New technology facilitates adherence for patients
The future of drug delivery involves 'smart' systems addressing issues like gut, skin, and lung penetration, promising improved patient compliance and treatment efficacy.
Analgesics
Articles tagged with Analgesics
Pain medication safe and effective for the elderly
A study by Casa Colina Centers for Rehabilitation found that elderly patients experienced decreased pain intensity and improved sleep disturbances with once-daily Kadian dosing. The trial, KRONUS-MSP, showed a lower incidence of side effects compared to other opioids, making it an ideal option for managing chronic pain in older adults.
Mayo Clinic study helps patients with pancreatic cancer experience significantly less pain
A Mayo Clinic study of 100 patients with advanced pancreatic cancer found that a nerve block technique, combined with pain-relieving medications, provided a 50% reduction in pain and improved quality of life. The study suggests that this treatment option could be beneficial for patients with pancreatic cancer, allowing them to live mor...
Depression can lead to back pain
A new study published in the journal Pain found that people with depression are four times more likely to develop intense or disabling neck and low back pain. Researchers hope to uncover why these conditions are commonly linked, exploring coping methods to break a vicious cycle.
Study shows positive results for novel, patient-controlled transdermal system (PCTS)...
A study published in Anesthesia & Analgesia found that patients who used E-TRANS Fentanyl HCI PCTS experienced better pain control and fewer withdrawals compared to those who received a placebo. The novel transdermal system, approximately the size of a credit card, allows patients to control their pain management without needles or pumps.
Anti-epilepsy drug, topiramate, effective at preventing migraine headaches
A 26-week study found that topiramate significantly reduced monthly migraine frequency (-2.1 and -2.4 mg/d) and days with migraines compared to placebo. The medication also decreased rescue medication use, providing improved treatment outcomes for patients.
Other highlights in the February 18 issue of JNCI
Two studies in the February 18 issue of JNCI investigated aspirin use and its association with two types of cancer. Regular aspirin use was found to lower Hodgkin's lymphoma risk, while patients with Barrett's esophagus may benefit from cost-effective aspirin therapy for esophageal cancer chemoprevention.
Study examines inappropriate medication prescribing for elderly patients
A study examined trends in potentially inappropriate drug prescribing at ambulatory care visits among older adults from 1995 to 2000. The research found that pain relievers and central nervous system drugs made up most of the inappropriate prescriptions, with rates higher for patients with multiple prescriptions and women.
Popular drug for chest pain may promote blood vessel damage
A new study found that nitroglycerin can cause long-term blood vessel damage in rats, leading to increased risk of heart disease and mortality. The drug's ability to dilate blood vessels was found to be short-lived, with mitochondria producing free radicals that can damage heart cells and blood vessel walls.
Baby and coated aspirin equally effective in thinning of blood when taken in combination with Plavix
A study by Northwestern Memorial researchers found that taking baby aspirin or enteric-coated aspirin with Plavix provides a good blood-thinning effect, similar to full adult-dose aspirin. The results suggest that combining these medications can enhance the effectiveness of Plavix in reducing vascular events.
Puffer fish biotoxin provides promising relief in cancer pain
Researchers found that 68% of patients experienced a reduction in pain intensity of greater than 33%, indicating promising relief. The biotoxin blocks slow sodium channel nocicipetive pain fibers in a highly selective way, making it a potential treatment option for cancer pain.
Annals of Internal Medicine tip sheet February 3, 2004
The decline in hormone therapy (HT) use was attributed to the release of data from two long-term studies showing that HT did not protect against heart disease and may even increase the risk. The study found that women who took HT had a higher risk for heart disease and breast cancer compared to those who did not take HT.
Study supports role of aspirin in reducing risk of colorectal cancer
A study of over 27,000 nurses found that aspirin use was associated with a lower risk of developing adenomas, which can develop into cancer. The findings suggest that higher doses may pose greater risks of side effects such as bleeding.
For leg-bypass patients, drugs can save lives and limbs, but many patients go without them
A study found that patients taking statins before leg bypass surgery had better graft patency and lower risk of amputation. Patients on ACE inhibitors also had a lower risk of dying after surgery. The medications' effects outweighed PAD severity and other medical issues.
