Research on measurable signals of health and disease. Covers ultrasound imaging pipelines, fetal-distress detection, cancer monitoring, and fatigue biology.
Researchers at the University of Pittsburgh Medical Center have identified protein biomarkers that accurately diagnose ALS with near 100% specificity and sensitivity. The findings may lead to a new test for early-stage ALS, enabling faster diagnosis and monitoring of treatment efficacy.
Research suggests green tea consumption may prevent cancer and reduce oxidative DNA damage, with potential chemopreventive effects of green tea polyphenols. The study also identified novel EGCG analogs with potent anti-tumor activity.
A study by Pollack and colleagues finds that a high Ki-67 biomarker is linked to increased risk of distant metastasis and death in prostate cancer patients. The researchers also suggest that Ki-67 can help identify high-risk patients who may benefit from alternative treatment strategies.
CYC202 demonstrates significant cancer cell death, with 54% of patients testing positive for apoptosis following single agent treatment. Seven patients experienced long-lasting tumour stabilisation in Phase I trials, showcasing potential for selective treatment based on genetic profiles.
Researchers at PNNL and UCLA have discovered six times more proteins in NAF than previously identified, suggesting its potential as a biomarker for breast cancer. The study aims to develop a more accurate, non-invasive method for early diagnosis.
Researchers identified a strong association between EZH2 and ECAD biomarkers and prostate cancer recurrence. Moderate or strong expression of EZH2 coupled with at most moderate expression of ECAD is most strongly associated with biochemical recurrence.
A new study has found that cerebrospinal fluid biomarkers may be effective in detecting early stages of Alzheimer's disease, with a sensitivity of 92% and specificity of 89%. The researchers suggest that these biomarkers could be used to identify people at risk of developing the disease.
A new study finds that ethyl glucuronide (EtG) is a highly effective and sensitive marker of recent alcohol use, detecting consumption up to 80 hours after complete elimination. The marker helps identify patients who have lapsed or relapsed in treatment, ensuring they are alcohol-free for work and other activities.
This year's AACR honorees have made significant advances in understanding and treating cancer. The winners include Mario R. Capecchi, Ronald A. DePinho, Carlos L. Arteaga, Malcom F. Stevens, Martin J. Blaser, David S. Alberts, Graham A. Colditz, Janet D. Rowley, who will receive awards for their outstanding research in various areas of...
Researchers found a connection between HIV antiretroviral therapy and impaired triglyceride metabolism, increasing risk of atherosclerosis. Elevated ApoC-III levels were associated with higher triglycerides in both treatment groups.
The Fred Hutchinson Cancer Center is developing a blood test for breast cancer detection, using biomarkers such as circulating breast-tumor cells and growth factors. The project aims to improve breast-cancer detection and diagnosis by complementing mammography with molecular-screening tools.
The Osteoarthritis Initiative will recruit 5,000 participants aged 50+ at high risk for knee osteoarthritis. The project aims to establish a natural history database for osteoarthritis, allowing researchers to identify potential new disease targets and develop tools for understanding disease progression.
Researchers analyzed biomarker data from over 700 healthy men and 60 rhesus monkeys, finding lower body temperatures, blood insulin levels, and higher DHEAS levels in those on a calorically restricted diet were associated with longer lifespan. The study suggests potential for developing compounds that mimic the benefits of caloric rest...
Researchers develop surface-enhanced laser desorption/ionization time-of-flight mass spectrometry (SELDI) for identifying potential biomarkers of early stage breast cancer. The study achieved high sensitivity and specificity, suggesting SELDI may lead to the discovery of additional biomarkers.
Researchers from SurroMed and Penn State University have developed Nanobarcodes particles, which can identify individual particles using optical microscopy. This technology enables multiplexed bioassays in solution, revolutionizing life science research and disease diagnosis.
A study published in The American Journal of Clinical Nutrition found that two major US dietary patterns, prudent and Western, result in distinct health risks. The prudent diet was associated with a favorable biomarker profile, while the Western diet was linked to higher plasma levels of biomarkers for cardiovascular disease risk and l...
A study discovered a link between lower platelet adenylyl cyclase activity and increased risk of alcoholism. Recent alcohol consumption was found to be a confounding variable, and other factors such as major depression and hyperlipidemia were also associated with low AC activity.
Researchers discovered that high levels of BAG-1 protein correlate with better long-term survival and overall survival rates for women with early breast cancer. The study found a significant difference in 10-year survival rates between women with high and low BAG-1 protein levels.
Free-radical activity was found to be roughly doubled in the frontal and temporal lobes of brains of people who died of Alzheimer's disease. The levels of two biochemical markers of free-radical tissue damage were also elevated in these areas, which are critical for memory and intellectual function.