Articles tagged with Analgesics
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
A recent study published in the Archives of Internal Medicine found that aspirin use is underutilized among diabetic women and young adults. The researchers discovered a significant disparity in aspirin use between men and women with diabetes, with only 34% of women using aspirin regularly compared to 42% of men.
Price promotions benefit consumers overall, but not manufacturers or retailers in the long run. Introducing store brands is beneficial to premium brand manufacturers and offers increased profit margins for retailers.
Researchers at Brown Medical School and Quality Partners tested a rapid-cycle quality improvement model to address persistent pain in nursing home residents. The study showed a significant reduction in pain, with 44% of homes using appropriate pain assessments and 82% using non-drug pain treatments.
A study found that virtual colonoscopy can detect significant polyps as accurately as conventional colonoscopy, reducing the need for invasive procedures. The research suggests reserving conventional colonoscopy for patients with a higher likelihood of harboring significant polyps.
A study found that Concord grape juice increased high-density lipoprotein (HDL) levels and decreased inflammatory markers, including soluble CD40 ligand, in patients with coronary artery disease. The positive effects were attributed to the polyphenolic compounds in the grape juice.
A subanalysis of a broader study found that patient-controlled, transdermal pain management system IONSYS TM provided similar pain relief to IV PCA morphine after gynecologic surgery. The study showed no significant differences in overall pain control, supplemental medication use, or adverse events between the two groups.
A new study published in Gastroenterology found that generic anti-inflammatory drug etodolac reduces rates of gastrointestinal complication by more than 60% compared to naproxen, resulting in fewer hospitalizations and cost savings. This significant finding has led the Pharmacy Benefits Management Strategic Healthcare Group for the Vet...
Researchers from Rutgers University found that acetaminophen significantly reduced infarct size in treated dogs, with reductions of up to 63% compared to untreated control groups. The study also suggested anti-arrhythmic action of acetaminophen, with treated hearts appearing more stable electrically during ischemia and reperfusion.
Chronic daily headache (CDH) affects a significant percentage of the population, with substantial disability and quality-of-life impact. Physicians and patients need to be educated on medication-overuse headaches, which can be prevented by carefully examining medical history.
Researchers discover marijuana-like compounds can slow disease progression in ALS patients and protect brain cells from Parkinson's damage. THC and cannabidiol treatments delay disease progression by seven days and extend survival by six days in mouse models.
DepoDur offers a safe and effective alternative to traditional epidural analgesia, providing up to 48 hours of effective pain control without the need for continuous infusion. This single-shot epidural formulation has been shown to improve treatment of postoperative pain following major surgery.
Researchers found that systematic relaxation significantly reduced post-operative pain and increased patients' sense of control, leading to fewer requests for pain medication. The study used a random sample of 102 adults who underwent various abdominal surgeries.
Researchers found complete pain relief in 76% of patients treated with low-dose ketamine infusions, with some experiencing relief lasting over three years. The study's findings suggest a novel approach to treating complex regional pain syndrome (CRPS).
Researchers at NIST studied four pharmaceuticals and their reactions with chlorine, finding multiple products some of which are highly toxic. The resulting compounds were more hydrophobic than the original drugs, raising concerns about potential environmental and health impacts.
The new guideline suggests tricyclic antidepressants, gabapentin, lidocaine skin patch, and opioids as effective in reducing pain from postherpetic neuralgia. However, the long-term effects of these treatments are not yet supported by sufficient data.
A study found that imagery reduced children's post-operative pain and anxiety after elective tonsillectomy or adenoidectomy. The 'To Tame the Hurting Thing' intervention, which included deep breathing and relaxation techniques, was effective in reducing pain levels.
A retrospective study found that low-dose ketamine infusions provided complete relief from CRPS pain for 76% of patients, with 54% remaining pain-free for three months or more. The therapy's effectiveness was linked to its ability to block NMDA-receptor complexes involved in pain processing.
Researchers at Duke University Medical Center found that acupuncture is more effective than medication in reducing postoperative nausea and vomiting, as well as decreasing pain levels. The study, which used electro-acupuncture, showed significant improvements in patient satisfaction and comfort after major breast surgery.
A recent study found that IV access does not provide a significant advantage for healthy children undergoing minor ear surgery. Children without IV access experienced reduced pain requirements and shorter hospital stays. Meanwhile, parents whose children did not receive IV access reported higher satisfaction rates with the procedure.
The ACTION study found that adding nifedipine to existing treatments for stable angina reduces the need for hospital interventions by 13% and prevents heart attacks and strokes. Nifedipine also reduces hospitalizations for heart failure in patients with stable angina.