Heavy drinkers use narcotics to relieve back pain, despite possible interactions, UMHS study finds
A UMHS study found that heavy drinkers with chronic back pain showed less physical disability than light drinkers on functional tests. Women were underreported for heavy drinking, suggesting doctors should be more vigilant about prescribing narcotic pain relievers.
Aspirin use may be associated with increased risk of pancreatic cancer
A study of over 88,000 women found no significant difference in pancreatic cancer risk between aspirin users and non-users. However, extended regular aspirin use was associated with a 58% increased risk, while higher doses were linked to an 86% increased risk.
New drug combination might be more effective pain reliever
Researchers discovered a synergistic effect when combining glucosamine with ibuprofen, resulting in enhanced pain relief. The study suggests that adding glucosamine to existing pain medications could lead to improved efficacy without increasing side effects.
Ecstasy use falls for second year in a row, overall teen drug use drops
Teen ecstasy use declined for the second consecutive year due to increased perception of its risks, according to a University of Michigan study. Marijuana use also decreased in upper grades, with perceived risk increasing and overall use falling.
Study suggests 1% risk of DVT for long-distance air travellers
A study of long-haul air travelers found a 1% risk of venous thromboembolism (VTE), including pulmonary embolism and deep vein thrombosis. Traditional risk factors and prophylactic measures may need further investigation to reduce the risk.
Popular anti-epileptic drug also effective in controlling debilitating symptom of multiple sclerosis
Researchers discovered levetiracetam reduces phasic spasticity in MS patients, improving balance and walking difficulties. The medication also shows promise in treating other symptoms associated with the disease.
Aspirin use safe and effective in patients with abnormal red cell counts (or with polycythemia)
A clinical trial found that aspirin treatment significantly reduced the risk of thrombosis, cardiovascular death, and minor bleeding events in patients with polycythemia vera. The study suggests that aspirin can be a safe and effective treatment option for these patients.
The evolving management of migraine
The American Medical Association highlights the growing importance of migraine prevention, which can reduce attack frequency and severity. Preventive therapy has shown dramatic results in patients transitioning from acute to combination acute and preventive therapy.
Treatment options expand for patients with neuropathic pain
The guidelines recommend five medication types to treat neuropathic pain, including gabapentin, lidocaine patches, and narcotics. Neuropathic pain affects 4-6 million people in the US, caused by nerve damage from conditions like shingles, diabetes, and cancer.
Microneedles: Report describes progress in new technology for painless drug delivery
Researchers at Georgia Tech have made significant progress in developing hollow and solid microneedles that can deliver proteins, nanoparticles, and large molecules through the skin with minimal pain. The technology has potential applications in treating various diseases, including diabetes.
In some people, overuse of some analgesics can lead to kidney damage
Research finds that heavy use of analgesics for at least nine years prior to irreversible kidney failure is associated with anatomic changes of SICK. Over 7% of dialysis patients had SICK, with 33% having overused analgesics preceding dialysis start.
Antidepressants decrease chronic pain by inhibiting TNF production in brain, UB researchers find
UB researchers found that antidepressant drugs decrease chronic pain by inhibiting TNF production in the brain. The study showed that these drugs also increase norepinephrine release, leading to a decrease in pain and its symptoms. This finding may contribute to new strategies for treating chronic pain.
Aspirin may not be strong enough to prevent clots in some heart patients
Researchers found that platelets in heart disease patients clot more easily despite taking aspirin, increasing the risk of heart attack. Further studies will investigate additional anti-clotting agents and genetic factors affecting platelet function.
What makes peppers hot may also be cool for what ails you
The chemical capsaicin in peppers has been found to stimulate circulation, trigger pain relief, and even ease arthritis symptoms. It is also used in repellent sprays, marine coatings, and various drugs.
Aspirin withdrawal may pose risk to coronary patients
Patients with a history of coronary disease are at high risk of experiencing acute coronary events, including unstable angina and heart attacks, after aspirin withdrawal. Aspirin therapy is essential in reducing the risk of developing acute blockage in coronary arteries.
New medicines at risk from biodiversity loss
Conotoxins have extraordinary promise for developing powerful new drugs, including treatments for pain, cancer, epilepsy, and depression. However, habitat loss and uncontrolled exploitation threaten the extinction of cone snail species, which are a valuable source of these medicines.
