Articles tagged with Analgesics
A study published in Diabetes Care found that alpha lipoic acid significantly improved symptoms of diabetic neuropathy, including a 5.7-point total symptom score improvement. The treatment had no unfavorable side effects and may be a promising lead for future research into the cause and prevention of diabetic neuropathy.
A nationwide study found that frovatriptan succinate prevented menstrually associated migraines (MAM) in as many as half the women evaluated. The drug significantly reduced MAM severity and duration, as well as patients' functional impairment and use of rescue medications.
A single application of high-concentration capsaicin patches has been shown to provide significant long-term pain relief for patients with postherpetic neuralgia, a condition that often persists for years. The patch-based treatment avoids systemic side effects associated with traditional treatments.
Researchers found that high doses of acetaminophen (up to 8g/day) were quickly eliminated from the bloodstream, with no accumulation or liver damage. The study's findings suggest that consumers can safely take higher doses than recommended, but emphasize the importance of adhering to the standard daily limit.
A new study conducted in 33 Michigan hospitals shows significant improvements in the use of proven treatments and lifestyle counseling for heart attack patients. The study, led by researchers at the University of Michigan Cardiovascular Center, found that hospitals that implemented a system of reminders and checklists saw increases in ...
Researchers found that using nonsteroidal anti-inflammatory drugs (NSAIDs) may help slow the progression of Alzheimer's disease. However, data suggests that low-dose aspirin use does not provide a significant protective effect against developing Alzheimer's.
A new study found that levorphanol's ability to reduce pain is comparable to tricyclic antidepressants and gabapentin, commonly used drugs for neuropathic pain treatment. High-dose treatment provided greater pain reduction without tolerance, but also led to more side effects and participant dropout.
Researchers have developed a glycosylated enkephalin that appears promising in studies using mice, triggering behavior consistent with reduced addiction and fewer side effects than morphine. The compound interacts with both mu and delta receptors to increase analgesic strength while limiting narcotic side effects.
A new study by McGill University found that redheaded women respond better to a painkilling drug due to a genetic variation in the Mc1r gene. This gene is associated with pigmentation and variants cause red hair and fair skin, leading to a heightened response to kappa-specific analgesics.
A study found that Keppra, when used in combination with conventional treatments, provided significant pain relief for multiple sclerosis (MS) patients. Over half of the participants showed marked improvement and continued treatment with Keppra.
A new study finds Keppra alleviates severe nerve pain in cancer patients by reducing VAS scores to 0-3 within 3-14 days, with a significant decrease in opioid use. The medication was well-tolerated and showed potential therapeutic benefits for further investigation.
A community study of 400 patients with various pain types found that Keppra was well-tolerated and provided significant pain relief. The medication was effective in treating a range of conditions, including migraine headaches, nerve pain, and diabetic pain.
African Americans with chronic pain experience significantly more symptoms than whites when seeking treatment, including greater levels of pain, depression, and impairment. Economic factors also play a significant role in producing these disparities.
According to Dr. Robert Kaniecki, a University of Pittsburgh neurologist, migraine headaches are often underdiagnosed, with over 50% of patients being mislabeled as having 'sinus headache' or 'tension headache'. This can lead to excessive prescriptions for antibiotics and decongestants, contributing to antibiotic resistance.
A major study shows that taking 325 milligrams of aspirin daily can reduce the risk of developing polyps in the colon by 35%, a significant step towards preventing colorectal cancer. The study involved over 100 medical centers and clinics across the US, with patients who had previously suffered from colorectal cancer.
A large randomized trial found that daily aspirin use reduced the incidence of adenomas and prolonged time to appearance in colon cancer patients, offering strong evidence for its protective properties.
A daily aspirin regimen was found to significantly reduce the occurrence of pre-cancerous polyps in patients with a history of colorectal cancer, lowering their risk by about one-third. Aspirin's protective effect also prevented the development of new adenomas and reduced the number of existing polyps.
A randomized, double-blind study of over 1100 patients found that low-dose aspirin reduced the incidence of polyps by 19% and advanced lesions by more than 40%. Regular aspirin tablets also showed significant reductions in adenoma occurrence.
A landmark analysis found that oxycodone was involved in only a small percentage of drug abuse deaths, with multiple drugs present in most cases. The study suggests that abusing opioids with other substances increases risk and calls for enhanced classification methods.
A study published in the American Association for the Advancement of Science suggests that estrogen levels influence women's ability to suppress pain. The researchers used PET scans to examine the brain's response to pain in individuals with different gender, hormone, and genetic profiles.
