Articles tagged with Clinical Trials
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A combination of short-course hormonal therapy and stereotactic body radiation therapy has been shown to be safe and effective in treating metastatic prostate cancer. In a preliminary study, 50% of patients remained recurrence-free six months after treatment, with less than a quarter experiencing severe side effects.
A new acceptable practice standard for hypofractionated post-prostatectomy radiotherapy has been established based on the NRG Oncology trial findings. The study showed that HYPORT was non-inferior to COPORT in terms of late GI or GU toxicity, with greater short-term GI toxicity associated with HYPORT but resolving at 6 months following...
The RUBY Part 2 trial shows significant improvement in progression-free survival for patients with primary advanced or recurrent endometrial cancer treated with dostarlimab. Dostarlimab plus niraparib plus carboplatin/paclitaxel demonstrates a role for PARP inhibitor maintenance in improving patient outcomes.
A study published in Lancet Gastroenterology & Hepatology found that not placing a drain during distal pancreatectomy surgery improves patient outcomes. The study, involving 282 patients across ten Dutch and two Italian hospitals, demonstrated a significant reduction in postoperative pancreatic leaks and overall morbidity.
Researchers at Mass General Cancer Center have achieved dramatic tumor regression in glioblastoma patients after receiving next generation CAR-T therapy. The treatment, known as INCIPIENT, combines two forms of therapy to target mixed cell populations within tumors.
Early trial results from six patients with recurrent glioblastoma show reduced tumor sizes after administering dual-target CAR T cells targeting EGFR and IL13Rα2 intrathecally. This 'dual-target' approach may outsmart the defense systems of GBM, leading to more effective therapies.
A randomized clinical trial of 345 patients with mild-to-moderate COVID-19 found that viral load and symptom rebound were common after a standard 5-day course of antiviral treatment. Prolonging treatment duration may help reduce COVID-19 rebound
Researchers used generative AI to design a lead molecule for treating fibrosis, a biological process associated with aging. The compound, INS018_055, demonstrated significant efficacy in preclinical studies and showed promising results in clinical trials, accelerating drug discovery and providing new therapeutic options.
A multicenter randomized trial showed a paclitaxel-coated balloon to be superior to an uncoated balloon in preventing target lesion failure in patients with coronary in-stent restenosis. The study included 600 patients and demonstrated the effectiveness of paclitaxel-coated balloons as a treatment option.
A randomized clinical trial found that linkage case management intervention did not improve 12-month mortality outcomes for hospitalized people with HIV. The study involved 500 participants and sheds light on the potential role of this intervention among hospitalized individuals with HIV.
A new study combines virtual reality exposure with transcranial direct current stimulation to treat post-traumatic stress disorder in military veterans. The innovative approach shows significant reductions in PTSD symptom severity and accelerates psychological adjustment, offering hope for an effective treatment.
Researchers have developed an injectable hydrogel that mitigates damage to the right ventricle of the heart in children with hypoplastic left heart syndrome. The treatment, made from cardiac extracellular matrix, improves heart function and slows tissue scarring, potentially increasing patient survival time.
A pilot study has confirmed the feasibility and acceptability of a bowel symptom intervention for rectal cancer survivors. The intervention, which included dietary changes and phone-based support, showed some benefits in reducing symptoms such as frequent bowel movements and bloating.
A UTEP clinical trial will enroll local school district employees in a program challenging them to walk at least 50K steps per week. The study aims to improve health equity and measure the effectiveness of group fitness challenges in Hispanic populations.
The latest American Psychiatric Association journals feature new treatments across the lifespan for anxiety, depression, and substance use disorder. The March issue of The American Journal of Psychiatry highlights several studies with these findings.
Seven high-impact studies will be showcased, exploring novel therapies and improving treatment outcomes for patients with head and neck squamous cell carcinoma. These findings highlight advancements in immunotherapy, risk-directed adjuvant therapy, and FDG-PET-based selective de-escalation of radiotherapy.
A team of scientists at The Hospital for Sick Children developed an innovative statistical approach to demonstrate the effectiveness of a medication in reducing disease progression and liver transplants in children with Alagille syndrome. Using data from an international real-world cohort, they found a 70% improvement in event-free sur...
A new study found that high-dose inhaled nitric oxide improves oxygenation and reduces mortality risk among critically ill Black patients with COVID-19. The treatment was more effective for Black patients, who have a suppressed nitric oxide system at baseline.
PandaOmics uses advanced AI algorithms to process vast quantities of diverse data, performing gene and pathway analysis and target predictions. The platform has been extensively validated in multiple therapeutic areas, including oncology, inflammation, and immunology.
The MUSC Florence Research Center is one of four community-based clinical research sites selected to participate in the EQBMED Initiative, aiming to attract more people of color to clinical research. The program seeks to provide easy access to clinical trials in local communities and adapt trial designs to suit regional hospitals' needs.
