly accurate, with an error margin of nine years.
A study published in Immunity describes a mechanism by which an infected cell can alert neighboring uninfected cells, leading to amplified inflammation and enhanced immunity. This 'cell-to-cell communication' strategy enables the host to circumvent immunosuppressive bacterial activity and defeat invaders.
Research finds that unrelated male macaques in the wild form close relationships with select males, resembling human friendship. These bonds are linked to future social dominance and successful mating, suggesting a role of politics in shaping male social dynamics.
Researchers identify 47 copy-number variant regions associated with sporadic and familial aortic aneurysms (TAAD), highlighting disrupted smooth muscle function as key mechanism. The findings have significant implications for other adult-onset cardiovascular disorders, suggesting potential targets for screening and prevention.
A new study has uncovered the role of Sortilin in regulating Progranulin levels in neurons, which may hold promise for treating frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS). The research found that Sortilin-mediated PGRN endocytosis is a key pathway underlying FTLD-TDP pathophysiology.
A new study reveals that adenosine tri-phosphate (ATP) works in synergy with lactic acid to sense muscle pain. The researchers found that ATP increases the sensitivity of acid sensing channel #3 (ASIC3) on sensory neurons, helping to explain why acid alone is unable to trigger ischemic pain.
A study found that targeting HDMX overcomes p53 suppression and resistance to selective HDM2 inhibition, restoring tumor suppressor pathway in cancers expressing both proteins. The research enables new therapeutic strategies for human cancer, including those resistant to current treatments.
Cell Press introduces Cell DNA, a free daily news aggregation service covering life sciences topics. Readers can subscribe to receive daily email digests with news summaries and comment on stories.
Researchers found that adult cells from patients with Rett Syndrome could be transformed into induced pluripotent stem cells, which formed functional neurons in cell culture. However, these cells exhibited abnormalities that could be reversed by treating them with drugs, suggesting a potential therapeutic window before disease onset.
Researchers identified a common pain gene across species, including humans, which is linked to synesthesia and acts primarily in the brain, not peripheral nerves. The discovery opens up new avenues for understanding pain and developing more effective treatments.
A recent study found that the brains of newborn humans and Neanderthals are similar in size and appearance, but differ significantly in shape after birth. The differences reflect changes in brain circuitry and may underlie cognitive differences between the two species.
Research identifies a key mechanism in bone formation after resorption, revealing the importance of TGF-?1 and skeletal stem cell recruitment. The study suggests that using PTH before antiresorptive drugs could be an effective therapy for osteoporosis treatment.
A study analyzing genomic DNA from over 23,000 patients with ASD, developmental delay, or schizophrenia found a common deletion on chromosome 17 that increases the risk of developing either condition by at least 13.58 times.
Researchers discovered that reef fish punish blennies for stealing food without punishment, resulting in reduced future attacks on punishers. This behavior creates a public good, as all members of the species benefit from the punishment.