For patients who need non-cardiac surgery a short time after an interventional heart procedure, bare metal stents provide a safer choice. Drug-eluting stents can lead to life-threatening cardiac complications in these patients, according to a study by Thomas Jefferson University Hospital.
A new study identified genetic markers that can distinguish between chronic pancreatitis and pancreatic cancer, as well as predict patient outcomes. The discovery represents a significant advancement in cancer diagnostics and may lead to improved therapy options.
Researchers at Thomas Jefferson University found that the LC8 protein is actually a transcription factor that enhances viral replication, not a transport mechanism. This discovery may change how scientists think about central nervous system-attacking viruses like rabies and herpes.
Researchers at Jefferson University have developed a method to expand immune system natural killer cells from blood cells outside the body. Adding these cells to anti-cancer therapies involving monoclonal antibodies is more effective in killing cancer cells, offering new treatment possibilities.
Researchers at Jefferson University identified a protein called Akt1 that plays a crucial role in helping breast cancer cells spread. The finding could lead to the development of new drugs targeting this protein, potentially slowing or stopping the growth and progression of breast cancer.
Immunology researchers at Jefferson University have found that blood-brain barrier damage correlates with multiple sclerosis (MS) severity. The study used mice models and found that permeability changes are critical in disease development, with even mice lacking immune system components able to develop disease.
Researchers at Thomas Jefferson University found that a weakened rabies virus can ferry HIV-related proteins into animals, vaccinating them against an AIDS-like disease. After two years of challenge with SIV/HIV viruses, vaccinated non-human primates showed protection from disease and high CD4 cell counts.
A new study by Jefferson researchers found that taking Plavix with aspirin after off-pump heart bypass surgery does not increase bleeding risk. Patients who took clopidogrel and aspirin experienced less gastrointestinal bleeding and fewer strokes compared to those on aspirin alone.
Researchers at Thomas Jefferson University have found that outpatient medication usage is not associated with anemia in patients admitted with decompensated heart failure. Additionally, the team discovered that beta blocker dose adjustment upon hospitalization for acute decompensated heart failure can increase length of stay, and Fibul...
A new study found that drug-eluting stents are less effective in bypassed veins with longer blockages, particularly those with diffuse disease. In patients with focal disease, the success rate was high, but those with diffuse disease had a higher need for additional procedures to treat restenosis.
Researchers at Thomas Jefferson University discovered a gene mutation that reduces the number of colon polyps, potentially cutting the risk of colon cancer. The Atp5a1 mutation is found in mice and has been linked to a significant decrease in polyp formation.
The number of spinal cord injuries among senior citizens has increased significantly over the past 30 years, with admissions by geriatric patients increasing five-fold. Mortality rates are also higher for elderly patients, with approximately eight times the mortality rate as younger patients.
Researchers at Thomas Jefferson University have discovered a new strategy against heart failure by targeting the adrenal gland. By blocking GRK2, an enzyme that regulates fight or flight hormones, they were able to reduce hormone production and improve heart function.
Researchers found that 201 patients (23%) lived five years after surgery, with at least half being 65 years old or older. Of those survivors, 65% lived another five years, nearly matching the general population's survival rate.
Researchers at Thomas Jefferson University Hospital report a case of a seemingly healthy man who suffered from unexplained chest pain after a silent heart attack. The team discovered a subepicardial aneurysm, a rarely diagnosed complication that can be fatal if left untreated.
Researchers found that the p53 gene's ability to direct a damaged cell to stop growing or commit suicide depends on turning on separate groups of target genes. Alterations in an amino acid, lysine 120, can influence this decision, potentially leading to new strategies in chemotherapy drug development.
Scientists at Thomas Jefferson University have identified a new mechanism for controlling gene expression in fruit flies, involving non-coding RNAs that regulate HOX genes. This discovery could lead to improved understanding of diseases like ALL and its connection to misregulated HOX genes.
A study published in Catheterization and Cardiovascular Interventions found that an olive oil emulsion improved stent delivery in patients with abnormal heart arteries. The emulsion was successfully used to place lubricated stents in 85% of patients with no negative effects months after the procedure.
Researchers at Thomas Jefferson University found that common blood pressure medications can reduce tumor-feeding blood vessels in laboratory studies. High levels of angiotensin II have been linked to poor cancer prognosis and early recurrence, making these drugs a potential treatment option for pancreatic cancer.
A recent study by Thomas Jefferson University researchers shows that providing extra support to caregivers can lead to less depression and increased use of adult day services. This approach also reduces the need for nursing home placements.
Thomas Jefferson University researchers have found a connection between an aging gene and the prevention of prostate cancer cell growth. The study reveals that SIRT1, a sirtuin enzyme, can block cancer growth by inhibiting the activity of mutated androgen receptors, which are resistant to current therapies.
Researchers at Thomas Jefferson University have found that the protein fragment endorepellin blocks both skin and lung cancer tumors from progressing in animal models by preventing their ability to recruit new blood vessels. Endorepellin has surprisingly powerful effects on halting a cancer tumor's ability to move about and spread.
Researchers at Thomas Jefferson University have found a nanoparticle that can protect normal tissue from radiation damage as effectively as standard drugs. The nanoparticle, called DF-1, acts like an oxygen sink, binding to dangerous oxygen radicals and reducing their production.
Inhibiting cyclin D1, a gene present in excessive amounts in half of breast cancers, improves cell-killing effects of radiation. Flavopiridol was found to add to ionizing radiation's effects without toxicity, using zebrafish models.
Researchers at Thomas Jefferson University found that lower doses of radiation are equally effective in treating acoustic schwannomas, a benign but potentially devastating brain tumor. This treatment approach may preserve more hearing and reduce the need for surgery.
