A study using molecular simulations suggests that polyunsaturated lipids can alter the binding rate of dopamine and adenosine receptors, affecting cell function in neurodegenerative diseases. This discovery could lead to new therapeutic pathways for regulating receptor binding.
Researchers have found an epigenetic mechanism implicated in the regulation of blood sugar, with the TXNIP gene associated with diabetes mellitus type 2 and poor glucose control. The study's results could help identify patients at risk of developing diabetes and develop new therapies.
A recent study found that a higher monetary cost of dietary intake is associated with improved diet quality, increased fruit and vegetable consumption, and weight management. The researchers monitored 2181 Spanish adults for ten years and discovered that spending more on food led to better health outcomes.
Researchers from IMIM and partner institutions developed a new integrated computational method to predict adverse drug reactions more reliably. The method combines structure-based detection of labile fragments with information on the mechanism of action of the drug, resulting in improved ability to foresee possible adverse effects.
Researchers at IMIM have found that Notch protein activation intensity determines cell fate, revealing a competition between two proteins for hematopoietic stem cell formation. This study could lead to more efficient and reproducible lab-grown blood stem cells for patients with no compatible donors.
A new therapeutic strategy has been identified for treating colorectal cancer with the BRAF mutated gene, which is associated with poor prognosis. Inhibition of endosomal activity and P45-IKKα enzyme inhibition show promise in preventing tumour growth and metastasis.
Researchers used a new computational method to predict the interactions between small molecules and thousands of proteins, revealing that many chemical probes are not selective but instead interact with multiple proteins. This study highlights the importance of understanding protein functions to develop more efficient and safer medicines.
Researchers at IMIM have identified galectin-1 as a potential therapeutic target for pancreatic cancer, demonstrating improved survival rates of 20% in mice. The inhibition of this protein mainly affects the immune system and surrounding tumor cells, suggesting a new strategy for treating pancreatic cancer with minimal side effects.
Researchers uncover the growing concern of animal hoarding in Europe, characterized by poor animal care and neglect, with implications for mental health and public well-being. The study highlights the need for standardized intervention protocols and collaboration between sectors to address this issue.
Researchers have discovered a novel immunological mechanism that regulates B lymphocytes to fight encapsulated bacteria, clearing the path for more efficient vaccines. This discovery improves our understanding of the immune system's protection against infections.
A study published in PLOS ONE found that including waist circumference measurements in clinical practice can help identify children and adolescents at higher risk for cardiovascular disease and type 2 diabetes. In Spanish children aged 6-17, 21.3% have abdominal obesity, with traditional screening methods missing 70% of cases.
Researchers at IMIM have discovered a new function for transcription factor Snail1 and enzyme LOXL2 in the process of Epithelial-Mesenchymal Transition (EMT), enabling tumor cells to invade other tissues. LOXL2 is identified as a potential therapeutic target for cancers such as breast, lung, or skin cancer.
Researchers at IMIM discovered that intestinal mucus prevents inflammatory reactions against commensal bacteria and dietary antigens, offering a promising complementary way to treat ulcerative colitis and Crohn's disease. The study also suggests potential applications in cancer therapy due to mucus' anti-inflammatory properties.
Researchers at IMIM have discovered a new function of the IB protein involved in squamous-cell carcinoma development. The study found that nuclear IB is lost during tumour progression, making it a potential biomarker for diagnosis and prognosis.
Researchers found that Omalizumab eliminated symptoms in 23% and 53% of patients with chronic urticaria. The treatment has faster effectiveness and fewer side effects than current immunosuppressors, offering hope to millions suffering from the condition.
The study reveals that the Notch protein activates GATA2 gene to produce hematopoietic stem cells and regulates its expression through HES-1 repressor. This basic circuit is essential for generating limited production of GATA2, necessary for hematopoietic stem cell production.
A study found that smoke-free legislation implemented in 2006 led to a 11% decrease in acute myocardial infarctions, mainly among non-smokers and older adults. The reduction is attributed to decreased passive exposure to tobacco smoke.
Researchers have deciphered the mechanism of anophelin's interaction with thrombin, a key enzyme in blood coagulation. This discovery opens the door to designing new anticoagulant drugs with improved efficacy and reduced side effects, as well as fighting against malaria by developing inhibitors for this substance.
Scientists at IMIM and UPF have simulated the release of HIV protease, a protein responsible for the virus's maturation process. This breakthrough could lead to the design of new antiretroviral therapies by understanding how free protease appears during the maturation process.
Researchers have identified a new function of the IKKalpha enzyme variant in colorectal cancer progression. This breakthrough could lead to the design of targeted drugs that inhibit this specific form of the enzyme, reducing harm to healthy cells.
Researchers from IMIM have deciphered the role of β-catenin in generating haematopoietic stem cells, which can be used to treat leukaemia patients without compatible donors. The study lays the foundation for laboratory-generated stem cells that can improve transplant quality and quantity.
Researchers have discovered a new indicator for breast cancer relapse, directly associated with the activation of NF-kB signaling in tumour cells. The absence of the 14-3-3 protein sigma is not itself a prognosis factor, but its lack enables chronic NF-kB activity linked to tumour progression.
Researchers warn of the risks of MXE, a dissociative drug similar to ketamine, as it spreads quickly online and is often sold as a legal alternative. The study highlights the need for greater international collaboration to address the issue of easily accessible psychoactive drugs.
Researchers from IMIM and UPF identified 115 proteins in silico that could be highly relevant to treat colon-rectal cancer, enabling the design of new generation anti-cancer drugs. The study uses a computational method to predict proteins that interact with molecules showing differential cytotoxicity.
Researchers at IMIM discover LOXL2 protein plays a crucial role in gene silencing, leading to tumor growth. The study opens new avenues for developing treatments that block LOXL2's activity.
Researchers at IMIM have discovered a new mechanism of resistance to colon cancer treatment, where a mutation in the EGFR oncogene causes resistance to drug cetuximab. The finding has significant clinical implications and opens up possibilities for using alternative treatments like panitumumab.
Researchers discovered neutrophils exist in the spleen without an infection, contributing new knowledge to biology. These cells have an immunoregulating role, interacting with B lymphocytes to produce antibodies.