Articles tagged with Analgesics
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
A study by UCSF found that cancer patients often prefer to experience pain over the side effects of opioid analgesics. Effective pain management requires repeated assessment and adjustments in dosage, according to experts.
A new UCSF study found that many cancer patients are not taking around-the-clock and as-needed pain medicines as prescribed by their physicians. This results in inadequate pain relief, with only 29.2% of patients receiving both long-acting and short-acting opioids.
A recent study published in the New England Journal of Medicine found that warfarin and aspirin provide no significant difference in preventing another stroke in ischemic stroke patients without atrial fibrillation. The study, which followed 2,206 individuals for two years, showed no statistically significant differences between the tw...
A 7-year clinical trial comparing aspirin and warfarin found that both drugs are safe and effective in preventing recurrent strokes in most patients. Aspirin slows clotting of blood platelets, while warfarin inhibits circulating clotting proteins.
Researchers find that heparin and compression stockings can effectively prevent deep-vein thrombosis (DVT) in people at high risk for clots, particularly those with a history of heart disease or stroke. Compression stockings were found to significantly reduce DVT incidence by 18.75 times compared to controls.
A new study by Johns Hopkins Medicine suggests that nitroglycerin relief does not accurately predict coronary artery disease, challenging the long-held assumption. The study found that only 28% of patients with heart disease experienced chest pain relief from nitroglycerin.
A recent study published by the American Academy of Neurology found bupropion SR to be clinically effective for treating neuropathic pain. Approximately three-quarters of patients experienced a 30% reduction in pain symptoms with bupropion SR, while those on placebo saw little improvement.
Researchers found that aspirin does not reduce costs and increase life expectancy for colorectal cancer prevention. Regular screening tests remain highly effective and cost-effective, even for patients taking aspirin for other reasons.
Researchers found that aspirin is not cost-effective addition to national strategy for reducing death from colorectal cancer. Screening methods, such as flexible sigmoidoscopy and yearly fecal occult blood testing, remain highly effective and cost-efficient options.
Researchers found that morphine significantly relieved both types of pain, while lidocaine only relieved stump pain. The study suggests different therapeutic sensitivities and mechanisms for stump and phantom pain. Morphine's action on both peripheral and central nervous systems may provide new treatment options.
A clinical trial found acupuncture to be as effective as the commonly used medication ondansetron in reducing postoperative nausea and vomiting. Additionally, women who received acupuncture reported lower levels of moderate to severe pain after breast surgery, a surprising discovery that opens up new possibilities for pain management.
Researchers at Saint Louis University School of Medicine found that small doses of botulinum toxin Type A effectively relaxed muscles involved in triggering tension headaches, resulting in reduced frequency and intensity for most patients. The injections were also easier to control symptoms.
A UCSF study found that patients with substance abuse-related medical conditions benefit from integrated medical and addiction treatment, leading to improved abstinence rates and reduced inpatient use. The two-year study showed no significant differences in total abstinence rates between the integrated and independent care groups.
Researchers discovered a new drug that can restore bowel function without affecting pain relief, enabling patients to recover faster and be discharged sooner. The study found significant improvements in recovery times for patients taking the 6mg dose of ADL 8-2698.
A double-blind, placebo-controlled study found that patients with diabetic neuropathy experienced significant pain reduction with Lamictal treatment. Almost half of the patients achieved a 50% reduction in pain, and most were able to reduce their need for additional pain medication.
Victor Snieckus has invented more efficient methods for creating organometallic compounds, which have applications in pharmaceuticals, agriculture, and electronics. His research has led to the development of a new painkiller, fungicides for wheat crops, and conducting materials.
Murray Goodman, a bioorganic chemist at the University of California, San Diego, has developed new strategies to create more effective and selective drugs. His research aims to mimic the action of peptides, which help direct processes in the body, and improve upon their natural opioids.
Studies reveal a connection between neuronal plasticity and chronic neuropathic pain. Gene therapy targeting protein kinase C shows promise in reducing sensitivity to pain. Such findings may lead to innovative treatments for persistent and debilitating pain conditions.
Dr. Barr will investigate the relationship between rising acetaminophen use and a 20-year increase in asthma prevalence, exploring potential mechanisms behind the association. The research aims to inform treatment strategies and public education about pain medication use.
A study in Calicut, India found no instances of misuse or diversion of oral morphine over 2 years. The research shows that opioids can be dispensed safely for home use with proper controls in place, overcoming regulatory barriers.