Cancer patients find more pain relief when treatment guidelines are followed
A study published in the American Journal of Managed Care found that guideline-based cancer pain management offers effective pain relief in 80% of patients compared to 30% effectiveness for non-specialty providers. The targeted approach ensures a pre-determined treatment plan, reducing variability and increasing patient outcomes.
Investigational drug may protect cancer and AIDS patients from side effects of pain relief therapy
A laboratory study found that methylnaltrexone blocked increases in HIV entry and replication when immune cells are exposed to therapeutic doses of morphine. The study suggests that the drug may improve care for patients with AIDS who require pain relief, potentially reducing the risk of severe constipation.
For those who take painkillers regularly, a heartburn pill a day may keep ulcers away
A new international study found that a heartburn medication called esomeprazole effectively prevented ulcers among long-term painkiller users. The study showed the drug produced few side effects and was safe for daily use, offering hope to patients who need to take painkillers regularly.
Study: Racial, ethnic disparities seen in all types of pain
A study found racial and ethnic disparities in pain perception, diagnosis, and treatment across various specialties. Disparities were seen in emergency departments, cancer clinics, chronic pain, and disability, with African Americans and Hispanics facing unequal access to pain medication and treatment.
Tylenol awards $250,000 to outstanding healthcare students
The Tylenol Scholarship is one of the largest merit scholarship programs in the United States for all health-related studies. Since its inception in 1991, more than $6 million in scholarship grants have been awarded to over 5,000 students by McNeil Consumer & Specialty Pharmaceuticals.
Mt. Sinai researchers report that aspirin reduces risk of first heart attack by one-third
Mt. Sinai researchers found that aspirin significantly reduces the risk of a first heart attack in apparently healthy individuals by one-third. The study's findings support treatment guidelines issued by the American Heart Association and U.S. Preventive Services Task Force, recommending aspirin use for those at high risk.
Study finds music can ease labor pain
Researchers at Case Western Reserve University found that listening to calming music during early active labor can significantly reduce the sensation and distress of pain. The study, led by Sasitorn Phumdoung, suggests that music may be a widely-used alternative to medication for easing pain during childbirth.
Existing anti-inflammatory drug could help children suffering from an inherited bone disease
Researchers found that Indomethacin keeps phosphate levels normalized without causing life-threatening complications, offering a potential treatment alternative to conventional therapies for X-linked hypophosphatemia.
New compound that acts on peripheral receptors may be treatment for some nerve pain
Researchers have identified a new compound, AM1241, that acts on CB2 cannabinoid receptors and shows promise in alleviating neuropathic pain. The study suggests that this compound may provide pain relief without the debilitating side effects of existing pharmaceuticals.
What is the answer for pain?
A new study investigates the relationship between pain and selected medications, using genotyping to predict clinical outcomes and adjust drug therapy. By analyzing plasma concentrations of analgesics metabolized by CYP2D6, researchers aim to improve pain management therapy and reduce adverse effects.
Aspirin could reduce the risk of deadly infections
Research found that salicylic acid in aspirin disrupts the stress system of S. aureus bacteria, reducing its ability to cause infection and adhere to host tissue. This finding offers hope for treating sepsis, a blood poisoning disease responsible for 750,000 US deaths annually.
Ibuprofen, Aspirin may reduce woman's risk of developing breast cancer
A study of nearly 81,000 women found that regular use of ibuprofen reduced breast cancer risk by 28%, while aspirin use reduced it by 22%. Both NSAIDs showed a significant effect in reducing the incidence of breast cancer, especially among high-risk groups.
An aspirin a day keeps Staphylococcus aureus away
Treatment with salicylic acid (SAL) induces activation of the S. aureus stress response gene sigB, downregulating virulence factors and reducing ability to adhere to host cells. This finding represents a new prospect for using aspirin as an adjunct therapy to combat Staphylococcus aureus infections.
Regional not racial difference in use of pain medications in children
A recent study by the American College of Emergency Physicians found no significant racial differences in the administration of pain medications to children, but did reveal regional variations. Children in the South and West received narcotics more frequently than those in other parts of the country.
Once weekly ENBREL significantly reduced rheumatoid arthritis pain, inflammation & improved function
In a multi-center, double-blind study, ENBREL 50 mg administered once weekly achieved an ACR 20 response in 50% of patients, compared to 19% in the placebo group. ENBREL also showed comparable improvement in HAQ and patient-reported measures of global status and pain.