The TARGET study found that COX2 inhibitor lumiracoxib significantly reduces ulcer complications in osteoarthritis patients, but no significant difference was seen in cardiovascular events. Lumiracoxib showed a three to four-fold reduction in ulcer complications compared with non-steroidal anti-inflammatory drugs.
A new study led by Cincinnati Children's Hospital Medical Center found that imagining a favorite place reduced pain in children after surgery. The study used audio tapes and video tapes to help children manage their anxiety and pain, suggesting a potential multi-faceted approach to pain management.
A study found that adding aspirin to clopidogrel therapy increased the risk of intracranial and gastrointestinal bleeding in patients with a history of ischemic stroke or transient ischemic attack. Despite this, combination therapy did not significantly reduce the primary outcome measure at 18 months.
Experts disagree on acetaminophen's safety; William M. Lee advocates for stricter regulation to reduce overdoses, while Barry H. Rumack suggests therapeutic doses are safe and most cases may be intentional overdose attempts.
Researchers at Vanderbilt University Medical Center found that chronic high-dose consumption of Vioxx raises blood pressure and increases the risk of serious heart problems. A substantial number of patients continue to receive high doses of the drug, despite evidence suggesting its potential harm.
A new study found that pain medications NSAIDs and COX-2 inhibitors can slow healing after shoulder surgery. The research used laboratory rats to test the effects of these medications on tendon-bone healing.
Researchers discover COX-2 enzymes can produce DNA-damaging genotoxins, increasing cancer risk. Vitamin C may also contribute to DNA damage under certain conditions.
Researchers found that over half of COX-2 patients take aspirin, leading to a loss of GI protective effects and increased risk of bleeding. Patients should consider alternative NSAIDs or proton pump inhibitors for added protection.
A new clinical trial demonstrates that treating migraine with Relpax during mild pain provides greater efficacy than waiting for pain to become more severe. Patients who treated early experienced significantly higher two-hour pain-free rates compared to those who waited.
Researchers found that Cox-2 inhibitors slowed disease progression in men with recurrent prostate cancer by inhibiting tumor growth and increasing programmed cell death. The study showed significant results in 22 of 24 patients, with a 92% reduction in PSA levels after three months.
Researchers found that COX-2 inhibitors significantly reduced postoperative pain, nausea and vomiting, and allowed patients to return home sooner. The study showed a 21% reduction in opiate use and improved patient satisfaction with minimally invasive surgery.
A new study suggests that aspirin reduces breast cancer risk by 20% among women with ER-positive tumors, a type of postmenopausal breast cancer. The protection is strongest among daily aspirin users and those taking seven or more tablets per week.
A study found that frequent users of aspirin and other NSAIDs had a 20-28% lower risk of breast cancer compared to nonusers. The inverse association was most pronounced among frequent users and those with hormone receptor-positive tumors.
The US Preventive Services Task Force recommends against routine ovarian cancer screening due to no evidence that it reduces mortality. In contrast, they support regular eye exams for children under 5 to detect amblyopia and other causes of visual impairment. Early detection can improve visual acuity and prevent long-term harm.
Researchers found that African-American and Hispanic outpatients with back pain were less likely to receive painkillers than white patients. The study attributes this disparity to racial stereotypes among physicians, suggesting a potential issue with racism in the US healthcare system.
Researchers found that consumer awareness of NSAID side effects has increased over time, but many patients still take excessive doses, putting themselves at risk for serious complications. The study emphasizes the need for education and discussion with physicians to recognize risk factors and prevent adverse reactions.
A new molecule, AM1172, has been identified as a potential treatment for overeating and drug dependency. By regulating the brain's natural 'bliss' system, AM1172 may help counterbalance feelings of anxiety and depression that contribute to obesity and substance dependence.
A multicentre, randomized, double-blind and placebo-controlled study is underway to evaluate the efficacy and safety of Tectin in moderate to severe inadequately controlled cancer-related pain. The trial has shown promising results, with almost three-quarters of patients experiencing a clinically meaningful analgesic response.
A University of Michigan team found that only half of pharmacies in non-white areas had a sufficient supply of opioid painkillers. Pharmacies in wealthier ZIP codes tended to have better supplies, while those in poorer areas were less likely to carry the drugs due to perceived threats of robbery and street value.
A multicenter study found that the maximum daily OTC dose of acetaminophen (4000mg) was as effective as prescription doses of naproxen (750mg) for osteoarthritis pain relief. The study involved 551 patients with mild-to-moderate OA and showed no significant differences in efficacy between the two treatments over a six-month period.
The KRONUS-MSP trial found that switching to sustained-release opioid Kadian improves pain relief and quality of life, while reducing the need for medication. Patients who previously exceeded recommended doses of OxyContin or MS Contin found relief with Kadian.