A large clinical trial found that an intervention for pregnant women in Pakistan significantly reduced the likelihood of developing moderate-to-severe anxiety and depression after birth. The intervention, led by Dr. Pamela J. Surkan, was administered by non-specialized providers and showed promising results.
A combination of CS1002 and CS1003 showed promising anti-tumor activity and a manageable safety profile across various dosing ranges in patients with advanced solid tumors. The treatment was found to be effective in certain types of cancers, including melanoma and skin cancer.
A new off-the-shelf vaccine has shown promise in treating pancreatic and colorectal cancers in patients with KRAS mutations. The study found that the vaccine significantly decreased tumor biomarkers and produced strong T-cell responses, leading to a reduced risk of relapse and death.
The REHAB-HFpEF study, led by Dalane Kitzman, aims to reduce rehospitalizations and mortality in older patients with HFpEF. A novel physical rehabilitation intervention is being tested at Advocate Christ Medical Center in Chicago.
Three Virginia health systems are part of a new NIH research network studying emerging cancer screening technologies, aiming to reduce cancer-related illnesses and deaths. The network will evaluate the benefits and harms of multi-cancer detection tests, which screen for multiple types of cancers simultaneously.
Researchers created Elenagen, a novel DNA immunotherapy for deadly ovarian cancer, which significantly enhances standard chemotherapy and provides clinical benefits. The study shows that Elenagen delays disease progression in patients with stage III and IV platinum-resistant ovarian cancer.
Researchers identified a putative paclitaxel response predictive biomarker for glioblastoma and breast cancer using the whole genome CRISPR knockout screen. The biomarker candidate was validated in two independent breast cancer patient cohorts that received taxane treatment.
Using intravascular imaging to guide stent implantation significantly improves survival and reduces adverse cardiovascular events compared to angiography-guided PCI. The study found a 25% reduction in all-cause death, 45% reduction in cardiac death, and improved outcomes for patients with coronary artery disease.
A team of researchers from the University of Tokyo demonstrated that a drug, valemetostat, reduces tumor growth in blood cancer by targeting H3K27me3, a protein modification silencing tumor suppressor genes. The treatment restores expression of many tumor suppressor genes and sustains inhibiting tumor cell growth.
A randomized clinical trial found acupuncture to be clinically efficacious and favorably affect PTSD symptoms in combat veterans. The study suggests that further research is needed to explore the efficacy and mechanisms of acupuncture for PTSD treatment.
The American Gastroenterological Association recommends fecal microbiota transplant (FMT) as a safe and effective treatment for most patients with recurrent Clostridioides difficile infection. FMT offers hope to patients suffering from debilitating C. diff, enabling them to lead happy and healthy lives.
A fasting-mimicking diet has been shown to reduce signs of immune system aging, insulin resistance, and liver fat in humans, resulting in a lower biological age. The study found that patients who followed the diet had lower disease risk factors and improved immune function.
In a phase 2 clinical trial, zilebesiran significantly reduced 24-hour mean ambulatory systolic blood pressure in adults with mild to moderate hypertension. The treatment was administered subcutaneously at varying doses and intervals, demonstrating its potential as an RNA interference therapeutic for managing hypertension.
A study co-led by Prof. Kelly Metcalfe finds risk-reducing mastectomies significantly reduce breast cancer risk and death probability in women with a BRCA1 or BRCA2 genetic variant. The procedure reduces the risk of breast cancer by 80% and decreases mortality to less than 1%.
Researchers at UCLA Health Jonsson Comprehensive Cancer Center have identified the protein TYRP1 as a promising target for CAR T-cell therapy. The study demonstrates potent antitumor responses against cutaneous and rare melanoma types, offering new hope for treating these challenging-to-treat cancers.
The Phase 2 SMART trial demonstrates that ablative stereotactic magnetic resonance-guided adaptive radiation therapy improves local control (LC) and overall survival (OS) in patients with borderline resectable and locally advanced pancreas cancer. Long-term outcomes show encouraging OS and limited toxicity.
The D-CARE Study successfully enrolled 2,176 racially/ethnically diverse persons with Alzheimer's disease or related dementias and their caregivers, highlighting the importance of adaptable recruitment strategies. The study provides valuable insights into how to better support patients with dementia and their caregivers.
A new treatment combining a novel drug with traditional chemotherapy has been shown to increase the survival of patients with malignant mesothelioma, a rare and aggressive cancer. The ATOMIC-meso trial found that this treatment quadrupled the survival at 36 months compared to placebo-chemotherapy.
A new study has found that routinely changing surgical gloves and instruments is cost-effective and safer, reducing surgical site infections (SSIs) by 13% in seven low- and middle-income countries. The economic evaluation, funded by the UK's National Institute for Health and Care Research, compared the costs and SSIs associated with ro...
A new clinical trial demonstrates a small reduction in the latent reservoir of HIV-infected cells using a combination of vorinostat and immunotherapy. While the results are promising, further research is needed to create more effective approaches to flush out the virus and attack it when it emerges from latency.
