Articles tagged with Analgesics
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
A new study found that nitroglycerin can cause long-term blood vessel damage in rats, leading to increased risk of heart disease and mortality. The drug's ability to dilate blood vessels was found to be short-lived, with mitochondria producing free radicals that can damage heart cells and blood vessel walls.
A study by Northwestern Memorial researchers found that taking baby aspirin or enteric-coated aspirin with Plavix provides a good blood-thinning effect, similar to full adult-dose aspirin. The results suggest that combining these medications can enhance the effectiveness of Plavix in reducing vascular events.
Researchers found that 68% of patients experienced a reduction in pain intensity of greater than 33%, indicating promising relief. The biotoxin blocks slow sodium channel nocicipetive pain fibers in a highly selective way, making it a potential treatment option for cancer pain.
The decline in hormone therapy (HT) use was attributed to the release of data from two long-term studies showing that HT did not protect against heart disease and may even increase the risk. The study found that women who took HT had a higher risk for heart disease and breast cancer compared to those who did not take HT.
A study of over 27,000 nurses found that aspirin use was associated with a lower risk of developing adenomas, which can develop into cancer. The findings suggest that higher doses may pose greater risks of side effects such as bleeding.
A study found that patients taking statins before leg bypass surgery had better graft patency and lower risk of amputation. Patients on ACE inhibitors also had a lower risk of dying after surgery. The medications' effects outweighed PAD severity and other medical issues.
A UMHS study found that heavy drinkers with chronic back pain showed less physical disability than light drinkers on functional tests. Women were underreported for heavy drinking, suggesting doctors should be more vigilant about prescribing narcotic pain relievers.
A study of over 88,000 women found no significant difference in pancreatic cancer risk between aspirin users and non-users. However, extended regular aspirin use was associated with a 58% increased risk, while higher doses were linked to an 86% increased risk.
Researchers discovered a synergistic effect when combining glucosamine with ibuprofen, resulting in enhanced pain relief. The study suggests that adding glucosamine to existing pain medications could lead to improved efficacy without increasing side effects.
Teen ecstasy use declined for the second consecutive year due to increased perception of its risks, according to a University of Michigan study. Marijuana use also decreased in upper grades, with perceived risk increasing and overall use falling.
A study of long-haul air travelers found a 1% risk of venous thromboembolism (VTE), including pulmonary embolism and deep vein thrombosis. Traditional risk factors and prophylactic measures may need further investigation to reduce the risk.
Researchers discovered levetiracetam reduces phasic spasticity in MS patients, improving balance and walking difficulties. The medication also shows promise in treating other symptoms associated with the disease.
A clinical trial found that aspirin treatment significantly reduced the risk of thrombosis, cardiovascular death, and minor bleeding events in patients with polycythemia vera. The study suggests that aspirin can be a safe and effective treatment option for these patients.
The American Medical Association highlights the growing importance of migraine prevention, which can reduce attack frequency and severity. Preventive therapy has shown dramatic results in patients transitioning from acute to combination acute and preventive therapy.
The guidelines recommend five medication types to treat neuropathic pain, including gabapentin, lidocaine patches, and narcotics. Neuropathic pain affects 4-6 million people in the US, caused by nerve damage from conditions like shingles, diabetes, and cancer.
Researchers at Georgia Tech have made significant progress in developing hollow and solid microneedles that can deliver proteins, nanoparticles, and large molecules through the skin with minimal pain. The technology has potential applications in treating various diseases, including diabetes.
Research finds that heavy use of analgesics for at least nine years prior to irreversible kidney failure is associated with anatomic changes of SICK. Over 7% of dialysis patients had SICK, with 33% having overused analgesics preceding dialysis start.
UB researchers found that antidepressant drugs decrease chronic pain by inhibiting TNF production in the brain. The study showed that these drugs also increase norepinephrine release, leading to a decrease in pain and its symptoms. This finding may contribute to new strategies for treating chronic pain.
Researchers found that platelets in heart disease patients clot more easily despite taking aspirin, increasing the risk of heart attack. Further studies will investigate additional anti-clotting agents and genetic factors affecting platelet function.
The chemical capsaicin in peppers has been found to stimulate circulation, trigger pain relief, and even ease arthritis symptoms. It is also used in repellent sprays, marine coatings, and various drugs.
Patients with a history of coronary disease are at high risk of experiencing acute coronary events, including unstable angina and heart attacks, after aspirin withdrawal. Aspirin therapy is essential in reducing the risk of developing acute blockage in coronary arteries.