A unique experiment studying chemical activity in human brains while experiencing sustained pain revealed long-suspected connections between pain-dampening changes in brain chemistry and sensory/emotional responses. The findings may help researchers better understand prolonged pain and find more effective ways to relieve it.
A study by Stock et al. reveals that genetic disruption of the PGE2 receptor EP1 significantly reduces pain behavior and blood pressure responses to inflammation. The findings suggest that NSAID treatment's analgesic effect can be explained by inhibition of signaling through this single receptor type.
A new drug, lamotrigine, has been shown to reduce central post-stroke pain in patients by an average of 30 percent. The treatment was found to be effective for patients who could not tolerate amitriptyline due to its side effects.
A long duration of regular aspirin use is associated with a significant increase in pancreatic cancer risk among women. Women taking 14 or more tablets per week experience nearly an 86% increased risk, while those taking six to 13 tablets per week see a 41% higher risk.
A new study establishes a link between gastroesophageal reflux and allergies, including environmental allergens like pollens and molds. The discovery could lead to new treatments for children with eosinophilic esophagitis and adults with refractory reflux.
A recent study by OHSU researchers found that 96% of physicians and nurses believe increased family expectations for pain management contributed to the observed increase in family reports of pain among dying patients. Additionally, decreased physician prescribing of pain medications (66%) and reduced nurse administration of pain medica...
A new clinical trial will compare the effectiveness of aspirin, clopidogrel, and warfarin in preventing heart attacks, strokes, and deaths in patients with chronic heart failure. The study, funded by the VA, will enroll 4,500 patients and provide insights into which medication is most effective, safe, and cost-efficient.
A Yale study of over 51,000 participants found that taking aspirin daily reduces the risk of a first heart attack by 32%. However, it did not significantly reduce overall stroke or cardiovascular death rates, and may increase the risk of hemorrhagic stroke.
A study published in the Lancet found that a catheter laser procedure combined with medication is more effective than medication alone in treating severe chest pain. The procedure, known as PTMR, stimulates new blood vessel growth and increases circulation to relieve angina symptoms.
A survey conducted by Dr. Maria Silveira found that many patients and families in Oregon are unaware of their basic rights regarding end-of-life care. The results suggest a need for healthcare providers to actively educate patients about their options, including refusal of treatment, withdrawal of care, assisted suicide, and euthanasia.
A University of Maryland study found that high cholesterol hinders the effectiveness of aspirin in reducing platelet aggregation and preventing heart attacks. The study showed that 60% of patients with high cholesterol levels above 220mg/dL remained at increased risk despite taking daily aspirin doses.
Researchers at UCLA and Cambridge report a breakthrough in pain medicine that delivers painkillers directly to affected areas, eliminating unwanted side effects. A single injection of the new medication can alleviate pain for several days, offering a significant improvement over current treatments.
A University of Pennsylvania study suggests that taking ibuprofen before aspirin can inhibit the cardioprotective benefits gained from a daily aspirin regimen. The study found no competitive interaction between aspirin and Tylenol or Vioxx when taken separately.
Researchers found that 6-beta naltrexol, a metabolite of naltrexone, can reduce alcohol drinking in rats. The study suggests that 6-beta naltrexol is a potential new medication for treating alcohol dependence.
A comprehensive program involving exercise, weight loss, and joint protection principles is necessary for effective osteoarthritis management. Over-the-counter acetaminophen may be the only required medication for mild-to-moderate pain relief.
A study published in JAMA found that patients taking Celebrex had two- to threefold fewer serious gastrointestinal complications compared to those receiving ibuprofen or diclofenac. The medication was also associated with lower incidence of stomach upset, abdominal pain, and nausea.
The European Respiratory Society warns that hundreds of medicines can cause lung diseases, with 310 therapeutic substances identified as having iatrogenic effects. Early withdrawal of these medicines can reduce the risk of damaging sequelae in 70% of cases.
Researchers present innovative solutions for weight management, metal protection, and pharmaceutical advancements. A dietary supplement may help control weight, fat, and diabetes, while a new coating extends the life of metals tenfold. Additionally, a gentler form of aspirin is developed using polymers.
A potentially safer, more potent form of aspirin made from polymers called PolyAspirin could eliminate stomach irritation and other side effects. The polymer-based drug consists of linked aspirin molecules that break down in the intestine, allowing for efficient delivery and reduced side effects.
Researchers found that ibuprofen significantly reduced inflammation and amyloid plaques in an animal model of Alzheimer's disease, which may help prevent the disease. The study suggests that taking anti-inflammatory drugs early on could delay the onset of AD by about a decade.