Researchers found baby aspirin to be less effective in reducing the risk of stroke compared to adult and coated formulas. The study suggests that age and gender play a role in a person's response to aspirin, with women being more effective than men.
Researchers found that combining ibuprofen with aspirin increased the risk of death from any cause and cardiovascular disease by 75% and 200%, respectively. Patients taking both medications also had a higher risk of bleeding from stomach ulcers.
A new study provides validated guidelines for emergency physicians to care for chest-pain patients using cocaine, improving treatment outcomes and reducing complications. The protocol divides patients into high-risk and low-risk categories, allowing doctors to determine which patients can be safely discharged home.
A Stanford study found a significant link between depression and chronic pain, suggesting that pain may guide doctors to effective treatments for depressed patients. The research also indicates that continuous pain increases the likelihood of major depressive disorder diagnosis.
A $1.4 million NIH-funded study will use genetically altered mice to find morphine-regulated genes that cause tolerance and dependence. The researchers aim to create better therapeutics and prevent dependence, with potential benefits for children born to drug-dependent mothers.
A new study by UT Southwestern researchers found that acetaminophen overdoses are the leading cause of acute liver failure in the US, affecting 39% of patients. The three-year study also revealed that most cases were unintentional and affected mostly women.
A meta-analysis of randomized trials confirms that aspirin significantly reduces first heart attack risk and combined cardiovascular events. The study supports recent guidelines recommending aspirin therapy for individuals with a 10% or greater 10-year coronary event risk.
A new study by the American Heart Association found that death rates are significantly lower in hospitals that follow established guidelines for treating heart attacks. The study examined adherence to clinical practice guidelines at 1,085 US hospitals and found that leading hospitals had a 50% higher rate of beta-blocker use and a 30% ...
A new study published in Obstetrics and Gynecology found that aspirin inhibited ovarian tumor cell growth by as much as 68 percent. Combining aspirin with a monoclonal antibody targeting the HER-2/neu protein resulted in an even greater suppression of growth, decreasing cancer cell growth by 84 percent.
A study of 75 patients found that postponing care for those with non-serious illnesses had comparable health outcomes to immediate care. Additionally, a new combination therapy for arthritis patients showed promise in reducing joint symptoms and improving function.
Patients receiving enzyme replacement therapy for a near-two-year period show improved pain levels and reduced organ damage. The treatment continues to be effective despite the presence of antibodies in some patients.
A study reveals a new mechanism in acetaminophen toxicity and suggests blocking the CAR receptor as a potential approach to treating liver damage. Researchers found that CAR plays a critical role in mediating acetaminophen's toxic effects, and a drug called androstanol shows promise in reversing this effect.
Researchers from Johns Hopkins University and National Institutes of Health found opioids to be highly effective in reducing pain in PHN patients, while causing no appreciable cognitive decline. The study's results provide convincing evidence for the use of opioids as an alternative treatment option for neuropathic pain.
The Mayo Clinic study highlights the effectiveness of opioids in relieving chronic lower back pain, despite controversy over misuse and potential drug dependence. The research emphasizes the need for careful patient selection and close monitoring to ensure safe treatment outcomes.
Researchers found that aspirin use did not decrease the effectiveness of ACE inhibitor therapy in patients. The combination of both treatments significantly reduced major vascular outcomes by 22%, producing substantial additional benefits for patients at high risk of events.
A double-blind, randomized controlled trial found that taking aspirin at bedtime significantly reduced the risk of preterm labor and preeclampsia in pregnant women with high blood pressure. The study also showed significant weight gains in babies born to mothers who took aspirin at night.
Research suggests that long-term use of nonsteroidal anti-inflammatory drugs (NSAIDs) may reduce the risk of Alzheimer's disease by up to 45% if started before the onset of dementia. Aspirin compounds and other medications showed similar protective effects, while recent or late use offered little protection.
Researchers from Leiden discovered that vitamins C and E can prevent breathing problems in patients after surgery by reducing the impact of sedatives and painkillers. The study found that stress and pain play a significant role in maintaining alertness, which may help counteract breathing issues.
Researchers found that low-dose aspirin changes the composition of arterial plaques, reducing cholesterol-rich cells and increasing collagen and smooth muscle cells. This shift in plaque composition is associated with reduced inflammation and lower risk of rupture.
A new compound, ajulemic acid, is being tested for its effectiveness in treating chronic pain, arthritis, and multiple sclerosis. Results from animal studies have shown promising results, and the compound has been found to be safe and effective with minimal side effects.