Conotoxins have extraordinary promise for developing powerful new drugs, including treatments for pain, cancer, epilepsy, and depression. However, habitat loss and uncontrolled exploitation threaten the extinction of cone snail species, which are a valuable source of these medicines.
A study published in the American Journal of Managed Care found that guideline-based cancer pain management offers effective pain relief in 80% of patients compared to 30% effectiveness for non-specialty providers. The targeted approach ensures a pre-determined treatment plan, reducing variability and increasing patient outcomes.
A laboratory study found that methylnaltrexone blocked increases in HIV entry and replication when immune cells are exposed to therapeutic doses of morphine. The study suggests that the drug may improve care for patients with AIDS who require pain relief, potentially reducing the risk of severe constipation.
A new international study found that a heartburn medication called esomeprazole effectively prevented ulcers among long-term painkiller users. The study showed the drug produced few side effects and was safe for daily use, offering hope to patients who need to take painkillers regularly.
A study found racial and ethnic disparities in pain perception, diagnosis, and treatment across various specialties. Disparities were seen in emergency departments, cancer clinics, chronic pain, and disability, with African Americans and Hispanics facing unequal access to pain medication and treatment.
The Tylenol Scholarship is one of the largest merit scholarship programs in the United States for all health-related studies. Since its inception in 1991, more than $6 million in scholarship grants have been awarded to over 5,000 students by McNeil Consumer & Specialty Pharmaceuticals.
Mt. Sinai researchers found that aspirin significantly reduces the risk of a first heart attack in apparently healthy individuals by one-third. The study's findings support treatment guidelines issued by the American Heart Association and U.S. Preventive Services Task Force, recommending aspirin use for those at high risk.
Researchers at Case Western Reserve University found that listening to calming music during early active labor can significantly reduce the sensation and distress of pain. The study, led by Sasitorn Phumdoung, suggests that music may be a widely-used alternative to medication for easing pain during childbirth.
Researchers found that Indomethacin keeps phosphate levels normalized without causing life-threatening complications, offering a potential treatment alternative to conventional therapies for X-linked hypophosphatemia.
Researchers have identified a new compound, AM1241, that acts on CB2 cannabinoid receptors and shows promise in alleviating neuropathic pain. The study suggests that this compound may provide pain relief without the debilitating side effects of existing pharmaceuticals.
A new study investigates the relationship between pain and selected medications, using genotyping to predict clinical outcomes and adjust drug therapy. By analyzing plasma concentrations of analgesics metabolized by CYP2D6, researchers aim to improve pain management therapy and reduce adverse effects.
Research found that salicylic acid in aspirin disrupts the stress system of S. aureus bacteria, reducing its ability to cause infection and adhere to host tissue. This finding offers hope for treating sepsis, a blood poisoning disease responsible for 750,000 US deaths annually.
A study of nearly 81,000 women found that regular use of ibuprofen reduced breast cancer risk by 28%, while aspirin use reduced it by 22%. Both NSAIDs showed a significant effect in reducing the incidence of breast cancer, especially among high-risk groups.
Treatment with salicylic acid (SAL) induces activation of the S. aureus stress response gene sigB, downregulating virulence factors and reducing ability to adhere to host cells. This finding represents a new prospect for using aspirin as an adjunct therapy to combat Staphylococcus aureus infections.
A recent study by the American College of Emergency Physicians found no significant racial differences in the administration of pain medications to children, but did reveal regional variations. Children in the South and West received narcotics more frequently than those in other parts of the country.
In a multi-center, double-blind study, ENBREL 50 mg administered once weekly achieved an ACR 20 response in 50% of patients, compared to 19% in the placebo group. ENBREL also showed comparable improvement in HAQ and patient-reported measures of global status and pain.
A new blood test can detect heart attacks in just five minutes with a 99% accuracy rate, improving diagnosis and treatment outcomes. The test identifies two proteins associated with the earliest stages of a heart attack, reducing unnecessary hospital stays.
The study shows that aspirin is likely a better choice than ticlopidine for recurrent stroke prevention in African Americans, who face higher stroke risks. Aspirin is readily available and inexpensive, while ticlopidine has serious side effects and is more difficult to use.
A recent study published in Annals of Internal Medicine suggests that spinal manipulation, a key component of chiropractic care, is an effective and safer alternative to pharmaceuticals for treating back pain. The American Chiropractic Association applauds the findings, which align with its long-standing advocacy for evidence-based care.