Blood test could detect heart attack early
A new blood test can detect heart attacks in just five minutes with a 99% accuracy rate, improving diagnosis and treatment outcomes. The test identifies two proteins associated with the earliest stages of a heart attack, reducing unnecessary hospital stays.
Aspirin as effective as Ticlopidine in African American stroke prevention
The study shows that aspirin is likely a better choice than ticlopidine for recurrent stroke prevention in African Americans, who face higher stroke risks. Aspirin is readily available and inexpensive, while ticlopidine has serious side effects and is more difficult to use.
'Annals' study shows that spinal manipulation is safe alternative to drugs, says ACA
A recent study published in Annals of Internal Medicine suggests that spinal manipulation, a key component of chiropractic care, is an effective and safer alternative to pharmaceuticals for treating back pain. The American Chiropractic Association applauds the findings, which align with its long-standing advocacy for evidence-based care.
Drugs that treat back pain also improve productivity
A study by the University of Alberta has found that giving people drugs to treat back pain can improve performance. The research team led by Dr. Saifee Rashiq ran a randomized controlled trial where participants were injected with a strong narcotic painkiller and completed the Sorensen test, showing a significant increase in functional...
Camera pill reveals damage from anti-inflammatory drugs
A study using camera pills found that people taking NSAIDs regularly are at increased risk of small intestinal mucosal ulceration and bleeding. The study, which used capsule endoscopy to visualize the entire small intestine, detected erosions in 62% of NSAID users compared to 5% of non-users.
Study at Mt. Everest finds acetaminophen as effective as ibuprofen for high-altitude headache
A study conducted at Mt. Everest found that acetaminophen was as effective as ibuprofen in treating high-altitude headaches, with both medications providing similar levels of pain relief and reduced nausea. The results suggest that acetaminophen could be a safer alternative for patients suffering from high-altitude headache.
CT-guided interventional procedures
A study of 120 patients found that less than 3% required surgical treatment after CT-guided interventional procedures. The procedure was effective in reducing analgesic drug consumption and may be used as a complement to physical therapy.
Poor pain pump designs increase patient risk: University of Toronto study
A University of Toronto study estimates that pain pump programming errors could result in up to 667 deaths, with reporting rates ranging from 1.2% to 7.7%. The researchers recommend redesigning the control panel using human factors engineering techniques to reduce human error.
Pain control bandage now available for clinical use
The CT1 is a small, wireless device providing pain relief with minimal side effects. It can be used for various conditions such as arthritis, minor cuts, and surgical procedures.
Over-the-counter pain relievers effective in protecting against breast cancer
Women taking two or more NSAIDs per week for five to nine years reduced their breast cancer risk by 21-28%. Ibuprofen was found to be more effective than aspirin in preventing breast cancer. The study's findings suggest that COX-2 inhibition may play a role in limiting breast tumor growth.
Over-the-counter pain relievers may prevent breast cancer
Regular NSAID use for five to nine years reduces breast cancer risk by 21%, while ten-year use increases the reduction to 28%. The study enrolled 80,741 post-menopausal women with no reported history of cancer, other than non-melanoma skin cancer.
Antioxidant alpha lipoic acid (ALA) significantly improves symptoms of diabetic neuropathy
A study published in Diabetes Care found that alpha lipoic acid significantly improved symptoms of diabetic neuropathy, including a 5.7-point total symptom score improvement. The treatment had no unfavorable side effects and may be a promising lead for future research into the cause and prevention of diabetic neuropathy.
Significant pain reduction for post-shingles patients
A single application of high-concentration capsaicin patches has been shown to provide significant long-term pain relief for patients with postherpetic neuralgia, a condition that often persists for years. The patch-based treatment avoids systemic side effects associated with traditional treatments.
Research shows high doses of acetaminophen clear rapidly and consistently from bloodstream
Researchers found that high doses of acetaminophen (up to 8g/day) were quickly eliminated from the bloodstream, with no accumulation or liver damage. The study's findings suggest that consumers can safely take higher doses than recommended, but emphasize the importance of adhering to the standard daily limit.
Marked improvement in heart attack care seen in 33-hospital study
A new study conducted in 33 Michigan hospitals shows significant improvements in the use of proven treatments and lifestyle counseling for heart attack patients. The study, led by researchers at the University of Michigan Cardiovascular Center, found that hospitals that implemented a system of reminders and checklists saw increases in ...