Newborn infants exhibit increased pain response after repeated painful procedures, learning to anticipate pain. The study supports efforts to decrease pain in infants undergoing medical procedures.
Panek and his research team have discovered a process that leads to an almost pure form of 'handed' tetrahydropyridine, a component found in many drugs. The molecule's unusual chemical properties can control a reaction's three-dimensional orientation.
A study of over 7 years found that women taking aspirin two to five times per week had a lower risk of pancreatic cancer compared to those not taking it. The researchers estimate that aspirin use might prevent up to 43% of pancreatic cancer cases in women who do not normally take aspirin.
A study examines the potential of pharmacogenomic testing to help drug-treatment centers select suitable treatment regimens for opiate-addicted patients. The research investigates genetic polymorphisms affecting opioid metabolism, aiming to improve pain management and drug-abuse treatment.
Rutgers researchers found that acetaminophen can exert an antioxidant effect on heart muscle cells, blocking damage caused by oxidants. The study suggests that acetaminophen may play a role in preventing some of the damaging effects of cardiovascular disease and hardening of the arteries.
A combination therapy of aspirin and coumarin reduced artery re-closure after heart attacks by 45% in a clinical trial. The therapy also improved problem-free survival rates and reduced the incidence of second heart attacks, according to researchers from the American Heart Association.
Researchers at the University of Melbourne have developed a new compound, ACV1, derived from cone shell venom that is more powerful and longer-lasting than morphine. The compound has shown promising results in laboratory studies, treating pain by blocking transmission along peripheral nervous systems without addictive side effects.
A new study suggests that taking aspirin three or more times a week for six months may reduce the risk of developing non-small cell lung cancer in women. However, larger studies are needed to confirm these findings and determine the optimal dose due to potential side effects like gastrointestinal bleeding.
Researchers at Ohio University found that a behavioral therapy program reduced migraine frequency and severity in teens by 80%, with no medication required. The study suggests an alternative approach to treating migraines in children and teens.
A study by Michigan Medicine researchers found that 11% of doctors are willing to misrepresent patient information to obtain HMO approval for surgery or additional procedures. The 'hassle factor' plays a significant role in this behavior, with more physicians willing to deceive if the appeal process is longer or more burdensome.
Researchers found that implantable pain pumps improved cancer patients' quality of life by increasing survival rates, reducing pain and side effects. Patients treated with the pump had significantly less fatigue, constipation, and nausea compared to those on medical management.
Neuropathic pain is a complex condition that can be difficult to treat, but research suggests that psychological factors play a crucial role. Dr. Bushnell's work highlights the importance of catching pain early and treating it aggressively, as well as exploring alternative approaches such as meditation and drawing
A study found XALACOM to be more effective than Cosopt in reducing intraocular pressure by 1.00 mmHg, with fewer reported eye pain and irritation. XALACOM was also well-tolerated systemically, with no taste disturbances reported.
A UCSF study shows that 80% of patients taking etanercept experience significant relief from ankylosing spondylitis symptoms. The drug reduces spinal inflammation and slows disease progression, offering a new therapeutic option for the chronic inflammatory arthritis.
New research adds to evidence that acetaminophen may prevent colon cancer in lab animals. The study found that pretreating animals with acetaminophen significantly protected them against cellular changes indicative of colon cancer. However, more animal research is needed before humans can be studied in clinical trials.
The balancing act between COX-1 and COX-2 enzymes plays a crucial role in protecting the heart from cardiovascular disease. The study found that PGI2 production is stimulated as a response to platelet interactions with the vessel wall, limiting the harmful effects of thromboxane.
A study of 93 patients hospitalised due to acetaminophen overdose found that those who accidentally overdosed fared less well, despite lower drug levels. Delayed treatment and alcohol consumption exacerbated liver damage and death risk.
A recent study by Ohio State University found that the DentiPatch, a small adhesive patch containing lidocaine, delivers longer and deeper relief from dental pain. The patch's anesthetic effects last up to 45 minutes, whereas traditional gel-based treatments only last about a minute.
A recent study found that migraine prevalence in the US has remained stable over the past decade, with many sufferers relying on over-the-counter medications. The study suggests that millions of people could benefit from proper medical attention, which can lead to more effective treatment and improved quality of life.
A USGS survey found 82 organic wastewater contaminants in at least one stream across the US, including medications, caffeine and antimicrobial soaps. The presence of mixtures was a surprising finding, with some streams containing up to 38 chemicals.