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Clalit Research Institute


Israeli breakthrough identifies key gene in common heart disease, unlocking life-saving diagnostic potential

A pioneering Israeli study identifies TRIM63 as a significant genetic contributor to hypertrophic cardiomyopathy (HCM), which could transform genetic screening and treatment protocols. The findings provide compelling evidence for the gene’s role in both causing and increasing susceptibility to HCM.

SourceClalit Research Institute·JournalCirculation Genomic and Precision Medicine·TypeData/statistical analysis·DateApr 23, 2025

Large study on the effectiveness of the Pfizer Covid-19 vaccine in children aged 5-11 published in The New England Journal of Medicine

A large study found moderate protection against SARS-CoV-2 infection and symptomatic Covid-19 illness among vaccinated children, with greater protection observed in younger age subgroups. The research used Israel's Clalit Health Services database to control for confounding variables.

SourceClalit Research Institute·JournalNew England Journal of Medicine·TypeData/statistical analysis·DateJun 29, 2022

Parental vaccination against coronavirus offers substantial protection to children as well

A large real-world study published by Israel's Clalit Research Institute found that parental vaccination with the BNT162b2 vaccine decreased the risk of infection for unvaccinated children by 58.1%, regardless of household size or child age. Vaccination also reduced transmission from infected parents to their unvaccinated children.

SourceClalit Research Institute·JournalScience·TypeObservational study·DateJan 27, 2022

COVID-19 vaccine effectiveness in adolescents

The study shows that COVID-19 vaccine effectiveness is substantial in adolescents, with a 93% decrease in symptomatic cases and a 90% decrease in documented infections after the second dose. Vaccine effectiveness was lower but still significant before the second dose.

SourceClalit Research Institute·JournalNew England Journal of Medicine·TypeData/statistical analysis·DateOct 20, 2021

Largest real-world study of COVID-19 vaccine safety published by Israel's Clalit Research Institute in The New England Journal of Medicine

A large-scale analysis of Israel's COVID-19 vaccination data found that the Pfizer/BioNTech BNT162B2 vaccine is very safe, with only a few potential side effects. The study also revealed that coronavirus infection poses a much higher risk of serious adverse events compared to vaccination.

SourceClalit Research Institute·JournalNew England Journal of Medicine·TypeData/statistical analysis·DateAug 25, 2021