An experimental mRNA vaccine against CMV elicited promising immune responses, outperforming a previous vaccine candidate in preventing the virus from infecting epithelial cells. The new vaccine may protect adults against CMV, potentially preventing women from passing the infection to their babies during pregnancy.
Researchers found that injecting a substance to block an artery and combining it with surgery significantly reduced the risk of repeat surgery for patients with subdural hematomas. The study, published at the American Stroke Association's International Stroke Conference, showed a nearly 3-fold reduction in re-operation rates.
Parents who received nutritional epigenetics education reduced ultra-processed food consumption and increased whole organic foods intake, leading to improved behavior and cognition in their children. The education intervention also reduced heavy metal exposures and dietary deficits that disrupt gene function.
A randomized clinical trial of 1,680 patients with acute ischemic stroke due to large-vessel occlusion found no significant improvement in disability with adjunctive methylprednisolone. The study suggests that methylprednisolone may not be effective as an adjunct therapy after endovascular thrombectomy for this patient population.
A randomized clinical trial of 336 patients with extensive ischemic stroke found that endovascular thrombectomy improved clinical outcomes across a range of infarct volumes. However, the treatment's effectiveness was limited by low enrollment rates among patients with minimal penumbra volume.
A randomized clinical trial of 1,015 participants found that apixaban did not significantly reduce recurrent stroke risk compared to aspirin in patients with cryptogenic stroke and atrial cardiopathy. The study suggests that alternative treatments may be more effective for preventing stroke recurrence in these patients.
Researchers found that positioning stroke patients with large vessel ischemic strokes at 0-degrees resulted in significant improvements in neurological function compared to those with 30-degree head positioning. This approach optimized blood flow through the narrowed artery and improved collateral arteries, leading to better outcomes.
A real-world study published in Pain Practice found that patients with neuropathic back pain, postoperative/posttraumatic pain, or shingles experienced reduced pain intensity after multiple high-concentration capsaicin patch applications. The study also showed a significant reduction in opioid use among participants.
A new set of guidelines for reporting clinical trials of biofield therapies has been introduced, providing a 15-item intervention checklist to include detailed information on intervention protocols. The goal is to expedite peer review, facilitate trial replication, and inform decision-making in the clinical practice of biofield therapies.
Intravenous thrombolysis (IVT) plus thrombectomy demonstrates significant benefits over thrombectomy alone when administered within a short timeframe after symptom onset. This study, based on individual participant data from six randomized clinical trials, found IVT before thrombectomy to be time-dependent and statistically significant.
The study found that only 67.5% of trial publications reported patient-reported outcomes data, with a median time between publication and analysis of 10.5 months. The quality score of the data was low, with a mean score of 11.10 out of 24 points.
A Phase I first-in-human clinical trial has demonstrated the safety and anti-tumor activity of OMO-103, a novel MYC inhibitor. The study showed favorable safety profile with only mild side effects, and notable clinical benefits in patients, including disease stabilization and tumor shrinkage.
A clinical trial is underway to help patients with opioid use disorder (OUD) and post-traumatic stress disorder (PTSD) stick with medication treatment. The trial uses a patient-administered wearable device that delivers mild electrical stimulation to alleviate symptoms of both conditions.
A global study has identified evidence-based approaches to prevent breast cancer-related arm lymphoedema (BCRAL) by addressing risk factors and implementing surveillance programs. The research provides a clinical guide for healthcare teams worldwide to adopt a proactive approach in preventing this irreversible complication.
A meta-analysis of New Jersey clinical trials from 2017 to 2022 reveals an uptick in diversity among trial participants, with 97% reporting on race and/or ethnicity. Despite this progress, there is still work to be done to match U.S. Census demographics, but the study suggests recent efforts are having a positive impact.
The Butantan-DV vaccine has been shown to be effective in preventing dengue development in 79.6% of vaccinated individuals, regardless of age group or prior exposure history. The vaccine also demonstrated safety for all participants, with mild to moderate side effects reported.
New research finds that Black, Indigenous, and People of Color (BIPOC) individuals experience greater negative impacts on their health status, activity levels, and ability to work after COVID-19 infection compared to white participants. The study highlights the need for equitable health interventions for underserved populations.
A new study found that structured telephone-based psychological care can significantly reduce depression levels and combat loneliness. The trial, which lasted eight weeks, showed benefits even after the phone calls ceased.
A phase II clinical trial found Muse cell-based product CL2020 to be highly tolerated and improved ALS symptoms, but may not halt disease progression. The treatment's efficacy depends on combining it with other drugs for future treatments.
A large multicenter clinical trial found that an antiseptic containing iodine resulted in about one-quarter fewer post-surgical infections in patients with limb fractures compared to another frequently used skin antiseptic. The study included nearly 8,500 patients across the US and Canada.