Researchers found that administering low to moderate doses of kappa-opioids in conjunction with naloxone causes profound, prolonged pain relief in both men and women. This discovery provides a significant alternative to morphine with minimal side effects.
A large randomized clinical trial shows that self-hypnotic relaxation techniques can decrease pain medication use, reduce operating room time, and improve vital signs during surgery. The study's findings suggest that hypnosis can be a safe and effective method for reducing anxiety and pain in patients undergoing invasive procedures.
A new study published in Thorax suggests that daily or weekly use of paracetamol may be associated with an increased risk of asthma. The research found that frequent users of paracetamol were more likely to develop severe asthma and experience rhinitis, highlighting the potential risks of this analgesic.
A clinical trial revealed that regular aspirin was as effective as sibrafiban in preventing blood clots, while high-dose sibrafiban showed increased risk of death and second heart attacks. Aspirin's minimal risks make it a hard-to-beat option.
Despite evidence supporting aspirin's effectiveness in preventing future heart problems, low usage rates were found among patients with coronary artery disease. The study, published in Circulation: Journal of the American Heart Association, highlights the need for optimal use of life-saving medications.
Researchers found that an experimental pain drug, kappa-opioid, provides effective pain relief to female rats, but has no effect on males. The study suggests a fundamental difference in brain responses between genders, which may lead to the development of more effective and non-addictive pain treatments for women.
A new study reveals that sleep disruption is a primary reason older adults with arthritis seek medical care, outweighing other symptoms like reduced mobility. The research suggests addressing sleep issues can be crucial in managing arthritis, particularly for those who may not connect their pain with sleep disruptions.
A study found that top hospitals in the US are falling short in stroke prevention, with 40% of patients not receiving necessary clot-preventing medications. The study, which analyzed data from 961 patients, also showed that certain groups, such as older adults and those with major heart disease, were more likely to receive treatment.
Methylnaltrexone reverses opioid-induced constipation in over 90% of patients, providing relief from debilitating symptoms. The drug is designed to block morphine's effects on gut motility without interfering with pain relief.
Scientists at Duke University Medical Center discovered a biological mechanism in mice that prolongs morphine's painkilling effects by eliminating a protein switch called beta-arrestin 2. This finding may lead to the development of new drugs that enhance morphine's action and reduce side effects.
A groundbreaking mouse study has identified the molecular mechanism behind morphine tolerance, offering new hope for more effective pain management. The research found that genetically engineered mice lacking a key protein exhibited prolonged analgesia and reduced tolerance to morphine.
A six-year randomized study of 5,059 U.S. veterans found that taking one aspirin a day after a heart attack is as effective as combining it with an anti-clotting drug in reducing post-heart attack risk. The study recommends solo aspirin use due to its cost-effectiveness and lack of need for monitoring.
Millions of patients mix prescription medicines with alternative therapies without informing their doctors, raising concerns about herb-drug interactions. Studies have shown that herbs like St. John's wort and ginkgo can be effective in treating depression, anxiety, and memory problems, but may also cause side effects.
A new clinical trial confirms zaleplon's safety and tolerability for the long-term treatment of insomnia, lasting up to 12 months. The medication showed no withdrawal symptoms upon discontinuation, making it a good option for chronic insomnia sufferers.
UCSF researchers discovered that pain elicits analgesia via the brain's reward pathway, releasing opioids and dopamine. This finding provides a new understanding of pain relief and its connection to addiction.
The Interstitial Cystitis Clinical Trials Group is conducting a clinical trial using pentosan polysulfate sodium (ElmironR) and hydroxyzine hydrochloride (AtaraxR) to treat IC. The trial aims to evaluate the effectiveness of these oral drugs in relieving symptoms in patients with IC.
A new study by the NIH/NINDS found that lower doses of aspirin (81-325mg) taken before and after carotid endarterectomy surgery are more effective in preventing strokes than higher doses. The results suggest that lower doses may be better tolerated and easier to take, making them a promising option for stroke prevention.
A study of over 1,000 older, disabled women reveals that nearly two-thirds report significant pain in multiple areas, yet many use inadequate or ineffective doses of medication. This mismatch suggests a need for better pain management strategies among older adults.
Research found that relaxation and music reduce pain more than pain medication alone, providing complete relief without side effects. These self-care methods can hasten recovery and improve hospital stays for millions of Americans who undergo surgery annually.
The Emory-led WASID study aims to compare the effectiveness of warfarin and aspirin in preventing stroke and vascular death in patients with intracranial stenosis. The five-year trial will evaluate 806 high-risk patients at 50 sites across North America.