Researchers developed a new technique to selectively delete C-fiber neurons, which transmit chronic pain signals, using the drug resiniferatoxin. In animal studies, this approach reduced pain and improved behavior without side effects.
A study of 160 pregnant women with genetic risk factors for thrombophilia found that enoxaparin significantly reduced pregnancy loss compared to low-dose aspirin. Women taking enoxaparin had a normal live birth rate of 86% and healthy newborns, while those on aspirin suffered more pregnancy losses.
Researchers found that statin use was associated with a 50% reduced risk of developing wet AMD, while aspirin use was linked to a 40% lower risk. The study suggests that these medications may prevent irreversible vision loss in older adults.
A new AAN guideline has resolved debate surrounding the role of Patent Foramen Ovale (PFO) in stroke risk. The guideline found no evidence to support or refute closing PFOs, but notes an increased risk for younger patients with both a PFO and atrial septal aneurysm (ASA). Further research is needed to determine the best treatment options.
Patients with chronic obstructive pulmonary disease (COPD) are at increased risk of nonvertebral fractures from high-dose inhaled corticosteroid treatment. Researchers also found greater acetaminophen use linked to newly diagnosed asthma in women. Air pollution exposure worsens cystic fibrosis patients' pulmonary exacerbations.
A new transdermal system, E-TRANS fentanyl PCTS, has been shown to be as effective as traditional IV pumps for post-surgical pain relief. The system delivers pain medication through the skin with a low-level electric current and can be used for patients with moderate to severe post-operative pain after various surgeries.
A study published in JAMA found that a transdermal patch delivering fentanyl is equivalent to an intravenous pump for postoperative pain control. The patch, called PCTS, eliminated the need for needles and mobility restrictions. Patient assessments showed high rates of good or excellent pain control with both methods.
A multi-center trial comparing three medications in patients with heart failure showed no significant differences between warfarin and antiplatelet therapies in terms of death, non-fatal heart attacks and strokes. However, hospitalizations for worsening heart failure were significantly less frequent in patients treated with warfarin.
A new study from Michigan Medicine found that heart attack and angina patients experience difficulties sticking to their medication regimens six months after hospitalization. Forgetfulness, carelessness, and side effects are among the top reasons for non-adherence, affecting up to half of the patients studied.
A recent study found that sumatriptan nasal spray provides good to excellent headache relief in over three-quarters of children with chronic migraines. The off-label use of the medication has been shown to be effective and safe for treating this condition, especially when other treatments have failed.
A study by Duke University Medical Center researchers found that state-mandated continuing medical education (CME) programs for physicians have little association with improved heart attack care outcomes. However, CME-required states showed a significant increase in the use of branded thrombolytic therapies, which may be influenced by ...
A study by Casa Colina Centers for Rehabilitation found that elderly patients experienced decreased pain intensity and improved sleep disturbances with once-daily Kadian dosing. The trial, KRONUS-MSP, showed a lower incidence of side effects compared to other opioids, making it an ideal option for managing chronic pain in older adults.
The future of drug delivery involves 'smart' systems addressing issues like gut, skin, and lung penetration, promising improved patient compliance and treatment efficacy.
A Mayo Clinic study of 100 patients with advanced pancreatic cancer found that a nerve block technique, combined with pain-relieving medications, provided a 50% reduction in pain and improved quality of life. The study suggests that this treatment option could be beneficial for patients with pancreatic cancer, allowing them to live mor...
A new study published in the journal Pain found that people with depression are four times more likely to develop intense or disabling neck and low back pain. Researchers hope to uncover why these conditions are commonly linked, exploring coping methods to break a vicious cycle.
A 26-week study found that topiramate significantly reduced monthly migraine frequency (-2.1 and -2.4 mg/d) and days with migraines compared to placebo. The medication also decreased rescue medication use, providing improved treatment outcomes for patients.
A study published in Anesthesia & Analgesia found that patients who used E-TRANS Fentanyl HCI PCTS experienced better pain control and fewer withdrawals compared to those who received a placebo. The novel transdermal system, approximately the size of a credit card, allows patients to control their pain management without needles or pumps.
Two studies in the February 18 issue of JNCI investigated aspirin use and its association with two types of cancer. Regular aspirin use was found to lower Hodgkin's lymphoma risk, while patients with Barrett's esophagus may benefit from cost-effective aspirin therapy for esophageal cancer chemoprevention.
A study examined trends in potentially inappropriate drug prescribing at ambulatory care visits among older adults from 1995 to 2000. The research found that pain relievers and central nervous system drugs made up most of the inappropriate prescriptions, with rates higher for patients with multiple prescriptions and women.