Researchers found that the caveolin-1 gene can protect against pre-cancerous development in breast cells and may be a potential target for preventing breast cancer. The study also suggests a crucial role of the tumor microenvironment in the cancerous process.
Researchers at Thomas Jefferson University found that a specific gene, Dachshund, helps predict breast cancer prognosis. The study showed that higher expression of this gene is associated with better patient outcomes.
Researchers created a biosensor using quantum dots to mimic the clustering of MHC proteins on target cells, revealing strong contributions from non-viral peptide-MHC interaction with co-receptors. This cooperativity suggests that a single virus-MHC complex recognized in self-MHC complexes can activate a T-cell response.
Researchers found that patients with uncontrolled high blood sugar before surgery are 6.2 times more likely to develop pulmonary embolism, a life-threatening condition. Tightening glucose control can reduce this risk and hospital stays.
Nicardipine has been found to be highly effective and safe in reversing the 'no-reflow' phenomenon, a condition that affects up to 50,000 patients annually. The study involved 1,454 patients who were treated with nicardipine, resulting in a success rate of 98%.
A study by Dr. John Ratliff found that obese patients are more likely to experience complications during spine surgery, including blood clots and wound infections. The risk increases with the degree of obesity, emphasizing the importance of weight loss before undergoing elective spinal surgery.
Researchers at Thomas Jefferson University have discovered a new way to sidestep gleevec resistance in leukemia cells. By reactivating the protein C/EBP-alpha, they found that leukemia development is halted. This discovery could lead to new treatment strategies for leukemias resistant to gleevec and other cancers.
Researchers at Thomas Jefferson University found that GRK2 protein levels are elevated in patients with failing hearts compared to those with normal heart function. The study suggests that GRK2 could be a biomarker for heart failure and potentially predict patient response to treatment.
Researchers at Thomas Jefferson University have found that cyclin D1 inhibits the size and activity of mitochondria in cancer cells, shifting their metabolism from energy production to proliferation. This discovery may lead to new treatments targeting cancer cell metabolism.
A study by Thomas Force and his team found that Gleevec, a 'miracle' cancer drug, can cause heart failure in patients with CML due to its effect on the Abelson tyrosine kinase protein. The researchers also discovered that second-generation Gleevec drugs may have similar toxicities.
Researchers at Thomas Jefferson University found that blocking Rho kinase activity could be a viable treatment for gastrointestinal disorders such as constipation, anal fissures, and hemorrhoids. The study showed that Rho kinase inhibitors can cause direct smooth muscle relaxation and may provide a new strategy to treat these conditions.
Researchers at Thomas Jefferson University have identified proepithelin as a crucial protein in the spread of bladder cancer. The study found that proepithelin promotes migration and invasion of bladder cancer cells, suggesting it could be a potential target for new drugs.
A personalized program of occupational and physical therapy, combined with home modifications, has been shown to improve daily living tasks and increase survival rates among the elderly. The six-month intervention helped participants build confidence, use effective coping strategies, and make their homes safer.
Researchers found that missing portions of chromosomes can predict which patients will likely do better with therapy. Patients with tumors having deletions in chromosome locations 1p and 19q tended to live nearly two and a half times longer than those without such deletions.
A recent study found that major pancreatic cancer surgery can be successfully performed on patients in their 80s, 90s, and older with comparable five-year survival rates to the general population. This challenges common misconceptions about the suitability of elderly patients for such surgery.
Researchers found a known Caveolin-1 gene mutation present in 19% of breast cancers fed by estrogen. They also discovered six new mutations associated with estrogen-driven breast cancers. The study suggests that Caveolin-1 mutations may play a role in the development of these cancers.
Researchers discover a gene, dubbed fat free, that disrupts lipid absorption in zebrafish and reveals potential targets for intervention. The study provides new insights into lipid metabolism and opens the way for screening drugs to rescue defective cholesterol processing.
Researchers found that mice with APC mutations are more resistant to radiation when receiving staggered doses, potentially impacting radiation treatment protocols for colon cancer patients. The study's findings could lead to adjustments in treatment timing to minimize damage and optimize repair processes.
Researchers at Thomas Jefferson University have discovered a nanoparticle that provides significant protection against radiation-induced damage, including hair loss and organ damage. The fullerene-based agent showed promise in reducing organ damage by half to two-thirds, even when given before or after radiation exposure.
Researchers at Thomas Jefferson University discovered a genetic signature that predicts colon cancer, distinguishing between stem cell and non-stem cell activity in colon crypts. This finding could lead to the development of new drugs by replacing lost molecules involved in cancer development.
Researchers found that MMP-9 is highly expressed by colon cancer cells and is key to initiating metastasis. By blocking the enzyme, colorectal cancer cells cannot metastasize to other tissue, suggesting a new target for preventing metastasis in colon cancer.
Researchers from Thomas Jefferson University Hospital tested a new device to close Patent Foramen Ovale (PFO) holes, finding it effective in sealing the opening and preventing recurrent strokes. The study used the Cardia PFO closure device, which was successful in closing PFOs in 89 out of 90 patients.
Researchers at Thomas Jefferson University Hospital found that topical lubrication improves outcomes in coronary stent procedures, particularly for patients with abnormal arteries. The study showed that lubricated stents were successfully placed in 85% of patients with no negative effects months after the procedure.
Liver injuries continue to plague the nation's drug development system, causing costly problems for pharmaceutical companies. Dr. Navarro proposes that patients speak with their physicians about their medications to detect liver injury early, as certain individuals are more likely to develop problems due to genetic makeup.
Hematologists say coagulation-factor concentrates from plasma are now deemed safe from most infectious agents, but challenges from new agents remain. Recombinant products offer a risk-free alternative, but safety studies have not definitively made the case for either.