A study by the University of Alberta has found that giving people drugs to treat back pain can improve performance. The research team led by Dr. Saifee Rashiq ran a randomized controlled trial where participants were injected with a strong narcotic painkiller and completed the Sorensen test, showing a significant increase in functional...
A study using camera pills found that people taking NSAIDs regularly are at increased risk of small intestinal mucosal ulceration and bleeding. The study, which used capsule endoscopy to visualize the entire small intestine, detected erosions in 62% of NSAID users compared to 5% of non-users.
A study conducted at Mt. Everest found that acetaminophen was as effective as ibuprofen in treating high-altitude headaches, with both medications providing similar levels of pain relief and reduced nausea. The results suggest that acetaminophen could be a safer alternative for patients suffering from high-altitude headache.
A study of 120 patients found that less than 3% required surgical treatment after CT-guided interventional procedures. The procedure was effective in reducing analgesic drug consumption and may be used as a complement to physical therapy.
A University of Toronto study estimates that pain pump programming errors could result in up to 667 deaths, with reporting rates ranging from 1.2% to 7.7%. The researchers recommend redesigning the control panel using human factors engineering techniques to reduce human error.
The CT1 is a small, wireless device providing pain relief with minimal side effects. It can be used for various conditions such as arthritis, minor cuts, and surgical procedures.
Women taking two or more NSAIDs per week for five to nine years reduced their breast cancer risk by 21-28%. Ibuprofen was found to be more effective than aspirin in preventing breast cancer. The study's findings suggest that COX-2 inhibition may play a role in limiting breast tumor growth.
Regular NSAID use for five to nine years reduces breast cancer risk by 21%, while ten-year use increases the reduction to 28%. The study enrolled 80,741 post-menopausal women with no reported history of cancer, other than non-melanoma skin cancer.
A study published in Diabetes Care found that alpha lipoic acid significantly improved symptoms of diabetic neuropathy, including a 5.7-point total symptom score improvement. The treatment had no unfavorable side effects and may be a promising lead for future research into the cause and prevention of diabetic neuropathy.
A single application of high-concentration capsaicin patches has been shown to provide significant long-term pain relief for patients with postherpetic neuralgia, a condition that often persists for years. The patch-based treatment avoids systemic side effects associated with traditional treatments.
Researchers found that high doses of acetaminophen (up to 8g/day) were quickly eliminated from the bloodstream, with no accumulation or liver damage. The study's findings suggest that consumers can safely take higher doses than recommended, but emphasize the importance of adhering to the standard daily limit.
A new study conducted in 33 Michigan hospitals shows significant improvements in the use of proven treatments and lifestyle counseling for heart attack patients. The study, led by researchers at the University of Michigan Cardiovascular Center, found that hospitals that implemented a system of reminders and checklists saw increases in ...
A nationwide study found that frovatriptan succinate prevented menstrually associated migraines (MAM) in as many as half the women evaluated. The drug significantly reduced MAM severity and duration, as well as patients' functional impairment and use of rescue medications.
Researchers found that using nonsteroidal anti-inflammatory drugs (NSAIDs) may help slow the progression of Alzheimer's disease. However, data suggests that low-dose aspirin use does not provide a significant protective effect against developing Alzheimer's.
A new study found that levorphanol's ability to reduce pain is comparable to tricyclic antidepressants and gabapentin, commonly used drugs for neuropathic pain treatment. High-dose treatment provided greater pain reduction without tolerance, but also led to more side effects and participant dropout.
A new study by McGill University found that redheaded women respond better to a painkilling drug due to a genetic variation in the Mc1r gene. This gene is associated with pigmentation and variants cause red hair and fair skin, leading to a heightened response to kappa-specific analgesics.
Researchers have developed a glycosylated enkephalin that appears promising in studies using mice, triggering behavior consistent with reduced addiction and fewer side effects than morphine. The compound interacts with both mu and delta receptors to increase analgesic strength while limiting narcotic side effects.
African Americans with chronic pain experience significantly more symptoms than whites when seeking treatment, including greater levels of pain, depression, and impairment. Economic factors also play a significant role in producing these disparities.
A study found that Keppra, when used in combination with conventional treatments, provided significant pain relief for multiple sclerosis (MS) patients. Over half of the participants showed marked improvement and continued treatment with Keppra.
A new study finds Keppra alleviates severe nerve pain in cancer patients by reducing VAS scores to 0-3 within 3-14 days, with a significant decrease in opioid use. The medication was well-tolerated and showed potential therapeutic benefits for further investigation.